Bradycardia

1
Pipeline Programs
3
Companies
23
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
0
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Biotronik
BiotronikGermany - Berlin
5 programs
1
Closed Loop StimulationPhase 41 trial
Amvia Sky pacemaker or CRT-P deviceN/A1 trial
Amvia/Solvia pacemaker familyN/A1 trial
Eluna pacemaker familyN/A1 trial
Solia S leadN/A1 trial
Active Trials
NCT05610176Completed52Est. Jun 2024
NCT06018818Completed129Est. Jul 2025
NCT02059629Completed167Est. Apr 2016
+2 more trials
Rhythm Pharmaceuticals
10 programs
Advisa IPGN/A1 trial
China market released 3.0T Magnetic resonanceN/A1 trial
Evaluation GroupN/A1 trial
Implantable Pulse GeneratorN/A1 trial
Medtronic Adapta Dual Chamber PacemakerN/A1 trial
+5 more programs
Active Trials
NCT00839384Completed79Est. Jul 2009
NCT06038123Completed64Est. Oct 2024
NCT03518658Completed257Est. Dec 2019
+7 more trials
Abbott
AbbottABBOTT PARK, IL
8 programs
CRT-P OFFN/A1 trial
Cardiac Rhythm Management deviceN/A1 trial
Implantation of the Tendril 2088 lead in the LBBAN/A1 trial
Intervention/treatmentN/A1 trial
LBBAP leadN/A1 trial
+3 more programs
Active Trials
NCT01559311Completed98Est. Apr 2016
NCT01754064Completed10,957Est. Jul 2020
NCT05887323Completed221Est. Jul 2023
+5 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
BiotronikClosed Loop Stimulation
AbbottLBBAP lead
Rhythm PharmaceuticalsChina market released 3.0T Magnetic resonance
BiotronikAmvia/Solvia pacemaker family
AbbottImplantation of the Tendril 2088 lead in the LBBA
BiotronikSolia S lead
BiotronikAmvia Sky pacemaker or CRT-P device
AbbottPhysiologic pacing device implant
Rhythm PharmaceuticalsMicra Transcatheter Pacing System
Rhythm PharmaceuticalsEvaluation Group
AbbottSJM Implantable cardiac devices
AbbottLeadless Pacemaker
BiotronikEluna pacemaker family
Rhythm PharmaceuticalsRemote Implant Support Capability
AbbottCRT-P OFF

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 20,331 patients across 23 trials

NCT00355797BiotronikClosed Loop Stimulation

Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response

Start: May 2006Est. completion: Dec 20101,491 patients
Phase 4Completed
NCT07217392AbbottLBBAP lead

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Start: Jul 2025Est. completion: Apr 2027200 patients
N/ARecruiting
NCT06038123Rhythm PharmaceuticalsChina market released 3.0T Magnetic resonance

China 3T MRI Study

Start: Nov 2023Est. completion: Oct 202464 patients
N/ACompleted
NCT06018818BiotronikAmvia/Solvia pacemaker family

Post Market Clinical Follow-up Study for the Amvia/Solvia Pacemaker Family

Start: Aug 2023Est. completion: Jul 2025129 patients
N/ACompleted
NCT05887323AbbottImplantation of the Tendril 2088 lead in the LBBA

LBBAP Data Collection Registry

Start: Apr 2023Est. completion: Jul 2023221 patients
N/ACompleted
NCT05251363BiotronikSolia S lead

BIOTRONIK Conduction System Pacing With the Solia Lead

Start: Dec 2022Est. completion: Oct 2024194 patients
N/ACompleted
NCT05610176BiotronikAmvia Sky pacemaker or CRT-P device

BIO|CONCEPT.Amvia Study

Start: Nov 2022Est. completion: Jun 202452 patients
N/ACompleted
NCT03719040AbbottPhysiologic pacing device implant

Physiologic Pacing Registry

Start: Nov 2018Est. completion: Oct 2021870 patients
N/ACompleted
NCT03624504Rhythm PharmaceuticalsMicra Transcatheter Pacing System

China Micra Transcatheter Pacing Study

Start: Jul 2018Est. completion: Jan 202082 patients
N/ACompleted
NCT03518658Rhythm PharmaceuticalsEvaluation Group

BlueSync Field Evaluation

Start: Apr 2018Est. completion: Dec 2019257 patients
N/ACompleted
NCT03012568AbbottSJM Implantable cardiac devices

Clinical Study to Confirm MRI Safety and Effectiveness Using St. Jude Medical (SJM) Cardiac Rhythm Management Systems

Start: Nov 2016Est. completion: Mar 2018119 patients
N/ACompleted
NCT02030418AbbottLeadless Pacemaker

The LEADLESS II IDE Study for the Nanostim Leadless Pacemaker

Start: Feb 2014Est. completion: Jul 2022952 patients
N/ACompleted
NCT02059629BiotronikEluna pacemaker family

Eluna Family / Sentus BP Master Study

Start: Feb 2014Est. completion: Apr 2016167 patients
N/ACompleted
NCT01809652Rhythm PharmaceuticalsRemote Implant Support Capability

Feasibility Study of Remote Support for Implantable Pulse Generator (IPG)/Implantable Cardioverter Defibrillator (ICD) Implant

Start: Dec 2013Est. completion: Apr 201437 patients
N/ACompleted
NCT01559311AbbottCRT-P OFF

ENHANCE-Efficacy of the Presence of Right Ventricular Apical Pacing Induced Ventricular Dyssynchrony as a Guiding Parameter for Biventricular Pacing in Patients With Bradycardia and Normal Ejection Fraction

Start: Feb 2012Est. completion: Apr 201698 patients
N/ACompleted
NCT01039467Rhythm PharmaceuticalsMedtronic Adapta Dual Chamber Pacemaker

A Comparison of the Pacemaker Automatic Features in Reduction of Ventricular Pacing

Start: Jun 2009Est. completion: Apr 2014385 patients
N/ACompleted
NCT00839384Rhythm PharmaceuticalsAdvisa IPG

AdvisaTM IPG Clinical Evaluation Study

Start: Feb 2009Est. completion: Jul 200979 patients
N/ACompleted
NCT01754064AbbottCardiac Rhythm Management device

St. Jude Medical Product Longevity and Performance (SCORE) Registry

Start: Nov 2007Est. completion: Jul 202010,957 patients
N/ACompleted
NCT00433654Rhythm PharmaceuticalsImplantable Pulse Generator

EMRI SureScan™ Clinical Study

Start: Feb 2007Est. completion: Aug 2010484 patients
N/ACompleted
NCT00311168AbbottIntervention/treatment

Reduction of Right Ventricular Pacing Using the Feature Ventricular Intrinsic Preference (VIP)

Start: Feb 2006Est. completion: Sep 2008135 patients
N/ACompleted
NCT00294645Rhythm PharmaceuticalsTranstelephonic monitoring

PREFER (Pacemaker Remote Follow-Up Evaluation and Review)

Start: Apr 2004Est. completion: Apr 2008980 patients
N/ACompleted
NCT00294060Rhythm PharmaceuticalsP3: Pacemaker Patient Profiling Study

P3: Pacemaker Patient Profiling Study

Start: Mar 2004Est. completion: Nov 20072,013 patients
N/ATerminated
NCT00266682Rhythm PharmaceuticalsPacing Lead

Clinical Investigation of the SelectSecure Pacing Lead

Start: Aug 2002Est. completion: Aug 2005365 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 20,331 patients
3 companies competing in this space