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Sinus Node Dysfunction

2
Pipeline Programs
4
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

LivaNova
LivaNovaUK - London
3 programs
2
PACEMAKER SYMPHONY 2550Phase 41 trial
Symphony D 2450Phase 41 trial
dual chamber pacemaker with SafeR algorithmN/A1 trial
Active Trials
NCT02586480Completed848Est. Dec 2015
NCT01170611Completed400Est. Jan 2007
NCT00655213Completed622Est. Dec 2006
Medtronic
MedtronicNJ - Phillipsburg
3 programs
Evidence based guidelines and toolsN/A1 trial
Pacemaker lower rate settingN/A1 trial
Reprogramming dual chamber pacemakerN/A1 trial
Active Trials
NCT01643707Completed1,342Est. Jan 2019
NCT05766462Completed73Est. Jan 2025
NCT02027909Completed8Est. Apr 2015
Rhythm Pharmaceuticals
2 programs
Evidence based guidelines and toolsN/A
Pacemaker lower rate settingN/A
Biotronik
BiotronikGermany - Berlin
1 program
Solia CSP S leadN/A1 trial
Active Trials
NCT06540079Active Not Recruiting192Est. Jun 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
LivaNovaPACEMAKER SYMPHONY 2550
LivaNovaSymphony D 2450
BiotronikSolia CSP S lead
MedtronicPacemaker lower rate setting
MedtronicEvidence based guidelines and tools
LivaNovadual chamber pacemaker with SafeR algorithm
MedtronicReprogramming dual chamber pacemaker

Clinical Trials (7)

Total enrollment: 3,485 patients across 7 trials

NCT01170611LivaNovaPACEMAKER SYMPHONY 2550

Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease

Start: Jul 2004Est. completion: Jan 2007400 patients
Phase 4Completed
NCT00655213LivaNovaSymphony D 2450

Spontaneous Atrio Ventricular Conduction Preservation

Start: Nov 2003Est. completion: Dec 2006622 patients
Phase 4Completed
NCT06540079BiotronikSolia CSP S lead

BIOTRONIK Conduction System Pacing With the Solia Lead - Solia CSP S

Start: Dec 2024Est. completion: Jun 2026192 patients
N/AActive Not Recruiting
NCT05766462MedtronicPacemaker lower rate setting

Allometric-Pace Study

Start: Mar 2023Est. completion: Jan 202573 patients
N/ACompleted
NCT01643707MedtronicEvidence based guidelines and tools

Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady)

Start: Jul 2012Est. completion: Jan 20191,342 patients
N/ACompleted
NCT02586480LivaNovadual chamber pacemaker with SafeR algorithm

Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode

Start: Apr 2012Est. completion: Dec 2015848 patients
N/ACompleted
NCT02027909MedtronicReprogramming dual chamber pacemaker

A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction

Start: Nov 2011Est. completion: Apr 20158 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.