Heart Diseases

Pipeline Programs

Companies

Clinical Trials

6 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

3100%

+ 28 programs with unclassified modality

Competitive Landscape

25 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Martin PharmaceuticalsNY - New York

1 program

RAS-antagonist and beta-blocker up-to maximal dosagesPhase 41 trial

Active Trials

NCT02817360Recruiting2,400Est. Dec 2026

AbbottABBOTT PARK, IL

2 programs

ProcedurePhase 32 trials

Amplatzer™ Occlusion DevicesN/A1 trial

Active Trials

NCT06590467Recruiting2,500Est. Nov 2039

NCT05847283Recruiting730Est. Dec 2027

NCT02924285Completed80Est. Mar 2021

IdorsiaSwitzerland - Allschwil

1 program

tezosentanPhase 31 trial

Active Trials

NCT00458276Terminated274Est. Mar 2008

MedtronicNJ - Phillipsburg

4 programs

Angiography onlyN/A1 trial

Bi-plane fluoroscopyN/A1 trial

Implantable Cardioverter DefibrillatorN/A1 trial

NIRS monitoringN/A1 trial

Active Trials

NCT07110922Recruiting50Est. Dec 2027

NCT03941275Completed51Est. Nov 2021

NCT00328705Completed65Est. Jan 2007

+1 more trials

Rhythm PharmaceuticalsBOSTON, MA

2 programs

Bi-plane fluoroscopyN/A

Implantable Cardioverter DefibrillatorN/A

Boston ScientificCA - Valencia

2 programs

Coronary stentN/A1 trial

Rate adaptive pacemakerN/A1 trial

Active Trials

NCT02015832Completed454Est. Feb 2021

NCT00757666Terminated566Est. Jan 2011

BiotronikGermany - Berlin

1 program

3-channel Holter ECG recordingN/A1 trial

Active Trials

NCT04243070Terminated89Est. Jul 2022

ElutiaSILVER SPRING, MD

1 program

CanGarooN/A1 trial

Active Trials

NCT04299282Withdrawn0Est. Mar 2022

SensydiaCA - Los Angeles

1 program

Cardiac Performance SystemN/A1 trial

Active Trials

NCT05104307Completed79Est. Jan 2024

Edwards LifesciencesCA - Irvine

1 program

Edwards SAPIEN 3 / SAPIEN 3 Ultra THVN/A1 trial

Active Trials

NCT03042104Active Not Recruiting901Est. Mar 2032

Angeles TherapeuticsCA - Los Angeles

1 program

Integrated CardioRespiratory SystemN/A1 trial

Active Trials

NCT02168049Completed150Est. Sep 2017

Colorado TherapeuticsCO - Louisville

1 program

InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD'sN/A1 trial

Active Trials

NCT03232736Completed22Est. Jan 2020

Boehringer IngelheimINGELHEIM, Germany

1 program

Intervention GroupN/A1 trial

Active Trials

NCT00985179Completed1,000Est. Mar 2012

Bilim PharmaceuticalsTurkey - Istanbul

1 program

PopulationN/A1 trial

Active Trials

NCT05429307Terminated450Est. Dec 2022

BiocorpFrance - Issoire

1 program

Rapamycin Drug-Eluting Bioresorbable Coronary Stent SystemN/A1 trial

Active Trials

NCT02844270Unknown45Est. Dec 2021

AstraZenecaCAMBRIDGE, United Kingdom

1 program

Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in GermanyN/A1 trial

Active Trials

NCT06336330Active Not Recruiting831Est. Dec 2026

Nordic PharmaFrance - Paris

1 program

Rigid Sternal FixationN/A1 trial

Active Trials

NCT06660186Recruiting250Est. Jun 2027

StrykerCA - San Jose

1 program

Rigid Sternal FixationN/A

Paragonix TechnologiesMA - Waltham

1 program

SherpaPak Cardiac Transport SystemN/A1 trial

Active Trials

NCT04141605Enrolling By Invitation3,000Est. Dec 2029

Sharp TherapeuticsPA - Pittsburgh

1 program

SimvastatinN/ASmall Molecule

Merck & Co.RAHWAY, NJ

1 program

SimvastatinN/ASmall Molecule

MSDIreland - Ballydine

1 program

SimvastatinN/ASmall Molecule1 trial

Active Trials

NCT00125060Completed72Est. Apr 2004

Supira MedicalCA - Los Gatos

1 program

Supira SystemN/A1 trial

Active Trials

NCT05864248Active Not Recruiting71Est. Mar 2026

Microvascular TherapeuticsAZ - Tucson

1 program

EchocardiogramPHASE_1_21 trial

Active Trials

NCT03882359Completed16Est. May 2025

BraccoItaly - Milan

1 program

Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]PHASE_31 trial

Active Trials

NCT06400004Recruiting106Est. Dec 2026

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

Martin PharmaceuticalsRAS-antagonist and beta-blocker up-to maximal dosages

BraccoSulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]

AbbottProcedure

Idorsiatezosentan

Microvascular TherapeuticsEchocardiogram

Nordic PharmaRigid Sternal Fixation

MedtronicAngiography only

AbbottAmplatzer™ Occlusion Devices

AstraZenecaReal-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany

Supira MedicalSupira System

AbbottProcedure

Bilim PharmaceuticalsPopulation

SensydiaCardiac Performance System

ElutiaCanGaroo

MedtronicNIRS monitoring

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 14,282 patients across 27 trials

NCT02817360 Martin PharmaceuticalsRAS-antagonist and beta-blocker up-to maximal dosages

NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Start: Feb 2016Est. completion: Dec 20262,400 patients

Phase 4Recruiting

NCT06400004 BraccoSulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]

Lumason® Infusion vs. Bolus Administrations

Start: Jul 2024Est. completion: Dec 2026106 patients

Phase 3Recruiting

NCT02924285 AbbottProcedure

Catheter Ablation Versus Amiodarone for Therapy of Premature Ventricular Contractions in Patients With Structural Heart Disease

Start: Nov 2017Est. completion: Mar 202180 patients

Phase 3Completed

NCT00458276 Idorsiatezosentan

Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery

Start: Apr 2007Est. completion: Mar 2008274 patients

Phase 3Terminated

NCT03882359 Microvascular TherapeuticsEchocardiogram

An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers

Start: Apr 2019Est. completion: May 202516 patients

Phase 1/2Completed

NCT06660186 Nordic PharmaRigid Sternal Fixation

Sternal Plating High Risk

Start: Mar 2026Est. completion: Jun 2027250 patients

N/ARecruiting

NCT07110922 MedtronicAngiography only

Angiography and Electrogram Guided Bachmann Bundle Pacing

Start: Aug 2025Est. completion: Dec 202750 patients

N/ARecruiting

NCT06590467 AbbottAmplatzer™ Occlusion Devices

Abbott Structural Heart Device Registry

Start: Aug 2024Est. completion: Nov 20392,500 patients

N/ARecruiting

NCT06336330 AstraZenecaReal-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany

Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany

Start: Apr 2024Est. completion: Dec 2026831 patients

N/AActive Not Recruiting

NCT05864248 Supira MedicalSupira System

Feasibility Study SA of the Supira System for HRPCI

Start: Sep 2023Est. completion: Mar 202671 patients

N/AActive Not Recruiting

NCT05847283 AbbottProcedure

DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT

Start: Jun 2023Est. completion: Dec 2027730 patients

N/ARecruiting

NCT05429307 Bilim PharmaceuticalsPopulation

Turkish Adaptation, Validity and Reliability of Exercise Sensitivity Questionnaire

Start: May 2022Est. completion: Dec 2022450 patients

N/ATerminated

NCT05104307 SensydiaCardiac Performance System

Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study

Start: Nov 2021Est. completion: Jan 202479 patients

N/ACompleted

NCT04299282 ElutiaCanGaroo

CIED Implantation in Low BMI Patients

Start: Jun 2021Est. completion: Mar 20220

N/AWithdrawn

NCT04058860 MedtronicNIRS monitoring

Study of Microcirculation During Extracorporeal Circulation in Cardiac Surgery

Start: Jun 2020Est. completion: Nov 202130 patients

N/ACompleted

NCT04243070 Biotronik3-channel Holter ECG recording

BIO|CONCEPT.ECG-Library (Collection of ECG Signals for Development of Algorithms)

Start: Mar 2020Est. completion: Jul 202289 patients

N/ATerminated

NCT04141605 Paragonix TechnologiesSherpaPak Cardiac Transport System

Global Utilization And Registry Database for Improved heArt preservatioN

Start: Feb 2020Est. completion: Dec 20293,000 patients

N/AEnrolling By Invitation

NCT03941275 MedtronicBi-plane fluoroscopy

SelectSecure 3830 Lead Imaging

Start: May 2019Est. completion: Nov 202151 patients

N/ACompleted

NCT03232736 Colorado TherapeuticsInterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's

InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's

Start: Oct 2017Est. completion: Jan 202022 patients

N/ACompleted

NCT03042104 Edwards LifesciencesEdwards SAPIEN 3 / SAPIEN 3 Ultra THV

EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis

Start: Jul 2017Est. completion: Mar 2032901 patients

N/AActive Not Recruiting

NCT02844270 BiocorpRapamycin Drug-Eluting Bioresorbable Coronary Stent System

Galaxy Rapamycin Drug-Eluting Bioresorbable Coronary Stent System First-in-man Study

Start: Aug 2016Est. completion: Dec 202145 patients

N/AUnknown

NCT02168049 Angeles TherapeuticsIntegrated CardioRespiratory System

Heart and Lung Function Monitoring System

Start: Nov 2014Est. completion: Sep 2017150 patients

N/ACompleted

NCT02015832 Boston ScientificCoronary stent

Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI

Start: Feb 2014Est. completion: Feb 2021454 patients

N/ACompleted

NCT00985179 Boehringer IngelheimIntervention Group

Increasing Vitamin Intake and Physical Activity

Start: Oct 2009Est. completion: Mar 20121,000 patients

N/ACompleted

NCT00757666 Boston ScientificRate adaptive pacemaker

APPROPRIATE - Rate Adaptive Pacing Sensor

Start: Dec 2008Est. completion: Jan 2011566 patients

N/ATerminated

NCT00328705 MedtronicImplantable Cardioverter Defibrillator

D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management

Start: May 2006Est. completion: Jan 200765 patients

N/ACompleted

NCT00125060 MSDSimvastatin

Transesophageal Magnetic Resonance Imaging (MRI) in Conjunction With Lipid Lowering Measures

Start: Aug 2000Est. completion: Apr 200472 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals

6 actively recruiting trials targeting 14,282 patients

28 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.