Precision BioSciences(DTIL)

DURHAM, NCBiotechnology1 H-1B visas (FY2023)

Focus: Precision BioSciences is a Durham-based public biotech (NASDAQ: DTIL) focused on genome-editing enzymes and CAR-T cell therapies for oncology and cell therapy applications. The company operates a mixed portfolio of generic/branded assets generating ~$69M annual revenue (FY2025) alongside an early-stage pipeline in gene therapy and immunotherapy.

Cell Therapy

Profile data last refreshed 7h ago · AI intelligence enriched 3w ago

Funding Stage

PUBLIC

Open Jobs

About Precision BioSciences

AI assessmentNot Hiring

No open roles listed right now. Follow Precision BioSciences to get notified when they start hiring — the background below is worth knowing for when they do.

Why Work Here

Data completeness

5/9 — Partial

Company HealthSolid

Pipeline

Early-stage

50 total

LOE Risk

Protected

No near-term cliffs

Hiring

0 open

Revenue

$69M

Key Products

FOSFOMYCIN TROMETHAMINE

Pyelonephritis, perinephric abscess

$2M

Post-LOE

Generic antibiotic driving 99% of company revenue; post-LOE status indicates mature, low-margin product with limited growth.

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

High R&D intensity (87%) signals genuine investment in novel genome-editing and CAR-T programs despite generic revenue base.
Public company status with growing revenue trajectory ($49M FY2024 → $69M FY2025, +41%) and positive net income ($7M FY2025) provides stability vs. pre-revenue biotech.
Exposure to cutting-edge CAR-T modalities (CD123, BCMA/CD70, CD19/CD22, CEA-targeted) with Phase 1/2 programs offer early-career scientists meaningful therapeutic validation.

Watch Out For

Extreme revenue concentration (99% from single antibiotic) creates existential dependency on a post-LOE generic product with minimal differentiation.
Pipeline shows early-stage immaturity: 15 Phase 1 programs, 4 Phase 2, zero Phase 3 trials—limited near-term catalysts and long timelines to market validation.
Recent earnings volatility and stock underperformance (May 2026 earnings miss) despite pipeline updates suggest market skepticism about clinical execution or commercial viability.

Generated by Claude from Precision BioSciences's SEC filings, pipeline programs, hiring velocity, FDA actions, and WARN data. Inference, not editorial — verify before quoting.

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

HYDROCORTISONE BUTYRATE

Atopic dermatitis

$12K

Post-LOE

Topical corticosteroid generating minimal Part D revenue; post-LOE generic with narrow therapeutic footprint.

RISPERIDONE

Atypical antipsychotic

Post-LOE

Generic atypical antipsychotic in post-LOE state; minimal commercial contribution.

PHENTOLAMINE MESYLATE

Alpha-adrenergic antagonist

Post-LOE

Niche injectable alpha-blocker in post-LOE; low-revenue specialty generic.

LOCOID

Atopic dermatitis

LOE Approaching

Branded topical corticosteroid approaching loss of exclusivity; limited remaining patent protection.

LOCOID LIPOCREAM

Atopic dermatitis

LOE Approaching

Lipid-based formulation of hydrocortisone butyrate nearing LOE; differentiation insufficient to sustain premium pricing.

Pipeline & Clinical Trials

Blood test: ClarityDX Prostate

Prostate Cancer

N/A

Clinical Trials (1)

NCT03957252Validation of ClarityDX Prostate as a Reflex Test to Refine the Prediction of Clinically-significant Prostate Cancer

N/A

Exploring a Potential Blood Test to Diagnose Major Depressive Disorder

Major Depressive Disorder

N/A

Puzolcabtagene Autoleucel Injection

Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia (r/r B-ALL)

N/A

Clinical Trials (1)

NCT07637929Non-Interventional Study of Puzol-cel for CD19-Positive Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

N/A

Biobanking with genetic analysis

Chronic Inflammatory Disease

N/A

Clinical Trials (1)

NCT04334031Deployment o the Multidisciplinary Prospective Cohort Imminent

N/A

Freedom SCS System

Back Pain

N/A

Data Mining: Precision Analytical Retrospective Data Correlation

Obesity; Endocrine

N/A

Clinical Trials (1)

NCT04305093Data Mining: Precision Analytical Retrospective Data Correlation

N/A

EPIONE® CT-Guided Percutaneous procedures

Cancer Abdomen

N/A

Clinical Trials (1)

NCT05529979Epione® Post-Market Clinical Follow-up Study

N/A

CGM

Type 2 Diabetes

N/A

Gynaecological laparoscopic surgery

Ovarian Cancer

N/A

Clinical Trials (1)

NCT05048407Sirius in Gynaecological Laparoscopic Surgery

N/A

Web-based CBT

Chronic Pancreatitis

N/A

Phlebotomy

COVID-19

N/A

Phase 1 Wonderlab Product

Diabetes

N/A

Clinical Trials (1)

NCT05756712The Efficacy of White Kidney Bean on Oral Glucose Tolerance Test

N/A

Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up

Breast Cancer Risk

N/A

Clinical Trials (1)

NCT05848856The RISC Registry--Risk Informed Screening Registry

N/A

ChemoFx

Ovarian Cancer

N/A

Clinical Trials (1)

NCT01048814Retrospective Case Study to Validate Existing Chemoresponse Marker Test in Ovarian, Peritoneal or Fallopian Cancer Cases

N/A

Common Elements Toolbox

Depressive Symptoms

N/A

Clinical Trials (1)

NCT04815681Evaluating an Online Wellness Intervention for Greek Adolescents

N/A

VIVO™

Premature Ventricular Contraction

N/A

The Quantum Surgical device

Hepatic Tumor

N/A

Clinical Trials (1)

NCT04230642Multicenter Study to Evaluate a New Robotic Device for Image-guided Percutaneous Needle Placement

N/A

EPIONE device

Lung Cancer

N/A

Clinical Trials (1)

NCT05651867EPIONE Guided Lung Evaluation

N/A

Biological analysis, Physical examination and Questionnaires

Diabetes

N/A

Clinical Trials (1)

NCT05717491Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France

N/A

Tissue Collection Study for Patients With Non-Small Cell Lung Cancer With Resectable Disease

Non-Small Cell Lung Cancer

N/A

Clinical Trials (1)

NCT01450553Tissue Collection Study for Patients With Non-Small Cell Lung Cancer With Resectable Disease

N/A

ClariCore Optical Biopsy System

Cellular Diagnosis, Prostate Cancer

N/A

Clinical Trials (1)

NCT03504761ClariCore System Used in Transrectal Ultrasound Guided Prostate Biopsy for Real-Time Tissue Evaluation

N/A

ChemoFx® PRO - A Post-Market Data Collection Study

Ovarian Cancer

N/A

Clinical Trials (1)

NCT00669422ChemoFx® PRO - A Post-Market Data Collection Study

N/A

Standardized assessments, guided tumor biopsy and biobanking

Decompensated Liver Cirrhosis

N/A

Clinical Trials (1)

NCT06723275LEOPARD Prospective Validation Cohort 1

N/A

mobile internet survey on self-test

Susceptibility to Viral and Mycobacterial Infection

N/A

Wonderlab Kids instant probiotics

Immunity

N/A

Clinical Trials (1)

NCT05585021Clinical Study on the Effect of Probiotic Compound Powder on the Immunity Improvement of Preschool Children

N/A

DermaTherapy® Linen and underpads.

Pressure Ulcers

N/A

Clinical Trials (1)

NCT01355666Silk-Like Fabric for the Prevention of Pressure Sores in a Long Term Care Setting

N/A

Custom Fabricated Splint

Arthritis

N/A

Clinical Trials (1)

NCT05351060Novel Splinting Technique Using 3D Models

N/A

Community Health Worker Support

Cancer

N/A

Clinical Trials (1)

NCT04843332Community Health Workers and Precision Medicine

N/A

Scleral lens wearing keratoconics

Keratoconus

N/A

Clinical Trials (1)

NCT03091101Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus

N/A

A Prospective, Remote Observational Study in Pediatric Participants With Early-Onset SCN2A-Developme

SCN2A-DEE

N/A

mNGS for pathogen detection

Encephalitis

N/A

Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring

Biliary Tract Cancer

N/A

Clinical Trials (1)

NCT04561453Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer

N/A

Silk-Like Linens

Pressure Ulcer

N/A

Clinical Trials (1)

NCT02925741Silk-Like Bed Linens for Prevention of Unit-Acquired Ulcers

N/A

6 Minute Walk Test

Aged

N/A

Clinical Trials (1)

NCT03123757Assessing the Determinants of 6-minute Walk Test and Its Correlation With Quality of Life

N/A

DermaTherapy® Linen and underpads.

Pressure Ulcers

N/A

Clinical Trials (1)

NCT01403272Evaluate the Efficacy of a Silk-Like Fabric for the Prevention of Pressure Sores in a Long Term Care Setting

N/A

Percutaneous procedure in the MSK structures of the pelvis and/or the spine

Bone Tumor

N/A

Clinical Trials (1)

NCT07325578U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures

N/A

A Study of ChemoFx® Chemoresponse Assay in Solid Tumors - ChemoFx® Registry Study

Solid Organ Tumors

N/A

Clinical Trials (1)

NCT01271959A Study of ChemoFx® Chemoresponse Assay in Solid Tumors - ChemoFx® Registry Study

N/A

CT-guided bone percutaneous procedure

Bone Metastases

N/A

Clinical Trials (1)

NCT06376682EPIBONE Study: a Prospective Study on Feasibility, Safety and Accuracy

N/A

Silk like Pillowcase

Acne Vulgaris

N/A

Clinical Trials (1)

NCT00767104Efficacy of Silk - Like Bedding Fabric Pillow Case in the Treatment of Acne Vulgaris

N/A

Optical coherence tomography

Optical Coherence Tomography

N/A

Clinical Trials (1)

NCT05517889Repeatability and Stability of Healthy Skin Features on OCT

N/A

Correlation of the Chemoresponse Assay With PFS in Patients With Recurrent Epithelial Ovarian, Perit

Ovarian Cancer

N/A

Clinical Trials (1)

NCT00288275Correlation of the Chemoresponse Assay With PFS in Patients With Recurrent Epithelial Ovarian, Peritoneal, or Fallopian Tube Cancer

N/A

MalariaSense device

Malaria

N/A

Clinical Trials (1)

NCT02672228Feasibility of the Vapor Nanobubble Technology for Malaria Diagnostics (MalariaSense)

N/A

VIVO

Ventricular Arrythmia

N/A

Chilean Gastric Cancer Task Force (FORCE 1)

Biomarkers

N/A

Clinical Trials (1)

NCT03158571Chilean Gastric Cancer Task Force (FORCE 1)

N/A

Education Program

Stress

N/A

detect HPV E7 ctDNA

Uterine Cervical Neoplasms

N/A

CPMRx

Opioid Misuse

N/A

Clinical Trials (1)

NCT05461196Decreasing Opioid Misuse and Habit-forming Behaviors Following Prescription in Patients Undergoing Cesarean Section

N/A

Trio Whole Genome Sequencing and Participant-Specific Research

Rare Diseases

N/A

CMV-VST

Cytomegalovirus Viremia

N/A

Clinical Trials (1)

NCT07015801CMV-specific Donor-derived T Lymphocytes for the Treatment of Recalcitrant CMV Infection in a Patient With Primary Immunodeficiency

N/A

Study product A

Overweight

N/A

Clinical Trials (1)

NCT05710055The Efficacy on Overweight With Oral Supplemenation of Probiotics and Prebiotics

N/A

Open Jobs (0)

No open positions listed yet. Check their careers page directly.

Interview Prep Quick Facts

Founded: 2021

Portfolio: 18 approved products, 131 clinical trials

Top TAs: Oncology, Immunology, Neurology

H-1B (2023): 1 approval

Publications: 25 in PubMed

SEC Filings: 2 available

Portfolio Health

Pre-Launch3 (17%)

LOE Approaching2 (11%)

Post-LOE13 (72%)

18 total products

Therapeutic Area Focus

Oncology

91 pipeline

Immunology

10 marketed11 pipeline

Neurology

5 pipeline

Metabolic Diseases

5 pipeline

Infectious Diseases

1 marketed3 pipeline

Financials (FY2025)

Revenue

$69M41%

R&D Spend

$60M(87%)12%

Net Income

$7M

Visa Sponsorship

Sponsors Work Visas

H-1B Petitions (FY2023)

Approved

Denied

100%

Rate

Source: USCIS H-1B Employer Data Hub

Research Publications(10)

Recent peer-reviewed publications with author affiliations at this company

Transient muscle expression of mitoARCUS in mice leads to sustained reductions in pathogenic mtDNA and reduces fatigability.

Molecular therapy : the journal of the American Society of Gene Therapy

2025

PMID:41445195

RHO1-2 meganuclease gene editing targets human P23H rhodopsin-induced retinitis pigmentosa to rejuvenate rods and maintain cones.

INJECTION · INJECTABLE

Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral administration. Following a 200 mg dose, normal adult volunteers averaged peak serum levels of 2.6 mcg/mL of doxycycline at 2 hours, decreasing to 1.45 mcg/mL at 24 hours. Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal function (creatinine clearance about 75 mL/min.). This percentage excretion may fall as low as 1-5%/72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min.). Studies have shown no significant difference in serum half-life of doxycycline (range 18-22 hours) in individuals with normal and severely impaired renal function. Hemodialysis does not alter serum half-life. Results of animal studies indicate that tetracyclines cross the placenta and are found in fetal tissues. Population pharmacokinetic analysis of sparse concentration-time data of doxycycline following standard of care intravenous and oral dosing in 44 pediatric patients (2-18 years of age) showed that allometrically -scaled clearance (CL) of doxycycline in pediatric patients ≥2 to ≤8 years of age (median [range] 3.58 [2.27-10.82] L/h/70 kg, N =11) did not differ significantly from pediatric patients >8 to 18 years of age (3 .27 [1.11-8.12] L/h/70 kg, N=33). For pediatric patients weighing ≤45 kg, body weight normalized doxycycline CL in those ≥2 to ≤8 years of age (median [range] 0.071 [0 .041-0.202] L/kg/h, N=10) did not differ significantly from those >8 to 18 years of age (0.081 [0.035-0.126] L/kg/h, N=8). In pediatric patients weighing >45 kg, no clinically significant differences in body weight normalized doxycycline CL were observed between those ≥2 to ≤8 years (0.050 L/kg/h, N=l) and those >8 to 18 years of age (0.044 [0.014-0.121] L/kg/h, N=25). No clinically significant difference in CL between oral and IV dosing was observed in the small cohort of pediatric patients who received the oral (N=19) or IV (N=21) formulation alone. Microbiology Mechanism of Action Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. Resistance Cross resistance with other tetracyclines is common. Antimicrobial Activity Doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section of the package insert for doxycycline hyclate tablets, USP. Gram-Negative Bacteria Acinetobacter species Bartonella bacilliformis Brucella species Klebsiella species Klebsiella granulomatis Campylobacter fetus Enterobacter aerogenes Escherichia coli Francisella tularensis Haemophilus ducrey

Respiratory

1 marketed1 pipeline

Gastroenterology

2 pipeline

Psychiatry

1 marketed

bioRxiv : the preprint server for biology

2025

PMID:41040161

Showing 5 of 10 publications

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Precision BioSciences(DTIL)

About Precision BioSciences

Why Work Here

Key Products

Watch Out For

Products & Portfolio (7)

Key Products by Revenue

Other Products (6)

Pipeline & Clinical Trials

Recent News · Precision BioSciences(10)

Open Jobs (0)

Financials (FY2025)

Visa Sponsorship

Research Publications(10)