Ventricular Tachycardia

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

MedtronicNJ - Phillipsburg

9 programs

Dual Chamber ICDPhase 41 trial

DF4 Connector System Post-Approval StudyN/A1 trial

ICDN/A

ICD lead implantN/A1 trial

Intrinsic Antitachycardia PacingN/A1 trial

+4 more programs

Active Trials

NCT01638897Completed1,778Est. Mar 2019

NCT00335036Terminated748Est. Jan 2009

NCT04496518Active Not Recruiting2,200Est. Jan 2028

+2 more trials

AbbottABBOTT PARK, IL

7 programs

amiodarone beta blocker sotalolPhase 41 trial

AVAI: Atrial Ventricular Arrythmia IncidenceN/A1 trial

Device ImplantationN/A1 trial

Implantable Cardioverter DefibrillatorN/A1 trial

Implantable DefibrillatorN/A1 trial

+2 more programs

Active Trials

NCT00832975Completed157Est. Dec 2013

NCT00745745Completed299Est. Jan 2013

NCT02844127Withdrawn0Est. Apr 2017

+4 more trials

Baili PharmaceuticalChina - Chengdu

1 program

Nifekalant hydrochloridePhase 42 trials

Active Trials

NCT03853369Unknown2,000Est. Dec 2019

NCT03855826Unknown756Est. Jan 2020

Boston ScientificCA - Valencia

5 programs

LEVER Acute Study SystemPhase 11 trial

Cognis 100-D, Teligen DR and VR 100 HEN/A1 trial

Endotak RelianceN/A1 trial

Endotak Reliance GN/A1 trial

Prizm, Vitality, RenewalN/A1 trial

Active Trials

NCT00711893Completed301Est. Feb 2010

NCT00180349Completed904Est. Jul 2009

NCT00180297Completed215Est. Sep 2012

+2 more trials

Rhythm PharmaceuticalsBOSTON, MA

5 programs

ICDN/A1 trial

RegistryN/A1 trial

Single Chamber Implantable Cardioverter DefibrillatorN/A1 trial

TPD RAMWareN/A1 trial

DOACPHASE_41 trial

Active Trials

NCT00279968Completed1,326Est. Jan 2006

NCT00270933Completed742Est. Dec 2005

NCT00157820Completed354Est. Oct 2005

+2 more trials

BiotronikGermany - Berlin

2 programs

Iforia/Ilesto ICD/CRT-D, Linox smart DF4 lead/ ProtegoN/A1 trial

SD01 ICD leadN/A1 trial

Active Trials

NCT01790841Completed240Est. Apr 2016

NCT01836497Completed163Est. Sep 2024

GE HealthCare

1 program

123I-metaiodobenzylguanidineN/A1 trial

Active Trials

NCT01250912Completed20Est. Jul 2019

LivaNovaUK - London

1 program

Impact of Ventricular Pacing in Unselected ICD/CRT-D PatientsN/A1 trial

Active Trials

NCT01169896Completed616Est. Dec 2011

ThermedicalMA - Waltham

1 program

Saline Enhanced RadiofrequencyN/A1 trial

Active Trials

NCT03628534Completed16Est. Jul 2022

Adagio MedicalCA - Laguna Hills

1 program

VT Cryoablation SystemN/A

Stuart TherapeuticsFL - Stuart

1 program

amiodarone beta blocker sotalolPHASE_4

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

Baili PharmaceuticalNifekalant hydrochloride

Rhythm PharmaceuticalsDOAC

MedtronicDual Chamber ICD

Abbottamiodarone beta blocker sotalol

Boston ScientificLEVER Acute Study System

MedtronicTemperature controlled DiamondTemp

AbbottOutcomes of Functional Substrate Mapping of Ventricular Tachycardia

MedtronicIntrinsic Antitachycardia Pacing

Baili PharmaceuticalNifekalant hydrochloride

ThermedicalSaline Enhanced Radiofrequency

Rhythm PharmaceuticalsTPD RAMWare

AbbottImplantable Cardioverter Defibrillator

BiotronikSD01 ICD lead

BiotronikIforia/Ilesto ICD/CRT-D, Linox smart DF4 lead/ Protego

MedtronicDF4 Connector System Post-Approval Study

Showing 15 of 29 trials with date data

Clinical Trials (29)

Total enrollment: 15,205 patients across 29 trials

NCT03855826 Baili PharmaceuticalNifekalant hydrochloride

Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection.

Start: Jan 2019Est. completion: Jan 2020756 patients

Phase 4Unknown

NCT02666742 Rhythm PharmaceuticalsDOAC

DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation

Start: Feb 2017Est. completion: Apr 2021246 patients

Phase 4Completed

NCT00787800 MedtronicDual Chamber ICD

The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock

Start: Nov 2008Est. completion: Dec 2011100 patients

Phase 4Completed

NCT00257959 Abbottamiodarone beta blocker sotalol

Optimal Pharmacological Therapy In Implantable Defibrillator Patients (OPTIC)

Start: Jan 2001Est. completion: Oct 2004400 patients

Phase 4Completed

NCT02891863 Boston ScientificLEVER Acute Study System

Low Energy Therapy to Convert Ventricular Tachycardias

Start: Sep 2015Est. completion: Mar 20169 patients

Phase 1Terminated

NCT06028919 MedtronicTemperature controlled DiamondTemp

Power Versus Temperature Controlled Ablation for Treatment of VT

Start: Sep 2022Est. completion: Nov 202561 patients

N/ACompleted

NCT05708131 AbbottOutcomes of Functional Substrate Mapping of Ventricular Tachycardia

Outcomes of Functional Substrate Mapping of Ventricular Tachycardia

Start: Jul 2022Est. completion: Dec 202470 patients

N/AUnknown

NCT04496518 MedtronicIntrinsic Antitachycardia Pacing

Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)

Start: Aug 2020Est. completion: Jan 20282,200 patients

N/AActive Not Recruiting

NCT03853369 Baili PharmaceuticalNifekalant hydrochloride

Post-marketing Registration Study of Nifekalant Hydrochloride (NIF) Injection

Start: Feb 2019Est. completion: Dec 20192,000 patients

N/AUnknown

NCT03628534 ThermedicalSaline Enhanced Radiofrequency

SERF VT Ablation Early Feasibility Study (EFS)

Start: Nov 2018Est. completion: Jul 202216 patients

N/ACompleted

NCT03402126 Rhythm PharmaceuticalsTPD RAMWare

Tachy Prediction Download Study

Start: Jan 2018Est. completion: Feb 2020138 patients

N/ACompleted

NCT02844127 AbbottImplantable Cardioverter Defibrillator

Effect of Right Ventricular Lead Position on Defibrillation Threshold

Start: Nov 2016Est. completion: Apr 20170

N/AWithdrawn

NCT01836497 BiotronikSD01 ICD lead

SD01 Master Study (Safety and Efficacy Study)

Start: May 2013Est. completion: Sep 2024163 patients

N/ACompleted

NCT01790841 BiotronikIforia/Ilesto ICD/CRT-D, Linox smart DF4 lead/ Protego

DF4 Master Study (Safety and Efficacy Study)

Start: Feb 2013Est. completion: Apr 2016240 patients

N/ACompleted

NCT01638897 MedtronicDF4 Connector System Post-Approval Study

DF4 Connector System Post-Approval Study

Start: Jan 2012Est. completion: Mar 20191,778 patients

N/ACompleted

NCT01250912 GE HealthCare123I-metaiodobenzylguanidine

Imaging With a Radio Tracer to Guide VT Ablations

Start: Mar 2010Est. completion: Jul 201920 patients

N/ACompleted

NCT00832975 AbbottAVAI: Atrial Ventricular Arrythmia Incidence

AVAI: Atrial Ventricular Arrythmia Incidence

Start: Dec 2008Est. completion: Dec 2013157 patients

N/ACompleted

NCT00745745 AbbottDevice Implantation

Septal Positioning of Ventricular Implanted Cardioverter Defibrillator (ICD) Leads

Start: Aug 2008Est. completion: Jan 2013299 patients

N/ACompleted

NCT00711893 Boston ScientificCognis 100-D, Teligen DR and VR 100 HE

Feature Assessment Study for Indications Based Programming

Start: Jun 2008Est. completion: Feb 2010301 patients

N/ACompleted

NCT01169896 LivaNovaImpact of Ventricular Pacing in Unselected ICD/CRT-D Patients

Impact of Ventricular Pacing in Unselected ICD/CRT-D Patients

Start: Nov 2007Est. completion: Dec 2011616 patients

N/ACompleted

NCT00335036 MedtronicICD lead implant

Pediatric Lead Extractability and Survival Evaluation (PLEASE)

Start: Jun 2006Est. completion: Jan 2009748 patients

N/ATerminated

NCT00180297 Boston ScientificEndotak Reliance G

Septal - Success Rate and Clinical Outcome of Septal Implant of Ventricular Defibrillation Lead

Start: Apr 2005Est. completion: Sep 2012215 patients

N/ACompleted

NCT00180349 Boston ScientificEndotak Reliance

Leader - Evaluation of Endotak Reliance

Start: Dec 2004Est. completion: Jul 2009904 patients

N/ACompleted

NCT00279968 Rhythm PharmaceuticalsICD

INSIGHTS ICD Registry

Start: Feb 2004Est. completion: Jan 20061,326 patients

N/ACompleted

NCT00270933 Rhythm PharmaceuticalsRegistry

MAVRIC VR ICD Registry

Start: Jan 2004Est. completion: Dec 2005742 patients

N/ACompleted

NCT00187187 AbbottImplantable Defibrillator

DAVID II (Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial II)

Start: Jun 2003Est. completion: Sep 2007600 patients

N/ACompleted

NCT00919373 AbbottSubstrate modification

Substrate Modification in Stable Ventricular Tachycardia in Addition to Implantable Cardioverter Defibrillator (ICD) Therapy

Start: Jul 2002Est. completion: Jan 2006110 patients

N/ACompleted

NCT00180375 Boston ScientificPrizm, Vitality, Renewal

OPERA: French Observational Study on Patients Implanted With a Guidant PRIZM or Vitality Defibrillator

Start: May 2002Est. completion: Aug 2007636 patients

N/ACompleted

NCT00157820 Rhythm PharmaceuticalsSingle Chamber Implantable Cardioverter Defibrillator

DATAS: The Dual Chamber & Atrial Tachyarrhythmias Adverse Events Study

Start: Nov 2000Est. completion: Oct 2005354 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.