Bradycardia

Pipeline Programs

Companies

Clinical Trials

6 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Boston ScientificCA - Valencia

11 programs

Pacemaker with Automatic CapturePhase 41 trial

sensor programmingPhase 41 trial

SITELINE 2 PolyurethanePhase 31 trial

Cardiac pacingN/A1 trial

Common Sensing and Right Ventricular Automatic Capture (COGNATE)N/A1 trial

+6 more programs

Active Trials

NCT06014866Completed1,383Est. Aug 2024

NCT01030705Completed80Est. Jun 2010

NCT00158925Completed100Est. Feb 2008

+8 more trials

LivaNovaUK - London

1 program

REPLY 200Phase 31 trial

Active Trials

NCT01537718Completed40Est. Nov 2012

MedtronicNJ - Phillipsburg

16 programs

Advisa IPGN/A1 trial

China market released 3.0T Magnetic resonanceN/A1 trial

ECG BeltN/A1 trial

Evaluation GroupN/A1 trial

Implantable Pulse GeneratorN/A1 trial

+11 more programs

Active Trials

NCT00839384Completed79Est. Jul 2009

NCT06038123Completed64Est. Oct 2024

NCT04583709Completed20Est. Jun 2021

+13 more trials

Rhythm PharmaceuticalsBOSTON, MA

10 programs

Advisa IPGN/A

China market released 3.0T Magnetic resonanceN/A

Evaluation GroupN/A

Implantable Pulse GeneratorN/A

Medtronic Adapta Dual Chamber PacemakerN/A

+5 more programs

AbbottABBOTT PARK, IL

9 programs

CRT-P OFFN/A1 trial

Cardiac Rhythm Management deviceN/A1 trial

Implantation of the Tendril 2088 lead in the LBBAN/A1 trial

Intervention/treatmentN/A1 trial

LBBAP leadN/A1 trial

+4 more programs

Active Trials

NCT01559311Completed98Est. Apr 2016

NCT01754064Completed10,957Est. Jul 2020

NCT05887323Completed221Est. Jul 2023

+6 more trials

MicroPortChina - Shanghai

7 programs

JX- XFINE leadN/A1 trial

LBBAP implantN/A1 trial

Pacemaker implantationN/A1 trial

Registry of Sleep Apnea Monitoring and Atrial Fibrillation in Pacemaker Patients (RESPIRE)N/A1 trial

Use of FLEXIGO delivery catheterN/A1 trial

+2 more programs

Active Trials

NCT05440071Unknown129Est. Sep 2024

NCT07254013Recruiting55Est. Mar 2026

NCT05165095Recruiting206Est. Jul 2027

+4 more trials

BiotronikGermany - Berlin

5 programs

Amvia Sky pacemaker or CRT-P deviceN/A1 trial

Amvia/Solvia pacemaker familyN/A1 trial

Eluna pacemaker familyN/A1 trial

Solia S leadN/A1 trial

Closed Loop StimulationPHASE_41 trial

Active Trials

NCT05610176Completed52Est. Jun 2024

NCT06018818Completed129Est. Jul 2025

NCT02059629Completed167Est. Apr 2016

+2 more trials

Scopus BioPharmaNY - New York

1 program

lead extractionN/A1 trial

Active Trials

NCT06115980Recruiting10Est. Jul 2025

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

BiotronikClosed Loop Stimulation

Boston ScientificPacemaker with Automatic Capture

Boston Scientificsensor programming

LivaNovaREPLY 200

Boston ScientificSITELINE 2 Polyurethane

MicroPortUse of LINEA cardiac pacing lead

Boston ScientificPacemaker lead

MicroPortLBBAP implant

AbbottLBBAP lead

MicroPortUse of FLEXIGO delivery catheter

MedtronicChina market released 3.0T Magnetic resonance

Boston ScientificCardiac pacing

Scopus BioPharmalead extraction

BiotronikAmvia/Solvia pacemaker family

AbbottImplantation of the Tendril 2088 lead in the LBBA

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 74,430 patients across 50 trials

NCT00355797 BiotronikClosed Loop Stimulation

Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response

Start: May 2006Est. completion: Dec 20101,491 patients

Phase 4Completed

NCT00133289 Boston ScientificPacemaker with Automatic Capture

ULTRA Study for Pacemaker Patients

Start: Jul 2005Est. completion: Jun 2007950 patients

Phase 4Completed

NCT00146861 Boston Scientificsensor programming

LIFE Study - Limiting Chronotropic Incompetence for Pacemaker Recipients

Start: Jul 2003Est. completion: Jan 20061,500 patients

Phase 4Completed

NCT01537718 LivaNovaREPLY 200

Evaluation of the Performances of the Sleep Disordered Breathing Monitoring Function in Pacemaker

Start: Mar 2012Est. completion: Nov 201240 patients

Phase 3Completed

NCT00180284 Boston ScientificSITELINE 2 Polyurethane

SITELINE 2 Polyurethane

Start: Nov 2004Est. completion: Feb 2008200 patients

Phase 3Completed

NCT07342608 MicroPortUse of LINEA cardiac pacing lead

Safety and Performances of the LINEA Cardiac Pacing Lead Optimized for the Implantation in Interventricular Septum

Start: Mar 2026Est. completion: Apr 2030450 patients

N/ANot Yet Recruiting

NCT07209852 Boston ScientificPacemaker lead

Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up

Start: Dec 2025Est. completion: Aug 2029140 patients

N/ARecruiting

NCT07254013 MicroPortLBBAP implant

Left Bundle Branch Area Pacing (LBBAP) Monitoring Assistant: Evaluation of Portable ECG Solution

Start: Nov 2025Est. completion: Mar 202655 patients

N/ARecruiting

NCT07217392 AbbottLBBAP lead

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Start: Jul 2025Est. completion: Apr 2027200 patients

N/ARecruiting

NCT06453850 MicroPortUse of FLEXIGO delivery catheter

Safety and Performance Evaluation of a New Catheter Range for Lead Implantation At Interventricular Septum

Start: Feb 2025Est. completion: Dec 2026216 patients

N/ARecruiting

NCT06038123 MedtronicChina market released 3.0T Magnetic resonance

China 3T MRI Study

Start: Nov 2023Est. completion: Oct 202464 patients

N/ACompleted

NCT06014866 Boston ScientificCardiac pacing

Conduction System Pacing With INGEVITY+

Start: Nov 2023Est. completion: Aug 20241,383 patients

N/ACompleted

NCT06115980 Scopus BioPharmalead extraction

Safety and Preliminary Performance of Xtrac O.S. System for Lead Extraction.

Start: Aug 2023Est. completion: Jul 202510 patients

N/ARecruiting

NCT06018818 BiotronikAmvia/Solvia pacemaker family

Post Market Clinical Follow-up Study for the Amvia/Solvia Pacemaker Family

Start: Aug 2023Est. completion: Jul 2025129 patients

N/ACompleted

NCT05887323 AbbottImplantation of the Tendril 2088 lead in the LBBA

LBBAP Data Collection Registry

Start: Apr 2023Est. completion: Jul 2023221 patients

N/ACompleted

NCT05251363 BiotronikSolia S lead

BIOTRONIK Conduction System Pacing With the Solia Lead

Start: Dec 2022Est. completion: Oct 2024194 patients

N/ACompleted

NCT05610176 BiotronikAmvia Sky pacemaker or CRT-P device

BIO|CONCEPT.Amvia Study

Start: Nov 2022Est. completion: Jun 202452 patients

N/ACompleted

NCT05440071 MicroPortJX- XFINE lead

PoSt-market Assessment on Safety and Performance of J-sHAPed xFINE Lead

Start: Sep 2022Est. completion: Sep 2024129 patients

N/AUnknown

NCT05165095 MicroPortPacemaker implantation

Clinical Assessment of Essential Remote Monitoring Functions in Pacemakers

Start: Mar 2022Est. completion: Jul 2027206 patients

N/ARecruiting

NCT04583709 MedtronicECG Belt

ECG Belt to Assess Electrical Synchronization

Start: Jan 2021Est. completion: Jun 202120 patients

N/ACompleted

NCT04346537 Boston ScientificINGEVITY+™ Pace/Sense Lead

INGEVITY+ Active Fixation Pace/Sense Lead Clinical Study

Start: Aug 2020Est. completion: Mar 2021109 patients

N/ACompleted

NCT04253184 MedtronicMicra AV Transcatheter Pacing System

Micra AV Transcatheter Pacing System Post-Approval Registry

Start: Feb 2020Est. completion: Jan 2026802 patients

N/ACompleted

NCT03922386 MicroPortXFINE leads

Safety and Electrical Performances of XFINE Leads

Start: Sep 2019Est. completion: Jul 2021188 patients

N/ACompleted

NCT03719040 AbbottPhysiologic pacing device implant

Physiologic Pacing Registry

Start: Nov 2018Est. completion: Oct 2021870 patients

N/ACompleted

NCT03624504 MedtronicMicra Transcatheter Pacing System

China Micra Transcatheter Pacing Study

Start: Jul 2018Est. completion: Jan 202082 patients

N/ACompleted

NCT03518658 MedtronicEvaluation Group

BlueSync Field Evaluation

Start: Apr 2018Est. completion: Dec 2019257 patients

N/ACompleted

NCT03039712 MedtronicLongitudinal Coverage With Evidence Development Study on Micra Leadless Pacemakers

Longitudinal Coverage With Evidence Development Study on Micra Leadless Pacemakers

Start: Mar 2017Est. completion: Jun 202937,000 patients

N/AActive Not Recruiting

NCT03012568 AbbottSJM Implantable cardiac devices

Clinical Study to Confirm MRI Safety and Effectiveness Using St. Jude Medical (SJM) Cardiac Rhythm Management Systems

Start: Nov 2016Est. completion: Mar 2018119 patients

N/ACompleted

NCT02536118 MedtronicMicra Transcatheter Pacing System

Micra Transcatheter Pacing System Post-Approval Registry

Start: Jul 2015Est. completion: Apr 20273,100 patients

N/AActive Not Recruiting

NCT02488681 MedtronicMicra Pacemaker Implant

Micra Transcatheter Pacing System Continued Access Study Protocol

Start: Jun 2015Est. completion: Jul 2016285 patients

N/ACompleted

NCT02166606 Boston ScientificImageReady MR Conditional Pacing System Implant

INGEVITY™ Observational Trial

Start: Apr 2014Est. completion: Sep 20161,184 patients

N/ACompleted

NCT02030418 AbbottLeadless Pacemaker

The LEADLESS II IDE Study for the Nanostim Leadless Pacemaker

Start: Feb 2014Est. completion: Jul 2022952 patients

N/ACompleted

NCT02059629 BiotronikEluna pacemaker family

Eluna Family / Sentus BP Master Study

Start: Feb 2014Est. completion: Apr 2016167 patients

N/ACompleted

NCT01809652 MedtronicRemote Implant Support Capability

Feasibility Study of Remote Support for Implantable Pulse Generator (IPG)/Implantable Cardioverter Defibrillator (ICD) Implant

Start: Dec 2013Est. completion: Apr 201437 patients

N/ACompleted

NCT01922726 MicroPortRegistry of Sleep Apnea Monitoring and Atrial Fibrillation in Pacemaker Patients (RESPIRE)

Registry of Sleep Apnea Monitoring and Atrial Fibrillation in Pacemaker Patients (RESPIRE)

Start: Jul 2013Est. completion: Dec 20171,257 patients

N/ACompleted

NCT01688843 Boston ScientificINGEVITY lead

Safety and Performance Study of the INGEVITY Lead

Start: Oct 2012Est. completion: Feb 20191,060 patients

N/ACompleted

NCT01559311 AbbottCRT-P OFF

ENHANCE-Efficacy of the Presence of Right Ventricular Apical Pacing Induced Ventricular Dyssynchrony as a Guiding Parameter for Biventricular Pacing in Patients With Bradycardia and Normal Ejection Fraction

Start: Feb 2012Est. completion: Apr 201698 patients

N/ACompleted

NCT01299675 MedtronicSureScan Post-Approval Study

SureScan Post-Approval Study

Start: Feb 2011Est. completion: Oct 20172,483 patients

N/ACompleted

NCT01030705 Boston ScientificCommon Sensing and Right Ventricular Automatic Capture (COGNATE)

Common Sensing and Right Ventricular Automatic Capture (COGNATE)

Start: Nov 2009Est. completion: Jun 201080 patients

N/ACompleted

NCT01039467 MedtronicMedtronic Adapta Dual Chamber Pacemaker

A Comparison of the Pacemaker Automatic Features in Reduction of Ventricular Pacing

Start: Jun 2009Est. completion: Apr 2014385 patients

N/ACompleted

NCT00839384 MedtronicAdvisa IPG

AdvisaTM IPG Clinical Evaluation Study

Start: Feb 2009Est. completion: Jul 200979 patients

N/ACompleted

NCT01754064 AbbottCardiac Rhythm Management device

St. Jude Medical Product Longevity and Performance (SCORE) Registry

Start: Nov 2007Est. completion: Jul 202010,957 patients

N/ACompleted

NCT00433654 MedtronicImplantable Pulse Generator

EMRI SureScan™ Clinical Study

Start: Feb 2007Est. completion: Aug 2010484 patients

N/ACompleted

NCT00286858 Boston ScientificInsignia Ultra and Insignia AVT

Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing

Start: Sep 2006Est. completion: Dec 2010903 patients

N/ACompleted

NCT00311168 AbbottIntervention/treatment

Reduction of Right Ventricular Pacing Using the Feature Ventricular Intrinsic Preference (VIP)

Start: Feb 2006Est. completion: Sep 2008135 patients

N/ACompleted

NCT00158925 Boston ScientificEASYTRAK EPI lead

The EASYTRAK EPI Clinical Investigation

Start: Sep 2004Est. completion: Feb 2008100 patients

N/ACompleted

NCT00294645 MedtronicTranstelephonic monitoring

PREFER (Pacemaker Remote Follow-Up Evaluation and Review)

Start: Apr 2004Est. completion: Apr 2008980 patients

N/ACompleted

NCT00294060 MedtronicP3: Pacemaker Patient Profiling Study

P3: Pacemaker Patient Profiling Study

Start: Mar 2004Est. completion: Nov 20072,013 patients

N/ATerminated

NCT00266682 MedtronicPacing Lead

Clinical Investigation of the SelectSecure Pacing Lead

Start: Aug 2002Est. completion: Aug 2005365 patients

N/ACompleted

NCT01912326 AbbottPacemaker Implantation

Prevention of Atrial Fibrillation by Optimized Overdrive Stimulation

Start: Jul 2002Est. completion: Apr 2008249 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals

6 actively recruiting trials targeting 74,430 patients

8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.