Healthy Subjects

118
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
112
1
0
0
2
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1292%
Vaccine
18%
+ 110 programs with unclassified modality

On Market (1)

Approved therapies currently available

Amgen
OTEZLAApproved
apremilast
Amgen
Phosphodiesterase 4 Inhibitor [EPC]oral2014

Competitive Landscape

41 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
15 programs
13
1
7-pneumococcal conjugate vaccinePhase 4Vaccine1 trial
AGG-523Phase 11 trial
ApixabanPhase 11 trial
BLI-489/PiperacillinPhase 11 trial
Donepezil plus placeboPhase 11 trial
+10 more programs
Active Trials
NCT00768833Completed242Est. Aug 2014
NCT00380900CompletedEst. Feb 2007
NCT02034591Completed37Est. Nov 2011
+25 more trials
UP
3 programs
2
1
Levetiracetam 250 mgPhase 41 trial
Certolizumab PegolPhase 11 trial
LacosamidePhase 11 trial
Active Trials
NCT02365948Completed36Est. Aug 2015
NCT01530386Completed25Est. Jul 2012
NCT01491113Completed30Est. Nov 2012
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
1
OTEZLA(Apremilast)Phase 15 trials
Active Trials
NCT06122649Completed203Est. Dec 2025
NCT06088199Active Not Recruiting51Est. Aug 2026
NCT05767047Recruiting48Est. Mar 2036
+2 more trials
Abbott
AbbottABBOTT PARK, IL
3 programs
2
1
Study product containing luteinPhase 31 trial
CortimentPhase 11 trial
SLV337 suspensionPhase 11 trial
Active Trials
NCT05519514Completed56Est. Nov 2021
NCT01176201Completed12Est. Oct 2010
NCT01730898Completed24Est. Mar 2013
ConvaTec
ConvaTecNJ - Bridgewater
1 program
1
Marketed electrodePhase 31 trial
Active Trials
NCT01590368UnknownEst. Jun 2012
Sintetica
SinteticaSwitzerland - Mendriosi
1 program
1
Ocular gelPhase 1/21 trial
Active Trials
NCT04779606Completed105Est. Oct 2020
E
21 programs
21
APD356 10 mgPhase 11 trial
E0302 SR1Phase 11 trial
E2006Phase 11 trial
E2007Phase 11 trial
E2022Phase 11 trial
+16 more programs
Active Trials
NCT02192515Completed40Est. Jan 2016
NCT03885882Completed24Est. Jun 2019
NCT02089412Completed59Est. Jun 2014
+18 more trials
Astellas
18 programs
18
ASP015KPhase 1
ASP015KPhase 11 trial
ASP2151Phase 12 trials
ASP2408Phase 11 trial
ASP3652Phase 11 trial
+13 more programs
Active Trials
NCT01387087Completed72Est. Nov 2008
NCT00487682Completed403Est. Sep 2008
NCT02796118Completed36Est. Oct 2006
+15 more trials
DS
Daiichi SankyoChina - Shanghai
8 programs
8
Bempedoic acidPhase 11 trial
Bempedoic acidPhase 11 trial
Bempedoic acidPhase 11 trial
Bempedoic acidPhase 11 trial
EfavirenzPhase 11 trial
+3 more programs
Active Trials
NCT07182383Completed58Est. Nov 2025
NCT07268625Completed58Est. Feb 2026
NCT07235189Completed58Est. Jan 2026
+5 more trials
Vigonvita
7 programs
7
Deuremidevir Hydrobromide for Suspension 100mgPhase 11 trial
LV232Phase 11 trial
LV232/PlaceboPhase 11 trial
TPN171H 10 mg GroupPhase 11 trial
VV116Phase 11 trial
+2 more programs
Active Trials
NCT05932459CompletedEst. Sep 2023
NCT06070857CompletedEst. Nov 2025
NCT06279533CompletedEst. Dec 2024
+4 more trials
BP
Basilea PharmaceuticaSwitzerland - Allschwil
5 programs
5
IsavuconazolePhase 1Small Molecule
VNRX-5024Phase 11 trial
VNRX-7145Phase 11 trial
isavuconazolePhase 1Small Molecule
isavuconazolePhase 1Small Molecule
Active Trials
NCT04314206CompletedEst. Dec 2020
NCT04877379CompletedEst. Nov 2021
Celltrion
CelltrionKorea - Incheon
3 programs
3
CT-P43Phase 11 trial
CT-P47Phase 11 trial
CT-P47Phase 11 trial
Active Trials
NCT04428814Completed271Est. Feb 2021
NCT05188378Unknown300Est. Jan 2023
NCT05617183Unknown268Est. Sep 2023
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
2
AZD7986Phase 11 trial
EpanovaPhase 11 trial
Active Trials
NCT02653872Completed15Est. Apr 2016
NCT03574142Completed14Est. Jun 2018
Celldex Therapeutics
2
CDX-0159Phase 11 trial
CDX-0159Phase 11 trial
Active Trials
NCT05031624Completed32Est. Jan 2022
NCT04146129Completed32Est. Jun 2020
Edgewise Therapeutics
2
EDG-7500Phase 11 trial
sevasemtenPhase 11 trial
Active Trials
NCT06011317Completed84Est. Jun 2024
NCT06916897Completed42Est. Feb 2025
Nxera Pharma
2 programs
2
HTL0016878Phase 11 trial
HTL0016878.HCl Solution 10 mgPhase 11 trial
Active Trials
NCT04849286CompletedEst. Dec 2018
NCT04935320CompletedEst. Oct 2021
InnoCare
InnoCareChina - Beijing
2 programs
2
ICP-332Phase 11 trial
ICP-332 TabletsPhase 11 trial
Active Trials
NCT05399030Completed72Est. Feb 2022
NCT06530966Recruiting24Est. Dec 2024
Tonix Pharmaceuticals
Tonix PharmaceuticalsBERKELEY HEIGHTS, NJ
2 programs
2
TNX-102 SLPhase 11 trial
TNX-102 SL 5.6 mgPhase 11 trial
Active Trials
NCT04164719Completed16Est. Dec 2019
NCT03443960Completed60Est. Apr 2018
BioLineRx
1 program
1
1.25 mg/kg BL-8040 + BL-8040-matching placeboPhase 11 trial
Active Trials
NCT05293171CompletedEst. Aug 2022
Biogen
BiogenCAMBRIDGE, MA
1 program
1
BIIB059Phase 12 trials
Active Trials
NCT06044337Enrolling By Invitation322Est. Dec 2029
NCT03224793Completed32Est. Jun 2018
BioVersys
1 program
1
BV100Phase 11 trial
Active Trials
NCT04636983Completed54Est. Jan 2022
SK Life Science
SK Life ScienceNJ - Paramus
1 program
1
CarisbamatePhase 11 trial
Active Trials
NCT04520360CompletedEst. Oct 2021
Ionis Pharmaceuticals
1 program
1
IONIS-ENaCRxPhase 11 trial
Active Trials
NCT03647228Completed98Est. Oct 2020
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
1
MSB11022Phase 11 trial
Active Trials
NCT03014947Completed237Est. Dec 2014
Alliance Pharmaceuticals
1 program
1
MellarilPhase 11 trial
Active Trials
NCT01765803Terminated6Est. Dec 2013
Inventiva
InventivaDAIX, France
1 program
1
MoxifloxacinPhase 1Small Molecule1 trial
Active Trials
NCT03866369CompletedEst. Aug 2019
ImmunityBio
ImmunityBioSAN DIEGO, CA
1 program
1
N-803Phase 11 trial
Active Trials
NCT06040918Completed10Est. Sep 2024
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
1
Nicotinic AcidsPhase 11 trial
Active Trials
NCT01258491Completed18Est. Dec 2005
One Biosciences
1
OWCP Orally Disintegrating TabletPhase 11 trial
Active Trials
NCT03936907CompletedEst. Jul 2019
Liminal BioSciences
1
PBI-4547Phase 11 trial
Active Trials
NCT04068259TerminatedEst. Oct 2019

+11 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AmgenApremilast
AmgenApremilast
AmgenApremilast
UCB PharmaLevetiracetam 250 mg
Pfizer7-pneumococcal conjugate vaccine
PfizerVenlafaxine
PfizerVenlafaxine
PfizerVenlafaxine
PfizerVenlafaxine
PfizerVenlafaxine
PfizerVenlafaxine
PfizerVenlafaxine
AmgenApremilast
AmgenApremilast
BiogenBIIB059

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 14,259 patients across 50 trials

A Study to Evaluate the Impact of Apremilast on Magnetic Resonance Imaging (MRI) Outcomes in Adults With Psoriatic Arthritis

Start: Feb 2019Est. completion: May 2022123 patients
Phase 4Completed

Efficacy, Safety, and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis.

Start: Dec 2018Est. completion: Jul 2023310 patients
Phase 4Completed

Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast

Start: May 2016Est. completion: Dec 201780 patients
Phase 4Completed
NCT01491113UCB PharmaLevetiracetam 250 mg

Pharmacokinetic (PK) Study in Japanese Non-epileptic Renal Impaired Patients

Start: Nov 2011Est. completion: Nov 201230 patients
Phase 4Completed
NCT01250756Pfizer7-pneumococcal conjugate vaccine

A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants.

Start: Nov 2010Est. completion: Mar 2012321 patients
Phase 4Completed

Determine The Percentage Of Depressed Outpatients Who Do Not Effectively Metabolize Extended-release Venlafaxine HCl

Start: Oct 2008Est. completion: Jul 2009971 patients
Phase 4Completed

Study Comparing the Efficacy of Venlafaxine XR Vs. SSRIs and Conventional Antidepressants in Depressed Patients

Start: Apr 2007Est. completion: Mar 20081,151 patients
Phase 4Completed

Study Evaluating Venlafaxine Extended-Release in Depressed and Anxious Patients

Start: Aug 2004Est. completion: Jun 2006210 patients
Phase 4Completed

Study Evaluating Effexor® (Venlafaxine) in Achieving Response and Maintaining Remission

Start: Feb 2004Est. completion: Mar 2005350 patients
Phase 4Completed

Physiologic Monitoring of Antidepressant Treatment Response

Start: Jun 2001Est. completion: Sep 200237 patients
Phase 4Completed

Study Evaluating Venlafaxine ER in Recurrent Depression

Start: Aug 2000Est. completion: Oct 20051,096 patients
Phase 4Completed

Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder

Est. completion: May 2005369 patients
Phase 3Completed

A Study to Investigate Efficacy and Safety of Apremilast 30 mg Twice Daily (BID) in Chinese Participants With Moderate to Severe Plaque-type Psoriasis (PsO)

Start: Nov 2023Est. completion: Dec 2025203 patients
Phase 3Completed

A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque Psoriasis

Start: Oct 2023Est. completion: Aug 202651 patients
Phase 3Active Not Recruiting

A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

Start: Oct 2023Est. completion: Dec 2029322 patients
Phase 3Enrolling By Invitation

A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis

Start: Mar 2023Est. completion: Mar 203648 patients
Phase 3Recruiting

A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis

Start: Jan 2023Est. completion: Sep 202617 patients
Phase 3Active Not Recruiting

Phase 3, Randomized Study of Apremilast in Japanese Participants With Palmoplantar Pustulosis (PPP)

Start: Mar 2022Est. completion: Jun 2024176 patients
Phase 3Completed

Study of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalized Patients

Start: Nov 2020Est. completion: Aug 2021515 patients
Phase 3Completed

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Start: Dec 2019Est. completion: Dec 2025160 patients
Phase 3Completed

Apremilast as a Direct Treatment for Mild-to-moderate Plaque Psoriasis Versus Placebo: an Analysis of Clinical Safety and Efficacy

Start: Mar 2019Est. completion: Jul 2020595 patients
Phase 3Completed

An Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate to Severe Genital Psoriasis

Start: Feb 2019Est. completion: Feb 2022289 patients
Phase 3Completed

Efficacy and Safety Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Start: Dec 2018Est. completion: Mar 2023245 patients
Phase 3Completed

A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behçet's Disease

Start: Dec 2014Est. completion: Jul 2020207 patients
Phase 3Completed

Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)

Start: Jan 2014Est. completion: Jun 2018
Phase 3Completed

Safety and Efficacy Study of Apremilast to Treat Psoriatic Arthritis

Start: Sep 2013Est. completion: Nov 2016219 patients
Phase 3Completed
NCT01730898AbbottStudy product containing lutein

Lutein Absorption in Healthy Adults

Start: Nov 2012Est. completion: Mar 201324 patients
Phase 3Completed
NCT01590368ConvaTecMarketed electrode

A Comparative Wear Test of Two Adhesives on the Unilect ™ Biotab Short Term Monitoring Electrode

Start: Jun 2012Est. completion: Jun 2012
Phase 3Unknown

Venlafaxine ER Long-Term Extension Study for Major Depressive Disorder (MDD)

Start: Jan 2012Est. completion: Jan 201450 patients
Phase 3Completed

TR-701 FA vs Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Start: Sep 2011Est. completion: Jan 2013
Phase 3Completed

Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)

Start: Dec 2010Est. completion: Aug 2017529 patients
Phase 3Completed

Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis.

Start: Nov 2010Est. completion: Nov 2016413 patients
Phase 3Completed

PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis

Start: Sep 2010Est. completion: Jan 2017488 patients
Phase 3Completed

TR-701 FA vs. Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections.

Start: Aug 2010Est. completion: Sep 2011667 patients
Phase 3Completed

Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis

Start: Jun 2010Est. completion: Oct 2016504 patients
Phase 3Completed

Study Evaluating Venlafaxine ER in Patients With Panic Disorder

Start: Nov 2001Est. completion: Apr 2003653 patients
Phase 3Completed

Study Evaluating Venlafaxine ER in Adults With Panic Disorder

Start: Apr 2001Est. completion: Dec 2002343 patients
Phase 3Completed

Study Evaluating Venlafaxine ER in Children and Adolescents With Social Anxiety Disorder

Start: Dec 1999Est. completion: Jun 2003293 patients
Phase 3Completed

The AP-GELP Study: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus

Start: Sep 2019Est. completion: Dec 202342 patients
Phase 2Unknown

A Study of Safety, Tolerability and Pharmacokinetics of Apremilast (CC-10004) in Pediatric Subjects With Moderate to Severe Plaque Psoriasis

Start: Oct 2015Est. completion: Jul 201942 patients
Phase 2Completed

Efficacy and Safety Study of Apremilast to Treat Active Ulcerative Colitis

Start: Jan 2015Est. completion: Jun 2019170 patients
Phase 2Completed

Efficacy and Safety Study of Apremilast in Subjects With Moderate to Severe Atopic Dermatitis

Start: Jun 2014Est. completion: Feb 2016191 patients
Phase 2Completed

Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) In Japanese Patients With Moderate-To-Severe Plaque-Type Psoriasis

Start: Jul 2013Est. completion: Dec 2015254 patients
Phase 2Completed

A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study

Start: Feb 2012Est. completion: Aug 2012200 patients
Phase 2Completed

Study of Apremilast to Evaluate the Safety and Effectiveness for Patients With Rheumatoid Arthritis

Start: Dec 2010Est. completion: Sep 2012237 patients
Phase 2Terminated

Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections

Start: Sep 2008Est. completion: Feb 2009
Phase 2Completed

Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate-to-Severe Plaque-Type Psoriasis (Core Study)

Start: Sep 2008Est. completion: May 2015352 patients
Phase 2Completed

Dose-finding Study of ASP2151 in Subjects With Herpes Zoster

Start: Nov 2007Est. completion: Sep 2008403 patients
Phase 2Completed

Phase II Study of Apremilast (CC-10004) in Adults With in Psoriatic Arthritis

Start: Mar 2007Est. completion: May 2009204 patients
Phase 2Completed

Efficacy, Safety and Local Tolerability Study of Chloroprocaine 3% Gel Eye Drops in Healthy Volunteers

Start: Jun 2020Est. completion: Oct 2020105 patients
Phase 1/2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 14,259 patients
30 companies competing in this space