Skip to main content

Low Back Pain

39
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
5
0
16
14
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
480%
Monoclonal Antibody
120%
+ 103 programs with unclassified modality

On Market (4)

Approved therapies currently available

ZORVOLEXApproved
diclofenac
Unknown Company
oral2013
6K Part D
Pfizer
BEXTRAApproved
valdecoxib
Pfizer
oral2001
DICLOFENAC SODIUMApproved
diclofenac
Unknown Company
topical2022
DICLOFENACApproved
diclofenac
Unknown Company
oral

Competitive Landscape

52 companies ranked by most advanced pipeline stage

Spine BioPharma
18 programs
2
4
Intracept ProcedurePhase 41 trial
Intrathecal Morphine InjectionPhase 41 trial
Normal saline infusionPhase 41 trial
functional anesthetic discographyPhase 4
Interspinous process and dynamic stabilizationPhase 3
+13 more programs
Active Trials
NCT01794962Terminated24Est. Mar 2018
NCT02122445Completed20Est. Sep 2015
NCT04494841Completed20Est. Feb 2021
+12 more trials
Pfizer
PfizerNEW YORK, NY
8 programs
2
3
2
DiclofenacPhase 41 trial
valdecoxibPhase 4Small Molecule1 trial
CelecoxibPhase 3Small Molecule1 trial
CelecoxibPhase 3Small Molecule1 trial
celecoxibPhase 3Small Molecule5 trials
+3 more programs
Active Trials
NCT01838057Terminated103Est. Jul 2014
NCT00584870Completed220Est. Sep 2008
NCT00924664Terminated849Est. Jun 2011
+9 more trials
Medtronic
MedtronicNJ - Phillipsburg
3 programs
2
Lumbar Interbody FusionPhase 41 trial
functional anesthetic discographyPhase 41 trial
SubQN/A1 trial
Active Trials
NCT01776749Completed100Est. Jul 2015
NCT00095095Terminated102Est. May 2006
NCT00443781Completed62Est. Jun 2009
Menarini
MenariniGermany - Dresden
1 program
1
Dexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 mgPhase 41 trial
Active Trials
NCT05170841Completed538Est. May 2022
Martin Pharmaceuticals
1
EscitalopramPhase 41 trial
Active Trials
NCT00227292Withdrawn0Est. Nov 2012
Purdue Pharma
Purdue PharmaCT - Stamford
4 programs
4
Buprenorphine transdermal systemPhase 31 trial
Oxycodone/Naloxone Controlled-releasePhase 31 trial
Oxycodone/Naloxone controlled-releasePhase 31 trial
Oxycodone/Naloxone controlled-releasePhase 31 trial
Active Trials
NCT00490919Completed539Est. Oct 2008
NCT01358526Completed1,095Est. Nov 2012
NCT01427283Completed450Est. Oct 2014
+1 more trials
MSD
MSDIreland - Ballydine
2 programs
1
MK-0663BPhase 3
Pain Quality StudyN/A
Sharp Therapeutics
1
MK-0663BPhase 31 trial
Pain Quality StudyN/A1 trial
Active Trials
NCT01321190Completed307Est. Apr 2013
NCT01979510Withdrawn0Est. May 2014
Innovation Pharmaceuticals
2 programs
1
1
Tolperisone HydrochloridePhase 31 trial
BSM device with bio-feedbackPhase 21 trial
Active Trials
NCT01572779Completed112Est. Jun 2013
NCT05544656Unknown150Est. Jun 2024
Zimmer Biomet
Zimmer BiometFL - Jacksonville
2 programs
2
Interspinous process and dynamic stabilizationPhase 31 trial
Interspinous process and dynamic stabilizationPhase 31 trial
Active Trials
NCT00134537Unknown300Est. Apr 2012
NCT00484458Unknown340Est. Nov 2014
Ache Laboratorios Farmaceuticos
2
Paracetamol + Carisoprodol + CaffeinePhase 3
Thermal BandPhase 31 trial
Active Trials
NCT03508167Withdrawn0Est. Nov 2020
Hanmi Pharmaceutical
1
Epirisone 50mg or placebo TIDPhase 21 trial
Active Trials
NCT01806818Completed98Est. Jul 2013
Sandoz
SandozAustria - Kundl
1 program
1
Zoledronic acid vs. placeboPhase 21 trial
Active Trials
NCT01330238Completed40Est. Mar 2012
Human BioSciences
1
Classification-directed treatmentPhase 11 trial
Core StabilizationN/A1 trial
Core StabilizationN/A1 trial
HVLA-SMN/A1 trial
Physical Therapy rehabilitation: Stabilization exercises.N/A1 trial
+1 more programs
Active Trials
NCT01360359Completed17Est. Mar 2015
NCT01085604Completed69Est. Jun 2015
NCT00285649Completed192Est. Mar 2007
+3 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD1940Phase 11 trial
Active Trials
NCT00689780Completed60Est. Nov 2008
Stayble Therapeutics
1
STA363Phase 11 trial
Active Trials
NCT03055845Completed15Est. Aug 2019
Daewon Pharma
1 program
1
Tramadol hydrochloride/Acetaminophen Tab.Phase 11 trial
Active Trials
NCT01776515CompletedEst. Jun 2012
Selva Therapeutics
Magnetic TapeN/A1 trial
Magnetic TapeN/A1 trial
Magnetic Tape®N/A1 trial
Magnetic Tape® aplicaciónN/A1 trial
Magnetic Tape® aplicationN/A1 trial
+2 more programs
Active Trials
NCT04878874Withdrawn0Est. Jun 2021
NCT04893967Completed40Est. Mar 2022
NCT04883112Withdrawn0Est. Jul 2021
+4 more trials
Aspen Medical products
3 programs
Lumbar Back BraceN/A1 trial
Lumbar CorsetN/A1 trial
Lumbar Sacral OrthosisN/A
Active Trials
NCT03484403Completed61Est. Sep 2019
NCT02251106Completed54Est. Jan 2014
Teva
TevaIsrael - Petach Tikva
3 programs
Hydrocodone ERPHASE_31 trial
Hydrocodone ERPHASE_31 trial
OraVescent FentanylPHASE_31 trial
Active Trials
NCT01789970Completed625Est. Feb 2014
NCT01922739Completed182Est. Aug 2014
NCT00228605Completed500Est. May 2007
Radiance Biopharma
Active PBMTN/A1 trial
Active PBMTN/A1 trial
Active Trials
NCT04476095Unknown72Est. Sep 2020
NCT06549660Recruiting68Est. Oct 2025
Oregon Therapeutics
Back Pain Outcomes Using Longitudinal Data (BOLD)N/A1 trial
FitBack on-line interventionN/A1 trial
Active Trials
NCT01776242Completed5,239Est. Sep 2013
NCT01950091Completed606Est. Jul 2013
Nordic Pharma
Nordic PharmaFrance - Paris
2 programs
Information materialN/A1 trial
Supervised Nordic WalkingN/A
Active Trials
NCT03088774Withdrawn0Est. Jan 2021
Utah Medical
2 programs
Physical TherapyN/A1 trial
Standard CareN/A1 trial
Active Trials
NCT04172038Active Not Recruiting850Est. Jul 2025
NCT04770480Active Not Recruiting267Est. Mar 2026
ZygoFix
2 programs
zLOCK Facet Stabilization SystemN/A1 trial
zLOCK Facet Stabilization SystemN/A1 trial
Active Trials
NCT05266521Unknown80Est. Sep 2025
NCT04229316Completed24Est. May 2024
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
2 programs
NKTR-181 BID tabletsPHASE_31 trial
NKTR-181 BID tabletsPHASE_31 trial
Active Trials
NCT02362672Completed1,189Est. Feb 2017
NCT02367820Completed638Est. Jan 2018
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
2 programs
tapentadolPHASE_31 trial
tapentadolPHASE_31 trial
Active Trials
NCT00449176Completed981Est. May 2008
NCT00594516Completed117Est. May 2008
Vivex Biologics
Vivex BiologicsGA - Atlanta
1 program
AlloGen-LIN/A1 trial
Active Trials
NCT02932020Withdrawn0Est. Sep 2017
Partner Therapeutics
Partner TherapeuticsMA - Lexington
1 program
Back ExosuitN/A1 trial
Active Trials
NCT05802914Completed97Est. Apr 2025
Allied Medical
Behavioral and managerialN/A1 trial
Active Trials
NCT00962169Unknown30Est. Dec 2009

+22 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Spine BioPharmaNormal saline infusion
Spine BioPharmaIntrathecal Morphine Injection
Mainstay MedicalMultifidus stimulator
Spine BioPharmaIntracept Procedure
MenariniDexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 mg
Martin PharmaceuticalsEscitalopram
Pfizercelecoxib
Medtronicfunctional anesthetic discography
RS MedicalVertis Percutaneous Neuromodulation Therapy
MedtronicLumbar Interbody Fusion
PfizerDiclofenac
Pfizervaldecoxib
SanofiITP FIRTECH
Ache Laboratorios FarmaceuticosThermal Band
Innovation PharmaceuticalsTolperisone Hydrochloride

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 15,231 patients across 50 trials

NCT06666621Spine BioPharmaNormal saline infusion

Endogenous Opioid Response to Injections

Start: Aug 2024Est. completion: Feb 202633 patients
Phase 4Recruiting
NCT05092828Spine BioPharmaIntrathecal Morphine Injection

Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery

Start: Dec 2021Est. completion: Dec 202340 patients
Phase 4Unknown
NCT04327817Mainstay MedicalMultifidus stimulator

Multifidus PET Scan Study

Start: Aug 2021Est. completion: Mar 202520 patients
Phase 4Completed
NCT05692440Spine BioPharmaIntracept Procedure

Basivertebral Nerve Ablation With the Intracept Procedure

Start: May 2021Est. completion: Jun 202670 patients
Phase 4Enrolling By Invitation
NCT05170841MenariniDexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 mg

Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain

Start: Sep 2020Est. completion: May 2022538 patients
Phase 4Completed

Cipralex in Treatment of Depressive Symptoms and Chronic Back Pain

Start: Nov 2007Est. completion: Nov 20120
Phase 4Withdrawn

Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain

Start: May 2007Est. completion: Apr 2008278 patients
Phase 4Completed
NCT00443781Medtronicfunctional anesthetic discography

Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain

Start: Mar 2007Est. completion: Jun 200962 patients
Phase 4Completed
NCT00290238RS MedicalVertis Percutaneous Neuromodulation Therapy

Percutaneous Neuromodulation Therapy (PNT) With Chronic Low Back Pain Patients

Start: Dec 2005Est. completion: Sep 2008122 patients
Phase 4Terminated
NCT00095095MedtronicLumbar Interbody Fusion

Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device

Start: Oct 2004Est. completion: May 2006102 patients
Phase 4Terminated

Safety And Efficacy Of Celecoxib Versus Sodium Diclofenac In The Treatment Of Acute Low Back Pain

Start: Oct 2003Est. completion: Oct 2004244 patients
Phase 4Completed

Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain

Start: Nov 2002Est. completion: May 2003340 patients
Phase 4Completed

Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain

Start: Nov 2021Est. completion: Nov 2022221 patients
Phase 3Completed

Security and Efficacy of Dorilax® (Fixed Association of Paracetamol 350 mg, Carisoprodol 150 mg and Caffeine 50 mg) Plus Thermal Band Compared to Placebo Plus Thermal Band in the Treatment of Acute Low Back Pain.

Start: Jan 2020Est. completion: Nov 20200
Phase 3Withdrawn
NCT05544656Innovation PharmaceuticalsTolperisone Hydrochloride

The Prognostic Value of Biomarkers and the Effect of Tolperisone in Acute Low Back Pain and Sciatic Pain "BETA"

Start: Dec 2019Est. completion: Jun 2024150 patients
Phase 3Unknown

Long Term Safety and Efficacy Study of Tanezumab in Japanese Adult Subjects With Chronic Low Back Pain

Start: May 2016Est. completion: Jun 2019277 patients
Phase 3Completed
NCT02367820Nektar TherapeuticsNKTR-181 BID tablets

Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain

Start: Apr 2015Est. completion: Jan 2018638 patients
Phase 3Completed
NCT02362672Nektar TherapeuticsNKTR-181 BID tablets

Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain

Start: Mar 2015Est. completion: Feb 20171,189 patients
Phase 3Completed
NCT02300311Boehringer Ingelheimnonivamide + nicoboxil

Efficacy and Safety of Finalgon® Cream Multiple Doses in Acute Low Back Pain

Start: Jan 2015Est. completion: May 2015138 patients
Phase 3Completed

Safety and Efficacy Study of an Etoricoxib and Tizanidine Fixed Dose Combination in Participants With Moderate to Severe Acute Low Back Pain (MK-0663B-164)

Start: Nov 2013Est. completion: May 20140
Phase 3Withdrawn
NCT01922739TevaHydrocodone ER

Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets

Start: Jul 2013Est. completion: Aug 2014182 patients
Phase 3Completed
NCT01789970TevaHydrocodone ER

Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain

Start: Mar 2013Est. completion: Feb 2014625 patients
Phase 3Completed
NCT01528332PhilipsPain Relief Patch

Blue Light Device for Pain Therapy

Start: Feb 2012Est. completion: Aug 2012171 patients
Phase 3Completed
NCT01427270Purdue PharmaOxycodone/Naloxone controlled-release

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Start: Aug 2011Est. completion: Oct 2014455 patients
Phase 3Completed
NCT01427283Purdue PharmaOxycodone/Naloxone controlled-release

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Start: Aug 2011Est. completion: Oct 2014450 patients
Phase 3Completed
NCT01358526Purdue PharmaOxycodone/Naloxone Controlled-release

Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Start: May 2011Est. completion: Nov 20121,095 patients
Phase 3Completed

Celebrex In Acute Gouty Arthritis Study

Start: Feb 2008Est. completion: Dec 2009402 patients
Phase 3Completed

A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain

Start: Jan 2008Est. completion: Sep 2008802 patients
Phase 3Completed

Study on the Safety and Effectiveness of Switching Between Two Forms of Tapentadol in Patients With Chronic Low Back Pain

Start: Dec 2007Est. completion: May 2008117 patients
Phase 3Completed
NCT00490919Purdue PharmaBuprenorphine transdermal system

Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain

Start: Jun 2007Est. completion: Oct 2008539 patients
Phase 3Completed

A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Low Back Pain

Start: Feb 2007Est. completion: May 2008981 patients
Phase 3Completed
NCT00484458Zimmer BiometInterspinous process and dynamic stabilization

Wallis Stabilization System for Low Back Pain

Start: Jan 2007Est. completion: Nov 2014340 patients
Phase 3Unknown
NCT00228605TevaOraVescent Fentanyl

Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain

Start: Mar 2005Est. completion: May 2007500 patients
Phase 3Completed
NCT00246155IpsenBotulinum toxin type A

Study on the Effects of Botulinum Toxin Type A on Back Muscle in Chronic Low Back Pain

Start: Jan 2005Est. completion: Jul 200535 patients
Phase 3Completed
NCT00134537Zimmer BiometInterspinous process and dynamic stabilization

Wallis Mechanical Normalization System for Low Back Pain

Start: Nov 2004Est. completion: Apr 2012300 patients
Phase 3Unknown

Comparison Of Celecoxib 200 Mg Bid, Loxoprofen Sodium 60 Mg Tid And Placebo In Low Back Pain In Japan

Start: Oct 20041,234 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Celecoxib Suspension Compared to Naproxen Suspension in Patients With JRA

Start: Oct 2002Est. completion: Apr 2005225 patients
Phase 3Completed

A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain

Start: Jan 2016Est. completion: Sep 2017563 patients
Phase 2/3Completed
NCT01806818Hanmi PharmaceuticalEpirisone 50mg or placebo TID

Comparing Efficacy and Safety Between Eperisone a BID and a TID Regimen in Acute Low Back Pain Patients

Start: Feb 2013Est. completion: Jul 201398 patients
Phase 2Completed
NCT01572779Innovation PharmaceuticalsBSM device with bio-feedback

A Study to Investigate the Effect of a New Postural Bio-feedback Device on Low Back Pain

Start: Nov 2009Est. completion: Jun 2013112 patients
Phase 2Completed
NCT00924664PfizerTanezumab 20 mg

Long Term Safety Study of Tanezumab in Chronic Low Back Pain

Start: Aug 2009Est. completion: Jun 2011849 patients
Phase 2Terminated
NCT01330238SandozZoledronic acid vs. placebo

The Efficacy of Zoledronic Acid in Modic Changes-related Low Back Pain (LBP)

Start: Dec 2008Est. completion: Mar 201240 patients
Phase 2Completed

RN624 In Adult Patients With Chronic Low Back Pain

Start: Jul 2007Est. completion: Sep 2008220 patients
Phase 2Completed

For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With Chemotherapy

Start: Apr 2002Est. completion: Jan 2003212 patients
Phase 2Terminated

Chemoprevention of Oral Premalignant Lesions

Start: Nov 2000Est. completion: Apr 200442 patients
Phase 2Completed

A Single Ascending Dose Study of Safety and Tolerability of STA363 Compared to Placebo in 15 Patients With Chronic Discogenic Low Back Pain

Start: Mar 2017Est. completion: Aug 201915 patients
Phase 1Completed

Intravitreal Celecoxib for Chronic Uveitis

Start: Jun 2015Est. completion: Nov 20164 patients
Phase 1Terminated
NCT01776515Daewon PharmaTramadol hydrochloride/Acetaminophen Tab.

Phase 3 Study of Tramadol Hydrochloride/Acetaminophen SR Tab. & Tramadol Hydrochloride/Acetaminophen Tab. in Low Back Pain Patients

Start: Jan 2012Est. completion: Jun 2012
Phase 1Completed

Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940

Start: Mar 2008Est. completion: Nov 200860 patients
Phase 1Completed
NCT00802724Human BioSciencesClassification-directed treatment

Classification-Directed Treatment of Low Back Pain

Start: Feb 2007Est. completion: Nov 2010101 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

16 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 15,231 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.