Rhythm Pharmaceuticals(RYTM)

BOSTON, MAPharmaceutical1 H-1B visas (FY2023)

Focus: Rhythm Pharmaceuticals is a public specialty pharma company focused on peptide therapeutics for rare genetic obesity and neurological indications. With 201-500 employees and $77M in FY2025 revenue, they operate as a focused, commercial-stage biotech.

Neurology

Profile data last refreshed 55m ago · AI intelligence enriched 2w ago

Funding Stage

PUBLIC

Employees

201-500

Open Jobs

28-4 this month

Stable — net -4 jobs in 30d

6 added, 10 removed. Backfill posture.

Should You Work at Rhythm Pharmaceuticals?

AI assessment

Attractive for commercial and regulatory talent betting on rare obesity upside, but R&D-heavy cash burn and shallow pipeline pose medium-term sustainability risk.

Why Work Here

Commercial ramp underway with 18 open positions targeting IMCIVREE (setmelanotide) market expansion, showing growth trajectory
Peak-stage blockbuster drug with $77M FY2025 revenue and expanding pipeline in high-unmet-need genetic obesity indications

Data completeness

7/9 — Strong

Company HealthStrong

Pipeline

Early-stage

50 total

LOE Risk

Protected

No near-term cliffs

Hiring

Stable

Revenue

$77M

Key Products

IMCIVREE

Genetic obesity (POMC, PCSK1, LEPR deficiency; Bardet-Biedl; Prader-Willi; hypothalamic obesity)

Peak

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Pipeline & Clinical Trials

Silverlon®

Infections

N/A

Clinical Trials (1)

NCT02781779Comparison of Outcomes Between the Use of Silverlon® Dressing and AQUACEL® AG Dressing Post Cardiac Device Implant

N/A

Observational

Bradycardia Sinus

N/A

Evera MRI ICD System

Arrhythmias, Cardiac

N/A

Pacemaker lower rate setting

Sinus Node Dysfunction

N/A

prayer

Coronavirus Infection

N/A

Clinical Trials (1)

NCT04361838The COVID-19 ICU PRAYER Study

N/A

Protecta VR-ICD

Tachyarrhythmias

N/A

Reveal® DX or Reveal® XT Insertable Cardiac Monitor

Arrhythmias, Cardiac

N/A

ICD or CRT-D Device

Sudden Cardiac Arrest

N/A

Treatment for intracranial aneurysms

Intracranial Aneurysm

N/A

the coronary sinus balloon pump

STEMI

N/A

Clinical Trials (1)

NCT07082153The First-In-Man Use of Coronary Sinus Balloon Pump in STEMI Patients Treated by Primary PCI

N/A

Melody valve implantation

Right Ventricular Congenital Cardiopathies

N/A

Study-required procedures include: tissue collection from device capsule, questionnaire collection, and photo collection

Cardiac Disease

N/A

Intracardiac electrode catheter

Cardiac Arrhythmias

N/A

Bi-plane fluoroscopy

Heart Diseases

N/A

Medtronic Dual-Chamber Pacemaker

Cardiac Pacing, Artificial

N/A

Defibrillation

Tachyarrhythmia

N/A

LINQ/LINQ II

Atrial Arrhythmia

N/A

Medtronic CoreValve System

Aortic Valve Stenosis

N/A

Medtronic CoreValve System

Severe Aortic Stenosis

N/A

Implantable Cardioverter Defibrillator

Heart Diseases

N/A

MARVEL 2 Algorithm Monitor Mode then Adaptive Mode

Atrioventricular Conduction Block

N/A

Medina Embolization Device In Neurovascular Aneurysm Study

Intracranial Aneurysm

N/A

Transvenous hypoglossal nerve stimulation

Sleep Apnea, Obstructive

N/A

RV lead placement site

Left Ventricular Dysfunction

N/A

Advisa IPG

Bradycardia

N/A

P3: Pacemaker Patient Profiling Study

Bradycardia

N/A

Implanted Device

Tachycardia, Ventricular

N/A

Kansas City Cardiac Dysautonomia Questionnaire

Cardiac Dysautonomia

N/A

Clinical Trials (1)

NCT06672861Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ)

N/A

Ventricular Electrical Synchronization by Stimulating Left and Right Bundle Branches Area in Pacing-

Cardiac Pacing

N/A

Evidence based guidelines and tools

Sinus Node Dysfunction

N/A

Out of cathlab insertion

Arrhythmia

N/A

Acute Subcutaneous Defibrillation

Ventricular Arrhythmias

N/A

Full Automaticity and Remote Follow-up

Tachyarrhythmia

N/A

Micra Pacemaker Implant

Class I or II Indication for Implantation of a Single Chamber Ventricular Pacemaker According to ACC/AHA/HRS 2001 Guidelines and Any National Guidelines

N/A

Image Location and Performance of Left Bundle Branch Pacing

Cardiac Pacing

N/A

The coronary sinus balloon pump

STEMI

N/A

Clinical Trials (1)

NCT07354035The Coronary Sinus Balloon Pump in STEMI

N/A

Carelink System

Arrhythmia

N/A

Development of AD/OI after BS

Autonomic Dysfunction

N/A

Clinical Trials (1)

NCT06289413Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study

N/A

ICD

Ventricular Tachycardia

N/A

High School Students Survey

Sudden Cardiac Arrest

N/A

Clinical Trials (1)

NCT04493970HS Students Mandatory Universal Student Instruction in CPR Appraised Learning- Is the Mandate Working?

N/A

PURE EP

Cardiac Arrhythmias

N/A

Clinical Trials (1)

NCT05450302Assessing the Predictive Value of High Frequency Algorithm of PURE EP for Low Amplitude Signal Detection

N/A

EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annu

Mitral Valve Insufficiency

N/A

Medtronic Engager Transcatheter Aortic Valve Implantation System

Aortic Valve Stenosis

N/A

Defibrillation using the Extravascular ICD

Tachycardia

N/A

INDIcators for Clarifying the bAckground of exTreme Obesity in childRen

Gene Abnormality

N/A

Clinical Trials (1)

NCT06420622INDIcators for Clarifying the bAckground of exTreme Obesity in childRen

N/A

Implantable Pulse Generators

Sick Sinus Syndrome

N/A

Melody Transcatheter Pulmonary Valve

Heart Valve Diseases

N/A

Non-slip Balloon Catheter of Shanghai MicroPort Rhythm

Coronary Artery Stenosis

N/A

Clinical Trials (1)

NCT05606367Coronary Non-slip Balloon Catheter in Patients With Coronary Artery Stenosis(CREST)

N/A

CoreValve Advance-II Study: Prospective International Post-market Study

Aortic Valve Stenosis

N/A

Single Chamber Implantable Cardioverter Defibrillator

Ventricular Tachycardia

N/A

Interview Prep Quick Facts

Founded: 2024

Portfolio: 1 approved product, 96 clinical trials

Top TAs: Cardiovascular, Metabolic Diseases, Neurology

H-1B (2023): 1 approval

Publications: 25 in PubMed

SEC Filings: 2 available

Open Roles: 28 active jobs

Portfolio Health

Peak1 (100%)

1 total products

Therapeutic Area Focus

Cardiovascular

39 pipeline

Metabolic Diseases

1 marketed24 pipeline

Neurology

6 pipeline

Endocrinology

1 pipeline

Nephrology

1 pipeline

Financials (FY2025)

Revenue

$77M228%

R&D Spend

$135M(174%)24%

Net Income

-$185M

Hiring Trend

Slowing Down

Open Roles

Added

-3

Filled/Removed

Based on last 4 crawl cycles

Visa Sponsorship

Sponsors Work Visas

H-1B Petitions (FY2023)

Approved

Denied

100%

Rate

Source: USCIS H-1B Employer Data Hub

Research Publications(10)

Recent peer-reviewed publications with author affiliations at this company

Setmelanotide in Bardet-Biedl Syndrome: A 52-Week Comparison of Phase 3 Trial Participants With a Matched Registry Cohort.

Obesity (Silver Spring, Md.)

2026

PMID:41703984

Epidemiology of acquired hypothalamic obesity following traumatic brain injury and nonspecific hypothalamic microinjury: A nationwide German claims data analysis.

Rhythm Pharmaceuticals(RYTM)

Should You Work at Rhythm Pharmaceuticals?

Why Work Here

Key Products

Watch Out For

Products & Portfolio (1)

Pipeline & Clinical Trials

Recent News · Rhythm Pharmaceuticals(10)

Open Jobs (28)

Manager, Drug Product

Director, Nonclinical Development

Chief of Staff

Senior Brand Manager Germany, Switzerland and Austria

Manager, Medical Information

Pharmacovigilance (PV) Specialist

Employee Experience Manager

Swiss Responsible Person and GDP Quality Assurance

Territory Manager (Pittsburgh, PA)

IT Systems Engineer

Business Operations Support – Germany, Switzerland, Austria (GSA)

Manager, Device Quality Assurance

Manager, Supply Chain

Payroll Manager

Associate Director, Regulatory Operations

Territory Manager (Atlanta, GA)

Area Development Manager (West)

Area Development Manager (Southeast)

Area Development Manager (South)

Area Development Manager (Northwest)

Senior Manager, International Market Access

Scientific Affairs Manager, Switzerland

Scientific Affairs Manager, Austria

Scientific Affairs Manager - Germany (Southwest)

Office & Operations Manager, The Netherlands

Financials (FY2025)

Hiring Trend

Visa Sponsorship

Research Publications(10)