Intracranial Aneurysm

Pipeline Programs

Companies

Clinical Trials

8 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

23 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

MedtronicNJ - Phillipsburg

11 programs

Artisse™ Intrasaccular DeviceN/A1 trial

Medina Embolization Device In Neurovascular Aneurysm StudyN/A1 trial

MicroFx™ PGLA COILSN/A1 trial

Pipeline Embolization DeviceN/A1 trial

Pipeline™ Embolization Device/ Pipeline™Flex Embolization DeviceN/A1 trial

+6 more programs

Active Trials

NCT02998229Recruiting300Est. Feb 2032

NCT02982200Terminated15Est. Oct 2018

NCT01194388Withdrawn0Est. Feb 2012

+8 more trials

BALTCA - Irvine

7 programs

BALT Medical DevicesN/A1 trial

Endovascular TreatmentN/A2 trials

Intracranial aneurysm treated with Silk vista and silk vista babyN/A1 trial

LEO+ StentN/A

OPTIMA Coil SystemN/A1 trial

+2 more programs

Active Trials

NCT04927156Recruiting10,000Est. Oct 2041

NCT03504436Completed176Est. Jan 2019

NCT01084681Unknown160Est. Oct 2012

+4 more trials

PhenoxGermany - Bochum

7 programs

Coated Mongolian Aneurysm Treatment Study 2N/A1 trial

Endovascular treatment of bifurcation aneurysm with pCONUS2N/A1 trial

Endovascular treatment of intracranial aneurysmsN/A1 trial

Endovascular treatment of unruptured aneurysms with p64 MW HPC Flow Modulation DeviceN/A1 trial

implantation of the pCONus Bifurcation Aneurysm ImplantN/A1 trial

+2 more programs

Active Trials

NCT04305704Unknown90Est. Dec 2023

NCT03273478Unknown100Est. Dec 2021

NCT04305626Unknown90Est. Dec 2023

+2 more trials

StrykerCA - San Jose

6 programs

Endovascular treatment of intracranial aneurysm.N/A1 trial

Endovascular treatment of intracranial aneurysms using a flow-diverting stentN/A1 trial

Neuroform Atlas Stent SystemN/A1 trial

Neuroform Atlas Stent for Intracranial Aneurysm TreatmentN/A1 trial

Next Generation Neuroform Stent SystemN/A1 trial

+1 more programs

Active Trials

NCT00928265Completed116Est. Dec 2010

NCT04572230Active Not Recruiting405Est. Aug 2025

NCT04162483Unknown310Est. Jul 2021

+3 more trials

CerusCA - Concord

5 programs

Contour Neurovascular SystemN/A1 trial

Contour Neurovascular System placementN/A1 trial

NeXsys Embolization SystemN/A1 trial

NeqstentN/A1 trial

Active Trials

NCT03680742Completed34Est. Feb 2021

NCT04579081Withdrawn0Est. Jun 2023

NCT02784431Terminated20Est. Oct 2018

+2 more trials

MicroPortChina - Shanghai

4 programs

Coil Embolization SystemN/A

Endovascular treatmentN/A

Microport NeuroTech Tubridge Plus flow-diverter StentN/A

Nufairy® Coil embolization system for intracranial aneurysmN/A

Neurotech PharmaceuticalsRI - Cumberland

4 programs

Coil Embolization SystemN/A1 trial

Endovascular treatmentN/A1 trial

Microport NeuroTech Tubridge Plus flow-diverter StentN/A1 trial

Nufairy® Coil embolization system for intracranial aneurysmN/A1 trial

Active Trials

NCT02990156Completed334Est. Nov 2020

NCT05646108Unknown5,000Est. May 2023

NCT05898893Unknown99Est. Dec 2024

+1 more trials

Rhythm PharmaceuticalsBOSTON, MA

3 programs

Medina Embolization Device In Neurovascular Aneurysm StudyN/A

Pipeline™ Flex Embolization Device with Shield Technology™N/A

Treatment for intracranial aneurysmsN/A

AcandisGermany - Pforzheim

2 programs

Accero®N/A1 trial

Flow Diverter Treatment with DERIVO 2 Heal Embolisation DeviceN/A1 trial

Active Trials

NCT03957382Active Not Recruiting130Est. Mar 2029

NCT05543447Recruiting158Est. Dec 2026

PhilipsNetherlands - Amsterdam

2 programs

AneurysmFlowN/A1 trial

Neurovascular treatment of intracranial aneurysmsN/A1 trial

Active Trials

NCT03663257Completed132Est. Nov 2023

NCT03161769Unknown30Est. Sep 2019

Wallaby MedicalCA - Laguna Hills

2 programs

p64/p48 MW HPC Flow Modulation DeviceN/A1 trial

pEGASUS Stent SystemN/A1 trial

Active Trials

NCT06158750Recruiting120Est. Jun 2026

NCT06158087Recruiting130Est. Jun 2026

Rapid MedicalIsrael - Yokneam

1 program

Comaneci Embolization Assist DeviceN/A1 trial

Active Trials

NCT04518670Completed90Est. Jul 2024

Spryte MedicalMA - Bedford

1 program

Endovascular Intracranial aneurysm treatmentN/A1 trial

Active Trials

NCT07214220Not Yet Recruiting67Est. Feb 2029

Medica CorpMA - Bedford

1 program

Flow diverter implantationN/A1 trial

Active Trials

NCT07339358Not Yet Recruiting72Est. Aug 2028

Human BioSciencesWV - Martinsburg

1 program

Genetic Analysis of Familial Brain AneurysmsN/A1 trial

Active Trials

NCT00011856Completed300Est. Mar 2002

Genome & CompanyKorea - Suwon

1 program

Genetic Analysis of Familial Brain AneurysmsN/A

Innovation PharmaceuticalsMA - Wakefield

1 program

Hydrogel coilN/A1 trial

Active Trials

NCT01516658Completed431Est. Jun 2019

Cardiovascular Systems IncMN - St. Paul

1 program

Implantation of an eCLIPs™ deviceN/A

Evasc Medical SystemsBC - Vancouver

1 program

Implantation of an eCLIPs™ deviceN/A1 trial

Active Trials

NCT05330897Active Not Recruiting119Est. Dec 2026

City TherapeuticsMA - Cambridge

1 program

NCVC-CS1N/A1 trial

Active Trials

NCT02907229CompletedEst. Mar 2019

Unimed PharmaSlovakia - Bratislava

1 program

ObervationN/A1 trial

Active Trials

NCT04872842Completed1,000Est. May 2022

UNION therapeuticsDenmark - Hellerup

1 program

ObervationN/A

PenumbraALAMEDA, CA

1 program

Penumbra Smart CoilN/A1 trial

Active Trials

NCT02729740Completed995Est. Dec 2019

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

Medica CorpFlow diverter implantation

Spryte MedicalEndovascular Intracranial aneurysm treatment

MedtronicTreatment of Intracranial Aneurysms

BALTSilk Vista Flow Diverter

StrykerSurpass Evolve Flow Diverter System

MedtronicArtisse™ Intrasaccular Device

Wallaby MedicalpEGASUS Stent System

Neurotech PharmaceuticalsNufairy® Coil embolization system for intracranial aneurysm

Wallaby Medicalp64/p48 MW HPC Flow Modulation Device

BALTOPTIMA and OPTIMAX Coils manufactured by Balt USA

Neurotech PharmaceuticalsMicroport NeuroTech Tubridge Plus flow-diverter Stent

AcandisFlow Diverter Treatment with DERIVO 2 Heal Embolisation Device

MedtronicPipeline™ Flex Embolization Device with Shield Technology™

MedtronicTreatment of Intracranial Aneurysms

Evasc Medical SystemsImplantation of an eCLIPs™ device

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 28,135 patients across 50 trials

NCT07339358 Medica CorpFlow diverter implantation

Safety & Performance of the World Medica World Diverter Embolization Device

Start: Mar 2026Est. completion: Aug 202872 patients

N/ANot Yet Recruiting

NCT07214220 Spryte MedicalEndovascular Intracranial aneurysm treatment

Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation

Start: Feb 2026Est. completion: Feb 202967 patients

N/ANot Yet Recruiting

NCT06604884 MedtronicTreatment of Intracranial Aneurysms

NV PSR INSPIRE-A Pipeline™ Vantage Post Approval Study

Start: Dec 2025Est. completion: Sep 2033118 patients

N/ARecruiting

NCT07073118 BALTSilk Vista Flow Diverter

Safety and EffecTiveness of the Silk Vista Flow DiverteR in the TrEatment of Unruptured IntracrAnial AneurysMs

Start: Sep 2025Est. completion: Dec 2027100 patients

N/ANot Yet Recruiting

NCT06368622 StrykerSurpass Evolve Flow Diverter System

Evolve China PMCF Study

Start: Apr 2024Est. completion: Aug 2031500 patients

N/AActive Not Recruiting

NCT02998229 MedtronicArtisse™ Intrasaccular Device

The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).

Start: Apr 2024Est. completion: Feb 2032300 patients

N/ARecruiting

NCT06158087 Wallaby MedicalpEGASUS Stent System

To Evaluate the Safety and Efficacy of Intracranial Stent Assisted Endovascular Treatment of Intracranial Aneurysms

Start: Dec 2023Est. completion: Jun 2026130 patients

N/ARecruiting

NCT06466564 Neurotech PharmaceuticalsNufairy® Coil embolization system for intracranial aneurysm

Bioabsorbable/Nufairy Coil Application Trial in China

Start: Dec 2023Est. completion: Jun 2026258 patients

N/AActive Not Recruiting

NCT06158750 Wallaby Medicalp64/p48 MW HPC Flow Modulation Device

To Evaluate the Safety and Effectiveness of Flow Modulation Device for Intracranial Aneurysms

Start: Nov 2023Est. completion: Jun 2026120 patients

N/ARecruiting

NCT06282939 BALTOPTIMA and OPTIMAX Coils manufactured by Balt USA

Optima Coil Performance in The Interventional Management of Intracranial Aneurysms Registry

Start: Nov 2023Est. completion: Dec 2027600 patients

N/ARecruiting

NCT05898893 Neurotech PharmaceuticalsMicroport NeuroTech Tubridge Plus flow-diverter Stent

PARAT PLUS (The Tubridge Plus For The Treatment Of Wide-Necked Intracranial Aneurysms)

Start: May 2023Est. completion: Dec 202499 patients

N/AUnknown

NCT05543447 AcandisFlow Diverter Treatment with DERIVO 2 Heal Embolisation Device

DERIVO® 2heal® Study: Clinical Safety and Efficacy of the DERIVO® 2heal® Embolisation Device

Start: Dec 2022Est. completion: Dec 2026158 patients

N/ARecruiting

NCT04391803 MedtronicPipeline™ Flex Embolization Device with Shield Technology™

EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms With the Pipeline™ Flex Embolization Device With Shield TEchnology™ (ELEVATE)

Start: May 2022Est. completion: Oct 202525 patients

N/ATerminated

NCT05071963 MedtronicTreatment of Intracranial Aneurysms

INSPIRE Pipeline™ Shield Post Approval Study

Start: Dec 2021Est. completion: Apr 2028246 patients

N/AActive Not Recruiting

NCT05330897 Evasc Medical SystemsImplantation of an eCLIPs™ device

French eCLIPs™ Efficacy and Safety Investigation

Start: Dec 2021Est. completion: Dec 2026119 patients

N/AActive Not Recruiting

NCT04579081 CerusContour Neurovascular System

Post Market Clinical Follow-up (PMCF)Study of the Contour Neurovascular SystemTM

Start: Dec 2021Est. completion: Jun 20230

N/AWithdrawn

NCT04870047 PhenoxEndovascular treatment of unruptured aneurysms with p64 MW HPC Flow Modulation Device

Coating to Optimize Aneurysm Treatment In The New Flow Diverter Generation

Start: Sep 2021Est. completion: Dec 2025171 patients

N/AActive Not Recruiting

NCT04872842 Unimed PharmaObervation

Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on 100 Regional Medical Centers in China and Population Follow-up Study

Start: Sep 2021Est. completion: May 20221,000 patients

N/ACompleted

NCT04927156 BALTBALT Medical Devices

Safety, Performance and Usability of BALT Medical Devices: The EVIDENCE Post Marketing Clinical Follow-up Platform

Start: Jul 2021Est. completion: Oct 204110,000 patients

N/ARecruiting

NCT04572230 StrykerEndovascular treatment of intracranial aneurysms using a flow-diverting stent

International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach

Start: Dec 2020Est. completion: Aug 2025405 patients

N/AActive Not Recruiting

NCT04518670 Rapid MedicalComaneci Embolization Assist Device

Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS)

Start: Nov 2020Est. completion: Jul 202490 patients

N/ACompleted

NCT03873714 MedtronicPipeline™ Vantage Embolization Device with Shield Technology™

Pipeline™ Vantage Embolization Device With Shield Technology™ for Wide-Necked Intracranial Aneurysms (ADVANCE)

Start: Apr 2020Est. completion: Sep 202314 patients

N/ATerminated

NCT04305704 PhenoxCoated Mongolian Aneurysm Treatment Study 2

Coated Mongolian Aneurysm Treatment Study 2

Start: Feb 2020Est. completion: Dec 202390 patients

N/AUnknown

NCT04187573 CerusNeqstent

Coil Assisted Flow Diversion Safety and Performance Study

Start: Jan 2020Est. completion: Nov 202338 patients

N/ACompleted

NCT04162483 StrykerNeuroform Atlas Stent System

Safety and Performance of the Neuroform Atlas™ Stent System

Start: Nov 2019Est. completion: Jul 2021310 patients

N/AUnknown

NCT04034810 BALTIntracranial aneurysm treated with Silk vista and silk vista baby

Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment

Start: Nov 2019Est. completion: Nov 2027234 patients

N/AActive Not Recruiting

NCT03957382 AcandisAccero®

Evaluation of Safety and Efficacy of the Accero® (Heal) Stent for Intracranial Aneurysm Treatment

Start: Jul 2019Est. completion: Mar 2029130 patients

N/AActive Not Recruiting

NCT04305626 PhenoxEndovascular treatment of intracranial aneurysms

Coated Mongolian Aneurysm Treatment Study 1

Start: Jun 2019Est. completion: Dec 202390 patients

N/AUnknown

NCT03642821 BALTOPTIMA Coil System

Intracranial Aneurysms Treatment With the OPTIMA Coil System

Start: Mar 2019Est. completion: Feb 2023300 patients

N/ACompleted

NCT03273478 PhenoxEndovascular treatment of bifurcation aneurysm with pCONUS2

pCONUS2 Treatment of Wide Neck Intracranial Aneurysms 2

Start: Dec 2018Est. completion: Dec 2021100 patients

N/AUnknown

NCT03663257 PhilipsAneurysmFlow

Study to Evaluate Cerebral AneurysmFlow Results in Occlusion

Start: Oct 2018Est. completion: Nov 2023132 patients

N/ACompleted

NCT03680742 CerusContour Neurovascular System

Contour Neurovascular System - European Pre-Market Unruptured Aneurysm

Start: Sep 2018Est. completion: Feb 202134 patients

N/ACompleted

NCT05646108 Neurotech PharmaceuticalsEndovascular treatment

Tubridge Flow Diverter Study For Intracranial Aneurysms

Start: Apr 2018Est. completion: May 20235,000 patients

N/AUnknown

NCT02990156 Neurotech PharmaceuticalsCoil Embolization System

CATCH [Short Name for: Coil Application Trial in China]

Start: Aug 2017Est. completion: Nov 2020334 patients

N/ACompleted

NCT03161769 PhilipsNeurovascular treatment of intracranial aneurysms

MAXimizing Flow Diversion Effect On the Treatment of Large Intracranial Aneurysms With Embolization Devices

Start: Apr 2017Est. completion: Sep 201930 patients

N/AUnknown

NCT02982200 MedtronicMedina Embolization Device In Neurovascular Aneurysm Study

Medina Embolization Device In Neurovascular Aneurysm Study

Start: Dec 2016Est. completion: Oct 201815 patients

N/ATerminated

NCT02988128 MedtronicTreatment for intracranial aneurysms

Neurovascular Product Surveillance Registry

Start: Dec 2016Est. completion: Aug 20324,000 patients

N/ARecruiting

NCT02783339 StrykerNeuroform Atlas Stent for Intracranial Aneurysm Treatment

Neuroform Atlas Stent for Intracranial Aneurysm Treatment

Start: Sep 2016Est. completion: Jul 2020105 patients

N/ACompleted

NCT02784431 CerusContour Neurovascular System placement

Pilot Study of the Contour Neurovascular SystemTM

Start: Jul 2016Est. completion: Oct 201820 patients

N/ATerminated

NCT02729740 PenumbraPenumbra Smart Coil

Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil

Start: Jun 2016Est. completion: Dec 2019995 patients

N/ACompleted

NCT02907229 City TherapeuticsNCVC-CS1

Safety and Efficacy of Honeycomb Microporous Covered Stents (NCVC-CS1) for the Treatment of Intracranial Aneurysms

Start: May 2016Est. completion: Mar 2019

N/ACompleted

NCT02507531 CerusNeXsys Embolization System

INCA: Intracranial Aneurysm Treatment With NeXsys

Start: May 2016Est. completion: Jan 20193 patients

N/ATerminated

NCT02719522 MedtronicPipeline™ Flex Embolization Device with Shield Technology™

Pipeline Flex With SHield Technology Embolization - An International MulticEnter ObservationaL Post Market StuDy

Start: Mar 2016Est. completion: Aug 2019205 patients

N/ACompleted

NCT02554708 Phenoximplantation of the pCONus Bifurcation Aneurysm Implant

pCONus Treatment of Wide Neck Intracranial Aneurysms

Start: Aug 2015Est. completion: Oct 2019116 patients

N/ACompleted

NCT02340585 StrykerNext Generation Neuroform Stent System

Neuroform Atlas Stent System Study

Start: Jun 2015Est. completion: Sep 2022298 patients

N/ACompleted

NCT03504436 BALTEndovascular Treatment

Endovascular Treatment of Wide Neck Intracranial Aneurysms With the LEO + Stent : The LEO + II Cohort Study

Start: Mar 2015Est. completion: Jan 2019176 patients

N/ACompleted

NCT02186561 MedtronicPipeline™ Embolization Device/ Pipeline™Flex Embolization Device

Prospective Study on Embolization of Intracranial Aneurysms With Pipeline™ Embolization Device

Start: Jul 2014Est. completion: Dec 2018197 patients

N/ACompleted

NCT01516658 Innovation PharmaceuticalsHydrogel coil

HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study

Start: Jun 2012Est. completion: Jun 2019431 patients

N/ACompleted

NCT01194388 MedtronicMicroFx™ PGLA COILS

Axium Coil in Completing Endovascular Aneurysm Surgery Study

Start: Sep 2010Est. completion: Feb 20120

N/AWithdrawn

NCT01084681 BALTEndovascular Treatment

Efficacy Trial of Intracranial Aneurysm Treatment Using Two Different Endovascular Techniques

Start: Mar 2010Est. completion: Oct 2012160 patients

N/AUnknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

8 actively recruiting trials targeting 28,135 patients

23 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.