Acute Coronary Syndromes

Cardiovascular
5
Pipeline Programs
7
Companies
8
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
150%
Small Molecule
150%
+ 6 programs with unclassified modality

On Market (1)

Approved therapies currently available

U
METOPROLOL TARTRATEApproved
metoprolol
Unknown Company
oral2013

Competitive Landscape

5 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
3 programs
1
MetoprololPhase 4Small Molecule1 trial
A Post Marketing Surveillance to Evaluate the Safety and Efficacy of BrilintaN/A1 trial
An Epidemiological Study of Acute Coronary Syndromes in The Greek Population. The TARGET StudyN/A1 trial
Active Trials
NCT01611272Completed3,402Est. Jul 2016
NCT01061086Completed418Est. Feb 2011
NCT00718406Completed
DS
Daiichi SankyoChina - Shanghai
2 programs
1
1
Triple oral lipid lowering treatmentPhase 31 trial
clopidogrelPhase 11 trial
Active Trials
NCT01107899Terminated29Est. Dec 2010
NCT07440381Not Yet Recruiting600Est. Aug 2027
Abcentra
AbcentraCA - Los Angeles
1 program
1
OrticumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT06927739RecruitingEst. Jun 2027
Design Therapeutics
1 program
ClopidogrelN/A1 trial
Active Trials
NCT04630288UnknownEst. Dec 2020
Sanofi
SanofiPARIS, France
1 program
knowledge translationN/A1 trial
Active Trials
NCT02672137Completed4,604Est. Jan 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Daiichi SankyoTriple oral lipid lowering treatment
AbcentraOrticumab
Daiichi Sankyoclopidogrel
Design TherapeuticsClopidogrel
AstraZenecaA Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta
AstraZenecaAn Epidemiological Study of Acute Coronary Syndromes in The Greek Population. The TARGET Study
Sanofiknowledge translation

Clinical Trials (8)

Total enrollment: 9,053 patients across 8 trials

NCT00718406AstraZenecaMetoprolol

Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

Phase 4Completed
NCT07440381Daiichi SankyoTriple oral lipid lowering treatment

triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE

Start: Sep 2026Est. completion: Aug 2027600 patients
Phase 3Not Yet Recruiting
NCT06927739AbcentraOrticumab

Focused Orticumab Research for Treating Inflammation in Coronary Arteries

Start: Aug 2025Est. completion: Jun 2027
Phase 2Recruiting
NCT01107899Daiichi Sankyoclopidogrel

Study to Learn When Platelets Return to Normal After One Loading Dose of Anti-platelet Drugs in Patients With Symptoms of Acute Coronary Syndromes

Start: Oct 2009Est. completion: Dec 201029 patients
Phase 1Terminated
NCT04630288Design TherapeuticsClopidogrel

Safety and Efficacy of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome

Start: Jul 2019Est. completion: Dec 2020
N/AUnknown
NCT01611272AstraZenecaA Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Start: Apr 2013Est. completion: Jul 20163,402 patients
N/ACompleted
NCT01061086AstraZenecaAn Epidemiological Study of Acute Coronary Syndromes in The Greek Population. The TARGET Study

An Epidemiological Study of Acute Coronary Syndromes in The Greek Population. The TARGET Study

Start: Jan 2010Est. completion: Feb 2011418 patients
N/ACompleted
NCT02672137Sanofiknowledge translation

Knowledge Translation for Patients With Acute Coronary Syndromes

Start: Jan 2010Est. completion: Jan 20164,604 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 9,053 patients
7 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Acute Coronary Syndrome(62)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)