Knee Osteoarthritis

33
Pipeline Programs
30
Companies
50
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
10
1
6
0
11
5
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

29 companies ranked by most advanced pipeline stage

Bioiberica
BioibericaSpain - Barcelona
3 programs
1
2
Chondroitin sulphatePhase 41 trial
Chondroitin/GlucosaminePhase 41 trial
Chondroitin sulfatePhase 31 trial
Active Trials
NCT01354145Completed194Est. Oct 2014
NCT01226615Unknown64Est. Dec 2012
NCT01425853Completed606Est. May 2013
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
1 program
1
EuflexxaPhase 41 trial
Active Trials
NCT01895959Completed12Est. Jan 2017
RS Medical
RS MedicalWA - Vancouver
1 program
1
Patterned Electrical Neuromuscular StimulationPhase 41 trial
Active Trials
NCT00701506Completed13Est. Nov 2010
Plus Therapeutics
1 program
1
Patterned Electrical Neuromuscular StimulationPhase 4
BT
5 programs
2
3
LorecivivintPhase 31 trial
LorecivivintPhase 31 trial
LorecivivintPhase 31 trial
SM04690Phase 21 trial
lorecivivintPhase 21 trial
Active Trials
NCT03122860CompletedEst. Apr 2018
NCT03706521TerminatedEst. Dec 2020
NCT03928184CompletedEst. Aug 2021
+2 more trials
Anika Therapeutics
2
CingalPhase 31 trial
CingalPhase 31 trial
Hyaluronic Acid and THN/A1 trial
Active Trials
NCT01891396CompletedEst. Sep 2014
NCT03191903CompletedEst. Apr 2018
NCT03390036CompletedEst. Jul 2018
IBSA Institut Biochimique
IBSA Institut BiochimiqueSwitzerland - Lugano-Pazzallo
3 programs
3
Chondroitin Sulfate SodiumPhase 31 trial
HL-01: high and low molecular weight hyaluronic acidPhase 31 trial
chondroitin sulfatePhase 31 trial
Active Trials
NCT05632783WithdrawnEst. Jul 2026
NCT03200288CompletedEst. Oct 2018
NCT02079727CompletedEst. Jun 2016
Organogenesis
OrganogenesisCANTON, MA
2 programs
2
Amniotic Suspension AllograftPhase 31 trial
Amniotic Suspension AllograftPhase 31 trial
Active Trials
NCT04636229CompletedEst. Aug 2025
NCT06000410CompletedEst. Nov 2025
MEDIPOST
MEDIPOSTKorea - Gyeonggi
4 programs
2
2
SMUP-IA-01Phase 21 trial
SMUP-IA-01Phase 21 trial
SMUP-IA-01Phase 11 trial
SMUP-IA-01Phase 11 trial
Active Trials
NCT04037345CompletedEst. Nov 2020
NCT04339504UnknownEst. Dec 2025
NCT06798727Active Not RecruitingEst. Nov 2027
+1 more trials
Century Therapeutics
Century TherapeuticsPHILADELPHIA, PA
1 program
1
Stromal-vascular fractionPhase 21 trial
Active Trials
NCT04050111Unknown30Est. Aug 2021
Novartis
NovartisBASEL, Switzerland
1 program
1
balicatibPhase 21 trial
Active Trials
NCT00371670Completed223
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
1
Placenta-derived MMSCsPhase 1/21 trial
Laboratory-based gait retrainingN/A1 trial
Active Trials
NCT03734380UnknownEst. Dec 2023
NCT04453111UnknownEst. Oct 2021
Bioventus
BioventusDURHAM, NC
3 programs
1
Biological: PTP-001Phase 11 trial
3ml hyaluronic acidN/A1 trial
ARTZN/A1 trial
Active Trials
NCT01543737Terminated290Est. Feb 2014
NCT01295580Completed349Est. Feb 2012
NCT04632966Unknown20Est. Dec 2022
M&
Merck & Co.RAHWAY, NJ
1 program
1
AS902330Phase 12 trials
Active Trials
NCT01033994Completed192Est. Dec 2010
NCT00911469Completed73Est. Jun 2010
Sanofi
SanofiPARIS, France
1 program
1
Hylan G-F 20Phase 11 trial
Active Trials
NCT01810848Terminated9Est. Jun 2015
Guerbet
GuerbetFrance - Villepinte
1 program
1
LipiodolPhase 11 trial
Active Trials
NCT04733092Completed22Est. Sep 2022
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
1
Low Dose of Mesenchymal stem cellPhase 11 trial
Active Trials
NCT04130100UnknownEst. Dec 2021
RION
RIONMN - Rochester
1 program
1
PEP/EuflexxaPhase 11 trial
Active Trials
NCT06463132Not Yet RecruitingEst. Nov 2025
Personalized Stem Cells, Inc.
1
PSC-01Phase 11 trial
Active Trials
NCT04043819Unknown125Est. Jan 2021
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
1
UC-MSCsPhase 11 trial
Active Trials
NCT06463847RecruitingEst. Oct 2026
Medacta
MedactaSwitzerland - Castel San Pietro
7 programs
GMK Sphere TKRN/A1 trial
Goal AttainmentN/A1 trial
MOTO Medial® UKAN/A1 trial
Mechanical AlignmentN/A1 trial
Medacta International, GMK Sphere medially stabilized kneeN/A1 trial
+2 more programs
Active Trials
NCT04017533CompletedEst. Oct 2024
NCT05652270Active Not RecruitingEst. Dec 2026
NCT03211663Active Not RecruitingEst. Dec 2025
+4 more trials
Tabuk Pharmaceuticals
Tabuk PharmaceuticalsSaudi Arabia - Riyadh
2 programs
KINESIO TAPINGN/A1 trial
Manual therapy techniquesN/A1 trial
Active Trials
NCT05151627CompletedEst. Jan 2021
NCT05659849CompletedEst. Jun 2024
Arthrex
ArthrexCA - Santa Barbara
1 program
ACP Max™N/A1 trial
Active Trials
NCT05765266CompletedEst. Feb 2026
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
Chondroitin sulfate and sodium hyaluronateN/A1 trial
Active Trials
NCT01469507Withdrawn0
Merit Medical
Merit MedicalSOUTH JORDAN, UT
1 program
Embosphere MicrospheresN/A1 trial
Active Trials
NCT05818150Active Not Recruiting264Est. Oct 2027
Varian Medical Systems
1 program
Embozene MicroSpheresN/A1 trial
Active Trials
NCT04682652RecruitingEst. Oct 2027
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
1 program
Genicular Artery EmbolisationN/A1 trial
Active Trials
NCT05423587RecruitingEst. Jun 2028
Design Therapeutics
1 program
Knee OA BraceN/A1 trial
Active Trials
NCT01886144Completed
GC Biopharma
GC BiopharmaKorea - Yongin
1 program
SMP groupN/A1 trial
Active Trials
NCT05633849CompletedEst. Oct 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Ferring PharmaceuticalsEuflexxa
BioibericaChondroitin/Glucosamine
BioibericaChondroitin sulphate
RS MedicalPatterned Electrical Neuromuscular Stimulation
IBSA Institut BiochimiqueChondroitin Sulfate Sodium
OrganogenesisAmniotic Suspension Allograft
Biosplice TherapeuticsLorecivivint
OrganogenesisAmniotic Suspension Allograft
Biosplice TherapeuticsLorecivivint
Biosplice TherapeuticsLorecivivint
Anika TherapeuticsCingal
IBSA Institut BiochimiqueHL-01: high and low molecular weight hyaluronic acid
Anika TherapeuticsCingal
IBSA Institut Biochimiquechondroitin sulfate
BioibericaChondroitin sulfate

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 1,847 patients across 50 trials

To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection

Start: Aug 2013Est. completion: Jan 201712 patients
Phase 4Completed
NCT01425853BioibericaChondroitin/Glucosamine

Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis

Start: Sep 2011Est. completion: May 2013606 patients
Phase 4Completed
NCT01226615BioibericaChondroitin sulphate

Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI)

Start: Oct 2010Est. completion: Dec 201264 patients
Phase 4Unknown
NCT00701506RS MedicalPatterned Electrical Neuromuscular Stimulation

Patterned Electrical Neuromuscular Stimulation and Therapeutic Exercise for Osteoarthritis of the Knee: Pilot Study

Start: May 2008Est. completion: Nov 201013 patients
Phase 4Completed
NCT05632783IBSA Institut BiochimiqueChondroitin Sulfate Sodium

TreatMent Of Knee osTeoarthritis wIth chONdroitin Sulfate - the OA MOTION Study

Start: Dec 2023Est. completion: Jul 2026
Phase 3Withdrawn
NCT06000410OrganogenesisAmniotic Suspension Allograft

A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee

Start: Sep 2023Est. completion: Nov 2025
Phase 3Completed

A Study Utilizing Patient-Reported Outcomes to Evaluate the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES)

Start: Nov 2022Est. completion: Feb 2024
Phase 3Completed
NCT04636229OrganogenesisAmniotic Suspension Allograft

Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee

Start: Dec 2020Est. completion: Aug 2025
Phase 3Completed

Patient-Reported Outcomes in Evaluating Lorecivivint (SM04690) for Moderate to Severe Knee Osteoarthritis (STRIDES-1)

Start: May 2020Est. completion: Sep 2021
Phase 3Completed

Patient-Reported and Radiographic Outcomes in Evaluating Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis

Start: May 2019Est. completion: Aug 2021
Phase 3Completed

Study of Cingal for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up

Start: Dec 2017Est. completion: Jul 2018
Phase 3Completed
NCT03200288IBSA Institut BiochimiqueHL-01: high and low molecular weight hyaluronic acid

A Study to Evaluate the Clinical Performance and Safety of an Intra-articular Hyaluronic Acid in Knee Osteoarthritis

Start: Jun 2017Est. completion: Oct 2018
Phase 3Completed

Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide

Start: May 2017Est. completion: Apr 2018
Phase 3Completed

Condrosulf vs Celebrex vs Placebo in the Treatment of Knee OA

Start: Jun 2014Est. completion: Jun 2016
Phase 3Completed
NCT01354145BioibericaChondroitin sulfate

Study of the Effect of Chondroitin Sulfate on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI

Start: Jun 2011Est. completion: Oct 2014194 patients
Phase 3Completed

Evaluation Safety and Explore Efficacy Long-term Follow-up Study on Subjects Receiving SMUP-IA-01 or Active Control

Start: Mar 2023Est. completion: Nov 2027
Phase 2Active Not Recruiting

Clinical Trial to Evaluate Efficacy and Safety of SMUP-IA-01 in Patients With Knee Osteoarthritis

Start: Feb 2022Est. completion: Oct 2023
Phase 2Completed
NCT04050111Century TherapeuticsStromal-vascular fraction

The Evaluation of Safety and Effectiveness of Intraarticular Administration of Autologous Stromal-Vascular Fraction of Adipose Tissue Cells for Treatment of Knee Joint Arthrosis

Start: Aug 2019Est. completion: Aug 202130 patients
Phase 2Unknown

MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis

Start: Mar 2019Est. completion: Dec 2020
Phase 2Terminated

A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

Start: Apr 2017Est. completion: Apr 2018
Phase 2Completed

Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee

Start: Dec 2004223 patients
Phase 2Completed
NCT04453111City TherapeuticsPlacenta-derived MMSCs

Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis

Start: Jan 2020Est. completion: Oct 2021
Phase 1/2Unknown
NCT06463132RIONPEP/Euflexxa

Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)

Start: Nov 2024Est. completion: Nov 2025
Phase 1Not Yet Recruiting

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Start: Jun 2024Est. completion: Oct 2026
Phase 1Recruiting

Safety and Efficacy of a Lipiodol Emulsion for the Embolization of Hypervascularizations in Patients With Knee Pain (LipioJoint1)

Start: Mar 2021Est. completion: Sep 202222 patients
Phase 1Completed
NCT04632966BioventusBiological: PTP-001

Safety Study of PTP-001 for Treating Knee Osteoarthritis

Start: Feb 2021Est. completion: Dec 202220 patients
Phase 1Unknown

Follow-up Safety and Efficacy Evaluation on Subjects Who Completed Phase I Clinical Trial

Start: Apr 2020Est. completion: Dec 2025
Phase 1Unknown

Evaluate Safety and Explore Efficacy of SMUP-IA-01 in Patients With Knee Osteoarthritis

Start: Oct 2019Est. completion: Nov 2020
Phase 1Completed

Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis

Start: Sep 2019Est. completion: Jan 2021125 patients
Phase 1Unknown
NCT04130100T-TherapeuticsLow Dose of Mesenchymal stem cell

Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis

Start: Apr 2019Est. completion: Dec 2021
Phase 1Unknown
NCT01810848SanofiHylan G-F 20

Pilot Study of Therapy With Hylan G-F 20 Exercise Capacity

Start: Jun 2014Est. completion: Jun 20159 patients
Phase 1Terminated

A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery

Start: Oct 2008Est. completion: Dec 2010192 patients
Phase 1Completed

Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement

Start: Nov 2007Est. completion: Jun 201073 patients
Phase 1Completed
NCT01469507Pierre FabreChondroitin sulfate and sodium hyaluronate

Efficacy and Safety Study in Patients Suffering From Knee Osteoarthritis

0
N/AWithdrawn
NCT06617871MedactaMechanical Alignment

Mechanical Alignment Vs Kalipered Kinematic Alignment Total Knee Arthroplasty

Start: Aug 2024Est. completion: Dec 2028
N/ARecruiting

ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial

Start: May 2024Est. completion: Feb 2026
N/ACompleted
NCT05818150Merit MedicalEmbosphere Microspheres

GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)

Start: Jan 2024Est. completion: Oct 2027264 patients
N/AActive Not Recruiting

Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis

Start: Aug 2023Est. completion: Oct 2027
N/ARecruiting
NCT05652270MedactaGoal Attainment

Maximizing Patient Goal Attainment

Start: Apr 2023Est. completion: Dec 2026
N/AActive Not Recruiting

Comparison of the in Vivo Stability of 2 Cementless TKA Designs

Start: Dec 2022Est. completion: Jan 2033
N/AActive Not Recruiting
NCT05423587Siemens HealthineersGenicular Artery Embolisation

Genicular Artery Embolisation for Knee Osteoarthritis II

Start: Oct 2022Est. completion: Jun 2028
N/ARecruiting
NCT05659849Tabuk PharmaceuticalsManual therapy techniques

Effectiveness of Manual Therapy and Neuromuscular Training in the Management of Knee Osteoarthritis

Start: Jun 2022Est. completion: Jun 2024
N/ACompleted
NCT04017533MedactaGMK Sphere TKR

Stability of Uncemented Medially Stabilized TKA

Start: Sep 2021Est. completion: Oct 2024
N/ACompleted
NCT03734380City TherapeuticsLaboratory-based gait retraining

Lower Knee Joint Loading by Real-time Biofeedback Stair Walking Rehabilitation for Patients With MCKOA

Start: Jan 2021Est. completion: Dec 2023
N/AUnknown

The Effectiveness of Kinesio Taping in Patients With Knee Osteoarthritis

Start: Jun 2020Est. completion: Jan 2021
N/ACompleted
NCT03618771MedactaTotal knee arthroplasty

A Functional Comparison of Two TKR Designs

Start: Feb 2019Est. completion: Dec 2024
N/ACompleted

Evaluation of the Effect of Pro Resolve® Sports on Treatment of Patients With Symptomatic Knee Osteoarthritis

Start: May 2018Est. completion: Oct 2021
N/ACompleted
NCT03211663MedactaMOTO Medial® UKA

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

Start: Oct 2017Est. completion: Dec 2025
N/AActive Not Recruiting
NCT02861794MedactaMedacta International, GMK Sphere medially stabilized knee

Stability of Contemporary Knee Arthroplasty

Start: May 2016Est. completion: Dec 2024
N/ACompleted

Effects of Bracing on Knee Osteoarthritis (OA)

Start: Jul 2013
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

11 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 1,847 patients
30 companies competing in this space