Design Pharmaceuticals

MA - CambridgePharmaceutical1 H-1B visas (FY2023)

Focus: Design Pharmaceuticals is a Cambridge-based specialty pharmaceutical company focused on small molecule drug design with primary concentration in neurology. The company generates 38% of revenue from Brinzolamide, indicating a portfolio heavily weighted toward established generic and post-LOE products.

Neurology

Profile data last refreshed 1h ago · AI intelligence enriched 2w ago

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Recent layoff filing — 25 affected

7/20/2026 — 4941 Allison Parkway, Suite B Vacaville CA 95688, CA · 25 affected · Layoff

Source: state DOL filings via Big Local News

About Design Pharmaceuticals

AI assessmentNot Hiring

No open roles listed right now. Follow Design Pharmaceuticals to get notified when they start hiring — the background below is worth knowing for when they do.

Why Work Here

Data completeness

3/9 — Basic

Company HealthWatch

Pipeline

Early-stage

50 total

LOE Risk

1 imminent

CLINDESSE

Hiring

0 open

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

Key Products

BRINZOLAMIDE

Elevated intraocular pressure in ocular hypertension, open-angle glaucoma, hypertension

$16M Part D

Post-LOE

Anchor product representing 38% of revenue; generic carbonic anhydrase inhibitor facing ongoing competitive pressure.

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Established revenue base with $16M Part D spending on Brinzolamide provides near-term cash stability and operational continuity.
Active pipeline spanning 30 programs across neurology, oncology, and rare disease with Phase 1–3 trials underway (Miraπ in stroke, DT-216 in Friedreich Ataxia, topotecan in SCLC).
Cambridge headquarters location provides access to biotech talent ecosystem and proximity to academic medical centers for research collaboration.

Watch Out For

Zero active job openings and absence of published hiring data suggest minimal growth trajectory or severely contracted headcount relative to pipeline ambitions.
Portfolio of 10 post-LOE products (Brinzolamide, Halobetasol, Ibuprofen, Loteprednol, Nystatin, Terconazole) indicates declining revenue base vulnerable to margin compression as generic competition intensifies.
Four active drug shortages (Triamcinolone Acetonide, Bacitracin Ophthalmic, Triamcinolone Hexacetonide, Cromolyn Sodium) signal potential manufacturing or supply-chain distress.
Sparse pipeline data quality (many programs lack phase designation, list devices/vaccines/observational studies alongside small molecules) raises questions about portfolio discipline and execution capability.

Generated by Claude from Design Pharmaceuticals's SEC filings, pipeline programs, hiring velocity, FDA actions, and WARN data. Inference, not editorial — verify before quoting.

HALOBETASOL PROPIONATE

Psoriasis

$8M Part D

Post-LOE

Post-LOE corticosteroid with limited growth runway; mechanism of action in plaque psoriasis remains incompletely defined.

IBUPROFEN

Minor aches, pains, headache, toothache, backache, menstrual cramps, common cold, muscular aches, minor arthritis pain, fever reduction

$4M Part D

Post-LOE

Generic NSAID with commoditized market and minimal differentiation; revenue reflects low-margin commodity status.

LOTEPREDNOL ETABONATE

Steroid-responsive inflammatory conditions of palpebral and bulbar conjunctiva and cornea

$4M Part D

Post-LOE

Ophthalmic corticosteroid with selective metabolism to inactive metabolites; demonstrates clinical efficacy in allergic conjunctivitis but faces generic competition.

NYSTOP

Cutaneous and mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species

$2M Part D

Post-LOE

Fungistatic and fungicidal agent with decades-old profile; limited revenue reflects saturated antifungal market.

TERCONAZOLE

$2M Part D

Post-LOE

Azole antifungal with minimal disclosed indication data; represents low-margin generic asset.

IBU

Minor aches, pains, headache, toothache, backache, menstrual cramps, common cold, muscular aches, minor arthritis pain, fever reduction

$2M Part D

Post-LOE

Duplicate NSAID entry indicating portfolio fragmentation; same generic profile as earlier IBUPROFEN SKU.

TAZAROTENE

Retinoid for acne vulgaris and dermatologic conditions

$1M Part D

Post-LOE

RAR-selective retinoid with anti-hyperproliferative effects; minimal revenue reflects highly competitive topical retinoid market.

COMPRO

Control of severe nausea and vomiting in adults

$1M Part D

Post-LOE

Phenothiazine antiemetic with well-established mechanism; low revenue reflects aging generic drug status.

PENCICLOVIR

Recurrent herpes labialis (cold sores) in adults and older patients

$1M Part D

Post-LOE

DNA polymerase inhibitor with limited systemic absorption; modest revenue reflects narrow indication and topical-only route.

Pipeline & Clinical Trials

Standard of Care

Oral Pre-exposure Prophylaxis (PrEP)

N/A

Multicenter Intervention Program to Optimize the Clinical Management of Community-acquired Pneumonia

Community Acquired Pneumonia

N/A

Clinical Trials (1)

NCT02224716Multicenter Intervention Program to Optimize the Clinical Management of Community-acquired Pneumonia in Hospitals

N/A

experimental foot device

Balance

N/A

Clinical Trials (1)

NCT03663816Villency-Proof of Action: Foot Device, Balance and Sway, Kinematics of Walking

N/A

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: In

Systemic Autoimmune Diseases

N/A

Clinical Trials (1)

NCT02890134Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Inception Cohort

N/A

Microbiological studies

Bacteremia by Enterobacteriaceae

N/A

Clinical Trials (1)

NCT02005159Study of the Impact of the Minimum Inhibitory Concentration and Susceptible Cut-off Points (CLSI, EUCAST, and Pharmacokinetics/Pharmacodynamics)in Prognosis of Bacteremia by Enterobacteriaceae

N/A

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases:

Systemic Autoimmune Diseases

N/A

Clinical Trials (1)

NCT02890121Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases:

N/A

Fourth Trimester Mobile Tool

Pregnancy Related

N/A

Clinical Trials (1)

NCT04475718Fourth Trimester - A Web-based Tool for Postpartum Care to Address the Needs of Underserved Women

N/A

Coronary stent procedure

Unprotected Left Main Coronary Artery Stenosis

N/A

Clinical Trials (1)

NCT01971749Register of Treatment of Unprotected Left Main Coronary Artery Stenosis in Andalucía

N/A

Cone Beam Computed Tomography

Healthy Ankle

N/A

Home for Life mobile application

Hip Replacement

N/A

Clinical Trials (1)

NCT03253419HotShOT: Home Safety Occupational Therapy

N/A

Bodytrak

Monitoring, Physiologic

N/A

Clinical Trials (1)

NCT03139955Bodytrak® Feasibility Study

N/A

Insole and ankle device

Mild Cognitive Impairment (MCI)

N/A

Clinical Trials (1)

NCT07127133An Insole and Ankle Device for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD)

N/A

Exersides

Acute Respiratory Failure

N/A

Clinical Trials (1)

NCT04067622Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

N/A

eADAPT training

Amputation

N/A

Clinical Trials (1)

NCT04238533Enhanced Auto-Diagnostic Adaptive Precision Trainer for Myoelectric Prosthetic Users

N/A

PrenaBelt

Sleep

N/A

Clinical Trials (1)

NCT02377817Halifax PrenaBelt Trial

N/A

Observational Translational Study

Sarcoma

N/A

Clinical Trials (1)

NCT07432932Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients

N/A

Knee OA Brace

Knee Osteoarthritis

N/A

Clinical Trials (1)

NCT01886144Effects of Bracing on Knee Osteoarthritis (OA)

N/A

Rehabilitation combined to a digital maintenance program

Post-COVID-19 Syndrome

N/A

Clinical Trials (1)

NCT06124625Effects of Rehabilitation Combined With a Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19

N/A

Non-Contact Sleep Quality Monitor System

Alzheimer Disease

N/A

Clinical Trials (1)

NCT06045988Automated, Assistive, Non-Contact Sleep Quality Monitor for Individuals With Alzheimer's Disease

N/A

COMMIT mHealth application

Depression

N/A

Clinical Trials (1)

NCT04510909COMMIT Depression Trial Nepal

N/A

Qualitative Study for Pain Measurement Using Innovative Health Technology

Pain Measurement

N/A

Clinical Trials (1)

NCT03727373Qualitative Study for Pain Measurement Using Innovative Health Technology

N/A

Telemonitoring Constant

Chronic Lung Disease

N/A

Clinical Trials (1)

NCT03018717Integral Clinical Plan Shared With or Without Telemonitoring of Constants in Patient With Chronic Diseases

N/A

Hemosphere platform® together with the FloTrac Acumen IQ® sensor

Intraoperative Hypotension

N/A

Clinical Trials (1)

NCT04301102The Predict H Trial

N/A

sampling blood

Amyotrophic Lateral Sclerosis (ALS)

N/A

Clinical Trials (1)

NCT07099066Generation of Cell Banks and Biomarker Isolation From Patients With Amyotrophic Lateral Sclerosis (ALS) (HCD-SLA)

N/A

Sixty device

End Stage Renal Disease

N/A

Clinical Trials (1)

NCT04623281Haemodialysis Outcomes & Patient Empowerment Study 02

N/A

Development of a Decision Aid to Facilitate Ovarian Cancer Patient's Choices Regarding Biomarker CA1

Ovarian Cancer

N/A

Clinical Trials (1)

NCT03004391Development of a Decision Aid to Facilitate Ovarian Cancer Patient's Choices Regarding Biomarker CA125

N/A

Hepatic Safety of Eviplera® in HIV/Hepatitis C (HCV)-Coinfected Patients Without HCV Treatment in th

Human Immunodeficiency Virus (HIV) Hepatitis C Virus (HCV) Coinfected Subjects

N/A

Clinical Trials (1)

NCT02196064Hepatic Safety of Eviplera® in HIV/Hepatitis C (HCV)-Coinfected Patients Without HCV Treatment in the "The HEPAVIR HEPATIC SAFETY Cohort."

N/A

Verio Pattern Alert® activated

Diabetes Mellitus

N/A

Clinical Trials (1)

NCT02521506Clinical Efficacy of OneTouch® Verio™IQ Meter

N/A

COMMIT mHealth application

Hiv

N/A

Clinical Trials (1)

NCT04462679COMMIT HIV Trial Nepal

N/A

Walkasins

Mild Cognitive Impairment

N/A

Clinical Trials (1)

NCT05723822Effects of Walkasins on Gait Speed of Individuals With Mild Cognitive Impairments

N/A

Miraπ

Stroke

N/A

Clinical Trials (1)

NCT06296628Rehabilitation Device for Hand Mirror Therapy

N/A

Hemodynamic Impact on Critical Care Patients With Lung Damage Secondary to COVID-19

Covid19

N/A

Clinical Trials (1)

NCT04556864Hemodynamic Impact on Critical Care Patients With Lung Damage Secondary to COVID-19

N/A

Follow recommendations based on scientific evidence to S. aureus bacteremia management

Staphylococcus Aureus Bacteremia

N/A

Clinical Trials (1)

NCT01971762Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology

N/A

Self monitoring of blood pressure using Health Gauge Device and monthly monitoring of weight gain

Hypertension, Pregnancy-Induced

N/A

Clinical Trials (1)

NCT03858595Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy

N/A

Clopidogrel

Acute Coronary Syndromes

N/A

Clinical Trials (1)

NCT04630288Safety and Efficacy of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome

N/A

Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Acute Coronary Syndrome

N/A

Clinical Trials (1)

NCT02500290Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

N/A

Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data

URTI

N/A

Clinical Trials (1)

NCT03169699Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data

N/A

PrenaBelt

Sleep

N/A

Clinical Trials (1)

NCT02379728Ghana PrenaBelt Trial: A Positional Therapy Device to Reduce Still-Birth

N/A

Etanercept Survival in Elderly Population

Psoriasis

N/A

Clinical Trials (1)

NCT02503059Etanercept Survival in Elderly Population

N/A

Intervention Technology

Low Back Pain

N/A

Clinical Trials (1)

NCT03478007Low-Cost Tool for Compliance and Treatment-Tracking of Low Back Pain Patients

N/A

Study Of Use Of Pemetrexed In Patients With Non-Small Lung Cancer Metastatic In Andalusian Public He

Carcinoma, Non-Small-Cell Lung

N/A

Clinical Trials (1)

NCT01877902Study Of Use Of Pemetrexed In Patients With Non-Small Lung Cancer Metastatic In Andalusian Public Health System

N/A

eslicarbacepine

Epilepsy

N/A

Clinical Trials (1)

NCT02573272Impact of Eslicarbazepine Acetate on Lipid Metabolism and Cardiovascular Risk Factors

N/A

Brain Computer Interface integrated HandyRehab platform

Stroke

N/A

Clinical Trials (1)

NCT06076928Brain Computer Interface (BCI) Integrated Wearable Hand Robotic Glove System for Upper Limb Stroke Rehabilitation

N/A

Intervention: Mental Health Technician

Depression

N/A

Clinical Trials (1)

NCT02345122CAMH PARTNERs Integrated Care Study

N/A

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Ca

Healthy Subjects

N/A

Clinical Trials (1)

NCT02890147Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Case-control

N/A

Standard health coaching

Metabolic Syndrome

N/A

Clinical Trials (1)

NCT04262401Promoting Healthy Habits in Metabolic Syndrome

N/A

Retrospective Observational Study to Define HBsAg Loss With or Without Seroconversion to antiHBs in

Chronic Hepatitis B Treated With Nucleoside/Nucleotide Analogues

N/A

Clinical Trials (1)

NCT02005146Retrospective Observational Study to Define HBsAg Loss With or Without Seroconversion to antiHBs in Patients With Chronic Hepatitis by B Virus Treated With Nucleoside/Nucleotide Analogs

N/A

TURBUHALER®

Asthma

N/A

Clinical Trials (1)

NCT02983994Errors in the Use of Turbuhaler and Spiromax Devices Patients With Asthma

N/A

Hepatitis C

N/A

Clinical Trials (1)

NCT02004379Register of Telaprevir and Boceprevir in Routine Clinical Practice

N/A

Emotion induction using video

Emotion, Expressed

N/A

Clinical Trials (1)

NCT04044261Study of Evoked Emotional Responses

N/A

Open Jobs (0)

No open positions listed yet.

Interview Prep Quick Facts

Portfolio: 652 approved products, 121 clinical trials

Top TAs: Immunology, Neurology, Infectious Diseases

H-1B (2023): 1 approval

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Portfolio Health

Pre-Launch76 (12%)

Peak6 (1%)

LOE Approaching49 (8%)

Post-LOE521 (80%)

652 total products

Therapeutic Area Focus

Immunology

133 marketed5 pipeline

Neurology

72 marketed17 pipeline

Infectious Diseases

37 marketed13 pipeline

Respiratory

39 marketed8 pipeline

Visa Sponsorship

Sponsors Work Visas

H-1B Petitions (FY2023)

Approved

Denied

100%

Rate

Source: USCIS H-1B Employer Data Hub

Risk Signals

WARN Act Layoff Notices (1)

2026-07-20

25 employees affected— 4941 Allison Parkway, Suite B Vacaville CA 95688, CA

source

Source: state DOL filings, aggregated via Big Local News

43 marketed1 pipeline

Oncology

27 marketed17 pipeline

Cardiovascular

33 marketed8 pipeline

Musculoskeletal

37 marketed

4 active drug shortages

Four active drug shortages (Triamcinolone Acetonide Injection, Bacitracin Ophthalmic Ointment, Triamcinolone Hexacetonide Injection, Cromolyn Sodium Concentrate) suggest manufacturing, supply-chain, or operational challenges that may presage workforce actions.

Design Pharmaceuticals

About Design Pharmaceuticals

Why Work Here

Key Products

Watch Out For

Products & Portfolio (124)

Key Products by Revenue

Other Products (119)

Pipeline & Clinical Trials

Open Jobs (0)

Visa Sponsorship

Risk Signals

WARN Act Layoff Notices (1)