Depression

Neurology
42
Pipeline Programs
30
Companies
50
Clinical Trials
5 recruiting
7
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
13
0
6
1
11
11
Early DiscoveryClinical DevelopmentMarket

On Market (7)

Approved therapies currently available

U
ARMODAFINILApproved
armodafinil
Unknown Company
oral2016
Eli Lilly and Company
CYMBALTAApproved
duloxetine hydrochloride
Eli Lilly and Company
oral2004
U
DULOXETINE HYDROCHLORIDEApproved
duloxetine hydrochloride
Unknown Company
oral2014
U
NUVIGILApproved
armodafinil
Unknown Company
oral2007
J&
SPRAVATOApproved
esketamine hydrochloride
Johnson & Johnson
nasal2019
U
VENLAFAXINE HYDROCHLORIDEApproved
venlafaxine
Unknown Company
oral2022
AbbVie
VRAYLARApproved
cariprazine
AbbVie
Atypical Antipsychotic [EPC]oral2015

Competitive Landscape

29 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
9 programs
4
1
VenlafaxinePhase 41 trial
DVS-233 SRPhase 31 trial
Effexor XRPhase 31 trial
Effexor XRPhase 31 trial
SertralinePhase 31 trial
+4 more programs
Active Trials
NCT02535390Completed73Est. Oct 2018
NCT03762460Completed60Est. Dec 2022
NCT00605813CompletedEst. Sep 2011
+6 more trials
Alliance Pharmaceuticals
8 programs
1
1
1
PramipexolePhase 41 trial
Fish OilPhase 31 trial
SertralinePhase 11 trial
Heart-Smile Training Intensive Introduction ProgramN/A1 trial
MI + CATCH-IT Internet SiteN/A1 trial
+3 more programs
Active Trials
NCT05564533Completed35Est. Sep 2024
NCT00145912Completed49Est. Oct 2011
NCT05646212Active Not Recruiting1,350Est. May 2026
+5 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
4 programs
1
1
Duloxetine HydrochloridePhase 31 trial
InterventionN/A1 trial
Meru Health ProgramN/A1 trial
rTMS TreatmentN/A1 trial
Active Trials
NCT01662817Completed525Est. Jul 2010
NCT05588622Completed22Est. Jul 2023
NCT00587639Completed8Est. Oct 2009
+1 more trials
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
1
BupropionN/A1 trial
InterventionN/A1 trial
SPRAVATO(Ketamine Hydrochloride)N/A1 trial
Active Trials
NCT02104128Completed80Est. May 2016
NCT01773629Completed194Est. Dec 2013
NCT04850911Unknown70Est. May 2023
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
1
CariprazinePhase 31 trial
Active Trials
NCT04777357Recruiting380Est. Mar 2027
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
duloxetinePhase 41 trial
Active Trials
NCT00666757Completed750Est. Mar 2009
Verona Pharma
Verona PharmaUK - London
1 program
1
lithiumPhase 41 trial
Active Trials
NCT00927550Unknown230Est. Dec 2012
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
2 programs
1
1
Electroconvulsive TherapyPhase 31 trial
Brief Temporoparietal ECTPhase 21 trial
Active Trials
NCT03297411Unknown15Est. Jun 2022
NCT03105245Completed54Est. Mar 2019
Teva
TevaIsrael - Petach Tikva
2 programs
2
ArmodafinilPhase 31 trial
ArmodafinilPhase 31 trial
Active Trials
NCT01072929Completed433Est. Mar 2012
NCT01072630Completed492Est. Nov 2012
Axsome Therapeutics
Axsome TherapeuticsNY - New York
1 program
1
AXS-05Phase 31 trial
Active Trials
NCT04019704Completed327Est. Dec 2019
LP
Lee's PharmaceuticalChina - Guangzhou
3 programs
2
1
TrazodonePhase 2/31 trial
Trazodone Hydrochloride prolonged-release tabletsPhase 11 trial
trazodone hydrochloride prolonged-release tabletPhase 11 trial
Active Trials
NCT02785601Completed15Est. Jan 2018
NCT02785614Completed12Est. Jan 2018
NCT01524497Completed382Est. Nov 2013
T-Therapeutics
T-TherapeuticsUK - Cambridge
2 programs
1
BCBTPhase 2
Dental pulp mesenchymal cell injectionN/A1 trial
Active Trials
NCT05127369UnknownEst. Jun 2024
Cook Medical
Cook MedicalIN - Bloomington
1 program
1
Computer-tailored interventionPhase 21 trial
Active Trials
NCT00497874CompletedEst. Jun 2006
Bristol Myers Squibb
1 program
1
DuloxetinePhase 21 trial
Active Trials
NCT01309945Completed889Est. Jan 2013
Tonix Pharmaceuticals
Tonix PharmaceuticalsBERKELEY HEIGHTS, NJ
1 program
1
TNX-601 ERPhase 21 trial
Active Trials
NCT05686408Completed132Est. Sep 2023
Beacon Therapeutics
Beacon TherapeuticsMA - Cambridge
1 program
1
telephone depression care managementPhase 2
Sandoz
SandozAustria - Kundl
8 programs
8
Bupropion HCI 300 mg Extended-Release Tablets EONPhase 11 trial
Clomipramine Hydrochloride 25 mg CapsulesPhase 11 trial
Desipramine HCL 100 mg Tablets Cord LaboratoriesPhase 11 trial
Desipramine HCl 50 mg Tablets Cord LaboratoriesPhase 11 trial
Desipramine Hydrochloride 100 mg TabletsPhase 11 trial
+3 more programs
Active Trials
NCT00861939CompletedEst. Apr 2004
NCT00913783CompletedEst. Dec 1992
NCT00913809CompletedEst. Dec 1987
+5 more trials
Novartis
NovartisBASEL, Switzerland
1 program
1
ABP688Phase 11 trial
Active Trials
NCT01528241Completed42Est. May 2010
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD6765Phase 15 trials
Active Trials
NCT01482221Completed542Est. Aug 2013
NCT01217645Completed6Est. Oct 2010
NCT01130909Terminated36Est. Jan 2011
+2 more trials
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
6 programs
ASCENSON/A1 trial
CBCT®N/A1 trial
CoLiPri interventionN/A1 trial
Depressive Symptoms and Emotion Regulation Following Cognitive Behavioral TherapyN/A1 trial
Purpose designed music and sound listening programN/A1 trial
+1 more programs
Active Trials
NCT03093467Completed167Est. Nov 2019
NCT03080025Completed140Est. Aug 2019
NCT04233853Completed82Est. Apr 2024
+3 more trials
Neuronetics
NeuroneticsMALVERN, PA
5 programs
NeuroStar Advanced TMS Therapy SystemN/A1 trial
Patients treated with NeuroStar TMSN/A1 trial
Repetitive Transcranial Magnetic StimulationN/A1 trial
Repetitive transcranial magnetic stimulationN/A1 trial
repetitive Transcranial Magnetic StimulationN/A1 trial
Active Trials
NCT06917339Recruiting156,000Est. Dec 2035
NCT06997549Recruiting12,000Est. Dec 2035
NCT01115699Terminated2Est. Mar 2012
+2 more trials
BrainsWay
BrainsWayJerusalem, Israel
2 programs
5 channels Multiway deep Transcranial Magnetic StimulatorN/A1 trial
dTMSN/A1 trial
Active Trials
NCT01501825UnknownEst. Aug 2013
NCT02260765WithdrawnEst. Sep 2020
Design Therapeutics
2 programs
COMMIT mHealth applicationN/A1 trial
Intervention: Mental Health TechnicianN/A1 trial
Active Trials
NCT04510909UnknownEst. Sep 2021
NCT02345122Active Not RecruitingEst. Dec 2025
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
Tele PROTECTN/A1 trial
therapeutic song-writing programN/A1 trial
Active Trials
NCT06039930RecruitingEst. Jan 2029
NCT07371962RecruitingEst. Oct 2027
Providence Therapeutics
2 programs
Transcranial Magnetic StimulationN/A1 trial
transcranial magnetic stimulationN/A1 trial
Active Trials
NCT05008198Active Not RecruitingEst. Sep 2026
NCT04663841Active Not RecruitingEst. May 2026
PEEL Therapeutics
PEEL TherapeuticsUT - Salt Lake City
1 program
Cognitive Behavioural TherapyN/A1 trial
Active Trials
Abbott
AbbottABBOTT PARK, IL
1 program
Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological DisorderN/A1 trial
Active Trials
NCT02043197Completed300Est. Nov 2015
Astellas
AstellasChina - Shenyang
1 program
QuetiapineN/A1 trial
Active Trials
NCT03403790Completed369Est. Mar 2020
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
computer-based confrontation with dysfunctional beliefsN/A1 trial
Active Trials
NCT03389464UnknownEst. Sep 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Alliance PharmaceuticalsPramipexole
Verona Pharmalithium
Boehringer Ingelheimduloxetine
PfizerVenlafaxine
PfizerDVS-233 SR
AbbVieCariprazine
Axsome TherapeuticsAXS-05
Mission TherapeuticsElectroconvulsive Therapy
TevaArmodafinil
TevaArmodafinil
Alliance PharmaceuticalsFish Oil
PfizerEffexor XR
PfizerEffexor XR
PfizerSertraline
Eli Lilly and CompanyDuloxetine Hydrochloride

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 173,942 patients across 50 trials

Imaging the Nucleus Accumbens in Major Depressed Patients 'Treated With Pramipexole

Start: Feb 2010Est. completion: Feb 201316 patients
Phase 4Terminated

Lithium and Standard Therapy in Resistant Depression

Start: Jun 2009Est. completion: Dec 2012230 patients
Phase 4Unknown

A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression

Start: May 2008Est. completion: Mar 2009750 patients
Phase 4Completed

Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression

Start: Aug 2005Est. completion: Jun 200988 patients
Phase 4Completed

Study Evaluating DVS-233 SR in Adult Outpatients With Major Depressive Disorder

Est. completion: May 2005
Phase 3Completed

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

Start: Apr 2021Est. completion: Mar 2027380 patients
Phase 3Recruiting

A Trial of AXS-05 in Patients With Major Depressive Disorder

Start: Jun 2019Est. completion: Dec 2019327 patients
Phase 3Completed
NCT03105245Mission TherapeuticsElectroconvulsive Therapy

Understanding How Anaesthesia Affects ECT Outcomes

Start: Mar 2017Est. completion: Mar 201954 patients
Phase 3Completed
NCT01072630TevaArmodafinil

Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder

Start: Mar 2010Est. completion: Nov 2012492 patients
Phase 3Completed
NCT01072929TevaArmodafinil

A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder

Start: Jan 2010Est. completion: Mar 2012433 patients
Phase 3Completed

Omega-3 Fatty Acids for Treatment of Depression in Adolescents

Start: Nov 2006Est. completion: Apr 20094 patients
Phase 3Completed

Study Evaluating Long-Term Safety of Effexor XR in Patients With Major Depression.

Start: Sep 2004150 patients
Phase 3Completed

Study Evaluating Effexor XR in Elderly Patients With Major Depression.

Start: Dec 2003100 patients
Phase 3Completed

A Randomised Trial of Sertraline, Cognitive Behaviour Therapy & Combined Therapy for Postnatal Depression

Start: Apr 2002Est. completion: Apr 200545 patients
Phase 3Completed
NCT00036335Eli Lilly and CompanyDuloxetine Hydrochloride

Subject Information and Consent Form F1J-US-HMCB Duloxetine Once-Daily Dosing Versus Placebo in Patients With Major Depression and Pain

Start: Mar 2002Est. completion: Jan 2003286 patients
Phase 3Completed

A Clinical Study of Trazodone Hydrochloride Prolonged-Release Tablets for Treatment of Depression

Start: Nov 2011Est. completion: Nov 2013382 patients
Phase 2/3Completed

Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)

Start: Mar 2023Est. completion: Sep 2023132 patients
Phase 2Completed
NCT03297411Mission TherapeuticsBrief Temporoparietal ECT

Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling

Start: Oct 2017Est. completion: Jun 202215 patients
Phase 2Unknown

A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder

Start: Dec 2011Est. completion: Aug 2013542 patients
Phase 2Completed

Efficacy and Safety of Flexibly Dosed BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression

Start: Apr 2011Est. completion: Jan 2013889 patients
Phase 2Completed

This is a Study to Determine the Antidepressant Effects of AZD6765

Start: Dec 2009Est. completion: Dec 201122 patients
Phase 2Completed

AZD6765 Severe Major Depressive Disorder (MDD) IV

Start: Oct 2008Est. completion: Mar 2010152 patients
Phase 2Completed

AZD6765 for Treatment Resistant Depression

Start: Jul 2007Est. completion: Nov 200734 patients
Phase 2Completed
NCT00497874Cook MedicalComputer-tailored intervention

An Expert System to Reduce Depression in Primary Care

Start: Jul 2003Est. completion: Jun 2006
Phase 2Completed
NCT00914004SandozDesipramine HCl 50 mg Tablets Cord Laboratories

To Demonstrate the Relative Bioequivalency of Comparing Single 100 mg Doses Of Cord's 50 mg Desipramine HCL Tablets To Merrell Dow's 50 mg Norpramin Tablets

Phase 1Completed
NCT02785614Lee's Pharmaceuticaltrazodone hydrochloride prolonged-release tablet

PK Study of Multi-dose Trazodone Hydrochloride Prolonged-released Tablets in Healthy Chinese

Start: May 2017Est. completion: Jan 201812 patients
Phase 1Completed
NCT02785601Lee's PharmaceuticalTrazodone Hydrochloride prolonged-release tablets

PK Study of Diet Effect of Trazodone Hydrochloride Prolonged-Released Tablets in Healthy Chinese

Start: May 2017Est. completion: Jan 201815 patients
Phase 1Completed

Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous Administration

Start: Sep 2010Est. completion: Oct 20106 patients
Phase 1Completed

A Blinded, Four-Way Crossover in Healthy Subjects to Assess EEG After Administration of Ketamine, Placebo and AZD6765

Start: May 2010Est. completion: Jan 201136 patients
Phase 1Terminated

A Study in Healthy Volunteers to Assess Effect of AZD6765 on Midazolam Blood Levels

Start: Feb 2010Est. completion: May 201046 patients
Phase 1Completed

Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects

Start: Dec 2009Est. completion: Mar 2011128 patients
Phase 1Completed

AZD6765 Oral Single Ascending Dose/Multiple Ascending Dose (SAD/MAD)

Start: Nov 2008Est. completion: Mar 20100
Phase 1Withdrawn

Characterize the Regional Distribution of [11C] ABP688 in Brain by Positron Emission Tomography (PET)

Start: Aug 2008Est. completion: May 201042 patients
Phase 1Completed

A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease

Start: Apr 2005Est. completion: Jan 20097 patients
Phase 1Terminated
NCT00861939SandozBupropion HCI 300 mg Extended-Release Tablets EON

To Demonstrate the Relative Bioavailability of Bupropion HCI 300 mg Extended-Release Tablets Under Fasting Conditions

Start: Mar 2004Est. completion: Apr 2004
Phase 1Completed
NCT00947076SandozFluoxetine Hydrochloride Capsules, 40 mg

To Demonstrate the Relative Bioavailability of Fluoxetine Hydrochloride Capsules, 40 mg

Start: Feb 2001Est. completion: Apr 2001
Phase 1Completed
NCT00913952SandozGeneva 25 mg Clomipramine Hydrochloride Capsules Under Fasting Conditions

To Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed and Fasted Conditions

Start: Apr 1994Est. completion: Jun 1994
Phase 1Completed
NCT00913783SandozClomipramine Hydrochloride 25 mg Capsules

To Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fasted Conditions

Start: Nov 1992Est. completion: Dec 1992
Phase 1Completed
NCT00913822SandozDesipramine Hydrochloride 100 mg Tablets

To Demonstrate the Relative Bioavailability of Desipramine Hydrochloride Tablets

Start: Dec 1987Est. completion: Dec 1987
Phase 1Completed
NCT00913809SandozDesipramine HCL 100 mg Tablets Cord Laboratories

To Demonstrate the Relative Bioequivalency of Cord's 100 mg Desipramine HCL Tablets To Merrell Dow's 100 mg Norpramin Tablets

Start: Dec 1987Est. completion: Dec 1987
Phase 1Completed
NCT00913237SandozDesipramine Hydrochloride 50 mg Tablets

To Demonstrate the Relative Bioavailability of Desipramine Hydrochloride 50 mg Tablets

Start: Jul 1987Est. completion: Aug 1987
Phase 1Completed
NCT07371962City Therapeuticstherapeutic song-writing program

Sound Bite-- a Therapeutic Song-writing Program

Start: Feb 2026Est. completion: Oct 2027
N/ARecruiting
NCT06997549NeuroneticsPatients treated with NeuroStar TMS

Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

Start: May 2025Est. completion: Dec 203512,000 patients
N/ARecruiting
NCT06917339NeuroneticsNeuroStar Advanced TMS Therapy System

Retrospective Analyses of TrakStar Database

Start: Feb 2025Est. completion: Dec 2035156,000 patients
N/ARecruiting

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

Start: Sep 2023Est. completion: Jan 2029
N/ARecruiting
NCT05564533Alliance PharmaceuticalsHeart-Smile Training Intensive Introduction Program

Heart-Smile Training Intensive Introduction Program

Start: Feb 2023Est. completion: Sep 202435 patients
N/ACompleted

Meru Health Program for Cancer Patients With Depression and Anxiety

Start: Sep 2022Est. completion: Jul 202322 patients
N/ACompleted
NCT05127369T-TherapeuticsDental pulp mesenchymal cell injection

Clinical Study on the Safety and Efficacy of Dental Pulp Mesenchymal Cells in the Treatment of Depression

Start: Jan 2022Est. completion: Jun 2024
N/AUnknown
NCT04850911Johnson & JohnsonKetamine Hydrochloride

Reward Emotion Learning and Ketamine Study

Start: Aug 2021Est. completion: May 202370 patients
N/AUnknown
NCT05008198Providence TherapeuticsTranscranial Magnetic Stimulation

Assessing an EEG Biomarker of Response to TMS for Major Depression

Start: Aug 2021Est. completion: Sep 2026
N/AActive Not Recruiting

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

11 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 173,942 patients
30 companies competing in this space