Carcinoma, Non-Small-Cell Lung

Oncology
124
Pipeline Programs
30
Companies
50
Clinical Trials
7 recruiting
9
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
34
8
46
1
23
12
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2959%
Monoclonal Antibody
1735%
ADC
36%
+ 87 programs with unclassified modality

On Market (9)

Approved therapies currently available

U
AFATINIBApproved
afatinib
Unknown Company
oral
Eli Lilly and Company
ALIMTAApproved
pemetrexed
Eli Lilly and Company
injection2004
U
BAVENCIOApproved
avelumab
Unknown Company
Programmed Death Ligand-1 Blocker [EPC]injection2017
U
BEIZRAYApproved
docetaxel
Unknown Company
Microtubule Inhibitor [EPC]intravenous2024
U
DOCETAXELApproved
docetaxel
Unknown Company
Microtubule Inhibitor [EPC]injection2017
Boehringer Ingelheim
GILOTRIFApproved
afatinib
Boehringer Ingelheim
Kinase Inhibitor [EPC]oral2013
Boehringer Ingelheim
OFEVApproved
nintedanib
Boehringer Ingelheim
oral2014
Eli Lilly and Company
RETEVMOApproved
selpercatinib
Eli Lilly and Company
Kinase Inhibitor [EPC]oral2020
Sanofi
TAXOTEREApproved
docetaxel
Sanofi
injection1996

Competitive Landscape

31 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
57 programs
18
12
11
3
AfatinibPhase 4Small Molecule1 trial
AfatinibPhase 4Small Molecule1 trial
AfatinibPhase 4Small Molecule1 trial
AfatinibPhase 3Small Molecule1 trial
AfatinibPhase 3Small Molecule1 trial
+52 more programs
Active Trials
NCT01931306Approved For Marketing
NCT03370770Completed204Est. Nov 2019
NCT02047903Completed161Est. Dec 2018
+54 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
6 programs
1
3
2
1
LY900003Phase 31 trial
RETEVMO(Selpercatinib)Phase 3Small Molecule1 trial
ALIMTAPhase 21 trial
Gemcitabine, Carboplatin, BevacizumabPhase 2Monoclonal Antibody1 trial
PemetrexedPhase 21 trial
+1 more programs
Active Trials
NCT02411591Completed66Est. May 2019
NCT01624467Completed75Est. Jun 2015
NCT00051493Completed50Est. Dec 2002
+4 more trials
Sanofi
SanofiPARIS, France
2 programs
2
1
Docetaxel and cisplatin followed by gemcitabinePhase 21 trial
Toxicity : Time to progression, 1 and 2 years survivalPhase 21 trial
Active Trials
NCT00424853Completed88Est. Aug 2008
NCT00210171Withdrawn0Est. May 2004
Pfizer
PfizerNEW YORK, NY
13 programs
3
6
3
CisplatinPhase 31 trial
PF-02341066Phase 31 trial
PF-3512676 + Paclitaxel + CarboplatinPhase 31 trial
Investigational drugPhase 21 trial
IrinotecanPhase 21 trial
+8 more programs
Active Trials
NCT06075615Withdrawn0Est. Sep 2026
NCT00907504Withdrawn0Est. May 2014
NCT00977561Terminated9Est. Oct 2011
+15 more trials
M&
Merck & Co.RAHWAY, NJ
5 programs
1
3
1
AvelumabPhase 3Monoclonal Antibody5 trials
DalotuzumabPhase 2Monoclonal Antibody1 trial
MK0457Phase 21 trial
Raludotatug DeruxtecanPhase 2ADC
IntravenousPhase 15 trials
Active Trials
NCT04665037Recruiting40Est. Dec 2026
NCT04678505Terminated9Est. Apr 2021
NCT04218851Completed31Est. Dec 2023
+9 more trials
Roche
RocheSTAVANGER NORWAY, Norway
3 programs
1
1
CabozantinibPhase 3Small Molecule1 trial
PemetrexedPhase 2
PD-L1 ImmunocytochemistryN/A1 trial
Active Trials
NCT03092739Completed184Est. Jun 2018
NCT04471428Completed366Est. Jan 2025
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
2 programs
2
QL1706 injectionPhase 31 trial
QL2107Phase 31 trial
Active Trials
NCT05487391RecruitingEst. May 2029
NCT07162883Not Yet RecruitingEst. May 2027
Moderna
ModernaCAMBRIDGE, MA
1 program
1
PembrolizumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT06623422Recruiting680Est. Jan 2038
Zai Lab
Zai LabCA - South SF
1 program
1
RepotrectinibPhase 3Small Molecule1 trial
Active Trials
NCT06140836Active Not Recruiting190Est. Mar 2027
Verona Pharma
Verona PharmaUK - London
1 program
1
Surgical removal of primary and/or of all oligometastasesPhase 31 trial
Active Trials
NCT03827577Unknown195Est. Sep 2022
Transgene
TransgeneFrance - Illkirch-Graffenstaden
1 program
1
MVA-MUC1-IL2Phase 2/31 trial
Active Trials
NCT00415818CompletedEst. Mar 2010
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
10 programs
1
1
3
AZD9291Phase 21 trial
DurvalumabPhase 2Monoclonal Antibody1 trial
DurvalumabPhase 2Monoclonal Antibody1 trial
AZD7789Phase 1/21 trial
GefitinibPhase 1Small Molecule1 trial
+5 more programs
Active Trials
NCT03761901Completed141Est. Jun 2019
NCT05826366Completed296Est. Apr 2025
NCT06494241Active Not Recruiting1,000Est. Nov 2027
+6 more trials
DS
Daiichi SankyoChina - Shanghai
5 programs
2
2
1
Raludotatug DeruxtecanPhase 2ADC1 trial
Datopotamab DeruxtecanPhase 1/2ADC1 trial
PembrolizumabPhase 1/2Monoclonal Antibody1 trial
CS-7017Phase 11 trial
CS-7017Phase 11 trial
Active Trials
NCT01199068Completed15Est. Dec 2011
NCT01199055Completed16Est. Jul 2011
NCT05460273Active Not Recruiting119Est. Jun 2026
+2 more trials
Genentech
4 programs
1
3
ErlotinibPhase 2Small Molecule
Gemcitabine, Carboplatin, BevacizumabPhase 2Monoclonal Antibody
MPDL3280APhase 21 trial
AtezolizumabPhase 1/2Monoclonal Antibody
Active Trials
NCT02716038Completed39Est. Oct 2022
Bristol Myers Squibb
2 programs
1
1
MORAb-202Phase 2
MDX-1106Phase 11 trial
Active Trials
NCT00441337Completed39Est. Nov 2009
Providence Therapeutics
2 programs
1
1
CyclophosphamidePhase 21 trial
MK-3475Phase 1/2
Active Trials
NCT01909752CompletedEst. Apr 2017
Pierre Fabre
Pierre FabreFrance - Aignan
2 programs
2
CarboplatinPhase 2
Oral vinorelbinePhase 21 trial
Active Trials
NCT02919462TerminatedEst. May 2017
MAIA Biotechnology
1 program
1
6-Thio-2'-DeoxyguanosinePhase 21 trial
Active Trials
NCT05208944RecruitingEst. Dec 2027
Abbott
AbbottABBOTT PARK, IL
1 program
1
ABT-510/Thrombospondin-1 mimeticPhase 21 trial
Active Trials
NCT00061646Terminated25
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY59-8862Phase 21 trial
Active Trials
NCT00044538Completed102Est. Jun 2004
Alliance Pharmaceuticals
1 program
1
ErlotinibPhase 2Small Molecule1 trial
Active Trials
NCT00391586Terminated45Est. May 2012
E
1 program
1
MORAb-202Phase 21 trial
Active Trials
NCT05577715Terminated31Est. Aug 2024
Achieve Life Sciences
1 program
1
S-8184 Paclitaxel Injectable EmulsionPhase 21 trial
Active Trials
NCT00034164CompletedEst. Sep 2007
CT
1
SintilimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05306847Not Yet RecruitingEst. Apr 2026
CASI Pharmaceuticals
CASI PharmaceuticalsBEIJING, China
1 program
1
recombinant human Angiostatin proteinPhase 21 trial
Active Trials
NCT00049790CompletedEst. Dec 2004
Novartis
NovartisBASEL, Switzerland
5 programs
3
1
PatupilonePhase 1/21 trial
KFA115Phase 11 trial
LBH589Phase 15 trials
QEQ278Phase 11 trial
Genomic Landscape of CeritinibN/ASmall Molecule1 trial
Active Trials
NCT02554591Terminated6Est. Feb 2018
NCT05544929Active Not Recruiting126Est. Sep 2027
NCT01028313Withdrawn0
+6 more trials
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
AMG 102 and erlotinibPhase 1/2Small Molecule1 trial
Active Trials
NCT01233687Completed49Est. Nov 2014
Vaccinex
VaccinexROCHESTER, NY
1 program
1
VX15/2503 + avelumabPhase 1/2Monoclonal Antibody
Takeda
TakedaTOKYO, Japan
2 programs
2
MidazolamPhase 11 trial
PembrolizumabPhase 1Monoclonal Antibody3 trials
Active Trials
NCT04051827Completed26Est. Dec 2021
NCT04879849Completed34Est. Apr 2024
NCT04381650Completed161Est. Oct 2024
+1 more trials
AB
Active BiotechSweden - Lund
1 program
1
ABR-217620Phase 11 trial
Active Trials
NCT00132379CompletedEst. Dec 2006

+1 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Boehringer IngelheimAfatinib
Boehringer IngelheimAfatinib
Boehringer IngelheimAfatinib
Qilu PharmaceuticalQL2107
ModernaPembrolizumab
Zai LabRepotrectinib
Qilu PharmaceuticalQL1706 injection
Eli Lilly and CompanySelpercatinib
RocheCabozantinib
Verona PharmaSurgical removal of primary and/or of all oligometastases
Merck & Co.Avelumab
Merck & Co.Avelumab
Merck & Co.Avelumab
Boehringer IngelheimBI 695502
Merck & Co.Avelumab

Showing 15 of 48 trials with date data

Clinical Trials (50)

Total enrollment: 11,759 patients across 50 trials

Afatinib in EGFR+NSCLC (Recurrent or Stage IV) - Patients With Poor Performance Status (ECOG 2 or 3)

Start: Mar 2016Est. completion: Aug 20161 patients
Phase 4Terminated

Afatinib Treatment for Patients With EGFR Mutation Positive NSCLC Who Are Age 70 or Older

Start: Aug 2015Est. completion: Apr 201925 patients
Phase 4Completed

Afatinib as Second-line Therapy for Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation

Start: Oct 2014Est. completion: Jun 201760 patients
Phase 4Completed

Pharmacokinetic Study of QL2107 Versus Keytruda® for Adjuvant Therapy of Non-Small Cell Lung Cancer (NSCLC)

Start: Sep 2025Est. completion: May 2027
Phase 3Not Yet Recruiting
NCT06623422ModernaPembrolizumab

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Start: Oct 2024Est. completion: Jan 2038680 patients
Phase 3Recruiting
NCT06140836Zai LabRepotrectinib

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Start: Dec 2023Est. completion: Mar 2027190 patients
Phase 3Active Not Recruiting

A Study of QL1706 Combined With Platinum-containing Chemotherapy in Adjuvant Treatment of Stage II-IIIB Non-small Cell Lung Cancer After Complete Surgical Resection.

Start: Dec 2022Est. completion: May 2029
Phase 3Recruiting

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

Start: Dec 2021Est. completion: May 2028152 patients
Phase 3Active Not Recruiting
NCT04471428RocheCabozantinib

Study of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small Cell Lung Cancer Previously Treated With an Anti-PD-L1/PD-1 Antibody and Platinum-Containing Chemotherapy

Start: Oct 2020Est. completion: Jan 2025366 patients
Phase 3Completed
NCT03827577Verona PharmaSurgical removal of primary and/or of all oligometastases

OMEGA, Local Ablative Therapy in Oligometastatic NSCLC

Start: Oct 2019Est. completion: Sep 2022195 patients
Phase 3Unknown

Avelumab Program Rollover Study

Start: Mar 2019Est. completion: Feb 2027
Phase 3Active Not Recruiting

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

Start: Dec 2015Est. completion: Nov 2019
Phase 3Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Start: Dec 2015Est. completion: Jun 2021499 patients
Phase 3Completed

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Start: Jul 2015Est. completion: Nov 2018671 patients
Phase 3Completed

Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200)

Start: Mar 2015Est. completion: Dec 2019792 patients
Phase 3Completed

LUME-Columbus: Nintedanib Plus Docetaxel in Advanced Non-small Cell Lung Cancer With Translational Research

Start: Oct 2014Est. completion: Dec 201512 patients
Phase 3Terminated

Afatinib in Patients With Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Mutations

Start: Mar 2014Est. completion: Feb 201614 patients
Phase 3Completed

Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR Mutation

Start: Sep 2013Est. completion: Jul 2018542 patients
Phase 3Completed

An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)

Start: Jul 2013Est. completion: Mar 2024481 patients
Phase 3Completed

ADAM-Afatinib Diarrhea Assessment and Management

Start: Apr 2013Est. completion: Jul 201540 patients
Phase 3Completed

LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy

Start: Mar 2012Est. completion: Dec 2017795 patients
Phase 3Completed

Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis

Start: Jun 2011Est. completion: Sep 2013558 patients
Phase 3Completed

Study Of The Effect Of CP-751,871 In Combination With Gemcitabine And Cisplatin In Patients With Advanced Non-Small Cell Lung Cancer

Start: Jul 2010Est. completion: May 20140
Phase 3Withdrawn
NCT01121393Boehringer IngelheimGemcitabine+Cisplatin

BIBW 2992 (Afatinib) vs Gemcitabine-cisplatin in 1st Line Non-small Cell Lung Cancer (NSCLC)

Start: Apr 2010Est. completion: Nov 2017364 patients
Phase 3Completed
NCT01085136Boehringer IngelheimInvestigator´s choice of chemotherapy

LUX-Lung 5: Afatinib Plus Weekly Paclitaxel Versus Investigator's Choice of Single Agent Chemotherapy Following Afatinib Monotherapy in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib

Start: Feb 2010Est. completion: Jan 20161,154 patients
Phase 3Completed

An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene

Start: Sep 2009Est. completion: Jan 2016347 patients
Phase 3Completed

BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation

Start: Aug 2009Est. completion: Mar 2017345 patients
Phase 3Completed

Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC

Start: Dec 2008Est. completion: Dec 2015718 patients
Phase 3Completed

Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced NSCLC Of Squamous, Large Cell And Adenosquamous Carcinoma Histology

Start: Apr 2008Est. completion: Sep 2012681 patients
Phase 3Terminated

Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC

Start: Nov 2005Est. completion: Jun 2008839 patients
Phase 3Terminated
NCT00254891PfizerPF-3512676 + Paclitaxel + Carboplatin

Trial of Paclitaxel/Carboplatin + PF-3512676 vs Paclitaxel/Carboplatin Alone in Patients With Advanced Non-Small Cell Lung Cancer

Start: Nov 2005Est. completion: Jul 2008828 patients
Phase 3Terminated

A Phase 3 Trial of LY900003 Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer

Start: Mar 2002
Phase 3Completed

Immunotherapy With TG4010 in Patients With Advanced Non-Small Cell Lung Cancer

Start: Dec 2005Est. completion: Mar 2010
Phase 2/3Completed

Study Evaluating MAC-321 in Colorectal Cancer

Est. completion: Feb 200445 patients
Phase 2Completed

A Study of Panobinostat (LBH589) as Second-Line Therapy in Patients With Chronic Graft-Versus-Host Disease

0
Phase 2Withdrawn
NCT00049790CASI Pharmaceuticalsrecombinant human Angiostatin protein

Safety and Efficacy Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer

Est. completion: Dec 2004
Phase 2Completed

Study Evaluating MAC-321 in Non-small Cell Lung Cancer Refractory to Platinum-based Therapy

Est. completion: Feb 200548 patients
Phase 2Completed

TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer - Stage IV

0
Phase 2Withdrawn
NCT00034957PfizerInvestigational drug

Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)

Est. completion: Oct 2002
Phase 2Completed

DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma

Start: Dec 2025Est. completion: Nov 203025 patients
Phase 2Recruiting
NCT06780085Daiichi SankyoRaludotatug Deruxtecan

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Start: May 2025Est. completion: Mar 203296 patients
Phase 2Recruiting

Study of Avelumab and Tuvusertib in Participants With Advanced Urothelial Cancer That Has Progressed on Prior Anti-PD-(L)1 Therapy (JAVELIN DDRiver Bladder)

Start: Aug 2024Est. completion: Jan 2026
Phase 2Withdrawn

Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer

Start: Dec 2022Est. completion: Dec 202664 patients
Phase 2Recruiting

A Study of MORAb-202 in Participants With Previously Treated Metastatic Non-Small Cell Lung Cancer (NSCLC) Adenocarcinoma (AC)

Start: Nov 2022Est. completion: Aug 202431 patients
Phase 2Terminated
NCT05208944MAIA Biotechnology6-Thio-2'-Deoxyguanosine

THIO Sequenced With Cemiplimab in Advanced NSCLC

Start: Jun 2022Est. completion: Dec 2027
Phase 2Recruiting

GEN-001 in Combination With Avelumab for Patients With PD-L1 Positive Gastric Cancer

Start: Apr 2022Est. completion: Aug 2024
Phase 2Completed

Sintilimab Combined With Anlotinib Therapy for Initially Unresectable Non-small Cell Lung Cancer

Start: Apr 2022Est. completion: Apr 2026
Phase 2Not Yet Recruiting

Cabozantinib in Combination With Avelumab in Patients Refractory to Standard Chemotherapy With Advanced Neuroendocrine Neoplasias G3 (NEN G3)

Start: Mar 2022Est. completion: Dec 202530 patients
Phase 2Active Not Recruiting

Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)

Start: Feb 2022Est. completion: Dec 202640 patients
Phase 2Recruiting

Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104)

Start: Jul 2020Est. completion: Dec 202331 patients
Phase 2Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

23 late-stage (Phase 3) programs — potential near-term approvals
7 actively recruiting trials targeting 11,759 patients
30 companies competing in this space