Depressive Symptoms

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Prevail TherapeuticsNY - New York

1 program

Atomoxetine HydrochloridePhase 41 trial

Active Trials

NCT00485862Completed214Est. Jan 2005

LundbeckDenmark - Copenhagen

1 program

RasagilinePhase 41 trial

Active Trials

NCT01055379Completed121Est. Jul 2012

ViiV HealthcareNC - Durham

1 program

paroxetine versus duloxetinePhase 2/3

EppendorfGermany - Hamburg

7 programs

MOODN/A1 trial

Metacognitive Training for Depression in Later LifeN/A1 trial

Metacognitive Training-Silver BeWellN/A1 trial

Open-label placeboN/A1 trial

Selfapy with therapeutic guidanceN/A1 trial

+2 more programs

Active Trials

NCT03795480Completed128Est. Jul 2018

NCT05640492Unknown120Est. Dec 2024

NCT06312241Unknown40Est. Dec 2025

+4 more trials

Angeles TherapeuticsCA - Los Angeles

6 programs

Online cognitive behavioral therapyN/A1 trial

Resiliency AppN/A1 trial

Resiliency ClassN/A1 trial

Sister Circle protocolN/A1 trial

+1 more programs

Active Trials

NCT04986969Completed444Est. Aug 2024

NCT02986945Completed30Est. Mar 2017

NCT01698047Completed168Est. Jun 2014

+3 more trials

Oregon TherapeuticsFrance - Paris

2 programs

Group-based therapyN/A1 trial

WPD and Depression Treatment GroupN/A1 trial

Active Trials

NCT04111887Completed91Est. Dec 2018

NCT00618566Completed82Est. Sep 2012

Young BioPharmaMA - Lowell

1 program

Collaborative stepped care and peer supportN/A1 trial

Active Trials

NCT04863300Completed5,239Est. Jun 2024

Precision BioSciencesDURHAM, NC

1 program

Common Elements ToolboxN/A1 trial

Active Trials

NCT04815681Withdrawn0Est. Dec 2022

Jerusalem PharmaceuticalsIsrael - Ramallah

1 program

GOLD-Cog+N/A1 trial

Active Trials

NCT06631781Recruiting42Est. Sep 2025

Human BioSciencesWV - Martinsburg

1 program

RAP ClubN/A1 trial

Active Trials

NCT03906682Completed615Est. Aug 2021

Innovation PharmaceuticalsMA - Wakefield

1 program

Resiliency ClassN/A

LabcorpBURLINGTON, NC

1 program

Socio-emotional mental trainingN/A3 trials

Active Trials

NCT07637422Not Yet Recruiting666Est. Apr 2027

NCT07637409Not Yet Recruiting900Est. Apr 2027

NCT04889508Completed285Est. Mar 2022

GSKLONDON, United Kingdom

1 program

paroxetine versus duloxetinePHASE_2_31 trial

Active Trials

NCT00136383Completed40Est. Jun 2007

TevaIsrael - Petach Tikva

1 program

RasagilinePHASE_4

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

LundbeckRasagiline

Prevail TherapeuticsAtomoxetine Hydrochloride

GSKparoxetine versus duloxetine

LabcorpSocio-emotional mental training

EppendorfMetacognitive Training-Silver BeWell

Jerusalem PharmaceuticalsGOLD-Cog+

EppendorfMetacognitive Training for Depression in Later Life

Angeles TherapeuticsSister Circle protocol

Angeles TherapeuticsSparkRx Mobile App

EppendorfTreatment 'discontinuation of antidepressant medication'

EppendorfOpen-label placebo

LabcorpSocio-emotional mental training

Angeles TherapeuticsOnline cognitive behavioral therapy

Precision BioSciencesCommon Elements Toolbox

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 9,788 patients across 25 trials

NCT01055379 LundbeckRasagiline

Rasagiline in Cognitive-impairment Related Depression: AzileCt in COgnitive-impairment Related DepressiOn

Start: Mar 2010Est. completion: Jul 2012121 patients

Phase 4Completed

NCT00485862 Prevail TherapeuticsAtomoxetine Hydrochloride

Combination Therapy in Patients With Depression

Start: Jun 2003Est. completion: Jan 2005214 patients

Phase 4Completed

NCT00136383 GSKparoxetine versus duloxetine

Comparing Paroxetine and Duloxetine on Cardiovascular Measures

Start: Mar 2005Est. completion: Jun 200740 patients

Phase 2/3Completed

NCT07637422 LabcorpSocio-emotional mental training

Online Socio-emotional Dyad Training for Healthcare Professionals' Well-being and Social Skills, Phase II.

Start: Aug 2026Est. completion: Apr 2027666 patients

N/ANot Yet Recruiting

NCT07637409 LabcorpSocio-emotional mental training

Online Socio-emotional Dyad Training for School Teachers' Well-being and Social Skills

Start: Jun 2026Est. completion: Apr 2027900 patients

N/ANot Yet Recruiting

NCT06312241 EppendorfMetacognitive Training-Silver BeWell

Metacognitive Training-Silver BeWell in Older Adults

Start: Feb 2024Est. completion: Dec 202540 patients

N/AUnknown

NCT06631781 Jerusalem PharmaceuticalsGOLD-Cog+

Cognitive Control Mechanisms in Older Adults

Start: Feb 2024Est. completion: Sep 202542 patients

N/ARecruiting

NCT05640492 EppendorfMetacognitive Training for Depression in Later Life

Metacognitive Training in the Older Adults With Depressive Symptoms (MCT-Silver)

Start: Jan 2023Est. completion: Dec 2024120 patients

N/AUnknown

NCT04837573 Angeles TherapeuticsSister Circle protocol

Feasibility & Acceptability of a Virtual Sister Circle Intervention for Black Women With Depressive Symptoms

Start: Sep 2022Est. completion: Apr 202330 patients

N/ACompleted

NCT05461599 Angeles TherapeuticsSparkRx Mobile App

Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology

Start: Aug 2022Est. completion: May 20232 patients

N/ATerminated

NCT05191277 EppendorfTreatment 'discontinuation of antidepressant medication'

Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation

Start: Aug 2022Est. completion: Nov 202556 patients

N/ACompleted

NCT05051995 EppendorfOpen-label placebo

Combined N-of-1 Trials to Assess Open-Label Placebo Treatment for Antidepressant Discontinuation Symptoms

Start: Feb 2022Est. completion: May 202425 patients

N/ACompleted

NCT04889508 LabcorpSocio-emotional mental training

Investigating Differential Effects of Online Mental Training Interventions on Mental Well-being and Social Cohesion

Start: May 2021Est. completion: Mar 2022285 patients

N/ACompleted

NCT04986969 Angeles TherapeuticsOnline cognitive behavioral therapy

Online Cognitive Behavioral Therapy for Depressive Symptoms in Rural Patients with Cardiac Disease

Start: Apr 2021Est. completion: Aug 2024444 patients

N/ACompleted

NCT04815681 Precision BioSciencesCommon Elements Toolbox

Evaluating an Online Wellness Intervention for Greek Adolescents

Start: Mar 2021Est. completion: Dec 20220

N/AWithdrawn

NCT04863300 Young BioPharmaCollaborative stepped care and peer support

Collaborative Stepped-Care and Productive Ageing Program for Older People With Depressive Symptoms

Start: Jan 2020Est. completion: Jun 20245,239 patients

N/ACompleted

NCT03795480 EppendorfMOOD

Online Intervention for Depression: MOOD

Start: May 2018Est. completion: Jul 2018128 patients

N/ACompleted

NCT03478527 EppendorfVivomixx® powder

Probiotics, Brain Structure and Psychological Variables

Start: Jan 2018Est. completion: Jan 202159 patients

N/ACompleted

NCT04111887 Oregon TherapeuticsGroup-based therapy

Pilot Study Comparing Two Versions of Group Cognitive-behavioral Indicated Prevention Programs

Start: Oct 2017Est. completion: Dec 201891 patients

N/ACompleted

NCT02986126 Angeles TherapeuticsResiliency Class

Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities)

Start: May 2017Est. completion: Nov 2019265 patients

N/AUnknown

NCT02986945 Angeles TherapeuticsResiliency App

Community-Partnered Participatory Development of Mobile Interventions

Start: Dec 2016Est. completion: Mar 201730 patients

N/ACompleted

NCT04551794 EppendorfSelfapy with therapeutic guidance

Different Levels of Guidance in iCBT for Depression (RCT)

Start: Aug 2016Est. completion: Dec 2016126 patients

N/ACompleted

NCT03906682 Human BioSciencesRAP Club

Improving Mental Health and School Performance in Urban Eighth Graders

Start: Jul 2016Est. completion: Aug 2021615 patients

N/ACompleted

NCT01698047 Angeles TherapeuticsResiliency Class

Building Resiliency and Increasing Community Hope

Start: Oct 2012Est. completion: Jun 2014168 patients

N/ACompleted

NCT00618566 Oregon TherapeuticsWPD and Depression Treatment Group

Group Therapy Program for Women With Physical Disabilities

Start: Oct 2007Est. completion: Sep 201282 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 9,788 patients

15 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.