Amputation

Pipeline Programs

Companies

Clinical Trials

5 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Human BioSciencesWV - Martinsburg

12 programs

Unrectified prosthetic socketPhase 21 trial

morphine and mexiletinePhase 21 trial

As-prescribed prosthetic foot stiffnessPhase 1

PSICON Measurement ApparatusPhase 11 trial

AMI transtibial amputationN/A1 trial

+7 more programs

Active Trials

NCT03913273Completed14Est. Jun 2025

NCT06539936Recruiting7Est. Mar 2026

NCT04038151Recruiting20Est. Jun 2025

+8 more trials

Colorado TherapeuticsCO - Louisville

3 programs

Walking Biobehavioral InterventionPhase 21 trial

As-prescribed prosthetic foot stiffnessPhase 11 trial

Limb Load Biofeedback Training InterventionN/A1 trial

Active Trials

NCT05695911Active Not Recruiting25Est. Jan 2027

NCT07263945Recruiting60Est. May 2030

NCT04083456Completed40Est. May 2025

Sound PharmaceuticalsWA - Seattle

4 programs

Liner perforated with very small diameter holesN/A1 trial

Multiaxial Prosthetic Foot EmulatorN/A1 trial

Prosthetic Foot EmulatorN/A1 trial

Standard-of-care prosthetic footN/A1 trial

Active Trials

NCT07024342Active Not Recruiting180Est. Sep 2026

NCT05473065Recruiting100Est. Jul 2026

NCT03651830Completed90Est. Jun 2022

+1 more trials

Design PharmaceuticalsMA - Cambridge

2 programs

Peer Visitation ProgramN/A

eADAPT trainingN/A

Design TherapeuticsCARLSBAD, CA

2 programs

Peer Visitation ProgramN/A1 trial

eADAPT trainingN/A1 trial

Active Trials

NCT03326115Unknown46Est. Aug 2021

NCT04238533Unknown10Est. Jul 2021

OttobockNEW YORK, NY

1 program

1C70N/A1 trial

Active Trials

NCT05628064Completed22Est. Jun 2023

Providence Medical TechnologyCA - Pleasanton

1 program

Active Knee ProsthesisN/A

Providence TherapeuticsAB - Calgary

1 program

Active Knee ProsthesisN/A1 trial

Active Trials

NCT00771589Unknown10Est. Apr 2009

VivonicsMA - Bedford

1 program

ICE ConditionN/A1 trial

Active Trials

NCT04484805Completed12Est. Nov 2020

Ability PharmaSpain - Cerdanyola

1 program

KinnexN/A1 trial

Active Trials

NCT02864693Completed30Est. Apr 2018

City TherapeuticsMA - Cambridge

1 program

Our Emergency Fasciotomy and Amputation ExperiencesN/A1 trial

Active Trials

NCT06764446CompletedEst. Mar 2025

UNION therapeuticsDenmark - Hellerup

1 program

SPCMN/A1 trial

Active Trials

NCT06522646Completed12Est. May 2023

Applied MedicalCA - Rancho Santa Margarita

1 program

Vibro-tactile FeedbackN/A

AtriCureCA - Pleasanton

1 program

cryoablationN/A1 trial

Active Trials

NCT06908538Recruiting2,000Est. Apr 2035

iFIT ProstheticsWI - Oconomowoc

1 program

iFIT Transtibial ProsthesisN/A1 trial

Active Trials

NCT02886936Completed71Est. May 2022

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

Colorado TherapeuticsWalking Biobehavioral Intervention

Human BioSciencesUnrectified prosthetic socket

Human BioSciencesmorphine and mexiletine

Colorado TherapeuticsAs-prescribed prosthetic foot stiffness

Human BioSciencesPSICON Measurement Apparatus

AtriCurecryoablation

City TherapeuticsOur Emergency Fasciotomy and Amputation Experiences

Human BioSciencesGlide

Sound PharmaceuticalsMultiaxial Prosthetic Foot Emulator

Human BioSciencesRobotic Knee/Ankle Prosthesis

Colorado TherapeuticsLimb Load Biofeedback Training Intervention

Ottobock1C70

Sound PharmaceuticalsLiner perforated with very small diameter holes

Human BioSciencesTranscutaneous spinal cord stimulation

Sound PharmaceuticalsStandard-of-care prosthetic foot

Showing 15 of 28 trials with date data

Clinical Trials (28)

Total enrollment: 2,997 patients across 28 trials

NCT04083456 Colorado TherapeuticsWalking Biobehavioral Intervention

Dysvascular Amputation Self-Management of Health

Start: Nov 2019Est. completion: May 202540 patients

Phase 2Completed

NCT00061217 Human BioSciencesUnrectified prosthetic socket

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

Start: Apr 2001Est. completion: Mar 200559 patients

Phase 2Unknown

NCT00383682 Human BioSciencesmorphine and mexiletine

Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain

Start: Jul 1997Est. completion: Apr 200360 patients

Phase 2Completed

NCT07263945 Colorado TherapeuticsAs-prescribed prosthetic foot stiffness

Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes

Start: Nov 2025Est. completion: May 203060 patients

Phase 1Recruiting

NCT04692571 Human BioSciencesPSICON Measurement Apparatus

EMG-Based Hand-Wrist Control: Study B Mirrored

Start: Jun 2017Est. completion: Aug 202020 patients

Phase 1Completed

NCT06908538 AtriCurecryoablation

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

Start: Apr 2025Est. completion: Apr 20352,000 patients

N/ARecruiting

NCT06764446 City TherapeuticsOur Emergency Fasciotomy and Amputation Experiences

Our Emergency Fasciotomy and Amputation Experiences

Start: Jan 2025Est. completion: Mar 2025

N/ACompleted

NCT06539936 Human BioSciencesGlide

Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses

Start: Sep 2024Est. completion: Mar 20267 patients

N/ARecruiting

NCT05473065 Sound PharmaceuticalsMultiaxial Prosthetic Foot Emulator

A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations

Start: Mar 2024Est. completion: Jul 2026100 patients

N/ARecruiting

NCT05537792 Human BioSciencesRobotic Knee/Ankle Prosthesis

Intent Recognition for Prosthesis Control

Start: Sep 2023Est. completion: May 202410 patients

N/ACompleted

NCT05695911 Colorado TherapeuticsLimb Load Biofeedback Training Intervention

Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training

Start: Jan 2023Est. completion: Jan 202725 patients

N/AActive Not Recruiting

NCT05628064 Ottobock1C70

1C70 Feasibility Study

Start: Nov 2022Est. completion: Jun 202322 patients

N/ACompleted

NCT07024342 Sound PharmaceuticalsLiner perforated with very small diameter holes

Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration

Start: Oct 2022Est. completion: Sep 2026180 patients

N/AActive Not Recruiting

NCT04543786 Human BioSciencesTranscutaneous spinal cord stimulation

Neuromodulation in Lower Limb Amputees

Start: Mar 2022Est. completion: Jun 20223 patients

N/ATerminated

NCT07159490 Sound PharmaceuticalsStandard-of-care prosthetic foot

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

Start: Dec 2020Est. completion: Oct 202513 patients

N/ACompleted

NCT03326115 Design TherapeuticsPeer Visitation Program

Effectiveness of a Peer Visitation Program to Improve Patient Activation and Quality of Life During Amputation Rehabilitation

Start: Dec 2020Est. completion: Aug 202146 patients

N/AUnknown

NCT04238533 Design TherapeuticseADAPT training

Enhanced Auto-Diagnostic Adaptive Precision Trainer for Myoelectric Prosthetic Users

Start: Mar 2020Est. completion: Jul 202110 patients

N/AUnknown

NCT03989063 Human BioSciencesInstructions to perform a motor task

Motor Learning in Individuals With Lower Limb Loss and Chronic Diabetes

Start: Oct 2019Est. completion: Jun 202455 patients

N/AUnknown

NCT04484805 VivonicsICE Condition

Socket Cooling Effectiveness Take Home Study

Start: Aug 2019Est. completion: Nov 202012 patients

N/ACompleted

NCT03913273 Human BioSciencesAMI transtibial amputation

Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation

Start: Jun 2019Est. completion: Jun 202514 patients

N/ACompleted

NCT03632252 Human BioSciencesPowered ankle prosthesis

Evaluating and Improving Assistive Robotic Devices Continuously and in Real-time

Start: May 2019Est. completion: Sep 20210

N/AWithdrawn

NCT04038151 Human BioSciencesHybrid Leg

Intuitive Control of a Hybrid Prosthetic Leg During Ambulation

Start: Dec 2018Est. completion: Jun 202520 patients

N/ARecruiting

NCT03651830 Sound PharmaceuticalsProsthetic Foot Emulator

A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations

Start: Sep 2018Est. completion: Jun 202290 patients

N/ACompleted

NCT06522646 UNION therapeuticsSPCM

Evaluation of a Microprocessor-controlled Prosthetic Knee-ankle System (SPCM)

Start: Jul 2018Est. completion: May 202312 patients

N/ACompleted

NCT02886936 iFIT ProstheticsiFIT Transtibial Prosthesis

Immediate Fit Using Innovative Technology Transtibial & Transfemoral Prosthesis

Start: May 2018Est. completion: May 202271 patients

N/ACompleted

NCT02864693 Ability PharmaKinnex

Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees

Start: Jun 2016Est. completion: Apr 201830 patients

N/ACompleted

NCT01161238 Human BioSciencesMonitored for limb volume

Amputee Residual Limb Volume Fluctuation

Start: May 2010Est. completion: Sep 201128 patients

N/ACompleted

NCT00771589 Providence TherapeuticsActive Knee Prosthesis

Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees

Start: May 2008Est. completion: Apr 200910 patients

N/AUnknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

5 actively recruiting trials targeting 2,997 patients

15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.