NDAORALTABLET, EXTENDED RELEASE
Approved
Feb 2012
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
2
Data completeness
7/8 — Comprehensive
JANUMET XR (sitagliptin and metformin hydrochloride) by Merck & Co. is 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (dpp-4) inhibitor, and metformin extended-release, a member of the biguanide class. First approved in 2012.
Drug data last refreshed 20h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JANUMET XR is a fixed-dose combination tablet combining sitagliptin (a DPP-4 inhibitor) and extended-release metformin (a biguanide) for oral treatment of type 2 diabetes mellitus. Sitagliptin works by slowing the inactivation of incretin hormones (GLP-1 and GIP), thereby increasing insulin release and decreasing glucagon in a glucose-dependent manner, while metformin decreases hepatic glucose production and improves insulin sensitivity. The extended-release formulation allows for once-daily dosing, improving patient compliance. JANUMET XR represents a combination approach that addresses multiple pathways in type 2 diabetes pathophysiology.
$0.4BPart D
1.1 years to LOEMechanism of Action
2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin extended-release, a member of the biguanide class. Sitagliptin Sitagliptin is a DPP-4 inhibitor, which exerts its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.