Non-Small Cell Lung Cancer

Oncology
231
Pipeline Programs
30
Companies
50
Clinical Trials
16 recruiting
15
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
45
29
81
4
55
17
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
4044%
Small Molecule
3842%
ADC
910%
Gene Therapy
11%
Cell Therapy
11%
RNA Therapeutic
11%
Peptide
11%
+ 154 programs with unclassified modality

On Market (15)

Approved therapies currently available

Eli Lilly and Company
ALIMTAApproved
pemetrexed
Eli Lilly and Company
injection2004
Amgen
ARANESPApproved
darbepoetin alfa
Amgen
Erythropoiesis-stimulating Agent [EPC]subcutaneous2001
Roche
AVASTINApproved
bevacizumab
Roche
Vascular Endothelial Growth Factor Inhibitor [EPC]intravenous2004
U
BEXAROTENEApproved
bexarotene
Unknown Company
Retinoid [EPC]topical2022
DS
DATROWAYApproved
datopotamab deruxtecan
Daiichi Sankyo
iv (infusion)2025
Boehringer Ingelheim
HERNEXEOSApproved
zongertinib
Boehringer Ingelheim
Kinase Inhibitor [EPC]oral2025
AstraZeneca
IMFINZIApproved
durvalumab
AstraZeneca
Programmed Death Ligand-1 Blocker [EPC]injection2017
M&
KEYTRUDAApproved
pembrolizumab
Merck & Co.
Programmed Death Receptor-1 Blocking Antibody [EPC]intravenous2014
Regeneron
LIBTAYOApproved
cemiplimab-rwlc
Regeneron
intravenous2018
Novartis
MEKINISTApproved
trametinib
Novartis
oral2023
Bristol Myers Squibb
OPDIVOApproved
nivolumab
Bristol Myers Squibb
injection2015
U
PEMETREXED DISODIUMApproved
pemetrexed
Unknown Company
intravenous2022
AstraZeneca
TAGRISSOApproved
osimertinib
AstraZeneca
Kinase Inhibitor [EPC]oral2015
Roche
TECENTRIQApproved
atezolizumab
Roche
injection2016
Novartis
ZYKADIAApproved
ceritinib
Novartis
oral2014

Competitive Landscape

69 companies ranked by most advanced pipeline stage

AstraZeneca
22 programs
6
8
2
1
DurvalumabPhase 3Monoclonal Antibody1 trial
OsimertinibPhase 3Small Molecule5 trials
AVENIO ctDNA Surveillance KitPhase 21 trial
AZD4547Phase 24 trials
AZD9291Phase 21 trial
+17 more programs
Active Trials
NCT07413757Not Yet Recruiting590Est. Jun 2026
NCT04430712Completed60Est. Aug 2022
NCT03219970Completed156Est. Oct 2020
+29 more trials
DS
13 programs
1
7
3
1
Datopotamab DeruxtecanPhase 3ADC1 trial
OsimertinibPhase 3Small Molecule1 trial
Trastuzumab DeruxtecanPhase 3ADC1 trial
CS-1008Phase 21 trial
DS-1062aPhase 21 trial
+8 more programs
Active Trials
NCT06557967Completed22,517Est. Sep 2024
NCT06809764Recruiting150Est. Feb 2027
NCT06644768Recruiting137Est. Apr 2030
+10 more trials
Novartis
NovartisBASEL, Switzerland
13 programs
4
1
5
1
1
bisphosphatesPhase 41 trial
CeritinibPhase 3Small Molecule1 trial
DovitinibPhase 2Small Molecule5 trials
Imatinib MesylatePhase 21 trial
LDK378Phase 21 trial
+8 more programs
Active Trials
NCT04575025Completed109Est. Oct 2024
NCT01071928Withdrawn0Est. Jun 2010
NCT01278758Terminated7
+22 more trials
Roche
RocheSTAVANGER NORWAY, Norway
11 programs
2
3
5
1
ErlotinibPhase 4Small Molecule1 trial
AlectinibPhase 3Small Molecule1 trial
AtezolizumabPhase 3Monoclonal Antibody1 trial
AtezolizumabPhase 3Monoclonal Antibody1 trial
DivarasibPhase 3
+6 more programs
Active Trials
NCT00453362Completed88Est. Apr 2010
NCT05240131Active Not Recruiting88Est. Nov 2025
NCT06862869Recruiting800Est. Apr 2029
+15 more trials
Bristol Myers Squibb
9 programs
1
6
1
1
NivolumabPhase 3Monoclonal Antibody1 trial
BMS-275183Phase 21 trial
BMS-275183Phase 21 trial
CetuximabPhase 2Monoclonal Antibody
CetuximabPhase 2Monoclonal Antibody1 trial
+4 more programs
Active Trials
NCT02910999Completed868Est. Dec 2023
NCT00103831Completed
NCT00099879Terminated
+5 more trials
Amgen
9 programs
1
1
3
2
1
AMG 706Phase 35 trials
Darbepoetin alfaPhase 31 trial
Intervention A: Irinotecan; Oxaliplatin; NeulastaPhase 21 trial
RMC-4630Phase 21 trial
darbepoetin alfaPhase 21 trial
+4 more programs
Active Trials
NCT07143513Recruiting115Est. Jun 2026
NCT05347797Completed495Est. Apr 2021
NCT04822298Terminated3Est. Jan 2022
+10 more trials
M&
Merck & Co.RAHWAY, NJ
9 programs
2
1
2
4
1
Intismeran autogenePhase 3
M7824Phase 35 trials
PembrolizumabPhase 3Monoclonal Antibody1 trial
TecemotidePhase 3Peptide5 trials
Lead-In RidaforolimusPhase 21 trial
+4 more programs
Active Trials
NCT06575933Completed28Est. Oct 2024
NCT02824965Unknown11Est. Oct 2021
NCT05882734Active Not RecruitingEst. Mar 2026
+12 more trials
Boehringer Ingelheim
1
2
1
1
ZongertinibPhase 3Small Molecule1 trial
AfatinibPhase 2Small Molecule1 trial
BIBW 2992Phase 21 trial
AfatinibPhase 1Small Molecule1 trial
AfatinibN/ASmall Molecule1 trial
+1 more programs
Active Trials
NCT04909073Recruiting69Est. Dec 2025
NCT01074177Completed24Est. Mar 2017
NCT01836341Withdrawn0Est. Apr 2015
+3 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
6 programs
1
3
1
1
PemetrexedPhase 31 trial
Bevacizumab, Oxaliplatin, PemetrexedPhase 21 trial
CetuximabPhase 2Monoclonal Antibody1 trial
Pemetrexed 500 mg/m2Phase 21 trial
enzastaurinPhase 1/21 trial
+1 more programs
Active Trials
NCT05254795Active Not Recruiting659Est. Dec 2026
NCT00452413Completed65Est. Nov 2013
NCT00251524Completed69Est. May 2009
+3 more trials
Regeneron
RegeneronTARRYTOWN, NY
5 programs
1
1
2
1
CemiplimabPhase 3Monoclonal Antibody1 trial
REGN2810/ipiPhase 3
fianlimabPhase 2/3Monoclonal Antibody1 trial
CemiplimabPhase 2Monoclonal Antibody1 trial
LIBTAYO(Cemiplimab)N/AMonoclonal Antibody5 trials
Active Trials
NCT07433673Recruiting20Est. Jan 2029
NCT06449313Recruiting21Est. Sep 2032
NCT07234058Not Yet Recruiting126Est. Sep 2029
+5 more trials
Genentech
14 programs
3
3
7
1
bevacizumabPhase 3Monoclonal Antibody1 trial
BevacizumabPhase 2Monoclonal Antibody1 trial
CarboplatinPhase 21 trial
DocetaxelPhase 2
ErlotinibPhase 2Small Molecule1 trial
+9 more programs
Active Trials
NCT04911166Terminated13Est. Apr 2025
NCT04449874Active Not Recruiting498Est. Dec 2027
NCT01026844Terminated27Est. Nov 2012
+6 more trials
CT
2
2
3
2
1
TQB2450 injection, docetaxel injection matching placebo, AL2846 capsulesPhase 31 trial
AnlotinibPhase 2/3Small Molecule1 trial
AnlotinibPhase 2/3Small Molecule1 trial
AnlotinibPhase 2Small Molecule1 trial
Anlotinib Plus DocetaxelPhase 21 trial
+6 more programs
Active Trials
NCT03998085UnknownEst. Dec 2021
NCT03910127UnknownEst. Jun 2021
NCT03754244TerminatedEst. Feb 2022
+8 more trials
Heidelberg Pharma
1
1
preoperative radiochemotherapyPhase 31 trial
AtezolizumabPhase 2Monoclonal Antibody1 trial
Bone marrow aspiration from the iliac crestN/A1 trial
PhotonsN/A1 trial
Preoperative radiationN/A1 trial
+1 more programs
Active Trials
NCT02515760Active Not Recruiting120Est. Sep 2025
NCT05237453Active Not Recruiting30Est. Mar 2028
NCT02319408Completed36Est. Feb 2020
+3 more trials
Sanofi
6 programs
5
1
REGN2810/ipiPhase 31 trial
Bevacizumab, Oxaliplatin, PemetrexedPhase 2
Docetaxel/Carboplatin/Bevacizumab/ErlotinibPhase 2Small Molecule1 trial
Intervention A: Irinotecan; Oxaliplatin; NeulastaPhase 2
RMC-4630Phase 2
+1 more programs
Active Trials
NCT00621049Completed112Est. Feb 2014
NCT07133425Recruiting29Est. Feb 2030
NCT03515629Terminated5Est. Jul 2021
E
6 programs
2
4
PembrolizumabPhase 3Monoclonal Antibody1 trial
PembrolizumabPhase 3Monoclonal Antibody1 trial
bexarotenePhase 31 trial
bexarotene with carboplatin and paclitaxelPhase 31 trial
LenvatinibPhase 2Small Molecule1 trial
+1 more programs
Active Trials
NCT01529112Completed135Est. Jun 2015
NCT01104155Completed123Est. Jan 2017
NCT04676412Completed107Est. Mar 2024
+3 more trials
GS
5 programs
1
1
3
Sacituzumab Govitecan-hziyPhase 3ADC1 trial
ZimberelimabPhase 3Monoclonal Antibody
ZimberelimabPhase 3Monoclonal Antibody5 trials
Sacituzumab Govitecan-hziyPhase 2ADC1 trial
CART-TnMUC1Phase 1Cell Therapy1 trial
Active Trials
NCT04025216Terminated16Est. Dec 2022
NCT05186974Active Not Recruiting193Est. Sep 2026
NCT05089734Active Not Recruiting603Est. Jan 2026
+5 more trials
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
5 programs
2
2
1
WX-0593 TabletsPhase 31 trial
WX-0593Phase 21 trial
WX-0593 TabletsPhase 21 trial
QLC1101Phase 11 trial
QLH11811Phase 11 trial
Active Trials
NCT06403735RecruitingEst. Apr 2027
NCT05555212UnknownEst. Dec 2025
NCT05801107UnknownEst. Dec 2023
+2 more trials
H
4 programs
1
1
2
SavolitinibPhase 3Small Molecule1 trial
Savolitinib + OsimertinibPhase 3Small Molecule1 trial
FruquintinibPhase 2Small Molecule1 trial
VolitinibPhase 1Small Molecule1 trial
Active Trials
NCT02374645Completed64Est. Sep 2018
NCT02590965Completed91Est. Feb 2017
NCT05009836Active Not Recruiting320Est. Aug 2026
+1 more trials
Astellas
AstellasChina - Shenyang
4 programs
1
1
2
ErlotinibPhase 3Small Molecule1 trial
ExisulindPhase 32 trials
TarcevaPhase 21 trial
ASP8273Phase 1/25 trials
Active Trials
NCT03082300Terminated3Est. Jun 2017
NCT03042013Withdrawn0Est. Feb 2017
NCT02674555Withdrawn0Est. Nov 2016
+6 more trials
Takeda
3 programs
1
1
AMG 706Phase 3
DocetaxelPhase 1/25 trials
RNAseqN/A1 trial
Active Trials
NCT05122806Recruiting100Est. Jun 2027
NCT07217301Recruiting600Est. Dec 2029
NCT03486314Completed20Est. Feb 2021
+3 more trials
Arcus Biosciences
3 programs
1
2
DurvalumabPhase 3Monoclonal Antibody
ZimberelimabPhase 3Monoclonal Antibody
EtrumadenantPhase 11 trial
Active Trials
NCT03629756CompletedEst. Sep 2021
CP
3 programs
1
2
DivarasibPhase 31 trial
DivarasibPhase 31 trial
RO7496353Phase 11 trial
Active Trials
NCT05867121Active Not Recruiting102Est. Jun 2026
NCT06793215Recruiting600Est. Oct 2030
NCT06497556Active Not Recruiting338Est. Nov 2029
MediLink Therapeutics
1
1
YL202Phase 31 trial
BNT326Phase 1/21 trial
Active Trials
NCT07111520RecruitingEst. Jan 2030
NCT07416994Not Yet RecruitingEst. Aug 2028
Alliance Pharmaceuticals
1
1
SBRTPhase 31 trial
IrinotecanPhase 1/21 trial
Active Trials
NCT01607554Terminated2Est. Mar 2013
NCT06686771Recruiting320Est. Dec 2030
Achieve Life Sciences
2 programs
1
1
CustirsenPhase 3RNA Therapeutic1 trial
custirsen sodiumPhase 1/21 trial
Active Trials
NCT00138658CompletedEst. Mar 2010
NCT01630733UnknownEst. Jul 2017
BeyondSpring Pharmaceuticals
2
Docetaxel + PlinabulinPhase 31 trial
PlinabulinPhase 31 trial
Active Trials
NCT02504489CompletedEst. May 2021
NCT07361484Not Yet RecruitingEst. Dec 2029
HM
2
Rehabilitation TrainingPhase 31 trial
Rehabilitation TrainingPhase 31 trial
Active Trials
NCT03372694UnknownEst. Dec 2019
NCT03244605UnknownEst. Dec 2019
FP
Fosun PharmaAustralia - Sydney
1 program
1
Drug: Foritinib SuccinatePhase 31 trial
Active Trials
NCT06569420Active Not Recruiting275Est. Dec 2027
InxMed
InxMedChina - Beijing
1 program
1
IN10018 in combination with D-1553Phase 31 trial
Active Trials
NCT07174908Recruiting400Est. Sep 2030
Moderna
1 program
1
Intismeran autogenePhase 31 trial
Active Trials
NCT06077760Recruiting868Est. Dec 2035

+39 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AstraZenecaOsimertinib
AstraZenecaOsimertinib
AstraZenecaOther
AstraZenecaOther
RocheErlotinib
AstraZenecaOther
AstraZenecaOther
RocheErlotinib
Novartisbisphosphates
AstraZenecaOther
AstraZenecaOther
AstraZenecaOther
Eisaibexarotene
AstraZenecaOther
BeyondSpring PharmaceuticalsPlinabulin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 19,701 patients across 50 trials

Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After Adjuvant Osimertinib for EGFRm Resectable SIB-IIIA NSCLC.

Start: Jan 2026Est. completion: May 2030100 patients
Phase 4Not Yet Recruiting

Real-World Study on Gene Profile in Patients With Advanced NSCLC Who Progressed on First-Line Osimertinib Therapy(GPS).

Start: Feb 2022Est. completion: Apr 2024182 patients
Phase 4Completed

Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2016-2017 Season

Start: May 2016Est. completion: Nov 2016301 patients
Phase 4Completed

Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults for the 2015-2016 Season

Start: Jun 2015Est. completion: Jan 2016301 patients
Phase 4Completed

Progression Free Survival (PFS) Using Erlotinib for Non-Small-Cell Lung Cancer (NSCLC) in Chinese Population

Start: Jan 2014Est. completion: Dec 201445 patients
Phase 4Completed

Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults

Start: May 2013Est. completion: Dec 2013300 patients
Phase 4Completed

A Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults

Start: May 2012Est. completion: Nov 2012303 patients
Phase 4Completed

A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Following 4 Cycles of Platinum-based Chemotherapy Without Disease Progression

Start: Mar 2011Est. completion: Sep 201351 patients
Phase 4Completed
NCT00765687Novartisbisphosphates

Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates

Start: Aug 2008Est. completion: May 2012432 patients
Phase 4Completed

Does Fluticasone Propionate Reduce the Late Allergic Reaction When the Drug is Given Post-allergen?

Start: Jul 2008Est. completion: Dec 20087 patients
Phase 4Completed

Chlorhydrate of Ropivacaine and Breast Cancer Surgery

Start: Sep 2006Est. completion: Nov 2008260 patients
Phase 4Completed

Compare the Value of Prophylactic Versus Therapeutic Breast Radiotherapy in CASODEX

Start: Jun 2003125 patients
Phase 4Completed

Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer

Est. completion: Mar 2005623 patients
Phase 3Completed

Protection of Ovarian Function With Goserelin Acetate in Premenopausal Early Breast Cancer Patients With Chemotherapy

Est. completion: Apr 2012102 patients
Phase 3Withdrawn

Docetaxel Plus Plinabulin vs Docetaxel Plus Placebo in Advanced/Metastatic Non-Squamous NSCLC After PD-1/PD-L1 Therapy and Platinum Chemotherapy (DUBLIN-4)

Start: Jun 2026Est. completion: Dec 2029
Phase 3Not Yet Recruiting

Pivotal Study to Evaluate YL202 Versus Docetaxel in Patients With Locally Advanced or Metastatic EGFR Sensitive Mutation Non-Squamous Non-Small Cell Lung Cancer

Start: Mar 2026Est. completion: Aug 2028
Phase 3Not Yet Recruiting

Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Start: Jan 2026Est. completion: Sep 2036400 patients
Phase 3Recruiting

A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy

Start: Jan 2026Est. completion: Mar 2029390 patients
Phase 3Recruiting

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

Start: Dec 2025Est. completion: Dec 2030320 patients
Phase 3Recruiting

IBI363 vs Docetaxel in Patients With Advanced Squamous Lung Cancer After Standard Treatments Have Failed

Start: Nov 2025Est. completion: Dec 2029600 patients
Phase 3Recruiting
NCT06899126Daiichi SankyoTrastuzumab Deruxtecan

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

Start: Oct 2025Est. completion: Jul 2032686 patients
Phase 3Recruiting

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Start: Oct 2025Est. completion: Oct 2030600 patients
Phase 3Recruiting
NCT07174908InxMedIN10018 in combination with D-1553

A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation

Start: Sep 2025Est. completion: Sep 2030400 patients
Phase 3Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

Start: Apr 2025Est. completion: Dec 2030830 patients
Phase 3Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

Start: Nov 2024Est. completion: Mar 2030878 patients
Phase 3Recruiting

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

Start: Oct 2024Est. completion: Aug 20321,000 patients
Phase 3Recruiting

A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

Start: Sep 2024Est. completion: Nov 2029338 patients
Phase 3Active Not Recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

Start: Sep 2024Est. completion: Jul 2033560 patients
Phase 3Recruiting

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

Start: Apr 2024Est. completion: May 2032582 patients
Phase 3Recruiting
NCT06357533Daiichi SankyoDatopotamab Deruxtecan

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Start: Apr 2024Est. completion: Dec 2029675 patients
Phase 3Recruiting
NCT06077760ModernaIntismeran autogene

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Start: Dec 2023Est. completion: Dec 2035868 patients
Phase 3Recruiting
NCT05922345Chia Tai TianQing Pharmaceutical GroupTQB2450 injection, docetaxel injection matching placebo, AL2846 capsules

Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.

Start: Jun 2023Est. completion: Dec 2025
Phase 3Recruiting

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)

Start: May 2023Est. completion: Feb 202737 patients
Phase 3Active Not Recruiting

Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer

Start: Oct 2022Est. completion: Jan 20291,021 patients
Phase 3Active Not Recruiting

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

Start: Aug 2022Est. completion: Dec 2026324 patients
Phase 3Recruiting

A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour Resection

Start: Feb 2022Est. completion: Nov 2032390 patients
Phase 3Active Not Recruiting

A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

Start: Feb 2022Est. completion: Jul 20301,051 patients
Phase 3Active Not Recruiting
NCT06569420Fosun PharmaDrug: Foritinib Succinate

Study Of Comparing SAF-189s With Crizotinib In First Line ALK-Positive Advanced and Metastatic NSCLC

Start: Dec 2021Est. completion: Dec 2027275 patients
Phase 3Active Not Recruiting
NCT05015608HutchmedSavolitinib + Osimertinib

Study on Savolitinib Combined With Osimertinib in Treatment of Advanced NSCLC With MET Amplification

Start: Nov 2021Est. completion: Dec 2025250 patients
Phase 3Active Not Recruiting
NCT05089734Gilead SciencesSacituzumab Govitecan-hziy

Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Start: Nov 2021Est. completion: Jan 2026603 patients
Phase 3Active Not Recruiting

A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer (NSCLC)

Start: Sep 2021Est. completion: Jun 202698 patients
Phase 3Active Not Recruiting

Clinical Study on Savolitinib + Osimertinib in Treatment of EGFRm+/MET+ Locally Advanced or Metastatic NSCLC

Start: Sep 2021Est. completion: Aug 2026320 patients
Phase 3Active Not Recruiting

A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

Start: Dec 2020Est. completion: Jun 2029358 patients
Phase 3Active Not Recruiting

Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer

Start: Oct 2020Est. completion: Sep 2026370 patients
Phase 3Active Not Recruiting
NCT04676412EisaiPembrolizumab

Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study

Start: Oct 2019Est. completion: Mar 2024107 patients
Phase 3Completed

A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

Start: Jul 2019Est. completion: Dec 2026587 patients
Phase 3Active Not Recruiting

Study Comparing WX-0593 to Crizotinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) Patients

Start: Jun 2019Est. completion: Dec 2024
Phase 3Unknown
NCT03829332EisaiPembrolizumab

Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007)

Start: Mar 2019Est. completion: Apr 2024623 patients
Phase 3Completed

Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

Start: Mar 2019Est. completion: Oct 2028724 patients
Phase 3Active Not Recruiting

M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)

Start: Oct 2018Est. completion: Jun 2024304 patients
Phase 3Completed

Related Jobs in Oncology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

55 late-stage (Phase 3) programs — potential near-term approvals
16 actively recruiting trials targeting 19,701 patients
30 companies competing in this space