Skip to main content

Back Pain

11
Pipeline Programs
24
Companies
31
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
6
4
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 36 programs with unclassified modality

Competitive Landscape

24 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
4 programs
1
Selective Nerve Root BlockPhase 41 trial
Freedom SCS SystemN/A
Pressure pain assessment using computer controlled cuff algometryN/A1 trial
Psychiatric Comorbidity in Back Pain DisordersN/A1 trial
Active Trials
NCT04193969Completed80Est. Sep 2021
NCT03825991Unknown500,000Est. Jun 2021
NCT03801356Terminated11Est. Dec 2020
Pfizer
PfizerNEW YORK, NY
3 programs
1
Tramadol Hydrochloride 50mgPhase 41 trial
Group 2N/A1 trial
painPREMIER cohortN/A1 trial
Active Trials
NCT02484937Terminated9Est. Jun 2022
NCT01787565Terminated86Est. Jan 2014
NCT00290901Completed754
Boston Scientific
Boston ScientificCA - Valencia
3 programs
1
Precision Spinal Cord Stimulation SystemPhase 41 trial
Precision Spinal Cord Stimulation SystemN/A1 trial
Precision Spinal Cord Stimulation SystemN/A1 trial
Active Trials
NCT00386724Terminated8Est. Aug 2008
NCT00370695Terminated15Est. Jul 2008
NCT00370773Terminated4Est. Feb 2007
Ferrosan
FerrosanDenmark - Søborg
1 program
1
Glucosamine sulphatePhase 41 trial
Active Trials
NCT00317655Completed175Est. Apr 2007
Purdue Pharma
Purdue PharmaCT - Stamford
2 programs
2
Buprenorphine transdermal delivery systemPhase 31 trial
Buprenorphine transdermal patchPhase 31 trial
Active Trials
NCT00315874Completed225Est. Jan 1998
NCT00315445Completed134Est. May 1998
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
2
CannabisPhase 31 trial
THC/CBDPhase 31 trial
Active Trials
NCT02892591Completed33Est. Jun 2023
NCT05052541Recruiting157Est. Jun 2027
EMS
EMSBrazil - Hortolândia
2 programs
2
Ketorolac TromethaminePhase 31 trial
Ketorolac TromethaminePhase 31 trial
Active Trials
NCT01471899Completed78Est. Apr 2014
NCT01471886Completed83Est. Nov 2013
Allodynic Therapeutics
Allodynic TherapeuticsFL - North Miami
1 program
1
Naltrexone and Clonidine CombinationPhase 21 trial
Active Trials
NCT01415895Completed78Est. Feb 2013
Aspen Medical products
3 programs
Aspen Horizon 627 LSON/A1 trial
Scoliosis Bracing SystemN/A1 trial
Thoracolumbosacral OrthosisN/A
Active Trials
NCT03100097Terminated62Est. Dec 2017
NCT02643290Completed20Est. Jan 2017
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
Freedom SCS SystemN/A1 trial
Gentle NudgeN/A1 trial
Active Trials
NCT02514590Completed49Est. Jul 2019
NCT03381885Completed20,000Est. Feb 2016
BOOST Pharma
BOOST PharmaDenmark - Copenhagen
1 program
Computer-vision Aided Community Back Pain Physiotherapy ServicesN/A1 trial
Active Trials
NCT04895826Unknown100Est. Jun 2022
Meagan Medical
Meagan MedicalWA - Vancouver
1 program
DISCSS DeviceN/A1 trial
Active Trials
NCT03341000Terminated18Est. Feb 2020
Precision Spine
Precision SpineNJ - Parsippany
1 program
Freedom SCS SystemN/A
Curonix
CuronixFL - Pompano Beach
1 program
Freedom SCS SystemN/A
Precision BioSciences
1 program
Freedom SCS SystemN/A
Compass Therapeutics
1 program
Freedom SCS SystemN/A
Nevro
NevroCA - Redwood City
1 program
HF10 TherapyN/A1 trial
Active Trials
NCT03680846Unknown211Est. Nov 2022
Selva Therapeutics
Selva TherapeuticsCA - Del Mar
1 program
Magnetic Tape® aplicaciónN/A1 trial
Active Trials
NCT04875273Completed39Est. Sep 2022
SPR Therapeutics
SPR TherapeuticsOH - Cleveland
1 program
SPRINT Peripheral Nerve StimulationN/A1 trial
Active Trials
NCT03179202Completed166Est. May 2021
Verona Pharma
Verona PharmaUK - London
1 program
The FIT Therapy patchN/A1 trial
Active Trials
NCT04651426Completed54Est. Oct 2019
Alliance Pharmaceuticals
1 program
Usual Medical CareN/A1 trial
Active Trials
NCT06160947Not Yet Recruiting24Est. Mar 2028
Jerusalem Pharmaceuticals
Jerusalem PharmaceuticalsIsrael - Ramallah
1 program
GaAlAs 808nm laserPHASE_2_31 trial
Active Trials
NCT02665507Completed42Est. Jul 2024
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
ibuprofenPHASE_3Small Molecule1 trial
Active Trials
NCT03003000Completed635Est. Sep 2017
Ortho Development
1 program
tramadol hydrochloride , acetaminophenPHASE_41 trial
Active Trials
NCT00210561Terminated22Est. Apr 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Spine BioPharmaSelective Nerve Root Block
FerrosanGlucosamine sulphate
PfizerTramadol Hydrochloride 50mg
Boston ScientificPrecision Spinal Cord Stimulation System
Ortho Developmenttramadol hydrochloride , acetaminophen
Colorado TherapeuticsTHC/CBD
Colorado TherapeuticsCannabis
Boehringer Ingelheimibuprofen
EMSKetorolac Tromethamine
EMSKetorolac Tromethamine
Purdue PharmaBuprenorphine transdermal patch
Purdue PharmaBuprenorphine transdermal delivery system
Jerusalem PharmaceuticalsGaAlAs 808nm laser
Allodynic TherapeuticsNaltrexone and Clonidine Combination
Alliance PharmaceuticalsUsual Medical Care

Showing 15 of 31 trials with date data

Clinical Trials (31)

Total enrollment: 523,372 patients across 31 trials

NCT03801356Spine BioPharmaSelective Nerve Root Block

Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy

Start: Aug 2018Est. completion: Dec 202011 patients
Phase 4Terminated
NCT00317655FerrosanGlucosamine sulphate

Glucosamine Sulphate, Ginger, Ginger-Avocado-Soya and Ginger-Ibuprofen for Chronic Back Pain

Start: Apr 2006Est. completion: Apr 2007175 patients
Phase 4Completed
NCT00290901PfizerTramadol Hydrochloride 50mg

Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.

Start: Mar 2006754 patients
Phase 4Completed
NCT00370773Boston ScientificPrecision Spinal Cord Stimulation System

Comparison of Intraspinal Nerve Root Stimulation With Dorsal Column Stimulation

Start: Jan 2006Est. completion: Feb 20074 patients
Phase 4Terminated
NCT00210561Ortho Developmenttramadol hydrochloride , acetaminophen

A Study of the Effectiveness and Safety of Tramadol HCl/Acetaminophen Compared to Placebo in Treating Acute Low Back Pain

Start: Mar 2005Est. completion: Apr 200522 patients
Phase 4Terminated

Safety and Efficacy of Oral Cannabis in Chronic Spine Pain

Start: Jan 2026Est. completion: Jun 2027157 patients
Phase 3Recruiting

Cannabis Versus Oxycodone for Pain Relief

Start: Jun 2017Est. completion: Jun 202333 patients
Phase 3Completed

Ibuprofen/Caffeine Lower Back or Neck Pain Study

Start: Dec 2016Est. completion: Sep 2017635 patients
Phase 3Completed
NCT01471886EMSKetorolac Tromethamine

Comparison Of Ketorolac Tromethamine Versus Naproxen For Moderate to Severe Back Pain Treatment

Start: Mar 2013Est. completion: Nov 201383 patients
Phase 3Completed
NCT01471899EMSKetorolac Tromethamine

Comparison Of Ketorolac Tromethamine Oral Drops Versus Naproxen For Moderate to Severe Back Pain Treatment

Start: Mar 2013Est. completion: Apr 201478 patients
Phase 3Completed
NCT00315445Purdue PharmaBuprenorphine transdermal patch

The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain.

Start: Dec 1997Est. completion: May 1998134 patients
Phase 3Completed
NCT00315874Purdue PharmaBuprenorphine transdermal delivery system

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Low Back Pain.

Start: Apr 1997Est. completion: Jan 1998225 patients
Phase 3Completed

Light Therapy for the Treatment of Back Pain in Pilots (LLL&Pilots)

Start: Mar 2018Est. completion: Jul 202442 patients
Phase 2/3Completed
NCT01415895Allodynic TherapeuticsNaltrexone and Clonidine Combination

Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain

Start: Jul 2011Est. completion: Feb 201378 patients
Phase 2Completed

The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study

Start: Apr 2026Est. completion: Mar 202824 patients
N/ANot Yet Recruiting
NCT04875273Selva TherapeuticsMagnetic Tape® aplicación

Effects of Magnetic Tape on Perceived Spine Pain and Over Ankle Dorsiflexion in Patients With Low Back Pain

Start: Mar 2022Est. completion: Sep 202239 patients
N/ACompleted
NCT04895826BOOST PharmaComputer-vision Aided Community Back Pain Physiotherapy Services

Computer-vision Aided Community Back Pain Physiotherapy Services

Start: Apr 2021Est. completion: Jun 2022100 patients
N/AUnknown
NCT04193969Spine BioPharmaPressure pain assessment using computer controlled cuff algometry

Changes in Radicular Pain and Pain Modulation

Start: Nov 2019Est. completion: Sep 202180 patients
N/ACompleted
NCT04651426Verona PharmaThe FIT Therapy patch

Use of a Non-medicated Plaster in Chronic Lumbar Back Pain.

Start: Aug 2019Est. completion: Oct 201954 patients
N/ACompleted
NCT03825991Spine BioPharmaPsychiatric Comorbidity in Back Pain Disorders

Psychiatric Comorbidity in Back Pain Disorders

Start: Jul 2019Est. completion: Jun 2021500,000 patients
N/AUnknown
NCT03680846NevroHF10 Therapy

Comparison of HF10 Therapy Combined With CMM to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain

Start: Sep 2018Est. completion: Nov 2022211 patients
N/AUnknown

Pilot Study to Examine the Feasibility of the Dynamic Interferential Spinal Cord Stimulation System™ (DISCSS™)

Start: Dec 2017Est. completion: Feb 202018 patients
N/ATerminated
NCT03179202SPR TherapeuticsSPRINT Peripheral Nerve Stimulation

Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)

Start: Jun 2017Est. completion: May 2021166 patients
N/ACompleted

Wireless Spinal Cord Stimulation for Chronic Pain

Start: Jul 2016Est. completion: Jul 201949 patients
N/ACompleted
NCT02643290Aspen Medical productsScoliosis Bracing System

Efficacy of Peak Scoliosis Brace in Pain Management For Adult Scoliosis Patients

Start: Apr 2015Est. completion: Jan 201720 patients
N/ACompleted

Natural Experiment: "Gentle Nudge" Intervention, Eliminating Phone Call Requirement

Start: Feb 2015Est. completion: Feb 201620,000 patients
N/ACompleted

Improving Outcomes and Lowering Costs by Integration of Primary Care Providers and Pain Medicine Physicians for Pain Pts

Start: Jan 2015Est. completion: Jun 20229 patients
N/ATerminated

A Prospective, Multicenter, Randomized Control Study To Determine Clinical Effectiveness, Patient Wellness and Cost of Pain Related Care of In-Elastic Lumbar Sacral Orthoses Versus Standard Medical Treatment in Patients Presenting With Acute Low Back Pain In Primary Care Centers (The ARREST Study)

Start: Dec 2013Est. completion: Dec 201762 patients
N/ATerminated
NCT01787565PfizerpainPREMIER cohort

Pilot Evaluation to Assess the Clinical and Economic Impact of Pfizer's Pain Management Program (painPREMIER) in the Treatment of Low Back Pain, in an Occupational Health Care Setting in Finland

Start: Jan 2013Est. completion: Jan 201486 patients
N/ATerminated
NCT00386724Boston ScientificPrecision Spinal Cord Stimulation System

Effectiveness of Precision Spinal Cord Stimulation With Artisan Paddle Electrode

Start: Oct 2006Est. completion: Aug 20088 patients
N/ATerminated
NCT00370695Boston ScientificPrecision Spinal Cord Stimulation System

Spinal Cord Stimulation for Chronic and Intractable Back Pain

Start: Feb 2006Est. completion: Jul 200815 patients
N/ATerminated

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 523,372 patients
24 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.