Acute Coronary Syndrome

Cardiovascular
26
Pipeline Programs
24
Companies
46
Clinical Trials
5 recruiting
6
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
5
0
8
12
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
267%
Peptide
133%
+ 47 programs with unclassified modality

On Market (6)

Approved therapies currently available

Sanofi
ADLYXINApproved
lixisenatide
Sanofi
subcutaneous2016
AstraZeneca
BRILINTAApproved
ticagrelor
AstraZeneca
P2Y12 Platelet Inhibitor [EPC]oral2011
AstraZeneca
CRESTORApproved
rosuvastatin
AstraZeneca
oral2003
U
PRASUGRELApproved
prasugrel
Unknown Company
oral2017
U
PRASUGREL HYDROCHLORIDEApproved
prasugrel
Unknown Company
oral2023
U
TICAGRELORApproved
ticagrelor
Unknown Company
P2Y12 Platelet Inhibitor [EPC]oral2024

Competitive Landscape

21 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
11 programs
2
1
TicagrelorPhase 41 trial
RosuvastatinPhase 3Small Molecule1 trial
TicagrelorPhase 31 trial
A NIS Registry of the Prospective Structured Care In Acute Coronary SyndromeN/A1 trial
Active group with MEMSN/A1 trial
+6 more programs
Active Trials
NCT01490645Completed1,006Est. Aug 2014
NCT02615704Completed677Est. Mar 2019
NCT03823547Recruiting99,999Est. Jun 2050
+8 more trials
Abbott
AbbottABBOTT PARK, IL
8 programs
1
2
BS-DESPhase 41 trial
Triage CardioProfilERPhase 41 trial
ARCHITECT STAT High Sensitive Troponin I AssayPhase 31 trial
ESC 0/1 hour troponin pathwayN/A1 trial
High-sensitivity troponin I assayN/A1 trial
+3 more programs
Active Trials
NCT05322395Recruiting3,536Est. Nov 2024
NCT01852123Completed48,282Est. Mar 2017
NCT01172990Terminated108Est. Feb 2014
+5 more trials
Sanofi
SanofiPARIS, France
4 programs
2
1
LixisenatidePhase 3Peptide1 trial
Percutaneous Coronary InterventionPhase 31 trial
A Comparison of the TIMI, GRACE and HEART ScoresN/A1 trial
Decision Support SystemN/A1 trial
Active Trials
NCT01398631Completed2,440Est. Jul 2011
NCT05844566Completed1,139Est. Dec 2024
NCT01147250Completed6,068Est. Feb 2015
+1 more trials
DS
Daiichi SankyoChina - Shanghai
4 programs
1
1
30-day DAPTPhase 41 trial
PrasugrelPhase 31 trial
ADP receptor inhibitorsN/A1 trial
Immediate Invasive ManagementN/A
Active Trials
NCT01088503Completed12,227Est. Jan 2014
NCT00830960Completed720Est. Jun 2010
NCT04436978Recruiting2,000Est. Dec 2027
Biotronik
BiotronikGermany - Berlin
3 programs
1
Colchicine 0.6 mgPhase 41 trial
Percutaneous coronary interventionN/A1 trial
TicagrelorN/A1 trial
Active Trials
NCT03621501Active Not Recruiting1,525Est. Oct 2026
NCT02618733Completed120Est. Dec 2016
NCT06543082Recruiting490Est. Dec 2028
M&
Merck & Co.RAHWAY, NJ
2 programs
1
1
EnoxaparinPhase 41 trial
PantoprazolePhase 1Small Molecule1 trial
Active Trials
NCT01358344Completed173Est. Dec 2010
NCT00790387Completed60Est. Dec 2006
CSL Behring
CSL BehringIL - Bradley
1 program
1
Apolipoprotein A-I [human]Phase 31 trial
Active Trials
NCT03473223Completed18,226Est. Nov 2023
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
ClopidogrelPhase 3
E
EisaiChina - Liaoning
2 programs
2
E5555Phase 21 trial
E5555Phase 21 trial
Active Trials
NCT00548587Completed600Est. Aug 2009
NCT00619164Completed240
Bayer
BayerLEVERKUSEN, Germany
1 program
1
Acetylsalicylic acidPhase 2
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
RanolazinePhase 21 trial
Active Trials
NCT01767987Terminated6Est. Apr 2014
Astellas
AstellasChina - Shenyang
1 program
1
YM150Phase 21 trial
Active Trials
NCT00994292Completed1,276Est. Mar 2011
Angel Pharmaceuticals
Angel PharmaceuticalsChina - Zhejiang
2 programs
AngelMed Guardian SystemN/A1 trial
PMA P150009 AngelMed Guardian® SystemN/A1 trial
Active Trials
NCT04316481TerminatedEst. Jan 2022
NCT05412927RecruitingEst. Dec 2026
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
2 programs
TnThs Predicting Evolving Non-STEMIN/A1 trial
TnThs for Identification Myocardial InfarctionN/A1 trial
Active Trials
NCT00953251Completed115Est. Dec 2008
NCT00950469Completed94Est. Dec 2008
Novartis
NovartisBASEL, Switzerland
1 program
A Comparison of the TIMI, GRACE and HEART ScoresN/A
Design Therapeutics
1 program
Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching AntiplateletN/A1 trial
Active Trials
NCT02500290UnknownEst. Mar 2021
Genomics
GenomicsUK - Oxford
1 program
Compound Panax Notoginseng GranuleN/A1 trial
Active Trials
NCT03186625Unknown80Est. Aug 2018
Pfizer
PfizerNEW YORK, NY
1 program
DalteparinN/A1 trial
Active Trials
NCT00922766Completed618Est. Sep 2010
Miracor Medical
Miracor MedicalBelgium - Awans
1 program
PICSON/A1 trial
Active Trials
NCT02197325CompletedEst. Nov 2017
One Biosciences
One BiosciencesFrance - Paris
1 program
Randomized Trial of Prehospital Tropin Levels in Acute Coronary Syndrome (ACS)N/A1 trial
Active Trials
NCT00764205UnknownEst. Nov 2010
Microvascular Therapeutics
1 program
Use of intermittent high MI impulses during echocardiogramN/A1 trial
Active Trials
NCT00955136WithdrawnEst. Jan 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
BiotronikColchicine 0.6 mg
Daiichi Sankyo30-day DAPT
AbbottBS-DES
AstraZenecaTicagrelor
Merck & Co.Enoxaparin
AbbottTriage CardioProfilER
CSL BehringApolipoprotein A-I [human]
AbbottARCHITECT STAT High Sensitive Troponin I Assay
SanofiLixisenatide
Daiichi SankyoPrasugrel
AstraZenecaTicagrelor
SanofiPercutaneous Coronary Intervention
AstraZenecaRosuvastatin
Gilead SciencesRanolazine
AstellasYM150

Showing 15 of 46 trials with date data

Clinical Trials (46)

Total enrollment: 324,155 patients across 46 trials

NCT06543082BiotronikColchicine 0.6 mg

MACT (Mono Antiplatelet and Colchicine Therapy) Prospective Multicenter Study

Start: Aug 2024Est. completion: Dec 2028490 patients
Phase 4Recruiting
NCT04436978Daiichi Sankyo30-day DAPT

What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?

Start: Jan 2023Est. completion: Dec 20272,000 patients
Phase 4Recruiting
NCT02193971AbbottBS-DES

Harmonizing Optimal Strategy for Treatment of Coronary Artery Diseases Trial - Comparison of REDUCTION of PrasugrEl Dose & POLYmer TECHnology in ACS Patients (HOST REDUCE POLYTECH RCT Trial)

Start: Jul 2014Est. completion: Jun 20223,384 patients
Phase 4Unknown
NCT01826175AstraZenecaTicagrelor

Comparison of Ticagrelor Versus Clopidogrel on Residual Thrombus Burden During PCI: an OCT Study

Start: May 2013Est. completion: May 20140
Phase 4Withdrawn
NCT00790387Merck & Co.Enoxaparin

Tirofiban and Enoxaparin in High Risk Coronary Intervention

Start: Jun 2004Est. completion: Dec 200660 patients
Phase 4Completed
NCT00206817AbbottTriage CardioProfilER

Rapid Assessment of Cardiac Markers for the Evaluation of Acute Coronary Syndrome (RACE-ACS)

Start: Oct 20030
Phase 4Withdrawn
NCT03473223CSL BehringApolipoprotein A-I [human]

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Start: Mar 2018Est. completion: Nov 202318,226 patients
Phase 3Completed
NCT01608100AbbottARCHITECT STAT High Sensitive Troponin I Assay

Evaluation of a New Cardiac Biomarker Assay

Start: Jun 2012Est. completion: Sep 20141,101 patients
Phase 3Completed
NCT01147250SanofiLixisenatide

Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide)

Start: Jun 2010Est. completion: Feb 20156,068 patients
Phase 3Completed
NCT00830960Daiichi SankyoPrasugrel

A Comparison of Antiplatelet Therapies in Asian Subjects With Acute Coronary Syndrome

Start: Feb 2009Est. completion: Jun 2010720 patients
Phase 3Completed
NCT00391872AstraZenecaTicagrelor

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

Start: Oct 2006Est. completion: Mar 200918,624 patients
Phase 3Completed
NCT01014273SanofiPercutaneous Coronary Intervention

A Trial of Trans-radial Versus Trans-femoral Percutaneous Coronary Intervention (PCI) Access Site Approach in Patients With Unstable Angina or Myocardial Infarction Managed With an Invasive Strategy

Start: Jun 2006Est. completion: Mar 20117,021 patients
Phase 3Completed
NCT00296387AstraZenecaRosuvastatin

Effects in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome

Start: Jan 2006Est. completion: Oct 20071,160 patients
Phase 3Completed
NCT01767987Gilead SciencesRanolazine

Ranolazine Cardioprotection in PCI

Start: Nov 2012Est. completion: Apr 20146 patients
Phase 2Terminated
NCT00994292AstellasYM150

Study Evaluating Safety, Tolerability and Efficacy of YM150 in Subjects With Acute Coronary Syndromes

Start: Sep 2009Est. completion: Mar 20111,276 patients
Phase 2Completed
NCT00619164EisaiE5555

A Double-Blind Study of E5555 in Japanese Patients With Acute Coronary Syndrome

Start: Nov 2007240 patients
Phase 2Completed
NCT00548587EisaiE5555

Safety and Tolerability of E5555 and Its Effects on Markers of Intravascular Inflammation in Subjects With Acute Coronary Syndrome

Start: Oct 2007Est. completion: Aug 2009600 patients
Phase 2Completed
NCT01358344Merck & Co.Pantoprazole

A Bioequivalence Study of SCH 530348 2.5 mg Tablets (P06558)

Start: Aug 2010Est. completion: Dec 2010173 patients
Phase 1Completed
NCT05844566SanofiDecision Support System

OptimiZation Of Lipid Lowering Therapies Using a Decision Support System In Patients With Acute Coronary Syndrome.

Start: Apr 2023Est. completion: Dec 20241,139 patients
N/ACompleted
NCT05412927Angel PharmaceuticalsPMA P150009 AngelMed Guardian® System

AngelMed Guardian® System PMA Post Approval Study

Start: Sep 2022Est. completion: Dec 2026
N/ARecruiting
NCT05322395AbbottESC 0/1 hour troponin pathway

Pragmatic Randomised Trial of the ESC 0/1 Versus 0/3 Hour Troponin Pathway

Start: Dec 2021Est. completion: Nov 20243,536 patients
N/ARecruiting
NCT04316481Angel PharmaceuticalsAngelMed Guardian System

IDE-ALERTS Continued Access Study

Start: Sep 2020Est. completion: Jan 2022
N/ATerminated
NCT03621501BiotronikPercutaneous coronary intervention

Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease

Start: Jun 2018Est. completion: Oct 20261,525 patients
N/AActive Not Recruiting
NCT03186625GenomicsCompound Panax Notoginseng Granule

Impact of Traditional Chinese Medicine on the Gut Microbiota-dependent Trimethylamine N-oxide

Start: Dec 2017Est. completion: Aug 201880 patients
N/AUnknown
NCT02615704AstraZenecaActive group with MEMS

"Me and My Heart" Study

Start: Feb 2016Est. completion: Mar 2019677 patients
N/ACompleted
NCT02288260AstraZenecaRuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Start: Apr 2015Est. completion: Jul 20185,470 patients
N/ACompleted
NCT03823547AstraZenecaFuture Optimal Research and Care Evaluation

Future Optimal Research and Care Evaluation

Start: Jan 2015Est. completion: Jun 205099,999 patients
N/ARecruiting
NCT02197325Miracor MedicalPICSO

PiCSO in ACS Study

Start: Jan 2015Est. completion: Nov 2017
N/ACompleted
NCT02618733BiotronikTicagrelor

Comparing Ticagrelor Versus Clopidogrel on Microcirculation

Start: Dec 2014Est. completion: Dec 2016120 patients
N/ACompleted
NCT02500290Design TherapeuticsAntiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Start: Nov 2014Est. completion: Mar 2021
N/AUnknown
NCT02060760AbbottUse of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes

Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes

Start: Feb 2014Est. completion: Dec 20211,927 patients
N/ACompleted
NCT01952392AstraZenecaPrevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Start: Oct 2013Est. completion: Mar 20164,992 patients
N/ACompleted
NCT01852123AbbottHigh-sensitivity troponin I assay

High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome

Start: Jun 2013Est. completion: Mar 201748,282 patients
N/ACompleted
NCT01678339AstraZenecaSicilian Administrative Data Base Study in Acute Coronary Syndrome Patients

Sicilian Administrative Data Base Study in Acute Coronary Syndrome Patients

Start: Sep 2012Est. completion: Dec 20120
N/AWithdrawn
NCT01490645AstraZenecaA NIS Registry of the Prospective Structured Care In Acute Coronary Syndrome

A NIS Registry of the Prospective Structured Care In Acute Coronary Syndrome

Start: Dec 2011Est. completion: Aug 20141,006 patients
N/ACompleted
NCT01172990AbbottImmediate Invasive Management

Direct Angioplasty for Non ST Elevation Acute Coronary Events: DANCE Pilot Study

Start: Oct 2010Est. completion: Feb 2014108 patients
N/ATerminated
NCT01134913AbbottMulti-Markers In the Diagnosis of Acute Coronary Syndrome

Multi-Markers In the Diagnosis of Acute Coronary Syndrome

Start: Mar 2010Est. completion: Dec 2011621 patients
N/ACompleted
NCT01088503Daiichi SankyoADP receptor inhibitors

Treatment With Adenosine Diphosphate (ADP) Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome

Start: Mar 2010Est. completion: Jan 201412,227 patients
N/ACompleted
NCT00955136Microvascular TherapeuticsUse of intermittent high MI impulses during echocardiogram

Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes

Start: Jul 2009Est. completion: Jan 2010
N/AWithdrawn
NCT01398631SanofiA Comparison of the TIMI, GRACE and HEART Scores

A Comparison of the TIMI, GRACE and HEART Scores

Start: Jun 2009Est. completion: Jul 20112,440 patients
N/ACompleted
NCT00922766PfizerDalteparin

Effectiveness And Safety Of Dalteparin In Patients With Acute Coronary Syndromes Without ST Elevations In Clinical Practice

Start: May 2009Est. completion: Sep 2010618 patients
N/ACompleted
NCT00950469Heidelberg PharmaTnThs for Identification Myocardial Infarction

TnThs for Identification Myocardial Infarction

Start: May 2008Est. completion: Dec 200894 patients
N/ACompleted
NCT00953251Heidelberg PharmaTnThs Predicting Evolving Non-STEMI

TnThs Predicting Evolving Non-STEMI

Start: May 2008Est. completion: Dec 2008115 patients
N/ACompleted
NCT00764205One BiosciencesRandomized Trial of Prehospital Tropin Levels in Acute Coronary Syndrome (ACS)

Randomized Trial of Prehospital Tropin Levels in Acute Coronary Syndrome (ACS)

Start: Nov 2006Est. completion: Nov 2010
N/AUnknown
NCT00413309AstraZenecaVideo Capsule Endoscopy

Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention

Start: Apr 2006Est. completion: Dec 200830 patients
N/ACompleted
NCT01623700AstraZenecaOutcome of Longterm Antithrombotic Therapy in Acute Coronary Syndrome Patients

Outcome of Longterm Antithrombotic Therapy in Acute Coronary Syndrome Patients

Start: Jan 200678,000 patients
N/AUnknown

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

8 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 324,155 patients
24 companies competing in this space

Related Indications

Heart Failure(334)Hypertension(333)Coronary Artery Disease(295)Atrial Fibrillation(288)Pulmonary Arterial Hypertension(103)Pulmonary Hypertension(55)Essential Hypertension(32)Coronary Heart Disease(28)Aortic Valve Stenosis(27)Atherosclerosis(27)