Atopic Dermatitis

Immunology
115
Pipeline Programs
30
Companies
50
Clinical Trials
6 recruiting
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
15
3
40
1
27
29
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
2273%
Small Molecule
827%
+ 98 programs with unclassified modality

On Market (10)

Approved therapies currently available

U
BARICITINIBApproved
baricitinib
Unknown Company
oral2024
U
CRISABOROLEApproved
crisaborole
Unknown Company
Regeneron
DUPIXENTApproved
dupilumab
Regeneron
Interleukin-4 Receptor alpha Antagonist [EPC]injection2017
Eli Lilly and Company
EBGLYSSApproved
lebrikizumab-lbkz
Eli Lilly and Company
Interleukin-13 Antagonist [EPC]injection2024
U
LEVOCETIRIZINE DIHYDROCHLORIDEApproved
levocetirizine dihydrochloride
Unknown Company
oral2015
U
MONTELUKAST SODIUMApproved
montelukast
Unknown Company
oral2020
VP
NEREUSApproved
tradipitant
Vanda Pharmaceuticals
oral2025
U
OLUMIANTApproved
baricitinib
Unknown Company
oral2025
AbbVie
RINVOQApproved
upadacitinib
AbbVie
Janus Kinase Inhibitor [EPC]oral2019
AbbVie
RINVOQ LQApproved
upadacitinib
AbbVie
Janus Kinase Inhibitor [EPC]oral2024

Competitive Landscape

41 companies ranked by most advanced pipeline stage

Regeneron
RegeneronTARRYTOWN, NY
14 programs
3
3
6
DupilumabPhase 4Monoclonal Antibody
DupilumabPhase 4Monoclonal Antibody
DupilumabPhase 4Monoclonal Antibody1 trial
DupilumabPhase 4Monoclonal Antibody1 trial
Dupilumab Only ProductPhase 41 trial
+9 more programs
Active Trials
NCT05268107Recruiting30Est. Jun 2027
NCT05042258Recruiting40Est. Dec 2025
NCT04520308Unknown45Est. Mar 2021
+1 more trials
Pfizer
PfizerNEW YORK, NY
11 programs
2
1
1
3
CrisaborolePhase 41 trial
CrisaborolePhase 41 trial
Crisaborole 2%Phase 41 trial
Crisaborole OintmentPhase 35 trials
PF-07038124 ointmentPhase 21 trial
+6 more programs
Active Trials
NCT05387980Active Not Recruiting1,128Est. Aug 2028
NCT03770858Completed23Est. Aug 2022
NCT04008784Completed16Est. Sep 2020
+13 more trials
Sanofi
SanofiPARIS, France
7 programs
3
1
2
DupilumabPhase 4Monoclonal Antibody1 trial
DupilumabPhase 4Monoclonal Antibody1 trial
fexofenadine/AllegraPhase 2/31 trial
PRN473Phase 21 trial
REGN3500Phase 21 trial
+2 more programs
Active Trials
NCT06032403Active Not Recruiting200Est. Aug 2025
NCT04992546Completed39Est. Dec 2022
NCT03736967Terminated206Est. Jul 2020
+5 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
7 programs
3
4
1
BaricitinibPhase 3Small Molecule1 trial
BaricitinibPhase 3Small Molecule1 trial
BaricitinibPhase 3Small Molecule1 trial
EBGLYSS(Lebrikizumab)Phase 3Monoclonal Antibody3 trials
OLUMIANT(Baricitinib)Phase 2Small Molecule1 trial
+2 more programs
Active Trials
NCT02576938Completed124Est. Mar 2017
NCT01993420Completed21Est. Mar 2014
NCT03831191Terminated136Est. Feb 2020
+6 more trials
Bayer
BayerLEVERKUSEN, Germany
6 programs
4
1
Hydrogel vehiclePhase 41 trial
MapracoratPhase 21 trial
MapracoratPhase 21 trial
MapracoratPhase 21 trial
Sinecort creamPhase 21 trial
+1 more programs
Active Trials
NCT03441568Completed40Est. Aug 2019
NCT01408511Completed23Est. Dec 2011
NCT01407510Completed12Est. Apr 2012
+3 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
6 programs
1
2
2
1
UpadacitinibPhase 4Small Molecule1 trial
UpadacitinibPhase 3Small Molecule1 trial
UpadacitinibPhase 3Small Molecule1 trial
LutikizumabPhase 2Monoclonal Antibody5 trials
UpadacitinibPhase 2Small Molecule1 trial
+1 more programs
Active Trials
NCT04262791Terminated16Est. Jan 2022
NCT06718101Active Not Recruiting83Est. May 2027
NCT06548542Recruiting540Est. Aug 2028
+7 more trials
Novartis
NovartisBASEL, Switzerland
5 programs
1
1
2
PimecrolimusPhase 45 trials
PimecrolimusPhase 41 trial
ZPL389 30mgPhase 21 trial
CEE321Phase 11 trial
PimecrolimusN/A1 trial
Active Trials
NCT00946478Completed40Est. May 2011
NCT04612062Completed28Est. May 2021
NCT03948334Terminated123Est. Aug 2020
+6 more trials
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
4 programs
1
Sodium hypochloritePhase 41 trial
F# 11054-010N/A1 trial
Moisturizer Body LotionN/A1 trial
Moisturizer Body LotionN/A1 trial
Active Trials
NCT00886587Completed82Est. Jun 2009
NCT05062213Completed34Est. May 2022
NCT04950374Withdrawn0Est. Dec 2021
+1 more trials
UP
4 programs
2
1
1
Levocetirizine dihydrochloridePhase 41 trial
GalvokimigPhase 21 trial
UCB1381Phase 1/21 trial
UCB9741Phase 1/21 trial
Active Trials
NCT05277571Completed273Est. Sep 2025
NCT04643457Completed107Est. Jun 2024
NCT07277660Recruiting160Est. Mar 2028
+1 more trials
VP
Vanda PharmaceuticalsWASHINGTON, DC
3 programs
1
2
1
TradipitantPhase 31 trial
TradipitantPhase 31 trial
TradipitantPhase 21 trial
Active Trials
NCT02651714Completed168Est. Aug 2017
NCT03568331Completed375Est. Dec 2019
NCT04140695Terminated87Est. Oct 2020
Allergy Therapeutics
1
MontelukastPhase 41 trial
NevisenseN/A1 trial
Active Trials
NCT03581747UnknownEst. Dec 2019
NCT00557284CompletedEst. May 2009
Astellas
2 programs
1
1
AlefaceptPhase 41 trial
tacrolimus ointment 0.03%Phase 21 trial
Active Trials
NCT00801957Completed260Est. Nov 2004
NCT00832585Completed5Est. Oct 2009
Amgen
AmgenTHOUSAND OAKS, CA
7 programs
1
2
4
RocatinlimabPhase 3Monoclonal Antibody1 trial
RocatinlimabPhase 3Monoclonal Antibody1 trial
RocatinlimabPhase 3Monoclonal Antibody5 trials
Rocatinlimab Prefilled SyringePhase 31 trial
ApremilastPhase 21 trial
+2 more programs
Active Trials
NCT06268860Completed240Est. Oct 2024
NCT04306965Completed10Est. Aug 2022
NCT02525094Completed113Est. Jul 2016
+8 more trials
Pierre Fabre
Pierre FabreFrance - Aignan
6 programs
2
V0034CR01BPhase 31 trial
glycerol, paraffinPhase 31 trial
Clinical assessmentsN/A1 trial
Clinical evaluationsN/A1 trial
RT00401-GO0046N/A1 trial
+1 more programs
Active Trials
NCT07017348Completed50Est. May 2025
NCT04553224Completed17Est. Feb 2020
NCT06763939Completed32Est. Jun 2025
+3 more trials
Qilu Pharmaceutical
3
1
2
1.5% QLM3003 ointmentPhase 31 trial
QL2108 injectionPhase 31 trial
1.5% QLM3003Phase 21 trial
QL2108 injectionPhase 11 trial
QLM3003Phase 11 trial
+1 more programs
Active Trials
NCT06614907CompletedEst. Dec 2024
NCT05932888CompletedEst. Aug 2023
NCT06946641RecruitingEst. Apr 2026
+3 more trials
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
3 programs
2
IDP-124 LotionPhase 31 trial
IDP-124 LotionPhase 31 trial
PimecrolimusN/A1 trial
Active Trials
NCT00568997Active Not RecruitingEst. Jun 2028
NCT03058783CompletedEst. May 2020
NCT03002571CompletedEst. Apr 2020
CT
1
1
1
TQH2722 injectionPhase 31 trial
TQH2722 injection 300mg-150mgPhase 21 trial
TQH2722 injectionPhase 11 trial
Active Trials
NCT05409326UnknownEst. Aug 2023
NCT05970432UnknownEst. Mar 2024
NCT06552520Not Yet RecruitingEst. Jun 2026
Connect Biopharma
Connect BiopharmaSAN DIEGO, CA
2 programs
1
1
CBP-201Phase 31 trial
CBP-201Phase 21 trial
Active Trials
NCT05905133UnknownEst. Jun 2024
NCT05614817WithdrawnEst. Jul 2025
Acrotech Biopharma
2
DifamilastPhase 31 trial
DifamilastPhase 31 trial
Active Trials
NCT05608343CompletedEst. Oct 2023
NCT05571943CompletedEst. Jul 2024
InnoCare
InnoCareChina - Beijing
1 program
1
ICP-332 TabletsPhase 31 trial
Active Trials
NCT06775860Recruiting552Est. Dec 2026
Biogen
BiogenCAMBRIDGE, MA
2 programs
1
AlefaceptPhase 21 trial
Skin TapingN/A1 trial
Active Trials
NCT02125695Completed37Est. Aug 2016
NCT00376129Completed10Est. Jan 2007
DS
Daiichi SankyoChina - Shanghai
2 programs
1
1
SUN13834Phase 21 trial
DS-2741aPhase 11 trial
Active Trials
NCT04211415Terminated8Est. Dec 2020
NCT00717769Completed270Est. Apr 2009
RAPT Therapeutics
RAPT TherapeuticsSOUTH SAN FRANCISCO, CA
2 programs
1
1
RPT193Phase 21 trial
RPT193Phase 11 trial
Active Trials
NCT04271514CompletedEst. Apr 2021
NCT05399368TerminatedEst. May 2024
Yirui Pharma
Yirui PharmaChina - Hangzhou
2 programs
1
1
YR001 ointmentPhase 21 trial
YR001 Dose A on low body surface areaPhase 11 trial
Active Trials
NCT05718921CompletedEst. Dec 2023
NCT06309355CompletedEst. Nov 2025
DermBiont
DermBiontMA - Boston
2 programs
2
DBI-001Phase 21 trial
J. lividumPhase 21 trial
Active Trials
NCT05253755Terminated10Est. Sep 2022
NCT04192513Terminated9Est. Jun 2020
Galapagos
Galapagos2800 MECHELEN, Belgium
2 programs
2
MOR 106Phase 21 trial
MOR106Phase 21 trial
Active Trials
NCT03568071Terminated207Est. Mar 2020
NCT03864627Terminated33Est. Feb 2020
Q32 Bio
Q32 BioMA - Waltham
1 program
1
ADX-914Phase 21 trial
Active Trials
NCT05509023Active Not Recruiting102Est. Dec 2024
Celldex Therapeutics
1
BarzolvolimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT06727552Active Not Recruiting131Est. May 2027
AnaptysBio
AnaptysBioSAN DIEGO, CA
1 program
1
EtokimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03533751CompletedEst. Dec 2019
Bavarian Nordic
Bavarian NordicDenmark - Kvistgard
1 program
1
IMVAMUNEPhase 21 trial
Active Trials
NCT00316602Completed632Est. Apr 2010

+11 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
RegeneronDupilumab
AbbVieUpadacitinib
SanofiDupilumab
RegeneronDupilumab
PfizerCrisaborole 2%
RegeneronDupixent
RegeneronDupilumab Only Product
PfizerCrisaborole 2% Top Oint
PfizerCrisaborole
PfizerCrisaborole
SanofiDupilumab
PfizerCrisaborole Ointment
PfizerCrisaborole Ointment
BayerHydrogel vehicle
UCB PharmaLevocetirizine dihydrochloride

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 11,511 patients across 50 trials

Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis

Start: Aug 2024Est. completion: Dec 202540 patients
Phase 4Recruiting
NCT05507580AbbVieUpadacitinib

A Study to Assess Treat-to-Target and Dosing Flexibility of Oral Upadacitinib Tablets in Adult Participants With Moderate to Severe Atopic Dermatitis

Start: May 2023Est. completion: Aug 2024461 patients
Phase 4Completed

Dupilumab-pediatric Skin Barrier Function and Lipidomics Study in Patients With Atopic Dermatitis in China

Start: Feb 2023Est. completion: Mar 202434 patients
Phase 4Completed

Ethnic Differences in Mechanisms of Action of Dupilumab

Start: Jan 2023Est. completion: Jun 202730 patients
Phase 4Recruiting
NCT05200403PfizerCrisaborole 2%

Improvement In Scratch Behavior And Sleep In Patients With Atopic Dermatitis

Start: Jul 2022Est. completion: Feb 202472 patients
Phase 4Terminated

Dupixent and Narrowband UVB for Atopic Dermatitis

Start: Apr 2022Est. completion: Dec 202440 patients
Phase 4Recruiting
NCT04520308RegeneronDupilumab Only Product

An Open-label, Single-arm Longitudinal Study With Dupilumab for Patients With Atopic Dermatitis

Start: Sep 2020Est. completion: Mar 202145 patients
Phase 4Unknown
NCT04214197PfizerCrisaborole 2% Top Oint

Study of Crisaborole Ointment 2% in Mild to Moderate Atopic Dermatitis

Start: Feb 2020Est. completion: Aug 2021150 patients
Phase 4Unknown

Steroid-reducing Effects of Crisaborole

Start: Dec 2019Est. completion: Feb 202424 patients
Phase 4Completed

Response of Children With Atopic Dermatitis (Eczema) to Eucrisa

Start: Oct 2019Est. completion: Feb 202230 patients
Phase 4Completed

Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis

Start: Oct 2018Est. completion: Feb 202317 patients
Phase 4Completed
NCT03539601PfizerCrisaborole Ointment

A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD

Start: Apr 2018Est. completion: Dec 2020237 patients
Phase 4Terminated
NCT03356977PfizerCrisaborole Ointment

A Study of Crisaborole Ointment 2% in Children Aged 3-24 Months With Mild to Moderate Atopic Dermatitis

Start: Jan 2018Est. completion: Apr 2019137 patients
Phase 4Completed
NCT01065714BayerHydrogel vehicle

A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis

Start: Feb 2010Est. completion: Nov 201020 patients
Phase 4Completed
NCT00884325UCB PharmaLevocetirizine dihydrochloride

Management of Pruritus With Xyzal in Atopic Dermatitis

Start: Feb 2009Est. completion: Jan 201040 patients
Phase 4Completed

Efficacy Study of Montelukast in Atopic Dermatitis Induced by Food Allergens

Start: Mar 2008Est. completion: May 2009
Phase 4Completed

Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis

Start: Jan 2008Est. completion: Oct 20095 patients
Phase 4Completed

Study of Pimecrolimus Treatment for Atopic Dermatitis of African American Children

Start: Nov 2006Est. completion: Jun 200818 patients
Phase 4Terminated

Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis

Start: Mar 2006Est. completion: Dec 200741 patients
Phase 4Completed
NCT00179959Johnson & JohnsonSodium hypochlorite

The Impact of Treating Staphylococcus Aureus Infection and Colonization on the Clinical Severity of Atopic Dermatitis

Start: Sep 2005Est. completion: Mar 201131 patients
Phase 4Completed

Efficacy and Safety of Pimecrolimus Cream 1% in Patients (2 to 11 Years Old) With Mild to Moderate Facial Atopic Dermatitis

Start: Aug 2005Est. completion: Aug 2006200 patients
Phase 4Completed

Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis

Start: May 2005Est. completion: Jan 2007400 patients
Phase 4Completed

Open Label Study of Long Term Treatment of Pediatric Treatment of Atopic Dermatitis With Pimecrolimus Cream 1% Within a Usual Clinical Setting

Start: Apr 2005200 patients
Phase 4Completed

Quality of Life Study in Adults With Facial Eczema

Start: Mar 2005Est. completion: Jan 200676 patients
Phase 4Completed

Efficacy and Safety of Pimecrolimus Cream 1% in Patients ≥ 3 Months of Age With Mild or Moderate Atopic Dermatitis

Start: Dec 2004Est. completion: Dec 2005
Phase 4Completed

Assessment of Pruritus Improvement With Pimecrolimus Treatment on the Areas Affected by Mild-to-moderate AD, in Patients 2- to 11- Year-old

Start: Dec 2004117 patients
Phase 4Completed

A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis

Start: Oct 2004Est. completion: Dec 2004
Phase 4Completed

Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients

Start: Oct 2004Est. completion: Jul 2005200 patients
Phase 4Completed

Combination Therapy for Atopic Dermatitis

Start: Oct 2004Est. completion: Jun 200590 patients
Phase 4Completed

Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects

Start: Sep 2004Est. completion: Sep 2005
Phase 4Completed

Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis

Start: Apr 2004Est. completion: Jun 200570 patients
Phase 4Completed

Open-label Study to Investigate Systemic Exposure in Adult and Pediatric Atopic Dermatitis Patients Treated 8.5 Days With Pimecrolimus Cream 1% Under Occlusion

Start: Mar 200420 patients
Phase 4Completed

Safety and Efficacy of Pimecrolimus Cream 1% in Atopic Disease Modification

Start: Oct 2003Est. completion: Nov 20081,091 patients
Phase 4Terminated
NCT06880276Qilu Pharmaceutical1.5% QLM3003 ointment

Efficacy and Safety Study of QLM3003 Ointment in Participants With Mild or Moderate Atopic Dermatitis

Start: May 2025Est. completion: May 2027
Phase 3Recruiting

A Phase Ⅲ Comparative Study of QL2108 to Dupixent®

Start: Apr 2025Est. completion: Apr 2028
Phase 3Not Yet Recruiting
NCT06775860InnoCareICP-332 Tablets

ICP-332 in Subjects With Moderate to Severe Atopic Dermatitis

Start: Nov 2024Est. completion: Dec 2026552 patients
Phase 3Recruiting

To Evaluate the Phase III Clinical Trial of TQH2722 Injection in the Treatment of Moderate to Severe Atopic Dermatitis

Start: Sep 2024Est. completion: Jun 2026
Phase 3Not Yet Recruiting
NCT06527404AmgenRocatinlimab

A Phase 3, Placebo-controlled, Double-blind Study Assessing Rocatinlimab in Prurigo Nodularis

Start: Jul 2024Est. completion: Jan 2027469 patients
Phase 3Active Not Recruiting

A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Start: Jun 2024Est. completion: Dec 20261,280 patients
Phase 3Recruiting
NCT06224192AmgenRocatinlimab Prefilled Syringe

A Study With Self-administered Rocatinlimab in Adolescent and Adult Participants With Moderate-to-severe Atopic Dermatitis

Start: Apr 2024Est. completion: Mar 2026151 patients
Phase 3Active Not Recruiting
NCT05899816AmgenRocatinlimab

A Study Assessing Rocatinlimab on Vaccine Antibody Response in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET - VOYAGER)

Start: Jun 2023Est. completion: Nov 2024221 patients
Phase 3Completed
NCT05882877AmgenRocatinlimab

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Start: May 2023Est. completion: Jun 20272,621 patients
Phase 3Active Not Recruiting
NCT05704738AmgenRocatinlimab

A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Start: Apr 2023Est. completion: Nov 2025532 patients
Phase 3Completed
NCT05724199AmgenRocatinlimab

A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD)

Start: Feb 2023Est. completion: Dec 2024746 patients
Phase 3Completed
NCT05633355AmgenRocatinlimab

A Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

Start: Jan 2023Est. completion: Jul 2025187 patients
Phase 3Completed

A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Color

Start: Jan 2023Est. completion: Feb 202590 patients
Phase 3Completed
NCT05651711AmgenRocatinlimab

A Study Assessing Rocatinlimab (AMG 451) Monotherapy in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)

Start: Dec 2022Est. completion: Aug 2024726 patients
Phase 3Completed

CBP-201 in Adolescent and Adult Patients With Moderate-to-severe Atopic Dermatitis

Start: Dec 2022Est. completion: Jul 2025
Phase 3Withdrawn

This Study is to Assess the Efficacy of Difamilast Ointment in Mild to Moderate Atopic Dermatitis(AD)

Start: Oct 2022Est. completion: Oct 2023
Phase 3Completed

A Open-label Study to Assess the Long-term Safety of Difamilast Ointment 1% in Mild to Moderate Atopic Dermatitis

Start: Sep 2022Est. completion: Jul 2024
Phase 3Completed

Related Jobs in Immunology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

27 late-stage (Phase 3) programs — potential near-term approvals
6 actively recruiting trials targeting 11,511 patients
30 companies competing in this space