Galderma

TX - Dallas

Biotechnology

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Focus: Dermatological Consumer Products and Drugs

Galderma is a life sciences company focused on Dermatological Consumer Products and Drugs.

Dermatology

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Products & Portfolio (20)

8 discontinued products not shown

(RAR), with particular activity at the gamma subtype of RAR. Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation. The exact process by which trifarotene ameliorates acne is unknown.

2019

CLOBEX

clobetasol propionate

LOE Approaching

TOPICAL · LOTION

Lotion, 0.05% has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids in general is unclear. However, corticosteroids are thought to act by induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A 2 .

psoriasis

2003

CLOBEX

clobetasol propionate

LOE Approaching

TOPICAL · SHAMPOO

corticosteroids, Clobetasol Propionate Shampoo, 0.05%, has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A 2 .

moderate to severe scalp psoriasis in subjects 18 years of ageoldermoderate to severe forms of scalp psoriasis in subjects 18 years of age+1 more

2004

CLOBEX

clobetasol propionate

LOE Approaching

TOPICAL · SPRAY

signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action in corticosteroid responsive dermatoses is unknown.

moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of ageolderpsoriasis

Corticosteroid Hormone Receptor Agonists

protein. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown.

Mechanism of Action: Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

adapalene and benzoyl peroxide

LOE Approaching

TOPICAL · GEL

protein. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown. Benzoyl peroxide Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects.

2008

EPIDUO FORTE

adapalene and benzoyl peroxide

CLINICAL PHARMACOLOGY: The mechanisms by which metronidazole acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.

12.1 Mechanism of Action The mechanism of action of metronidazole in the treatment of rosacea is unknown. 12.2 Pharmacodynamics The pharmacodynamics of metronidazole in association with the treatment of rosacea are unknown. Cardiac Electrophysiology: The effect of Metronidazole Gel, 1% on the QTc interval has not been adequately characterized. 12.3 Pharmacokinetics Topical administration of a one gram dose of Metronidazole Gel, 1% to the face of 13 subjects with moderate to severe rosacea once daily for 7 days resulted in a mean ± SD C max of metronidazole of 32 ± 9 ng/mL. The mean ± SD AUC (0-24) was 595 ± 154 ng*hr/mL. The mean C max and AUC (0-24) are less than 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (T max ) was 6-10 hours after topical application.

2005

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Portfolio: 28 approved products

Top TAs: Dermatology, Immunology, Infectious Diseases

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Growth2 (7%)

Peak4 (14%)

LOE Approaching20 (71%)

Post-LOE2 (7%)

28 total products

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7 marketed

7 marketed

5 marketed

1 marketed

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