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Sick Sinus Syndrome

3
Pipeline Programs
4
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
4 programs
1
2
Pacing leads to be implanted according randomization.Phase 41 trial
Vitatron T70 DRPhase 41 trial
polymixin/bacitracinPhase 31 trial
Implantable Pulse GeneratorsN/A1 trial
Active Trials
NCT00284830Completed1,070Est. Feb 2008
NCT02809131Completed1,010Est. Sep 2021
NCT00161538Completed456Est. Jun 2006
+1 more trials
Biotronik
BiotronikGermany - Berlin
3 programs
Pacemaker with Fixed long AV delayN/A1 trial
Ventricular Pace SuppressionN/A1 trial
Home Monitoring of pacemakerPHASE_41 trial
Active Trials
NCT03843242Completed146Est. Nov 2022
NCT01528657Completed230Est. Aug 2015
NCT00475124Terminated123Est. Sep 2012
Abbott
AbbottABBOTT PARK, IL
2 programs
Accent PacemakerN/A1 trial
Device data collectionN/A1 trial
Active Trials
NCT01074749Terminated111Est. Jul 2014
NCT03564860Completed200Est. Sep 2020
Rhythm Pharmaceuticals
1 program
Implantable Pulse GeneratorsN/A

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
BiotronikHome Monitoring of pacemaker
MedtronicVitatron T70 DR
MedtronicPacing leads to be implanted according randomization.
Medtronicpolymixin/bacitracin
BiotronikPacemaker with Fixed long AV delay
AbbottDevice data collection
BiotronikVentricular Pace Suppression
AbbottAccent Pacemaker
MedtronicImplantable Pulse Generators

Clinical Trials (9)

Total enrollment: 3,748 patients across 9 trials

NCT00475124BiotronikHome Monitoring of pacemaker

Virtual Clinic Pacemaker Follow-up

Start: May 2007Est. completion: Sep 2012123 patients
Phase 4Terminated
NCT00161551MedtronicVitatron T70 DR

Mode Evaluation in Sick Sinus Syndrome Trial (MODEST)

Start: Nov 2004Est. completion: Dec 2010402 patients
Phase 4Unknown
NCT00161538MedtronicPacing leads to be implanted according randomization.

Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation

Start: Jul 2000Est. completion: Jun 2006456 patients
Phase 4Completed
NCT02809131Medtronicpolymixin/bacitracin

Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.

Start: Apr 2016Est. completion: Sep 20211,010 patients
Phase 3Completed
NCT03843242BiotronikPacemaker with Fixed long AV delay

Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber Pacemaker

Start: May 2019Est. completion: Nov 2022146 patients
N/ACompleted
NCT03564860AbbottDevice data collection

HBP Device EGM Data Collection

Start: Jul 2018Est. completion: Sep 2020200 patients
N/ACompleted
NCT01528657BiotronikVentricular Pace Suppression

Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study

Start: Dec 2011Est. completion: Aug 2015230 patients
N/ACompleted
NCT01074749AbbottAccent Pacemaker

Optimal Sensing in Atrial Tachyarrhythmia's Study

Start: Jul 2010Est. completion: Jul 2014111 patients
N/ATerminated
NCT00284830MedtronicImplantable Pulse Generators

SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction

Start: Jan 2003Est. completion: Feb 20081,070 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.