NDAORALTABLET, EXTENDED RELEASE
Approved
Feb 2012
Lifecycle
LOE Approaching
Competitive Pressure
25/100
Clinical Trials
2
Data completeness
6/8 — Strong
JANUMET XR (sitagliptin and metformin hydrochloride) by Merck & Co. is 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (dpp-4) inhibitor, and metformin extended-release, a member of the biguanide class. First approved in 2012.
Drug data last refreshed 3h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
JANUMET XR is a fixed-dose oral combination of sitagliptin (a DPP-4 inhibitor) and extended-release metformin for type 2 diabetes. It works by increasing incretin hormone activity to boost insulin secretion and reduce glucagon, while metformin decreases hepatic glucose production and improves insulin sensitivity. The combination provides complementary mechanisms to lower both basal and postprandial glucose levels.
$0.392BPart D
LOE ApproachingDeclining
7mo to LOEWith LOE approaching in 2027 and $392M in annual Part D spending, the brand team is likely preparing for generic erosion and transitioning to lifecycle management strategies focused on retention and lifecycle extension.
Mechanism of Action
2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin extended-release, a member of the biguanide class. Sitagliptin Sitagliptin is a DPP-4 inhibitor, which exerts its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones.…
Indications
Worked on JANUMET XR at Merck & Co.? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.