GS

Gilead Sciences(GILD)

FOSTER CITY, CA
Biotechnology1 H-1B visas (FY2023)
HIV/AIDSOncologyHepatitisInflammationInfectious Disease
Funding Stage
PUBLIC
Employees
18,000
Open Jobs
267

Products & Portfolio (30)

5 discontinued products not shown

BIKTARVY
bictegravir sodium, emtricitabine, and tenofovir alafenamide fumarate
Peak
ORAL · TABLET
Nucleoside Reverse Transcriptase Inhibitors
2018
0
CAYSTON
aztreonam
LOE Approaching
INHALATION · FOR SOLUTION
12.1 Mechanism of Action Aztreonam is an antibacterial drug [see ] . 12.3 Pharmacokinetics Sputum Concentrations Sputum aztreonam concentrations exhibited considerable variability between patients receiving CAYSTON (75 mg) in clinical trials. The mean sputum concentration 10 minutes following the first dose of CAYSTON (n = 195 patients with CF) was 726 mcg/g. Mean sputum concentrations of aztreonam in patients receiving CAYSTON 3 times a day for 28 days were 984 mcg/g, 793 mcg/g, and 715 mcg/g 10 minutes after dose administration on Days 0, 14, and 28, respectively, indicating no accumulation of aztreonam in sputum. Plasma Concentrations Plasma aztreonam concentrations exhibited considerable variability between patients receiving CAYSTON (75 mg) in the clinical trials. The mean plasma concentration one hour following the first dose of CAYSTON (at approximately the peak plasma concentration) was 0.59 mcg/mL. Mean peak plasma concentrations in patients receiving CAYSTON 3 times a day for 28 days were 0.55 mcg/mL, 0.67 mcg/mL, and 0.65 mcg/mL on Days 0, 14, and 28, respectively, indicating no systemic accumulation of aztreonam. In contrast, the serum concentration of aztreonam following administration of aztreonam for injection (500 mg) is approximately 54 mcg/mL. Absorption Evaluation of plasma and urine aztreonam concentrations following administration of CAYSTON indicates low systemic absorption of aztreonam. Approximately 10% of the total CAYSTON dose is excreted in the urine as unchanged drug, as compared to 60–65% following intravenous administration of aztreonam for injection. Distribution The protein binding of aztreonam in plasma is approximately 77% within the clinical dose range of concentrations achieved following CAYSTON administration. Metabolism Following intramuscular administration of aztreonam for injection 500 mg every 8 hours for 7 days, approximately 6% of the dose was excreted as a microbiologically inactive open β-lactam ring hydrolysis product in an 8-hour urine collection on the last day of multiple dosing. Excretion The elimination half-life of aztreonam from plasma is approximately 2.1 hours following administration of CAYSTON to adult patients with CF, similar to what has been reported for aztreonam for injection. Approximately 10% of the total CAYSTON dose is excreted in the urine as unchanged drug. Systemically absorbed aztreonam is eliminated about equally by active tubular secretion and glomerular filtration. Following administration of a single intravenous dose of radiolabeled aztreonam for injection, about 12% of the dose was recovered in the feces. 12.4 Microbiology Mechanism of Action Aztreonam exhibits activity in vitro against Gram-negative aerobic pathogens including P. aeruginosa . Aztreonam binds to penicillin-binding proteins of susceptible bacteria, which leads to inhibition of bacterial cell wall synthesis and death of the cell. Aztreonam activity is not decreased in the presence of CF lung secretions. Sus
respiratory symptoms in cystic fibrosis (CF) patients with Pseudomonas aeruginosa
2010
30
COMPLERA
emtricitabine, rilpivirine hydrochloride, and tenofovir disoproxil fumarate
Peak
ORAL · TABLET
Nucleoside Reverse Transcriptase Inhibitors
2011
0
DESCOVY
emtricitabine and tenofovir alafenamide
Peak
ORAL · TABLET
Nucleoside Reverse Transcriptase Inhibitors
HIV-1 infection in pediatric patients weighing at least 14 kg to less than 35 kg in combination with other antiretroviral agentsincluding darunavircobicistat but not other protease inhibitors+7 more
2016
0
EMTRIVA
emtricitabine
LOE Approaching
ORAL · CAPSULE
Nucleoside Reverse Transcriptase Inhibitors
combination with other antiretroviral agents for the treatment of HIV-1 infection
2003
30
EMTRIVA
emtricitabine
LOE Approaching
ORAL · SOLUTION
Nucleoside Reverse Transcriptase Inhibitors
combination with other antiretroviral agents for the treatment of HIV-1 infection
2005
30
EPCLUSA
velpatasvir and sofosbuvir
Peak
ORAL · PELLETS
Breast Cancer Resistance Protein Inhibitors
older with chronic HCV genotype 16 infection (): without cirrhosiscompensated cirrhosis with decompensated cirrhosis for use in combination with ribavirin+1 more
2021
0
EPCLUSA
velpatasvir and sofosbuvir
Peak
ORAL · TABLET
Breast Cancer Resistance Protein Inhibitors
older with chronic HCV genotype 16 infection (): without cirrhosiscompensated cirrhosis with decompensated cirrhosis for use in combination with ribavirin+1 more
2016
0
GENVOYA
elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide
Peak
ORAL · TABLET
Cytochrome P450 3A Inhibitors
2015
0
HARVONI
ledipasvir and sofosbuvir
Peak
ORAL · PELLETS
RNA Replicase Inhibitors
2019
0
HARVONI
ledipasvir and sofosbuvir
Peak
ORAL · TABLET
P-Glycoprotein Inhibitors
2014
0
LETAIRIS
ambrisentan
Peak
ORAL · TABLET
Endothelin Receptor Antagonists
2007
0
View all 30 products

Pipeline & Clinical Trials

WelTel
HIV
N/A
Clinical Trials (1)
NCT02603536WelTelOAKTREE: Text Messaging to Support Patients With HIV/AIDS in British Columbia
N/A
Neurological and Cognitive Dysfunction Following CAR-T Treatment. ICANS and Beyond
CAR T Cell Therapy
N/A
Clinical Trials (1)
NCT07375628Neurological and Cognitive Dysfunction Following CAR-T Treatment. ICANS and Beyond
N/A
Clinical Trials (1)
NCT05095818Impact of Nursing Involvement on Implementation of HIV Prevention Services
N/A
NewSpringForMe digital solution
Hematologic Diseases
N/A
Clinical Trials (1)
NCT06148610Evaluation of the Impact of the Use of NewSpringForMe on Transplanted Patients' Quality of Life and Support
N/A
tenofovir disoproxil fumarate
Chronic Hepatitis B
N/A
Clinical Trials (5)
NCT02957864Switching From Tenofovir Disoproxil Fumarate to Abacavir or Tenofovir Alafenamide
Phase 4
NCT02616783Switching From a Tenofovir Disoproxil Fumarate (TDF) Containing Regimen to Elvitegravir/Cobicistat/Emtricitabine/ Tenofovir Alafenamide (E/C/F/TAF) Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Adults Aged ≥ 60 Years
Phase 3
NCT01745822Maternal Antiviral Prophylaxis to Prevent Perinatal Transmission of Hepatitis B Virus in Thailand
Phase 3

+2 more

GeneXpert HCV VL Fingerstick test
Hepatitis C, Chronic
N/A
Clinical Trials (1)
NCT04610762HCV RNA Fingerstick Assay as Useful Point of Care of Diagnostic Tool for Drug Users in Brussels
N/A
Clinical Trials (1)
NCT07456332Effect on Body Weight Reduction of a Behavioral Intervention on Lifestyle Using a Digital Nutritional Program in People Living With HIV and Metabolic Dysfunction-associated Steatotic Liver Disease
N/A
Adaptability of an Undetectable = Untransmissible Model for HBV
Chronic Hepatitis b
N/A
Clinical Trials (1)
NCT07449091Adaptability of an Undetectable = Untransmissible Model for HBV
N/A
Biopsies and bloood samplings
HIV-1-infection
N/A
Clinical Trials (1)
NCT05222945A Study to Determine the Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Patients Treated by a First Line Treatment Containing bictégravir, Emtricitabine and ténofovir alafénamide
N/A
EC clinic support - whole of practice interventions delivery through nurse-led model
Hepatitis C
N/A
Clinical Trials (1)
NCT04061551Eliminate Hepatitis C/EC Partnership Evaluation Protocol
N/A
Burden of Hepatitis D Virus (HDV) Infection in Italy
Chronic Hepatitis D
N/A
Clinical Trials (1)
NCT05723068Burden of Hepatitis D Virus (HDV) Infection in Italy
N/A
Financial Incentive
Pre-Exposure Prophylaxis
N/A
Clinical Trials (1)
NCT03078153Effect of Social Media Support and Financial Incentives on PrEP Adherence
N/A
Remdesivir
COVID-19
N/A
Clinical Trials (1)
NCT04582266PK and Safety of Remdesivir for Treatment of COVID-19 in Pregnant and Non-Pregnant Women in the US
N/A
Axicabtagene Ciloleucel
Large B-cell Lymphoma
N/A
Clinical Trials (1)
NCT05776160Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Axicabtagene Ciloleucel
N/A
No intervention
Breast Cancer
N/A
Clinical Trials (2)
NCT00645736CHARM: Chronic Hepatitis B Antihepadnaviral Resistance Mutation Study
N/A
NCT06683482A Qualitative Study on Advanced Breast Cancer Patients and Their Caregivers in Spain
N/A
Directly Observed Therapy
HEPATITIS C
N/A
Clinical Trials (1)
NCT02573376Antiviral Pharmacology and Adherence in Drug Users
N/A
Clinical Trials (1)
NCT06780579Expanded Access for Bulevirtide
N/A
N/A
Clinical Trials (1)
NCT03580668Effectiveness, Safety, Adherence, and Health-related Quality of Life in HIV-1 Infected Adults Receiving Bictegravir/ Emtricitabine/Tenofovir Alafenamide
N/A
The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
HIV Positive
N/A
Clinical Trials (1)
NCT02258581Long Term Follow-up Registry of Individuals Treated in A Gilead-Sponsored Trial in Individuals With Chronic Hepatitis B Infection
N/A
Virtual clinical visits with home lab kits and mailed HIV PrEP
HIV Infections
N/A
Clinical Trials (1)
NCT05319613Reducing Disparities in Rural HIV Prevention
N/A
Rapid Treatment strategy
Hepatitis C
N/A
Clinical Trials (1)
NCT03627546HCV Seek, Test and Rapid Treatment for Young PWID
N/A
A Surveillance Program for the Detection of Hepatitis B Virus (HBV) Resistance to Tenofovir in HIV-H
HIV Infections
N/A
Clinical Trials (1)
NCT00660361A Surveillance Program for the Detection of Hepatitis B Virus (HBV) Resistance to Tenofovir in HIV-HBV co-Infected Patients
N/A
Clinical Trials (1)
NCT02562742Use-Results Surveillance Study of Sovaldi® Plus Rebetol® in Japanese Patients With Chronic Genotype 2 Hepatitis C Virus Infection
N/A
ELISA testing
Hepatitis B
N/A
Clinical Trials (1)
NCT01767597Application of HBV Rapid Tests as a Tool for Wide-Use Screening
N/A
Clinical Trials (1)
NCT03582098Clinical Outcomes and Routine Management of Adults With Chronic Lymphocytic Leukaemia Treated With Idelalisib and Rituximab in the United Kingdom (UK) and Ireland
N/A
Clinical Trials (1)
NCT05718700Study of Bulevirtide in Participants With Chronic Hepatitis D Infection
N/A
birth dose vaccination against hepatitis B strategy
Hepatitis B
N/A
Clinical Trials (1)
NCT04029454Neovac 2 Burkina Faso: Impact of the Integration of Hepatitis B Birth Dose Vaccine Into the Infant Immunization Schedule
N/A
TelePrEP
Hiv
N/A
Clinical Trials (1)
NCT05520905TelePrEP for At-risk Youth in Colorado
N/A
Hepatic Safety of Eviplera® in HIV/Hepatitis C (HCV)-Coinfected Patients Without HCV Treatment in th
Human Immunodeficiency Virus (HIV) Hepatitis C Virus (HCV) Coinfected Subjects
N/A
Clinical Trials (1)
NCT02196064Hepatic Safety of Eviplera® in HIV/Hepatitis C (HCV)-Coinfected Patients Without HCV Treatment in the "The HEPAVIR HEPATIC SAFETY Cohort."
N/A
N/A
Clinical Trials (1)
NCT02907996Evaluate the Safety and Effectiveness of Sovaldi in Participants With Chronic Hepatitis C Virus (HCV) Infection in Korea
N/A
Biospecimen Collection
Absence of Signs or Symptoms
N/A
Clinical Trials (1)
NCT02928510Mechanisms of Idelalisib-Associated Diarrhea in Patients With Relapsed Chronic Lymphocytic Leukemia, Indolent Non-hodgkin Lymphoma, or Small Lymphocytic Lymphoma
N/A
Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery
Pulmonary Hypertension
N/A
Clinical Trials (1)
NCT01646541Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery
N/A
Evaluating the Chain of Addiction Care (CAC)
Hepatitis C, Chronic
N/A
Clinical Trials (1)
NCT05401136Evaluating the Chain of Addiction Care (CAC)
N/A
Hepatitis C Treatment Alerts in CHORUS™
Hepatitis C
N/A
Clinical Trials (1)
NCT05725109Hepatitis C Diagnosis to Treatment Management
N/A
Clinical Trials (1)
NCT05978232NAVAH Impact on Radiation Therapy Completion in Black Breast & Prostate Cancer Patients
N/A
Bictegravir/Emtricitabine/Tenofovir Alafenamide 50 MG-200 MG-25 MG Oral Tablet [BIKTARVY]
HIV-1-infection
N/A
Clinical Trials (1)
NCT05064020Bictegravir in the Elderly Living With HIV (BICEP)
N/A
A chatbot designed to promote PrEP awareness and uptake for Black MSM
HIV Prevention
N/A
Clinical Trials (1)
NCT05968755Leveraging Chatbot to Improve PrEP in the Southern United States
N/A
Tenofovir disoproxil fumarate
HIV Infections
N/A
Clinical Trials (1)
NCT01066858Study of Effects of Tenofovir on Bone Health and Kidneys During Pregnancy and Breastfeeding
N/A
Effects of Newly-Initiated QUAD Therapy on Aortic/Coronary Inflammation in ART-Naïve Infected Patien
HIV
N/A
Clinical Trials (1)
NCT01766726Effects of Newly-Initiated QUAD Therapy on Aortic/Coronary Inflammation in ART-Naïve Infected Patients
N/A
Clinical Trials (1)
NCT01505179The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
N/A
N/A
Clinical Trials (1)
NCT04323761Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
N/A
Clinical Trials (1)
NCT04868864The Ontario Multi-Regional Hospital COVID-19 Registry (COREG)- Recovery Trajectory Sub-study
N/A
Clinical Trials (1)
NCT01815957Impact of Ranolazine on Coronary Microcirculatory Resistance
N/A
N/A
Clinical Trials (1)
NCT05690815Express Testing and Same-day Initiation of PrEP Study
N/A
N/A
Clinical Trials (1)
NCT05481216HIV-1 & Coronavirus-Coinfection in Europe: Morbidity & Risk Factors of COVID-19 in People Living With HIV
N/A
Tenofovir Alafenamide
Chronic Hepatitis b
N/A
Clinical Trials (1)
NCT03752658TAF Real World Study for Universal Effectiveness
N/A
Ranolazine
Cardiomyopathy
N/A
Clinical Trials (1)
NCT01705509The Effects of Ranolazine on CPET Parameters in Ischemic Cardiomyopathy Patients (ERIC)
N/A
A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjec
Limited Scleroderma
N/A
Clinical Trials (1)
NCT01881529A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma
N/A

Open Jobs (267)

Cell Therapy Account Manager(北陸)

Japan - Tokyo
Commercial
Just now

Associate Director, Insights & Analytics Platform Technology Lead

United States - California - Foster City
20h ago
$196K - $253K/yr

Cell Therapy Account Manager

Taiwan - Taipei
Commercial
20h ago

Director (m/f/d) Medical Sciences (MSL Lead) - Oncology, Solid Tumors

Germany - Berlin
Medical Affairs
20h ago

Sr Research Associate, Analytical Operations

United States - California - Oceanside
Research & Development
20h ago
$86K - $112K/yr

Executive Director, Global Medical Expert HIV Prevention - GMA Virology & Inflammation

United States - Field
20h ago
$317K - $411K/yr

Director (m/f/d) Marketing Oncology - Solid Tumors

Germany - Munich
Commercial
20h ago

Executive Director, I.T.- Head of Security Architecture, Engineering, and Delivery

United States - California - Foster City
Engineering
20h ago
$281K - $364K/yr

Scientist, Pathobiology

United States - California - Foster City
Research & Development
Yesterday
$147K - $190K/yr

Principal Scientist, Oncology Research

United States - California - Foster City
Research & Development
Yesterday
$196K - $253K/yr

Sr Tax Analyst I

United States - California - Foster City
Yesterday
$118K - $153K/yr

Sr Counsel II

United States - California - Santa Monica
Yesterday
$221K - $286K/yr

Sr Therapeutic Specialist, Oncology - Orange County

United States - Field
Yesterday
$154K - $199K/yr

Director, Medicinal Chemistry, ADC Group Leader

United States - California - Foster City
Yesterday
$226K - $293K/yr

Director, Validation

United States - California - La Verne
Quality
Yesterday
$191K - $248K/yr

Director, R&D Quality, Inspection Management

United States - California - Foster City
Research & Development
Yesterday
$210K - $272K/yr

Senior Director (m/f/d) Medical Affairs Oncology Germany

Germany - Munich
Medical Affairs
Yesterday

QA Specialist III

United States - California - Foster City
Quality
Yesterday
$118K - $153K/yr

Device Engineer III

United States - California - Foster City
Engineering
4d ago
$118K - $153K/yr

Director, Direct-to-Patient Marketing

United States - California - Foster City
Commercial
4d ago
$226K - $293K/yr

Director, Product Management

United States - California - Foster City
4d ago
$226K - $293K/yr

Quality Engineer III

United States - California - Foster City
Engineering
4d ago
$118K - $153K/yr

Director, Marketing Sciences HIV PrEP

United States - California - Foster City
Commercial
4d ago
$226K - $293K/yr

Senior Manager of Omnichannel Analytics

United States - California - Foster City
4d ago
$169K - $219K/yr

Senior Therapeutic Specialist - Albany, NY

United States - Field
4d ago
$133K - $172K/yr
View all 267 open positions →
Interview Prep Quick Facts
Portfolio: 35 approved products, 153 clinical trials
Top TAs: Infectious Diseases, Oncology, Cardiovascular
H-1B (2023): 1 approval
Publications: 25 in PubMed
SEC Filings: 2 available
Open Roles: 267 active jobs
Portfolio Health
Launch2 (6%)
Growth1 (3%)
Peak24 (69%)
LOE Approaching8 (23%)
35 total products
Therapeutic Area Focus
Infectious Diseases
23 marketed597 pipeline
Oncology
1 marketed285 pipeline
Cardiovascular
1 marketed67 pipeline
Immunology
42 pipeline
Rare Diseases
1 marketed27 pipeline
Gastroenterology
1 marketed22 pipeline
Respiratory
19 pipeline
Marketed
Pipeline

Financials (FY2025)

Revenue
$27.1B1%
R&D Spend
$5.7B(21%)15%
Net Income
$5.7B

Hiring Trend

Actively Hiring
267
Open Roles
+268
Added
-1
Filled/Removed

Based on last 2 crawl cycles

Visa Sponsorship

Sponsors Work Visas
H-1B Petitions (FY2023)
1
Approved
0
Denied
100%
Rate

Source: USCIS H-1B Employer Data Hub