Depressive Symptoms

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Prevail TherapeuticsNY - New York

1 program

Atomoxetine HydrochloridePhase 41 trial

Active Trials

NCT00485862Completed214Est. Jan 2005

LundbeckDenmark - Copenhagen

1 program

RasagilinePhase 41 trial

Active Trials

NCT01055379Completed121Est. Jul 2012

ViiV HealthcareNC - Durham

1 program

paroxetine versus duloxetinePhase 2/3

EppendorfGermany - Hamburg

7 programs

MOODN/A1 trial

Metacognitive Training for Depression in Later LifeN/A1 trial

Metacognitive Training-Silver BeWellN/A1 trial

Open-label placeboN/A1 trial

Selfapy with therapeutic guidanceN/A1 trial

+2 more programs

Active Trials

NCT03795480Completed128Est. Jul 2018

NCT05640492Unknown120Est. Dec 2024

NCT06312241Unknown40Est. Dec 2025

+4 more trials

Angeles TherapeuticsCA - Los Angeles

6 programs

Online cognitive behavioral therapyN/A1 trial

Resiliency AppN/A1 trial

Resiliency ClassN/A1 trial

Sister Circle protocolN/A1 trial

+1 more programs

Active Trials

NCT04986969Completed444Est. Aug 2024

NCT02986945Completed30Est. Mar 2017

NCT02986126Unknown265Est. Nov 2019

+3 more trials

Oregon TherapeuticsFrance - Paris

2 programs

Group-based therapyN/A1 trial

WPD and Depression Treatment GroupN/A1 trial

Active Trials

NCT04111887Completed91Est. Dec 2018

NCT00618566Completed82Est. Sep 2012

Young BioPharmaMA - Lowell

1 program

Collaborative stepped care and peer supportN/A1 trial

Active Trials

NCT04863300Completed5,239Est. Jun 2024

Precision BioSciencesDURHAM, NC

1 program

Common Elements ToolboxN/A1 trial

Active Trials

NCT04815681Withdrawn0Est. Dec 2022

Jerusalem PharmaceuticalsIsrael - Ramallah

1 program

GOLD-Cog+N/A1 trial

Active Trials

NCT06631781Recruiting42Est. Sep 2025

Human BioSciencesWV - Martinsburg

1 program

RAP ClubN/A1 trial

Active Trials

NCT03906682Completed615Est. Aug 2021

Innovation PharmaceuticalsMA - Wakefield

1 program

Resiliency ClassN/A

LabcorpBURLINGTON, NC

1 program

Socio-emotional mental trainingN/A1 trial

Active Trials

NCT04889508Completed285Est. Mar 2022

GSKLONDON, United Kingdom

1 program

paroxetine versus duloxetinePHASE_2_31 trial

Active Trials

NCT00136383Completed40Est. Jun 2007

TevaIsrael - Petach Tikva

1 program

RasagilinePHASE_4

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

LundbeckRasagiline

Prevail TherapeuticsAtomoxetine Hydrochloride

GSKparoxetine versus duloxetine

EppendorfMetacognitive Training-Silver BeWell

Jerusalem PharmaceuticalsGOLD-Cog+

EppendorfMetacognitive Training for Depression in Later Life

Angeles TherapeuticsSister Circle protocol

Angeles TherapeuticsSparkRx Mobile App

EppendorfTreatment 'discontinuation of antidepressant medication'

EppendorfOpen-label placebo

LabcorpSocio-emotional mental training

Angeles TherapeuticsOnline cognitive behavioral therapy

Precision BioSciencesCommon Elements Toolbox

Young BioPharmaCollaborative stepped care and peer support

EppendorfMOOD

Showing 15 of 23 trials with date data

Clinical Trials (23)

Total enrollment: 8,222 patients across 23 trials

NCT01055379 LundbeckRasagiline

Rasagiline in Cognitive-impairment Related Depression: AzileCt in COgnitive-impairment Related DepressiOn

Start: Mar 2010Est. completion: Jul 2012121 patients

Phase 4Completed

NCT00485862 Prevail TherapeuticsAtomoxetine Hydrochloride

Combination Therapy in Patients With Depression

Start: Jun 2003Est. completion: Jan 2005214 patients

Phase 4Completed

NCT00136383 GSKparoxetine versus duloxetine

Comparing Paroxetine and Duloxetine on Cardiovascular Measures

Start: Mar 2005Est. completion: Jun 200740 patients

Phase 2/3Completed

NCT06312241 EppendorfMetacognitive Training-Silver BeWell

Metacognitive Training-Silver BeWell in Older Adults

Start: Feb 2024Est. completion: Dec 202540 patients

N/AUnknown

NCT06631781 Jerusalem PharmaceuticalsGOLD-Cog+

Cognitive Control Mechanisms in Older Adults

Start: Feb 2024Est. completion: Sep 202542 patients

N/ARecruiting

NCT05640492 EppendorfMetacognitive Training for Depression in Later Life

Metacognitive Training in the Older Adults With Depressive Symptoms (MCT-Silver)

Start: Jan 2023Est. completion: Dec 2024120 patients

N/AUnknown

NCT04837573 Angeles TherapeuticsSister Circle protocol

Feasibility & Acceptability of a Virtual Sister Circle Intervention for Black Women With Depressive Symptoms

Start: Sep 2022Est. completion: Apr 202330 patients

N/ACompleted

NCT05461599 Angeles TherapeuticsSparkRx Mobile App

Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology

Start: Aug 2022Est. completion: May 20232 patients

N/ATerminated

NCT05191277 EppendorfTreatment 'discontinuation of antidepressant medication'

Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation

Start: Aug 2022Est. completion: Nov 202556 patients

N/AActive Not Recruiting

NCT05051995 EppendorfOpen-label placebo

Combined N-of-1 Trials to Assess Open-Label Placebo Treatment for Antidepressant Discontinuation Symptoms

Start: Feb 2022Est. completion: May 202425 patients

N/ACompleted

NCT04889508 LabcorpSocio-emotional mental training

Investigating Differential Effects of Online Mental Training Interventions on Mental Well-being and Social Cohesion

Start: May 2021Est. completion: Mar 2022285 patients

N/ACompleted

NCT04986969 Angeles TherapeuticsOnline cognitive behavioral therapy

Online Cognitive Behavioral Therapy for Depressive Symptoms in Rural Patients with Cardiac Disease

Start: Apr 2021Est. completion: Aug 2024444 patients

N/ACompleted

NCT04815681 Precision BioSciencesCommon Elements Toolbox

Evaluating an Online Wellness Intervention for Greek Adolescents

Start: Mar 2021Est. completion: Dec 20220

N/AWithdrawn

NCT04863300 Young BioPharmaCollaborative stepped care and peer support

Collaborative Stepped-Care and Productive Ageing Program for Older People With Depressive Symptoms

Start: Jan 2020Est. completion: Jun 20245,239 patients

N/ACompleted

NCT03795480 EppendorfMOOD

Online Intervention for Depression: MOOD

Start: May 2018Est. completion: Jul 2018128 patients

N/ACompleted

NCT03478527 EppendorfVivomixx® powder

Probiotics, Brain Structure and Psychological Variables

Start: Jan 2018Est. completion: Jan 202159 patients

N/ACompleted

NCT04111887 Oregon TherapeuticsGroup-based therapy

Pilot Study Comparing Two Versions of Group Cognitive-behavioral Indicated Prevention Programs

Start: Oct 2017Est. completion: Dec 201891 patients

N/ACompleted

NCT02986126 Angeles TherapeuticsResiliency Class

Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities)

Start: May 2017Est. completion: Nov 2019265 patients

N/AUnknown

NCT02986945 Angeles TherapeuticsResiliency App

Community-Partnered Participatory Development of Mobile Interventions

Start: Dec 2016Est. completion: Mar 201730 patients

N/ACompleted

NCT04551794 EppendorfSelfapy with therapeutic guidance

Different Levels of Guidance in iCBT for Depression (RCT)

Start: Aug 2016Est. completion: Dec 2016126 patients

N/ACompleted

NCT03906682 Human BioSciencesRAP Club

Improving Mental Health and School Performance in Urban Eighth Graders

Start: Jul 2016Est. completion: Aug 2021615 patients

N/ACompleted

NCT01698047 Angeles TherapeuticsResiliency Class

Building Resiliency and Increasing Community Hope

Start: Oct 2012Est. completion: Jun 2014168 patients

N/ACompleted

NCT00618566 Oregon TherapeuticsWPD and Depression Treatment Group

Group Therapy Program for Women With Physical Disabilities

Start: Oct 2007Est. completion: Sep 201282 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 8,222 patients

15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.