NDAORALFOR SUSPENSIONPriority Review
Approved
Dec 2015
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
20
Data completeness
7/8 — Comprehensive
Priority Review
EMEND (aprepitant) by Merck & Co. is neurokinin 1 antagonists [moa]. First approved in 2015.
Drug data last refreshed 22h ago · AI intelligence enriched 2d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
EMEND (aprepitant) is an oral neurokinin-1 receptor antagonist approved by FDA in December 2015 for prevention of chemotherapy-induced nausea and vomiting (CINV). It works by blocking substance P signaling in the central nervous system, a mechanism distinct from 5-HT3 and NK1 antagonists. The drug is formulated as an oral suspension, making it accessible for patients unable to tolerate solid dosage forms.
$0.062BPart D
LOE ApproachingDeclining
1.0 years to LOEWith LOE arriving in September 2027 and only ~$62K in Part D spending, this product is in final commercial wind-down; expect reduced team headcount and reallocation of resources.
Mechanism of Action
Neurokinin 1 Antagonists
Pharmacologic Class:
Substance P/Neurokinin-1 Receptor Antagonist
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Aprepitant to Improve Same Day Discharge for TKA
Started Jul 2026
350 enrolled
PONV
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
Started Feb 2024
518 enrolled
Postoperative Nausea and Vomiting
Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)
Started Jul 2020
27 enrolled
COVID-19
Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)
Started Sep 2019
103 enrolled
Chemotherapy-induced Nausea and Vomiting
Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy
Started Nov 2018
690 enrolled
Malignant Neoplasm
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.