ARICEPT

LOE Approaching

donepezil hydrochloride

NDAORALTABLET
Approved
Jul 2010
Lifecycle
LOE Approaching
Competitive Pressure
25/100
Clinical Trials
20

Mechanism of Action

Alzheimer's disease attribute some of them to a deficiency of cholinergic neurotransmission. Donepezil hydrochloride is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition…

Clinical Trials (5)

NCT02448784N/ACompleted

Post-marketing Surveillance of Donepezil Hydrochloride - Investigation of Long Term Safety and Efficacy of Aricept as Well as Its Proper Use Information in Patients With Dementia With Lewy Bodies (DLB).

Started Apr 2015
591 enrolled
Dementia With Lewy Body Disease
NCT02158910N/ACompleted

A Plan on Investigation and Collection of Aricept Safety Information With a Dose Increase on Alzheimer's Disease Patients

Started Mar 2015
2,231 enrolled
Alzheimer's Disease
NCT02345213Phase 4Completed

A Post-Marketing Clinical Study of Aricept in Patients With Dementia With Lewy Bodies (DLB)

Started Mar 2015
160 enrolled
Dementia, Lewy BodyLewy Body Disease
NCT02262975N/ACompleted

A Multi-national Study to Identify Treatment Discontinuation Rate in de Novo Alzheimer's Disease Patients Who Have Been Newly Prescribed With Donepezil (Aricept) in Asia (ADOS)

Started Jul 2014
532 enrolled
Alzheimer's Disease
NCT02660983Phase 4Completed

A Study of Donepezil Hydrochloride in Patients With Dementia Associated With Cerebrovascular Disease

Started Aug 2013
302 enrolled
Dementia Associated With Cerebrovascular Disease

Loss of Exclusivity

LOE Date
Oct 4, 2026
7 months away
Patent Expiry
Oct 4, 2026

Patent Records (1)

Patent #ExpiryTypeUse Code
8481565
Oct 4, 2026
Product