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Mild Cognitive Impairment

28
Pipeline Programs
30
Companies
50
Clinical Trials
6 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
9
1
14
0
2
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
250%
Small Molecule
250%
+ 70 programs with unclassified modality

Competitive Landscape

50 companies ranked by most advanced pipeline stage

Hanmi Pharmaceutical
1
Acetyl-L-carnitine hydrochloride 500mgPhase 41 trial
Active Trials
NCT04346862Unknown636Est. Jun 2020
Chong Kun Dang Pharmaceutical
1
Choline AlfosceratePhase 41 trial
Active Trials
NCT05041790Unknown418Est. Nov 2024
Medpace
MedpaceCINCINNATI, OH
1 program
1
FlutemetamolPhase 3
Medica Corp
Medica CorpMA - Bedford
1 program
1
MMH-MAPPhase 31 trial
Active Trials
NCT03815292Completed276Est. Jan 2020
Angeles Therapeutics
2
1
Grape PowderPhase 21 trial
Grape PowderPhase 11 trial
bosutinibPhase 1Small Molecule
Memory TrainingN/A1 trial
Tai ChiN/A1 trial
+2 more programs
Active Trials
NCT03503669Completed100Est. Feb 2021
NCT05217849Completed77Est. Dec 2025
NCT02001441Completed35Est. Aug 2015
+2 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
4 programs
2
CannabidiolPhase 21 trial
PioglitazonePhase 21 trial
Advance Care Planning Group VisitsN/A1 trial
Cross-Cultural Use of Performance-Based Functional Assessment in Alzheimer's DiseaseN/A1 trial
Active Trials
NCT03711396Completed26Est. Jan 2021
NCT03081546Completed41Est. Sep 2018
NCT05822362Recruiting236Est. Apr 2029
+1 more trials
Sandoz
SandozAustria - Kundl
2 programs
1
CanakinumabPhase 2Monoclonal Antibody
Clinical Pathway for Alzheimer's Disease in China (CPAD)N/A
ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
1
1
RosiglitazonePhase 2
GSK239512Phase 1
Araclon Biotech
1
ABvac40Phase 21 trial
Active Trials
NCT03461276Completed134Est. Mar 2023
AgeneBio
1 program
1
AGB101Phase 21 trial
Active Trials
NCT05986721Withdrawn0Est. Dec 2028
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD5213Phase 21 trial
Active Trials
NCT01548287Completed164Est. Jan 2013
CuraSen Therapeutics
CuraSen TherapeuticsCA - San Carlos
1 program
1
CST-2032, matching placebo for CST-2032, CST-107, matching placebo for CST-107Phase 21 trial
Active Trials
NCT05104463Completed64Est. Feb 2024
RespireRx Pharmaceuticals
1
CX516Phase 21 trial
Active Trials
NCT00040443Completed175Est. Jun 2004
Biomed
1 program
1
N-831Phase 21 trial
Active Trials
NCT03538522Completed126Est. Oct 2019
Servier
ServierFrance - Suresnes
1 program
1
S18986Phase 21 trial
Active Trials
NCT00202540Terminated38Est. Mar 2006
Supernus Pharmaceuticals
1 program
1
SAGE-718Phase 21 trial
Active Trials
NCT05619692Completed174Est. Jul 2024
Navidea Biopharmaceuticals
1
[18F]NAV4694Phase 21 trial
Active Trials
NCT01812213Terminated76Est. Nov 2017
Oregon Therapeutics
2
1
Staying Sharp interventionPhase 1/21 trial
Active social engagement groupPhase 11 trial
Centella asiatica productPhase 11 trial
dual-task tai ji quanN/A1 trial
tai ji quanN/A1 trial
Active Trials
NCT05725668Recruiting336Est. Jan 2028
NCT05318703Completed69Est. Oct 2022
NCT01571427Completed83Est. Sep 2013
+2 more trials
Insightec
InsightecFL - Miami
1 program
1
AducanumabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT05469009Active Not Recruiting15Est. Jul 2029
Eyenuk
1 program
1
Retinal fundus photographyPhase 11 trial
Active Trials
NCT04567745Completed80Est. Sep 2021
Cognoptix
1 program
1
Sapphire IIPhase 11 trial
Active Trials
NCT02928211Unknown105Est. Jan 2019
Pfizer
PfizerNEW YORK, NY
1 program
1
bosutinibPhase 1Small Molecule1 trial
Active Trials
NCT02921477Unknown150Est. Dec 2025
Innovation Pharmaceuticals
3 programs
ABI Wellness ProgramN/A1 trial
Brain Blossom - Gamified Differential Outcome TrainingN/A
Shanghai Mild Cognitive Impairment Cohort StudyN/A1 trial
Active Trials
NCT04539132Unknown40Est. Oct 2021
NCT01552265Completed400Est. Jul 2017
Human BioSciences
APOE genotype and Alzheimer's disease risk disclosureN/A1 trial
One Resistance Training SetN/A1 trial
Transcutaneous vagal nerve stimulationN/A1 trial
Active Trials
NCT01434667Completed146Est. Jul 2014
NCT06185010Unknown80Est. Dec 2024
NCT03359902Completed59Est. May 2022
UNION therapeutics
Cybercycle-GameN/A1 trial
Lumbar punctureN/A1 trial
engAGE systemN/A1 trial
Active Trials
NCT02237560Completed111Est. Jul 2017
NCT01425957Completed229Est. Oct 2015
NCT06302686Unknown78Est. Jun 2024
Eisai
EisaiChina - Liaoning
2 programs
group cognitive interventionN/A1 trial
AriceptPHASE_41 trial
Active Trials
NCT01358955Completed293Est. Jan 2013
NCT00934375Completed145Est. Sep 2007
GSK
GSKLONDON, United Kingdom
2 programs
GSK239512PHASE_11 trial
RosiglitazonePHASE_21 trial
Active Trials
NCT00474513Completed5Est. Mar 2008
NCT00242593Unknown120Est. Dec 2011
GE HealthCare
2 programs
[18F] FlutemetamolPHASE_21 trial
FlutemetamolPHASE_31 trial
Active Trials
NCT02813070Completed70Est. May 2013
NCT01028053Completed365Est. Jan 2014
Genome & Company
APOE genotype and Alzheimer's disease risk disclosureN/A
Biocorp
1 program
Alzheimer's and Blood Glucose LevelsN/A1 trial
Active Trials
NCT04614376Unknown100Est. Mar 2022

+20 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Chong Kun Dang PharmaceuticalCholine Alfoscerate
Hanmi PharmaceuticalAcetyl-L-carnitine hydrochloride 500mg
EisaiAricept
Medica CorpMMH-MAP
GE HealthCareFlutemetamol
AgeneBioAGB101
Colorado TherapeuticsCannabidiol
Supernus PharmaceuticalsSAGE-718
CuraSen TherapeuticsCST-2032, matching placebo for CST-2032, CST-107, matching placebo for CST-107
Function TherapeuticsThe Computerized Functional Skills Assessment and Training Program
Precision BioSciencesAtorvastatin Oral Tablet
FUJIFILM PharmaT-817MA
BiomedN-831
Araclon BiotechABvac40
Angeles TherapeuticsGrape Powder

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 6,428 patients across 50 trials

A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate Compared to Placebo in Patients With Degenerative Mild Cognitive Impairment

Start: Sep 2021Est. completion: Nov 2024418 patients
Phase 4Unknown
NCT04346862Hanmi PharmaceuticalAcetyl-L-carnitine hydrochloride 500mg

Evaluation the Effect of Acetyl-L-carnitine in Patients With Mild Cognitive Impairment Accompanied With Chronic Cerebrovascular Disease

Start: Jan 2016Est. completion: Jun 2020636 patients
Phase 4Unknown

A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment

Start: Feb 2006Est. completion: Sep 2007145 patients
Phase 4Completed

Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Mild Cognitive Impairment in Early Recovery Stage After Ischemic Stroke

Start: Oct 2018Est. completion: Jan 2020276 patients
Phase 3Completed

Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease

Start: Dec 2009Est. completion: Jan 2014365 patients
Phase 3Completed

Clinical Trial of AGB101 for Mild Cognitive Impairment

Start: Dec 2024Est. completion: Dec 20280
Phase 2Withdrawn

CBD for Individuals at Risk for Alzheimer's Disease

Start: Jan 2024Est. completion: Apr 2029236 patients
Phase 2Recruiting

A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)

Start: Nov 2022Est. completion: Jul 2024174 patients
Phase 2Completed
NCT05104463CuraSen TherapeuticsCST-2032, matching placebo for CST-2032, CST-107, matching placebo for CST-107

A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease

Start: Apr 2022Est. completion: Feb 202464 patients
Phase 2Completed
NCT04679441Function TherapeuticsThe Computerized Functional Skills Assessment and Training Program

A Novel Computer-Based Functional Skills Assessment and Training Program

Start: Aug 2021Est. completion: May 2023180 patients
Phase 2Active Not Recruiting
NCT04765137Precision BioSciencesAtorvastatin Oral Tablet

Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Start: May 2021Est. completion: Dec 202720 patients
Phase 2Recruiting

Efficacy and Safety of T-817MA in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD

Start: Dec 2019Est. completion: Mar 2023221 patients
Phase 2Completed

A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831

Start: Sep 2018Est. completion: Oct 2019126 patients
Phase 2Completed

Safety and Immunogenicity of Repeated Doses of ABvac40 in Patients With a-MCI or Vm-AD

Start: Dec 2017Est. completion: Mar 2023134 patients
Phase 2Completed

Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year

Start: Nov 2017Est. completion: Oct 202232 patients
Phase 2Completed

Beta-Amyloid Imaging With [18F]NAV4694 PET in Predicting Progression to AD in Subjects MCI

Start: Mar 2013Est. completion: Nov 201776 patients
Phase 2Terminated

Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease

Start: Nov 201252 patients
Phase 2Completed
NCT02813070GE HealthCare[18F] Flutemetamol

Comparison of PET Amyloid Imaging in Japanese and Western Subjects

Start: Oct 2012Est. completion: May 201370 patients
Phase 2Completed

A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment

Start: Apr 2012Est. completion: Jan 2013164 patients
Phase 2Completed

Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI)

Start: Nov 2008Est. completion: Dec 201378 patients
Phase 2Completed
NCT00242593GSKRosiglitazone

Rosiglitazone Effects on Cognition for Adults in Later Life

Start: Jun 2006Est. completion: Dec 2011120 patients
Phase 2Unknown

Efficacy and Safety of S18986 in the Treatment of Mild Cognitive Impairment Patients

Start: Jun 2005Est. completion: Mar 200638 patients
Phase 2Terminated

Efficacy And Safety Of CX516 In Elderly Participants With Mild Cognitive Impairment.

Start: Apr 2002Est. completion: Jun 2004175 patients
Phase 2Completed
NCT05260515Oregon TherapeuticsStaying Sharp intervention

Protecting Alzheimer Caregivers Using Technology Through Staying Sharp

Start: Apr 2023Est. completion: Aug 2024138 patients
Phase 1/2Unknown
NCT05591027Oregon TherapeuticsCentella asiatica product

Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

Start: Dec 2022Est. completion: Mar 202648 patients
Phase 1Recruiting

Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

Start: Jul 2022Est. completion: Jul 202915 patients
Phase 1Active Not Recruiting
NCT01464515BrainsWayH-Coil Deep TMS

Efficiency of Deep Transcranial Magnetic Stimulation on Patients With Mild Cognitive Impairment

Start: Jan 2021Est. completion: Jan 202130 patients
Phase 1Unknown
NCT04567745EyenukRetinal fundus photography

Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers

Start: Sep 2020Est. completion: Sep 202180 patients
Phase 1Completed

A Novel Therapeutic Target for Alzheimer's Disease in Men and Women 50-85 Years of Age.

Start: May 2019Est. completion: May 20220
Phase 1Withdrawn

Study for the Use of TKIs for Treatment of Cognitive Decline Due to Degenerative Dementias

Start: Sep 2016Est. completion: Dec 2025150 patients
Phase 1Unknown

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

Start: Jul 2016Est. completion: Jan 2019105 patients
Phase 1Unknown

Impact of Grape Consumption on Brain Metabolism and Cognitive Function

Start: Apr 2012Est. completion: Nov 201412 patients
Phase 1Completed
NCT01571427Oregon TherapeuticsActive social engagement group

Conversations as a Means to Delay the Onset of Alzheimer's Disease

Start: Feb 2012Est. completion: Sep 201383 patients
Phase 1Completed

An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.

Start: Mar 2007Est. completion: Mar 20085 patients
Phase 1Completed

Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers

Start: Mar 2025Est. completion: Mar 2026500 patients
N/ARecruiting
NCT06762522Providence TherapeuticsNonlinear dynamical neurofeedback

Exploring Feasibility, Acceptability and Impact of Using Neurofeedback with Persons with Mild Cognitive Impairment

Start: Jan 2025Est. completion: Jan 202620 patients
N/ANot Yet Recruiting

Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)

Start: May 2024Est. completion: Dec 2027380 patients
N/ARecruiting
NCT06399978Eureka TherapeuticsBrain Blossom - Gamified Differential Outcome Training

The Feasibility and Effect of Digital Cognitive Training in Mild Cognitive Impairment

Start: May 2024Est. completion: Jan 202540 patients
N/AUnknown
NCT06185010Human BioSciencesOne Resistance Training Set

Resistance Training to Individuals for Cognitive Impairment With Dementia

Start: Dec 2023Est. completion: Dec 202480 patients
N/AUnknown
NCT05235113BiosensicsTele-Exergame Platform

Remote Game-based Exercise Program for Cognitive and Motor Function Improvement

Start: Nov 2023Est. completion: Jun 202684 patients
N/AActive Not Recruiting

engAGE: Managing cognitivE decliNe throuGh Theatre Therapy, Artificial Intelligence and Social Robots drivEn Interventions

Start: Oct 2023Est. completion: Jun 202478 patients
N/AUnknown
NCT05725668Oregon Therapeuticsdual-task tai ji quan

A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment

Start: Jul 2023Est. completion: Jan 2028336 patients
N/ARecruiting

Effects of Walkasins on Gait Speed of Individuals With Mild Cognitive Impairments

Start: Feb 2023Est. completion: Mar 202312 patients
N/ACompleted

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)

Start: Feb 2022Est. completion: Dec 202577 patients
N/ACompleted
NCT04954183SPARK BiopharmaDevelopment of an EEG Diagnostic for Alzheimer's Disease

Development of an EEG Diagnostic for Alzheimer's Disease

Start: Oct 2021Est. completion: Jul 202529 patients
N/ACompleted

Virtual Exercise For Older Adults With Mild Cognitive Impairment

Start: Jan 2021Est. completion: Oct 202269 patients
N/ACompleted
NCT04614376BiocorpAlzheimer's and Blood Glucose Levels

Alzheimer's and Blood Glucose Levels

Start: Nov 2020Est. completion: Mar 2022100 patients
N/AUnknown
NCT04683835NeurosteerNeurosteer Aurora system

Evaluation of Cognitive State in Senior Subjects Using Neurosteer EEG System

Start: Oct 2020Est. completion: Oct 202180 patients
N/ACompleted

Maintaining Independence and Quality of Life in Aging Adults Through Targeted Cognitive Training

Start: Sep 2020Est. completion: Oct 202140 patients
N/AUnknown
NCT03983655Actipulse NeuroscienceTranscranial Magnetic Stimulation

Effect of High Frequency/Low Intensity Transcranial Magnetic Stimulation in Cognitive Traits of an Elderly Population of Subjects With Mild Cognitive Impairment and Mild Dementia.

Start: May 2019Est. completion: Aug 202037 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
6 actively recruiting trials targeting 6,428 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.