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Heart Valve Diseases

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Pipeline Programs
12
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
6 programs
ATS 3f Aortic BioprosthesisN/A1 trial
ATS 3f Enable Aortic Bioprosthesis Model 6000N/A1 trial
ATS 3f® Aortic Bioprosthesis, Model 1000, 19mmN/A1 trial
ATS Medical 3f® Aortic Bioprosthesis, Model 1000 19mmN/A1 trial
Melody Transcatheter Pulmonary ValveN/A1 trial
+1 more programs
Active Trials
NCT01116037Terminated26Est. Nov 2015
NCT01116024Completed173Est. Aug 2012
NCT00657826Terminated22Est. Jul 2015
+3 more trials
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
Computed tomographic angiographyN/A1 trial
Study of Health Behavior in Patients After Heart Valve Replacement： Longitudinal StudiesN/A1 trial
Active Trials
NCT02632617Unknown2,644Est. Jun 2017
NCT06490952Unknown219Est. Dec 2024
Abbott
AbbottABBOTT PARK, IL
2 programs
Trifecta valveN/A1 trial
biological heart valve prosthesisN/A1 trial
Active Trials
NCT01514162Completed245Est. Oct 2014
NCT00377871Completed15Est. Jan 2010
Biotronik
BiotronikGermany - Berlin
1 program
BIOVALVE prosthesisN/A1 trial
Active Trials
NCT02249000Completed68Est. May 2023
Rhythm Pharmaceuticals
1 program
Melody Transcatheter Pulmonary ValveN/A
Rhine Pharma
Rhine PharmaGermany - Heidelberg
1 program
Patients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of LifeN/A1 trial
Active Trials
NCT00362401Completed90Est. Jan 2009
Philips
PhilipsNetherlands - Amsterdam
1 program
Surgical treatment of valvular heart diseaseN/A1 trial
Active Trials
NCT04068740Completed169Est. Jan 2019
LivaNova
LivaNovaUK - London
1 program
biological heart valve prosthesisN/A
Pfizer
PfizerNEW YORK, NY
1 program
cardiac echosonographyN/A1 trial
Active Trials
NCT00359489Completed30Est. Jul 2007
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
warfarin 1mgPHASE_21 trial
Active Trials
NCT01452347Terminated328Est. Jun 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boehringer Ingelheimwarfarin 1mg
UNION therapeuticsStudy of Health Behavior in Patients After Heart Valve Replacement： Longitudinal Studies
MedtronicMosaic model 305, model 310, and ultra model 305
PhilipsSurgical treatment of valvular heart disease
UNION therapeuticsComputed tomographic angiography
BiotronikBIOVALVE prosthesis
AbbottTrifecta valve
MedtronicATS Medical 3f® Aortic Bioprosthesis, Model 1000 19mm
MedtronicATS 3f Aortic Bioprosthesis
MedtronicMelody Transcatheter Pulmonary Valve
Abbottbiological heart valve prosthesis
Pfizercardiac echosonography
MedtronicATS 3f Enable Aortic Bioprosthesis Model 6000
Rhine PharmaPatients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life
MedtronicATS 3f® Aortic Bioprosthesis, Model 1000, 19mm

Clinical Trials (15)

Total enrollment: 4,214 patients across 15 trials

NCT01452347Boehringer Ingelheimwarfarin 1mg

Dabigatran Etexilate in Patients With Mechanical Heart Valves

Start: Oct 2011Est. completion: Jun 2013328 patients
Phase 2Terminated
NCT06490952UNION therapeuticsStudy of Health Behavior in Patients After Heart Valve Replacement： Longitudinal Studies

Study of Health Behavior in Patients After Heart Valve Replacement： Longitudinal Studies

Start: Jan 2024Est. completion: Dec 2024219 patients
N/AUnknown
NCT03139721MedtronicMosaic model 305, model 310, and ultra model 305

Medtronic HAMMOCK Post Approval Study

Start: Jun 2017Est. completion: Jun 2021122 patients
N/ACompleted
NCT04068740PhilipsSurgical treatment of valvular heart disease

Personalised Decision Support for Heart Valve Disease

Start: Jan 2016Est. completion: Jan 2019169 patients
N/ACompleted
NCT02632617UNION therapeuticsComputed tomographic angiography

coRonary assEssment of Preoperative vaLvulopathy pAtients Using ComputEd Tomographic Angiography (REPLACE)

Start: Dec 2015Est. completion: Jun 20172,644 patients
N/AUnknown
NCT02249000BiotronikBIOVALVE prosthesis

BIOVALVE - I / II Clincial Investigation

Start: Sep 2014Est. completion: May 202368 patients
N/ACompleted
NCT01514162AbbottTrifecta valve

Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve

Start: Feb 2012Est. completion: Oct 2014245 patients
N/ACompleted
NCT01156272MedtronicATS Medical 3f® Aortic Bioprosthesis, Model 1000 19mm

Post Market ATS 3f® Aortic Bioprosthesis, Model 1000, Size 19mm

Start: Jun 2010Est. completion: Jun 20110
N/AWithdrawn
NCT01116037MedtronicATS 3f Aortic Bioprosthesis

ATS 3f(r) Aortic Bioprosthesis Model 1000 Post Approval Study

Start: Sep 2009Est. completion: Nov 201526 patients
N/ATerminated
NCT00688571MedtronicMelody Transcatheter Pulmonary Valve

Melody Transcatheter Pulmonary Valve (TPV) Post-Market Surveillance Study

Start: Oct 2007Est. completion: Dec 201463 patients
N/ACompleted
NCT00377871Abbottbiological heart valve prosthesis

Hemodynamic Performance in Stentless Heart Valves

Start: May 2007Est. completion: Jan 201015 patients
N/ACompleted
NCT00359489Pfizercardiac echosonography

Methods Study to Evaluate Use of Cardiac Ultrasound to Assess Heart Valve Abnormality in People.

Start: Apr 2007Est. completion: Jul 200730 patients
N/ACompleted
NCT01116024MedtronicATS 3f Enable Aortic Bioprosthesis Model 6000

ATS 3f Enable(tm) Aortic Bioprosthesis, Model 6000

Start: May 2006Est. completion: Aug 2012173 patients
N/ACompleted
NCT00362401Rhine PharmaPatients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life

Patients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life

Start: Nov 2005Est. completion: Jan 200990 patients
N/ACompleted
NCT00657826MedtronicATS 3f® Aortic Bioprosthesis, Model 1000, 19mm

ATS 3f(r) Aortic Bioprosthesis Model 1000, 19mm

Start: Oct 2001Est. completion: Jul 201522 patients
N/ATerminated

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.