Tachycardia

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Boston ScientificCA - Valencia

7 programs

Implantable Cardioverter DefibrillatorPhase 41 trial

VITALITY 2 Implantable Cardioverter DefibrillatorPhase 41 trial

Cardiac resynchronization therapy with defibrillationN/A1 trial

RELIANCE 4-FRONT™ Passive Fixation lead implantationN/A1 trial

+2 more programs

Active Trials

NCT00180271Completed1,820Est. Sep 2010

NCT01856491Completed167Est. Nov 2017

NCT01772576Completed167Est. Aug 2016

+4 more trials

LivaNovaUK - London

1 program

Ovatio DR 6550Phase 41 trial

Active Trials

NCT00729703Completed462Est. Oct 2013

MedtronicNJ - Phillipsburg

5 programs

Defibrillation following induction of VT/VFN/A1 trial

Defibrillation using the Extravascular ICDN/A1 trial

Active Trials

NCT02772380Completed87Est. Aug 2017

NCT07091916Completed14Est. Jan 2025

NCT04060680Completed393Est. Jan 2024

+2 more trials

Rhythm PharmaceuticalsBOSTON, MA

4 programs

Defibrillation following induction of VT/VFN/A

Defibrillation using the Extravascular ICDN/A

BiotronikGermany - Berlin

1 program

CorSky ICD or CRT-DN/A1 trial

Active Trials

NCT06840509Active Not Recruiting52Est. Dec 2026

AbbottABBOTT PARK, IL

1 program

ICD with enhanced SVT discriminatorsN/A1 trial

Active Trials

NCT01963286Completed735Est. Oct 2016

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

LivaNovaOvatio DR 6550

Boston ScientificVITALITY 2 Implantable Cardioverter Defibrillator

Boston ScientificImplantable Cardioverter Defibrillator

BiotronikCorSky ICD or CRT-D

MedtronicDefibrillation using the Extravascular ICD

Boston ScientificSubcutaneous Implantable Cardioverter Defibrillator

MedtronicDefibrillation following induction of VT/VF

Boston ScientificRELIANCE 4-FRONT™ Passive Fixation lead implantation

AbbottICD with enhanced SVT discriminators

Boston ScientificReliance 4-Front lead implantation

Boston ScientificCardiac resynchronization therapy with defibrillation

Clinical Trials (15)

Total enrollment: 8,010 patients across 15 trials

NCT00729703 LivaNovaOvatio DR 6550

Optimal Anti-tachycardia Therapy in Implantable Cardioverter-defibrillator (ICD) Patients Without Pacing Indications

Start: Jun 2006Est. completion: Oct 2013462 patients

Phase 4Completed

NCT00148954 Boston ScientificVITALITY 2 Implantable Cardioverter Defibrillator

RIGHT: Rhythm ID Going Head-to-Head Trial

Start: Jul 2005Est. completion: Jul 20101,962 patients

Phase 4Completed

NCT00158912 Boston ScientificImplantable Cardioverter Defibrillator

VAST - Ventricular Arrhythmia Suppression Trial

Start: Aug 2003Est. completion: May 2005550 patients

Phase 4Completed

NCT00148967 Boston ScientificImplantable Cardioverter Defibrillator

INTRINSIC RV - Inhibition of Unnecessary RV Pacing With AV Search Hysteresis in ICDs

Start: Jul 2003Est. completion: Oct 20051,535 patients

Phase 4Completed

NCT06840509 BiotronikCorSky ICD or CRT-D

BIO|CONCEPT.CorSky, First in Human Study for the CorSky ICD Family

Start: Jul 2025Est. completion: Dec 202652 patients

N/AActive Not Recruiting

NCT07091916 MedtronicDefibrillation using the Extravascular ICD

ExtraVascular Implantable Cardioverter Defibrillator (EV ICD) Japan Study

Start: Feb 2023Est. completion: Jan 202514 patients

N/ACompleted

NCT05049720 MedtronicDefibrillation using the Extravascular ICD

ExtraVascular Implantable Cardiac Defibrillator Continued Access Study

Start: Sep 2022Est. completion: Jul 20230

N/AWithdrawn

NCT04060680 MedtronicDefibrillation using the Extravascular ICD

Extravascular ICD Pivotal Study

Start: Sep 2019Est. completion: Jan 2024393 patients

N/ACompleted

NCT03608670 MedtronicDefibrillation using the Extravascular ICD

Extravascular ICD Pilot Study

Start: Jul 2018Est. completion: Nov 202326 patients

N/ACompleted

NCT02787785 Boston ScientificSubcutaneous Implantable Cardioverter Defibrillator

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Start: Apr 2017Est. completion: Jun 202340 patients

N/ACompleted

NCT02772380 MedtronicDefibrillation following induction of VT/VF

Acute Study to Collect Electrical Signals From the Heart Using a Special Lead

Start: May 2016Est. completion: Aug 201787 patients

N/ACompleted

NCT01856491 Boston ScientificRELIANCE 4-FRONT™ Passive Fixation lead implantation

Safety and Performance Study of the RELIANCE 4-Front Passive Fixation Lead

Start: Dec 2013Est. completion: Nov 2017167 patients

N/ACompleted

NCT01963286 AbbottICD with enhanced SVT discriminators

Reduction of Inappropriate Shocks of Implantable Cardioverter Defibrillators (ICDs) With Enhanced SVT Discriminators

Start: Aug 2013Est. completion: Oct 2016735 patients

N/ACompleted

NCT01772576 Boston ScientificReliance 4-Front lead implantation

Safety and Performance Study of the Reliance 4-Front Lead

Start: Oct 2012Est. completion: Aug 2016167 patients

N/ACompleted

NCT00180271 Boston ScientificCardiac resynchronization therapy with defibrillation

MADIT-CRT: Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy

Start: Dec 2004Est. completion: Sep 20101,820 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.