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Career Signal

Patent Cliff Hiring Radar

Drugs losing exclusivity in the next 24 months, ranked by hiring velocity at the affected companies. The thesis: pharma companies hire ahead of patent cliffs to launch lifecycle-extension follow-ons, defend share, and transition reps to other portfolio drugs. A “Hot” company about to lose exclusivity is the most actionable career signal we surface.

100 branded drugs with LOE dates within 24 months · sorted by hiring velocity then by months-to-cliff

Cliff within 12 months

Most-time-sensitive — companies under active hiring pressure tend to be here.

FEXINIDAZOLE(fexinidazole)·Sanofi

Nitroimidazole Antimicrobial [EPC]

0.1yr
Hot+2451145 jobs
DUEXIS(famotidine; ibuprofen)·Amgen
0.1yr
Hot+13301508 jobs

PNAC

0.1yr
Hot+833116 jobs
DYMISTA(azelastine hydrochloride and fluticasone propionate)·Viatris (2)
0.2yr
Hot+392266 jobs
FLOVENT HFA(fluticasone propionate)·GSK
0.2yr
Hot+146743 jobs
SENSIPAR(cinacalcet hydrochloride)·Amgen
0.3yr
Hot+13301508 jobs
0.3yr
Hot+496820 jobs
ARICEPT(donepezil hydrochloride)·Eisai

dementia of the Alzheimer’s type

0.3yr
Hot+5656 jobs
ROZLYTREK(entrectinib)·Roche
0.3yr
Hot+6751235 jobs
NAROPIN(ropivacaine hydrochloride)·Fresenius Kabi
0.4yr
Hot+833116 jobs
PROTONIX(pantoprazole sodium)·Pfizer
0.5yr
Hot+201507 jobs
CORLANOR(ivabradine)·Amgen
0.5yr
Hot+13301508 jobs
VYNDAQEL(tafamidis meglumine)·Pfizer
0.5yr
Hot+201507 jobs
ADVIL ALLERGY SINUS(chlorpheniramine maleate, ibuprofen, pseudoephedrine hcl)·GSK

these symptoms associated with hay fever, other upper respiratory allergies, the common cold: runny nose itchy +3

0.7yr
Hot+146743 jobs
DUAVEE(conjugated estrogens/bazedoxifene)·Pfizer
0.7yr
Hot+201507 jobs
CHLORAPREP WITH TINT(chlorhexidine gluconate and isopropyl alcohol)·Becton Dickinson

bacteria

0.8yr
Hot+186538 jobs
CHLORAPREP ONE-STEP(chlorhexidine gluconate and isopropyl alcohol)·Becton Dickinson

bacteria

0.8yr
Hot+186538 jobs
CHLORAPREP ONE-STEP FREPP(chlorhexidine gluconate and isopropyl alcohol)·Becton Dickinson

bacteria

0.8yr
Hot+186538 jobs
LYRICA CR(pregabalin)·Viatris (2)
0.9yr
Hot+392266 jobs
JANUMET XR(sitagliptin and metformin hydrochloride)·Merck & Co.
0.9yr
Hot+428819 jobs
JANUVIA(sitagliptin)·Merck & Co.
0.9yr
Hot+428819 jobs
CORLANOR(ivabradine)·Amgen
1.0yr
Hot+13301508 jobs
0.0yr
Stable+14 jobs
0.0yr
Stable+14 jobs
SUMAVEL DOSEPRO(sumatriptan succinate)·Antares Therapeutics
0.4yr
Stable+24 jobs
VELETRI(epoprostenol)·Johnson & Johnson
0.7yr
Stable00 jobs
EDURANT(rilpivirine hydrochloride)·Johnson & Johnson
0.7yr
Stable00 jobs
0.9yr
Stable-110 jobs
BALCOLTRA(levonorgestrel and ethinyl estradiol)·Xeltis
0.9yr
Stable04 jobs
1.0yr
Stable00 jobs
1.0yr
Stable00 jobs
APLENZIN(bupropion hydrobromide)·Bausch + Lomb

major depressive disorder (MDD), seasonal affective disorder (SAD), defined by the Diagnostic +2

0.0yr
0 jobs
NUCYNTA(tapentadol hydrochloride)·Humanwell Pharmaceutical
0.0yr
0 jobs
NUCYNTA(tapentadol hydrochloride)·Humanwell Pharmaceutical
0.0yr
0 jobs
SPIRIVA(tiotropium bromide)·Boehringer Ingelheim
0.1yr
0 jobs
AKTEN(lidocaine hydrochloride anhydrous)·Thea Pharma
0.1yr
0 jobs
NUEDEXTA(dextromethorphan hydrobromide and quinidine sulfate)·R-Pharm US

pseudobulbar affect (PBA)

0.1yr
0 jobs
0.3yr
0 jobs
SAPHRIS(asenapine maleate)·AbbVie
0.3yr
0 jobs
0.3yr
0 jobs
ADASUVE(loxapine)·Teva
0.3yr
0 jobs
SYNRIBO(omacetaxine mepesuccinate)·Teva
0.3yr
0 jobs
CLINDESSE(clindamycin phosphate)·Design Pharmaceuticals
0.4yr
0 jobs
CRESEMBA(isavuconazonium sulfate)·Astellas
0.5yr
0 jobs
SIGNIFOR(pasireotide)·Recordati
0.5yr
0 jobs
VIBATIV(telavancin hydrochloride)·Cumberland Pharmaceuticals
0.5yr
0 jobs
STRIVERDI RESPIMAT(olodaterol respimat inhalation spray)·Boehringer Ingelheim
0.6yr
0 jobs
LEXISCAN(regadenoson)·Astellas

Adenosine Receptor Agonist [EPC]

0.6yr
0 jobs
LEGUBETI(acetylcysteine lysine)·R-Pharm US
0.6yr
0 jobs
COLAZAL(balsalazide disodium)·Bausch + Lomb
0.7yr
0 jobs
ABILIFY(aripiprazole)·Otsuka

Atypical Antipsychotic [EPC]

0.7yr
0 jobs
DYLOJECT(diclofenac sodium)·Inpharmus
0.8yr
0 jobs
XIMINO(minocycline hydrochloride)·Journey Medical
0.8yr
0 jobs
CLINOLIPID 20%(olive oil and soybean oil)·Baxter

including term, preterm neonates, a source of calories +4

0.8yr
0 jobs
MOXATAG(amoxicillin)·Pragma Bio
0.9yr
0 jobs
AVEED(testosterone undecanoate)·Verity Pharmaceuticals
0.9yr
0 jobs
LUMIGAN(bimatoprost)·AbbVie
1.0yr
0 jobs
ANTIZOL(fomepizole)·R-Pharm US
1.0yr
0 jobs

12 to 24 months out

Earlier signal — lifecycle-extension hiring usually kicks in here.

PRISTIQ(desvenlafaxine succinate)·Pfizer
1.0yr
Hot+201507 jobs
HALAVEN(eribulin mesylate)·Eisai
1.0yr
Hot+5656 jobs
ROWASA(mesalamine)·Viatris (2)
1.1yr
Hot+392266 jobs
SFROWASA(mesalamine)·Viatris (2)
1.1yr
Hot+392266 jobs
PROTONIX IV(pantoprazole sodium)·Pfizer
1.1yr
Hot+201507 jobs
EMEND(aprepitant)·Merck & Co.
1.3yr
Hot+428819 jobs
EMEND(aprepitant)·Merck & Co.

Substance P/Neurokinin-1 Receptor Antagonist [EPC]

1.3yr
Hot+428819 jobs
CHLORHEXIDINE GLUCONATE(chlorhexidine gluconate)·Becton Dickinson
1.3yr
Hot+186538 jobs
XYZAL ALLERGY 24HR(levocetirizine dihydrochloride)·Sanofi
1.3yr
Hot+2451145 jobs
AMITIZA(lubiprostone)·Pfizer
1.3yr
Hot+201507 jobs
TOVIAZ(fesoterodine fumarate)·Pfizer
1.5yr
Hot+201507 jobs
BRIDION(sugammadex)·Merck & Co.
1.5yr
Hot+428819 jobs
TROXYCA ER(naltrexone hydrochloride; oxycodone hydrochloride)·Pfizer
1.5yr
Hot+201507 jobs
INCRUSE ELLIPTA(umeclidinium)·GSK
1.5yr
Hot+146743 jobs
FIBRICOR(fenofibric acid)·Athena Bioscience
1.2yr
Growing+99 jobs

erectile dysfunction

1.1yr
Stable-22 jobs

Histone Deacetylase Inhibitor [EPC]

1.3yr
Stable00 jobs
1.5yr
Stable00 jobs
EPIDUO(adapalene and benzoyl peroxide)·Galderma
1.1yr
0 jobs
ONSOLIS(fentanyl citrate)·Hikma
1.1yr
0 jobs
ALSUMA(sumatriptan succinate)·CooperSurgical
1.2yr
0 jobs
AZILECT(rasagiline mesylate)·Teva
1.2yr
0 jobs
BYVALSON(nebivolol hydrochloride; valsartan)·AbbVie

hypertension, to lower blood pressure, to lower blood pressure [see Clinical Studies ( )] +2

1.3yr
0 jobs
MACRILEN(macimorelin acetate)·Azenta Life Sciences
1.3yr
0 jobs
ACULAR LS(ketorolac tromethamine)·AbbVie
1.4yr
0 jobs
VALCYTE(valganciclovir hydrochloride)·Lavipharm
1.5yr
0 jobs
ORACEA(doxycycline)·Galderma
1.5yr
0 jobs
LASTACAFT(alcaftadine)·AbbVie
1.5yr
0 jobs
ZONTIVITY(vorapaxar sulfate)·Passkey Therapeutics
1.5yr
0 jobs
CARDENE(nicardipine hydrochloride)·Chiesi
1.5yr
0 jobs

Methodology: LOE (loss of exclusivity) dates come from FDA Orange Book patent + exclusivity records, taking the earlier of the two. Hiring velocity is computed from CrawlRun deltas over the last 30 days (jobs created − jobs removed) at the company level. “Hot” ≥ +20, “Growing” ≥ +5, “Stable” ±5, “Cooling” ≤ −5, “Contracting” ≤ −20. Patent cliffs are not financial advice; companies adjust hiring for many reasons beyond exclusivity loss.