Skip to main content

Sleep Apnea, Obstructive

7
Pipeline Programs
18
Companies
31
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
5
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 34 programs with unclassified modality

Competitive Landscape

17 companies ranked by most advanced pipeline stage

Prevail Therapeutics
1 program
1
EloralintidePhase 3Peptide1 trial
Active Trials
NCT07369011Recruiting800Est. Apr 2028
Bayer
BayerLEVERKUSEN, Germany
4 programs
1
3
BAY2253651Phase 21 trial
BAY2586116Phase 21 trial
BAY2586116Phase 21 trial
BAY2586116Phase 11 trial
Active Trials
NCT05527457Completed10Est. Dec 2022
NCT03603678Completed34Est. Sep 2019
NCT04713826Completed93Est. Nov 2021
+1 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Comparator: MK0249Phase 2
MSD
MSDIreland - Ballydine
1 program
1
Comparator: MK0249Phase 21 trial
Active Trials
NCT00620659Terminated125Est. Feb 2009
ResMed
ResMedSAN DIEGO, CA
7 programs
AirSense™ 10 AutoSetN/A1 trial
ApneaLink AirN/A1 trial
Neo AppN/A1 trial
PSGN/A1 trial
RESMed S9 with humidifier H5i and heated tube Climate LineN/A1 trial
+2 more programs
Active Trials
NCT02963597Completed21Est. Aug 2018
NCT03748771Completed20Est. Feb 2020
NCT04912635Completed300Est. Mar 2021
+3 more trials
Philips
PhilipsNetherlands - Amsterdam
5 programs
DreamKitN/A1 trial
DreamKitN/A1 trial
Paced BreathingN/A1 trial
Real Life Pediatric Obstructive Sleep ApneaN/A1 trial
SparkleN/A1 trial
Active Trials
NCT04671342Completed306Est. Dec 2021
NCT04926077Completed11Est. Oct 2021
NCT01031914Completed36Est. Sep 2010
+2 more trials
Inspire Medical Systems
Inspire Medical SystemsMN - Golden Valley
2 programs
Inspire® Upper Airway Simulation SystemN/A1 trial
Pharyngeal width measurementN/A1 trial
Active Trials
NCT02344108Completed42Est. Sep 2021
NCT05428839Unknown300Est. Jan 2025
Ventus Therapeutics
2 programs
ProventN/A1 trial
Treatment sleep studyPHASE_1_2
Active Trials
NCT00901771Completed50Est. Dec 2009
Medtronic
MedtronicNJ - Phillipsburg
2 programs
Transvenous hypoglossal nerve stimulationN/A1 trial
soft palate implantN/A1 trial
Active Trials
NCT03210142Completed23Est. Jul 2018
NCT00263770Completed64Est. Oct 2007
Sommetrics
SommetricsCA - San Diego
2 programs
aerSleep IIN/A1 trial
cNEPN/A1 trial
Active Trials
NCT04861038Active Not Recruiting900Est. Dec 2025
NCT02677168Completed71Est. Nov 2017
Signifier Medical Technologies
2 programs
eXciteOSAN/A1 trial
eXciteOSAN/A1 trial
Active Trials
NCT05183009Unknown102Est. Dec 2022
NCT05252156Completed62Est. Oct 2022
Nyxoah
NyxoahBelgium - Mont-Saint-Guibert
1 program
Genio SystemN/A1 trial
Active Trials
NCT05592002Active Not Recruiting124Est. Sep 2028
LivaNova
LivaNovaUK - London
1 program
Kinesthetic stimulationN/A1 trial
Active Trials
NCT03300037Completed46Est. Apr 2015
Sensimed
SensimedSwitzerland - Etagnières
1 program
SENSIMED Triggerfish®N/A1 trial
Active Trials
NCT01560975Completed10Est. Nov 2012
Rhythm Pharmaceuticals
1 program
Transvenous hypoglossal nerve stimulationN/A
Somnomed
SomnomedTX - Plano
1 program
mandibular repositioning applianceN/A1 trial
Active Trials
NCT01588275Completed86Est. Dec 2017
Teva
TevaIsrael - Petach Tikva
1 program
ModafinilPHASE_31 trial
Active Trials
NCT00107809Completed140Est. Sep 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Prevail TherapeuticsEloralintide
TevaModafinil
BayerBAY2586116
BayerBAY2586116
BayerBAY2253651
MSDComparator: MK0249
ResMedTreatment sleep study
BayerBAY2586116
NyxoahGenio System
Inspire Medical SystemsPharyngeal width measurement
Signifier Medical TechnologieseXciteOSA
Signifier Medical TechnologieseXciteOSA
SommetricsaerSleep II
PhilipsDreamKit
PhilipsSparkle

Showing 15 of 31 trials with date data

Clinical Trials (31)

Total enrollment: 5,071 patients across 31 trials

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Start: Feb 2026Est. completion: Apr 2028800 patients
Phase 3Recruiting

Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome

Start: Oct 2004Est. completion: Sep 2005140 patients
Phase 3Completed

A Trial to Learn More About How Well BAY2586116 Works and How Safe it is in Participants With Moderate to Severe Obstructive Sleep Apnea

Start: Mar 2021Est. completion: Nov 202193 patients
Phase 2Completed

Study on the Safety of Drug BAY2586116 and How it Works in Patients With Obstructive Sleep Apnea (a Sleep Disorder Caused by the Narrowing and Collapse of the Airway During Sleep) Including the Blood Level of the Drug and Effect of Its Doses and Routes of Administration

Start: Feb 2020Est. completion: Jun 202114 patients
Phase 2Completed

Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor

Start: Aug 2018Est. completion: Sep 201934 patients
Phase 2Completed
NCT00620659MSDComparator: MK0249

Treatment of Refractory Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) Using Nasal Continuous Positive Airway Pressure (nCPAP) Therapy (0249-015)

Start: Feb 2008Est. completion: Feb 2009125 patients
Phase 2Terminated
NCT01061476ResMedTreatment sleep study

Sleep Apnea Treatment With Expiratory Resistance(Provent™)

Start: Jan 2010Est. completion: Jan 201112 patients
Phase 1/2Completed

BAY2586116 Nasal Spray and OSA Severity

Start: Aug 2022Est. completion: Dec 202210 patients
Phase 1Completed
NCT05592002NyxoahGenio System

Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.

Start: Dec 2022Est. completion: Sep 2028124 patients
N/AActive Not Recruiting
NCT05428839Inspire Medical SystemsPharyngeal width measurement

The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea

Start: May 2022Est. completion: Jan 2025300 patients
N/AUnknown

eXciteOSA for Treatment of Moderate Obstructive Sleep Apnea

Start: Mar 2022Est. completion: Oct 202262 patients
N/ACompleted

eXciteOSA for Treatment of Mild Obstructive Sleep Apnea

Start: Jan 2022Est. completion: Dec 2022102 patients
N/AUnknown

Study Using Negative Pressure to Reduce Apnea

Start: Nov 2021Est. completion: Dec 2025900 patients
N/AActive Not Recruiting

DreamKit Respiratory Effort Signal Validation

Start: Jun 2021Est. completion: Oct 202111 patients
N/ACompleted

Sparkle Respiratory Effort Validation

Start: Mar 2021Est. completion: Jun 20210
N/AWithdrawn

DreamKit Diagnostic Validation

Start: Jan 2021Est. completion: Dec 2021306 patients
N/ACompleted

Nebula Study - Screener Apps and HSAT vs. PSG Comparison

Start: Oct 2020Est. completion: Jan 202150 patients
N/ACompleted

Evaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project Neo

Start: Sep 2020Est. completion: Mar 2021300 patients
N/ACompleted
NCT03748771ResMedApneaLink Air

Validation of ApneaLink Air Home Sleep Testing in the Diagnosis of Obstructive Sleep Apnea in Adolescent Children

Start: Dec 2018Est. completion: Feb 202020 patients
N/ACompleted
NCT03950466PhilipsReal Life Pediatric Obstructive Sleep Apnea

Real Life Pediatric Obstructive Sleep Apnea

Start: Jan 2018Est. completion: Dec 20231,200 patients
N/AUnknown
NCT03210142MedtronicTransvenous hypoglossal nerve stimulation

Minimally Invasive Hypoglossal Nerve Stimulation Study (Lingual Study)

Start: Jun 2017Est. completion: Jul 201823 patients
N/ACompleted
NCT02963597ResMedAirSense™ 10 AutoSet

Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea.

Start: Oct 2016Est. completion: Aug 201821 patients
N/ACompleted

cNEP for the Treatment of Obstructive Sleep Apnea

Start: May 2016Est. completion: Nov 201771 patients
N/ACompleted
NCT02344108Inspire Medical SystemsInspire® Upper Airway Simulation System

A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea

Start: Feb 2015Est. completion: Sep 202142 patients
N/ACompleted
NCT03300037LivaNovaKinesthetic stimulation

HYpopnea and Apnea Detection and Treatment Performance of a New cardiOreSpiratory Holter Monitor

Start: Sep 2014Est. completion: Apr 201546 patients
N/ACompleted
NCT01588275Somnomedmandibular repositioning appliance

MRA Therapy Versus CPAP Therapy in Moderate OSAS

Start: May 2012Est. completion: Dec 201786 patients
N/ACompleted
NCT01560975SensimedSENSIMED Triggerfish®

IOP Fluctuations in Patients With Sleep Apnea With or Without Primary Open Angle Glaucoma Using Positive Airway Pressure

Start: Mar 2012Est. completion: Nov 201210 patients
N/ACompleted
NCT01462409ResMedRESMed S9 with humidifier H5i and heated tube Climate Line

Humidity Under Continuous Positive Airway Pressure

Start: Mar 2011Est. completion: Jan 201219 patients
N/ACompleted
NCT01031914PhilipsPaced Breathing

Evaluation of an Algorithm to Detect Sleep and Wake in Continuous Positive Airway Pressure (CPAP)

Start: Oct 2009Est. completion: Sep 201036 patients
N/ACompleted

Study of Provent Treatment of Obstructive Sleep Apnea in Patients Who Are Non-compliant With CPAP

Start: May 2009Est. completion: Dec 200950 patients
N/ACompleted
NCT00263770Medtronicsoft palate implant

Treatment Study of Soft Palatal Implants in Obstructive Sleep Apnea

Start: Dec 2005Est. completion: Oct 200764 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 5,071 patients
18 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.