Arrhythmia

Cardiovascular
3
Pipeline Programs
5
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Abbott
AbbottABBOTT PARK, IL
3 programs
1
Autointrinsic Conduction Search AlgorithmPhase 41 trial
Device: St. Jude Medical Victory dual-chamber pacemakerN/A1 trial
Perclose ProGlide SMC System and/or Perclose ProStyle SMCR SystemN/A1 trial
Active Trials
NCT00366158Completed461Est. Sep 2010
NCT04904809Completed36Est. May 2022
NCT00187239Completed157Est. Aug 2007
Pfizer
PfizerNEW YORK, NY
2 programs
2
GAP-134Phase 11 trial
GAP-134Phase 11 trial
Active Trials
NCT00543946Completed56Est. Mar 2008
NCT00510029Completed72Est. Jan 2008
Rhythm Pharmaceuticals
7 programs
Cardiac Rhythm Management deviceN/A1 trial
Carelink SystemN/A1 trial
Out of cathlab insertionN/A1 trial
PacemakerN/A1 trial
Remote ManagementN/A1 trial
+2 more programs
Active Trials
NCT00382525Completed8,586Est. Mar 2013
NCT03125382Completed141Est. Oct 2016
NCT02412488Completed191Est. Oct 2016
+4 more trials
Biotronik
BiotronikGermany - Berlin
2 programs
Cardiac StimulatorN/A1 trial
HM onN/A1 trial
Active Trials
NCT04390841Completed106Est. Apr 2021
NCT00325221Completed148Est. Oct 2012
GS
Gilead SciencesFOSTER CITY, CA
1 program
Amiodarone Plus RanolazineN/A1 trial
Active Trials
NCT01480336Completed19Est. Jan 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AbbottAutointrinsic Conduction Search Algorithm
PfizerGAP-134
PfizerGAP-134
AbbottPerclose ProGlide SMC System and/or Perclose ProStyle SMCR System
BiotronikCardiac Stimulator
Rhythm Pharmaceuticalsoffice setting
Rhythm PharmaceuticalsOut of cathlab insertion
Rhythm PharmaceuticalsCarelink System
Gilead SciencesAmiodarone Plus Ranolazine
Rhythm PharmaceuticalsRemote Management
AbbottDevice: St. Jude Medical Victory dual-chamber pacemaker
BiotronikHM on
Rhythm PharmaceuticalsCardiac Rhythm Management device
Rhythm PharmaceuticalsPacemaker
Rhythm PharmaceuticalsThe Atrial High Rate Episodes in Pacemaker Patients

Clinical Trials (15)

Total enrollment: 13,794 patients across 15 trials

NCT00187239AbbottAutointrinsic Conduction Search Algorithm

Reduce Ventricular Pacing in Dual Chamber Implantable Cardioverter Defibrillators Using AutoIntrinsic Conduction Search Study

Start: Jul 2005Est. completion: Aug 2007157 patients
Phase 4Completed
NCT00543946PfizerGAP-134

Single Ascending Dose of GAP-134 as a 24-hour IV Infusion in Healthy Japanese Males

Start: Oct 2007Est. completion: Mar 200856 patients
Phase 1Completed
NCT00510029PfizerGAP-134

Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of GAP-134 Administered Intravenously

Start: Sep 2007Est. completion: Jan 200872 patients
Phase 1Completed
NCT04904809AbbottPerclose ProGlide SMC System and/or Perclose ProStyle SMCR System

Perclose Multi-Access Duplex Ultrasound (DUS) Study

Start: Sep 2021Est. completion: May 202236 patients
N/ACompleted
NCT04390841BiotronikCardiac Stimulator

Qubic Stim Cardiac Stimulator in China

Start: Dec 2020Est. completion: Apr 2021106 patients
N/ACompleted
NCT02395536Rhythm Pharmaceuticalsoffice setting

Medtronic Reveal LINQ™ In-Office 2 (RIO 2) Study United States

Start: Mar 2015Est. completion: May 2016525 patients
N/ACompleted
NCT02412488Rhythm PharmaceuticalsOut of cathlab insertion

Reveal LINQ™ In-Office 2 (RIO2) Study International

Start: Feb 2015Est. completion: Oct 2016191 patients
N/ACompleted
NCT03125382Rhythm PharmaceuticalsCarelink System

PORTuguese Research on Telemonitoring With CareLink® (PORTLink)

Start: Apr 2012Est. completion: Oct 2016141 patients
N/ACompleted
NCT01480336Gilead SciencesAmiodarone Plus Ranolazine

The Adjunctive Ventricular Arrhythmia Suppression Trial (AVAST) Pilot

Start: Feb 2011Est. completion: Jan 201319 patients
N/ACompleted
NCT00402246Rhythm PharmaceuticalsRemote Management

CONNECT Study - Clinical Evaluation Of Remote NotificatioN to rEduCe Time to Clinical Decision

Start: Nov 2006Est. completion: Sep 20092,009 patients
N/ACompleted
NCT00366158AbbottDevice: St. Jude Medical Victory dual-chamber pacemaker

EVITA: Evaluation of VIP Feature in Pacemaker Patients

Start: Aug 2006Est. completion: Sep 2010461 patients
N/ACompleted
NCT00325221BiotronikHM on

Psychosomatic Effects of Implantable Cardioverter Defibrillator With Home Monitoring Function (QUANTUM)

Start: Aug 2006Est. completion: Oct 2012148 patients
N/ACompleted
NCT00382525Rhythm PharmaceuticalsCardiac Rhythm Management device

PANORAMA Observational Study

Start: Jan 2005Est. completion: Mar 20138,586 patients
N/ACompleted
NCT00275769Rhythm PharmaceuticalsPacemaker

CAPTURE - Complete Automatic Pacing Threshold Utilization Recorded by EnPulse

Start: Mar 2004Est. completion: Sep 2006860 patients
N/ACompleted
NCT00627328Rhythm PharmaceuticalsThe Atrial High Rate Episodes in Pacemaker Patients

The Atrial High Rate Episodes in Pacemaker Patients

Start: Jul 2000Est. completion: Sep 2004427 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)