NDAORALTABLET
Approved
Oct 2013
Lifecycle
LOE Approaching
Competitive Pressure
25/100
Clinical Trials
3
Data completeness
6/8 — Strong
DUAVEE (conjugated estrogens/bazedoxifene) by Pfizer is estrogen receptor agonists [moa]. First approved in 2013.
Drug data last refreshed 31m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUAVEE is an oral tablet combining conjugated estrogens with bazedoxifene, a selective estrogen receptor modulator (SERM), designed to treat vasomotor symptoms of menopause while providing endometrial protection. The combination works as an estrogen receptor agonist, delivering estrogen therapy without the endometrial proliferation risk associated with estrogen-only HRT. It targets menopausal women seeking symptom relief with a differentiated safety profile.
$0.334MPart D
LOE ApproachingDeclining
4mo to LOEWith LOE imminent (March 2027) and low Medicare spending ($334K annually), the brand team is contracting and transitioning to lifecycle management and generic transition planning rather than growth expansion.
Mechanism of Action
Estrogen Receptor Agonists
Pharmacologic Class:
Estrogen
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
The PROMISE Study: Duavee in Women With DCIS
Started Jan 2017
142 enrolled
Ductal Breast Carcinoma In SituPostmenopausal
Pilot Study of the Effect of Duavee® on Benign Breast Tissue Proliferation
Started May 2016
28 enrolled
Breast Cancer
Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women
Started Apr 2014
24 enrolled
Healthy
Why This Matters for Your Career
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.