Products & Portfolio (34)
16 discontinued products not shown
ACETAMINOPHEN
acetaminophen
Post-LOE
ORAL · TABLET, EXTENDED RELEASE
2000
30
ACETAMINOPHEN
acetaminophen
Post-LOE
RECTAL · SUPPOSITORY
1987
30
ACETAMINOPHEN
acetaminophen
Post-LOE
RECTAL · SUPPOSITORY
1986
30
ACETAMINOPHEN, ASPIRIN AND CAFFEINE
acetaminophen, aspirin, caffeine
Post-LOE
ORAL · TABLET
Cyclooxygenase Inhibitors
migraine
2001
30
ADAPALENE AND BENZOYL PEROXIDE
adapalene and benzoyl peroxide
Post-LOE
TOPICAL · GEL
protein. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown. Benzoyl peroxide Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects.
2018
30
ALBUTEROL SULFATE
albuterol sulfate
Post-LOE
INHALATION · AEROSOL, METERED
2 -adrenergic agonist. The pharmacologic effects of albuterol sulfate are attributable to activation of beta 2 -adrenergic receptors on airway smooth muscle. Activation of beta 2 -adrenergic receptors leads to the activation of adenylcyclase and to an increase in the intracellular concentration of cyclic-3', 5'-adenosine monophosphate (cyclic AMP). This increase of cyclic AMP is associated with the activation of protein kinase A, which in turn inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in muscle relaxation. Albuterol relaxes the smooth muscle of all airways, from the trachea to the terminal bronchioles. Albuterol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved, thus protecting against all bronchoconstrictor challenges. Increased cyclic AMP concentrations are also associated with the inhibition of release of mediators from mast cells in the airway. While it is recognized that beta 2 -adrenergic receptors are the predominant receptors on bronchial smooth muscle, data indicate that there are beta-receptors in the human heart, 10% to 50% of which are cardiac beta 2 -adrenergic receptors. The precise function of these receptors has not been established [see Warnings and Precautions (5.4)] . Albuterol has been shown in most controlled clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. However, inhaled albuterol, like other beta-adrenergic agonist drugs, can produce a significant cardiovascular effect in some patients, as measured by pulse rate, blood pressure, symptoms, and/or electrocardiographic changes [see Warnings and Precautions (5.4)] .
exercise-induced bronchospasm in patients 4 years of ageolder
2020
30
AMMONIUM LACTATE
ammonium lactate
Post-LOE
TOPICAL · CREAM
CLINICAL PHARMACOLOGY Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) are felt to act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. The mechanism(s) by which this is accomplished is not yet known. An in vitro study of percutaneous absorption of ammonium lactate cream using human cadaver skin indicates that approximately 6.1% of the material was absorbed after 68 hours.
ichthyosis vulgarisxerosis
2002
30
AMMONIUM LACTATE
ammonium lactate
Post-LOE
TOPICAL · LOTION
CLINICAL PHARMACOLOGY Lactic acid is an alpha-hydroxy acid, it is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion. The mechanism(s) by which this is accomplished is not yet known. An in vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.
scaly skin (xerosis)ichthyosis vulgarisfor the temporary relief of itching associated with these conditions
2004
30
AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE
azelastine hydrochloride, fluticasone propionate
Post-LOE
NASAL · SPRAY, METERED
spray: Azelastine hydrochloride and fluticasone propionate nasal spray contains both azelastine hydrochloride and fluticasone propionate; therefore, the mechanisms of actions described below for the individual components apply to azelastine hydrochloride and fluticasone propionate nasal spray. These drugs represent two different classes of medications (histamine H 1 -receptor antagonist and synthetic corticosteroid). Azelastine Hydrochloride: Azelastine hydrochloride, a phthalazinone derivative, exhibits histamine H 1 -receptor antagonist activity in isolated tissues, animal models, and humans. Azelastine hydrochloride in azelastine hydrochloride and fluticasone propionate nasal spray is administered as a racemic mixture with no difference in pharmacologic activity noted between the enantiomers in in vitro studies. The major metabolite, desmethylazelastine, also possesses H 1 -receptor antagonist activity. Fluticasone Propionate: Fluticasone propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. In vitro dose response studies on a cloned human glucocorticoid receptor system involving binding and gene expression afforded 50% responses at 1.25 and 0.17 nM concentrations, respectively. Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays. Data from the McKenzie vasoconstrictor assay in man also support its potent glucocorticoid activity. The clinical relevance of these findings is unknown. The precise mechanism through which fluticasone propionate affects allergic rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.
2021
30
BACITRACIN
bacitracin
Post-LOE
OPHTHALMIC · OINTMENT
CLINICAL PHARMACOLOGY: The antibiotic, Bacitracin, exerts a profound action against many gram-positive pathogens, including the common Streptococci and Staphylococci. It is also destructive for certain gram-negative organisms. It is ineffective against fungi.
1971
30
BACITRACIN ZINC AND POLYMYXIN B SULFATE
bacitracin zinc; polymyxin b sulfate
Post-LOE
OPHTHALMIC · OINTMENT
infection in minor cuts scrapes burns
2002
30
BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE
bacitracin zinc; hydrocortisone acetate; neomycin sulfate; polymyxin b sulfate
Post-LOE
OPHTHALMIC · OINTMENT
infection in minor:
1981
30
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Interview Prep Quick Facts
Portfolio: 267 approved products
Top TAs: Immunology, Neurology, Infectious Diseases
H-1B (2023): 1 approval
Portfolio Health
Pre-Launch28 (10%)
Peak1 (0%)
LOE Approaching10 (4%)
Post-LOE228 (85%)
267 total products
Therapeutic Area Focus
Immunology
23 marketed
Neurology
19 marketed
Infectious Diseases
13 marketed
Dermatology
13 marketed
Musculoskeletal
9 marketed
Gastroenterology
8 marketed
Cardiovascular
5 marketed
Respiratory
4 marketed
Marketed
Pipeline
Visa Sponsorship
Sponsors Work Visas
H-1B Petitions (FY2023)
1
Approved
0
Denied
100%
Rate
Source: USCIS H-1B Employer Data Hub