NDAORALTABLET, EXTENDED RELEASE
Approved
Oct 2017
Lifecycle
LOE Approaching
Competitive Pressure
25/100
Clinical Trials
20
Data completeness
6/8 — Strong
LYRICA CR (pregabalin) by Viatris is 2 ‑delta site (an auxiliary subunit of voltage‑gated calcium channels) in central nervous system tissues. First approved in 2017.
Drug data last refreshed 23h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LYRICA CR is an extended-release oral formulation of pregabalin, a small-molecule analog of gamma-aminobutyric acid (GABA) that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It is indicated for neuropathic pain conditions and works by reducing calcium-dependent release of pro-nociceptive neurotransmitters in the spinal cord and modulating descending pain pathways. The mechanism does not involve direct GABA receptor binding, benzodiazepine activity, or opioid receptor engagement.
$0.402BPart D
LOE Approaching7mo to LOEProduct is approaching loss of exclusivity with modest Part D utilization; brand team focus will shift toward lifecycle extension and managed market strategies within 6-12 months.
Mechanism of Action
2 ‑delta site (an auxiliary subunit of voltage‑gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin)…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.