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Intraoperative Hypotension

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Pipeline Programs
5
Companies
10
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
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0
0
0
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Eppendorf
EppendorfGermany - Hamburg
4 programs
Bispectral index MonitoringN/A1 trial
Continuous finger-cuff arterial pressure monitoringN/A1 trial
Continuous norepinephrine administrationN/A2 trials
Oscillometric blood pressure monitoringN/A1 trial
Active Trials
NCT02515019Completed60Est. Jan 2012
NCT06753097Completed930Est. Feb 2026
NCT07538388Not Yet Recruiting446Est. Dec 2026
+2 more trials
Edwards Lifesciences
4 programs
ClearSight feasibility testingN/A1 trial
GDT-based hemodynamic management based on Clearsight deviceN/A1 trial
HPI guided treatment adviceN/A1 trial
Hemosphere platform® together with the FloTrac Acumen IQ® sensorN/A
Active Trials
NCT03795831Unknown100Est. Dec 2019
NCT06291714Recruiting150Est. Mar 2026
NCT05821647Completed130Est. Mar 2023
Design Therapeutics
1 program
Hemosphere platform® together with the FloTrac Acumen IQ® sensorN/A
Design Pharmaceuticals
1 program
Hemosphere platform® together with the FloTrac Acumen IQ® sensorN/A1 trial
Active Trials
NCT04301102Completed80Est. Jun 2022
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Perioperative autonomic function assessmentN/A1 trial
Active Trials
NCT05425147Unknown180Est. Mar 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
EppendorfContinuous norepinephrine administration
EppendorfOscillometric blood pressure monitoring
EppendorfContinuous finger-cuff arterial pressure monitoring
Edwards LifesciencesGDT-based hemodynamic management based on Clearsight device
EppendorfContinuous norepinephrine administration
UNION therapeuticsPerioperative autonomic function assessment
Edwards LifesciencesHPI guided treatment advice
Design PharmaceuticalsHemosphere platform® together with the FloTrac Acumen IQ® sensor
Edwards LifesciencesClearSight feasibility testing
EppendorfBispectral index Monitoring

Clinical Trials (10)

Total enrollment: 2,548 patients across 10 trials

NCT07538388EppendorfContinuous norepinephrine administration

Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension

Start: Apr 2026Est. completion: Dec 2026446 patients
N/ANot Yet Recruiting
NCT07349186EppendorfOscillometric blood pressure monitoring

Oscillometric Versus Intraarterial Blood Pressure Monitoring During Robot-Assisted Prostatectomy

Start: Jan 2026Est. completion: Feb 2027210 patients
N/ARecruiting
NCT06753097EppendorfContinuous finger-cuff arterial pressure monitoring

Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized DETECT II Trial

Start: Jan 2025Est. completion: Feb 2026930 patients
N/ACompleted
NCT06291714Edwards LifesciencesGDT-based hemodynamic management based on Clearsight device

Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension

Start: Aug 2024Est. completion: Mar 2026150 patients
N/ARecruiting
NCT05940649EppendorfContinuous norepinephrine administration

Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction

Start: Jul 2023Est. completion: Jul 2024262 patients
N/ACompleted
NCT05425147UNION therapeuticsPerioperative autonomic function assessment

Correlation Between Perioperative Autonomic Function and Post-induction Hypotension in Elderly Patients

Start: Jul 2022Est. completion: Mar 2025180 patients
N/AUnknown
NCT05821647Edwards LifesciencesHPI guided treatment advice

Hypotension Prediction 2 Study in Cardiac Surgery and Postoperative ICU Admission

Start: May 2021Est. completion: Mar 2023130 patients
N/ACompleted
NCT04301102Design PharmaceuticalsHemosphere platform® together with the FloTrac Acumen IQ® sensor

The Predict H Trial

Start: Nov 2020Est. completion: Jun 202280 patients
N/ACompleted
NCT03795831Edwards LifesciencesClearSight feasibility testing

Validation Study in Patients of a Non-invasive Blood Pressure Monitor for Perioperative Use

Start: Mar 2017Est. completion: Dec 2019100 patients
N/AUnknown
NCT02515019EppendorfBispectral index Monitoring

Bispectral Index Guided Sevoflurane Titration

Start: Apr 2011Est. completion: Jan 201260 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 actively recruiting trials targeting 2,548 patients
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.