Acne Vulgaris

59
Pipeline Programs
13
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
10
2
9
0
16
22
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
150%
Small Molecule
150%
+ 66 programs with unclassified modality

Competitive Landscape

13 companies ranked by most advanced pipeline stage

GSK
GSKLONDON, United Kingdom
27 programs
7
1
5
13
BENZOYL PEROXIDE/ CLINDAMYCINPhase 41 trial
Clindamycin 1%/Benzoyl Peroxide 5% and 0.1% tazarotenePhase 41 trial
Clindamycin and BPO 5% gelPhase 41 trial
Clindamycin and benzoyl peroxidePhase 41 trial
Clindamycin and benzoyl peroxide gelPhase 41 trial
+22 more programs
Active Trials
NCT01446237Completed125Est. Dec 2011
NCT01929278Completed37Est. Dec 2008
NCT01132443Completed72Est. Jun 2010
+24 more trials
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
20 programs
1
6
6
5
Adapalene GelPhase 41 trial
Dapsone plus Tretinoin GelPhase 41 trial
Tretinoin Facial GelPhase 41 trial
Tretinoin gelPhase 41 trial
benzoyl peroxide washPhase 41 trial
+15 more programs
Active Trials
NCT00795327CompletedEst. Sep 2009
NCT07205107RecruitingEst. Aug 2026
NCT03653403CompletedEst. Jun 2019
+17 more trials
Bayer
BayerLEVERKUSEN, Germany
6 programs
2
2
Azelaic acidPhase 41 trial
skinorenPhase 41 trial
Azelaic Acid Gel 15%Phase 32 trials
ValettePhase 31 trial
Cyproterone / EthinylestradiolN/A1 trial
+1 more programs
Active Trials
NCT02349399Completed26,065Est. Mar 2016
NCT02410031Completed759Est. Mar 2016
NCT02602470Completed206Est. Mar 2016
+4 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
clindamycinPhase 41 trial
PF-05175157Phase 23 trials
Active Trials
NCT02100527Withdrawn0Est. Oct 2014
NCT01821079Completed12Est. Apr 2013
NCT01469468Completed14Est. Dec 2011
+1 more trials
Sanofi
SanofiPARIS, France
1 program
1
clindamycin 1% / benzoyl peroxide 5% gel pumpPhase 41 trial
Active Trials
NCT00377000Completed60Est. Mar 2006
Teva
TevaIsrael - Petach Tikva
2 programs
1
1
Trifarotene 0.005 % Topical CreamPhase 31 trial
AdapalenePhase 11 trial
Active Trials
NCT01182636Completed601Est. Apr 2008
NCT05550337Completed807Est. May 2023
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
Olumacostat Glasaretil Gel, 5.0%Phase 31 trial
Olumacostat Glasaretil Gel, 7.5%Phase 1/21 trial
Active Trials
NCT01936324Completed114Est. Jun 2014
NCT03127956Completed748Est. Apr 2018
LP
Lee's PharmaceuticalChina - Guangzhou
1 program
1
Adapalene-Clindamycin Combination GelPhase 31 trial
Active Trials
NCT03615768Completed1,617Est. Apr 2020
VP
Vanda PharmaceuticalsWASHINGTON, DC
1 program
1
ImsidolimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT04856917Completed123Est. Mar 2022
Xenon Pharmaceuticals
1 program
1
XPF-005Phase 1/21 trial
Active Trials
NCT02656043Completed213Est. Mar 2017
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
1
Study CleanserPhase 11 trial
Acne MaskN/A1 trial
Acne MaskN/A2 trials
Active Trials
NCT03128723Completed45Est. Jun 2017
NCT03124381Completed126Est. Sep 2017
NCT02698436Completed103Est. Aug 2016
+1 more trials
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
RV3278AN/A1 trial
Active Trials
NCT04301063Completed54Est. May 2020
Precision BioSciences
1 program
Silk like PillowcaseN/A1 trial
Active Trials
NCT00767104Completed40Est. Mar 2009

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Bayerskinoren
Bausch HealthDapsone plus Tretinoin Gel
BayerAzelaic acid
GSKClindamycin 1%/Benzoyl Peroxide 5% and 0.1% tazarotene
GSKMAXCLARITY II
GSKMAXCLARITY II
GSKMAXCLARITY II
GSKClindamycin and BPO 5% gel
GSKClindamycin and benzoyl peroxide gel
GSKclindamycin and benzoyl peroxide
Bausch HealthTretinoin Facial Gel
GSKClindamycin and benzoyl peroxide
Bausch HealthTretinoin gel
Bausch Healthbenzoyl peroxide wash
GSKBENZOYL PEROXIDE/ CLINDAMYCIN

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 12,289 patients across 50 trials

Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin

Start: Aug 2011Est. completion: Oct 201260 patients
Phase 4Completed
NCT01313728Bausch HealthDapsone plus Tretinoin Gel

A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products

Start: Dec 2010Est. completion: Jan 2011
Phase 4Completed
NCT01038869BayerAzelaic acid

Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammatory Hyperpigmentation (PIH)

Start: Dec 2009Est. completion: May 201020 patients
Phase 4Completed
NCT01016977GSKClindamycin 1%/Benzoyl Peroxide 5% and 0.1% tazarotene

A Phase 4, Single-Blind, Randomized, Study to Compare the Tolerability and Efficacy of 0.1% Tazorac Cream When Used in Combination With Either Duac Gel or Acanya Gel for the Treatment of Facial Acne Vulgaris

Start: Oct 2009Est. completion: Apr 201040 patients
Phase 4Completed
NCT02524665GSKMAXCLARITY II

8 Week Study to Evaluate and Compare the Efficacy and Tolerability of MAXCLARITY II and MURAD To Treat Acne

Start: Sep 2009Est. completion: Dec 200920 patients
Phase 4Completed
NCT01706250GSKMAXCLARITY II

U0289-401: Eight Week, Split-face, Study to Determine and Compare the Efficacy and Tolerability of MAXCLARITY™ II to PROACTIV™

Start: Sep 2009Est. completion: Jan 201020 patients
Phase 4Completed
NCT01706263GSKMAXCLARITY II

U0289-402: An Open Label, 8 Week Study to Evaluate the Efficacy and Tolerability of MAXCLARITY II in Subjects With Acne

Start: Aug 2009Est. completion: Nov 200928 patients
Phase 4Completed
NCT01015638GSKClindamycin and BPO 5% gel

Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications

Start: Aug 2009Est. completion: Sep 200936 patients
Phase 4Completed
NCT00964223GSKClindamycin and benzoyl peroxide gel

A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne

Start: Jul 2009Est. completion: Nov 200928 patients
Phase 4Completed
NCT00964366GSKclindamycin and benzoyl peroxide

Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications

Start: Jul 2009Est. completion: Aug 200953 patients
Phase 4Completed
NCT00952523Bausch HealthTretinoin Facial Gel

Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face

Start: Jul 2009Est. completion: Oct 2009
Phase 4Completed
NCT00926367GSKClindamycin and benzoyl peroxide

Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications

Start: May 2009Est. completion: Jul 200952 patients
Phase 4Completed

Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face

Start: Apr 2009Est. completion: May 2009
Phase 4Completed
NCT00907257Bausch Healthbenzoyl peroxide wash

A Study of Different Use Regimens Using Two Acne Treatments

Start: Feb 2009Est. completion: Sep 2009
Phase 4Completed
NCT00887484GSKBENZOYL PEROXIDE/ CLINDAMYCIN

A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne

Start: Feb 2009Est. completion: Jun 200950 patients
Phase 4Completed
NCT00757523GSKEpiduo Gel

Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris

Start: Sep 2008Est. completion: Jun 2009382 patients
Phase 4Completed

Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.

Start: Jan 2008Est. completion: Feb 2008
Phase 4Completed

Evaluation of Quality of Life, Efficacy, and Tolerance of Duac® Gel Compared to Differin® Gel in the Treatment of Acne

Start: Nov 2006Est. completion: Aug 2008169 patients
Phase 4Completed
NCT00377000Sanoficlindamycin 1% / benzoyl peroxide 5% gel pump

A Pilot, Multi-Center, Patient Preference Study Comparing Two Clindamycin/Benzoyl Peroxide Gels.

Start: Nov 2005Est. completion: Mar 200660 patients
Phase 4Completed

Dalacin-T Gel Post Approval Study

Start: Jan 2005Est. completion: Jun 2005134 patients
Phase 4Completed
NCT00160394GSKDuac® Gel / Differin® Gel

Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris

Start: Dec 2004Est. completion: Aug 2005130 patients
Phase 4Completed
NCT00240513GSKMinocycline

Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

Start: Aug 2004Est. completion: Dec 200638 patients
Phase 4Terminated
NCT05550337TevaTrifarotene 0.005 % Topical Cream

Study Comparing Trifarotene Cream, 0.005% To AKLIEF ® (Trifarotene 0.005% Cream) In The Treatment Of Acne Vulgaris

Start: Sep 2022Est. completion: May 2023807 patients
Phase 3Completed

Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris

Start: Jan 2020Est. completion: Mar 2021
Phase 3Completed

Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris

Start: Jan 2020Est. completion: Jan 2021
Phase 3Completed

Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris

Start: Dec 2018Est. completion: May 2020
Phase 3Completed

Study Comparing the Safety and Efficacy of IDP-120 Gel and IDP-120 Vehicle Gel in the Treatment of Acne Vulgaris

Start: Dec 2018Est. completion: Mar 2020
Phase 3Completed
NCT03615768Lee's PharmaceuticalAdapalene-Clindamycin Combination Gel

A Study to Evaluate the Efficacy and Safety of Adapalene-Clindamycin Combination Gel in the Treatment of Acne Vulgaris

Start: Aug 2018Est. completion: Apr 20201,617 patients
Phase 3Completed

A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)

Start: Jul 2017Est. completion: Jul 2018
Phase 3Completed

A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)

Start: Jun 2017Est. completion: Jun 2018
Phase 3Completed
NCT03127956Eli Lilly and CompanyOlumacostat Glasaretil Gel, 5.0%

A Long-term Safety Study of Olumacostat Glasaretil Gel in Subjects With Acne Vulgaris

Start: Mar 2017Est. completion: Apr 2018748 patients
Phase 3Completed
NCT01017146GSKTazarotene foam

A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne - W0260-301

Start: Oct 2009Est. completion: Nov 2010744 patients
Phase 3Completed
NCT01017120GSKTazarotene Foam

A Study to Evaluate the Safety and Efficacy of Tazarotene Foam, 0.1%, in Subjects With Common Facial Acne

Start: Oct 2009Est. completion: Nov 2010742 patients
Phase 3Completed
NCT00891982GSKCTGel/ BPO Wash

A Clinical Study to Evaluate the Tolerability of a Topical Antibiotic and Retinoid Used in a Combined Regimen With a BPO Wash

Start: Apr 2009Est. completion: Jun 200960 patients
Phase 3Completed
NCT00776919GSKclindamycin / benzoyl peroxide gel

Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne

Start: Oct 2008Est. completion: Sep 20091,315 patients
Phase 3Completed

A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel

Start: Apr 2008Est. completion: May 20091,649 patients
Phase 3Completed

Study on Safety and Efficacy of an Oral Contraceptive in Treating Acne Papulopustulosa

Start: Mar 2004Est. completion: May 20051,326 patients
Phase 3Completed
NCT00031096BayerAzelaic Acid Gel 15%

Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate Acne

Start: Jan 2002Est. completion: Jul 2002879 patients
Phase 3Completed

Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel

Start: Jun 2021Est. completion: Sep 2022
Phase 2Completed

A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris

Start: May 2021Est. completion: Mar 2022123 patients
Phase 2Completed

A Phase 2, Multicenter, Randomized, Double-Blind, Vehicle Controlled, Parallel-Group, Clinical Study in the Treatment of Acne Vulgaris

Start: Oct 2017Est. completion: Apr 2019
Phase 2Completed

Safety and Efficacy of IDP-123 Lotion to Tazorac® Cream, in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Sep 2016
Phase 2Completed

Efficacy and Safety of IDP-120 Gel in the Treatment of Acne Vulgaris

Start: Nov 2015Est. completion: Sep 2016
Phase 2Completed

Study Of Safety, Tolerability And Effects Of PF-05175157 In Adults With Moderate To Severe Acne Vulgaris

Start: Apr 2014Est. completion: Oct 20140
Phase 2Withdrawn
NCT01326780Bausch Health1.2% JNJ 10229570-AAA

A Study of a New Drug Treatment for Acne

Start: Mar 2011Est. completion: Mar 2012
Phase 2Completed
NCT00907335Bausch HealthRetin-A Micro 0.04% facial acne treatment

A Study of Acne Treatment in Children Ages 9 to 11

Start: Feb 2009Est. completion: Dec 2009
Phase 2Completed
NCT00713609GSKBenzoyl peroxide gel

Safety and Efficacy Study of Clindamycin/Benzoyl Peroxide/Tazarotene Cream in Subjects With Acne

Start: Jun 2008Est. completion: Mar 2009591 patients
Phase 2Completed

A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel

Start: Sep 2015Est. completion: Mar 2017213 patients
Phase 1/2Completed
NCT01936324Eli Lilly and CompanyOlumacostat Glasaretil Gel, 7.5%

A Safety, Tolerability and Preliminary Efficacy Study of DRM01B Topical Gel

Start: Aug 2013Est. completion: Jun 2014114 patients
Phase 1/2Completed

A Study of a Hydrocolloid Bandage on Pimples

Start: Jul 2021Est. completion: Sep 202141 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

16 late-stage (Phase 3) programs — potential near-term approvals
13 companies competing in this space