Major Depressive Disorder
Pipeline by Development Stage
On Market (22)
Approved therapies currently available
Competitive Landscape
39 companies ranked by most advanced pipeline stage
+9 more companies
Trial Timeline
Clinical trial activity over time
Showing 15 of 50 trials with date data
Clinical Trials (50)
Total enrollment: 6,498 patients across 50 trials
A 2-year Study of Patients With Schizophrenia Who Are Treated With Long-acting Injectable Risperidone.
A Study of the Effects of Risperidone and Olanzapine on Blood Glucose (Sugar) in Patients With Schizophrenia or Schizoaffective Disorder
Pharmacokinetic Study of Aprepitant in BEP Treatment of Patients With Testis Carcinoma (A-BEP)
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
A Study to Assess the Treatment of Schizophrenia With Paliperidone Palmitate in Rwandan Healthcare Settings
Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion
Leveraging EEG for Antidepressant Prediction With Sertraline and Escitalopram
Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)
Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes
Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment
Brainsway DTMS for Treatment of MDD Using iTBS
A Study to Evaluate the Ability of Conducting a Study of Oral Risperidone Followed by Paliperidone Palmitate in Rwandan Healthcare Facilities
Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
Vortioxetine for Posttraumatic Stress Disorder
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder
Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy Volunteers
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
Vortioxetine for MDD, Cognition, and Systemic Inflammatory Biomarkers
Adjunctive Vortioxetine in Schizophrenia
Vortioxetine for Menopausal Depression
Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD)
Desvenlafaxine in Opioid-Dependent Patients
A Study to Evaluate the Effect of Oral Paliperidone Extended-Release and Oral Risperidone Immediate-Release on Cognitive Function in Clinically Stable Patients With Schizophrenia
A Comparative Study of Patient Satisfaction Between Continued Administration of Previous Antipsychotics Versus Switched Administration to Paliperidone ER in Non-satisfied Patients With Previous Antipsychotic Drug
Effect of Antidepressants on White Matter Structure
Oral Risperidone Versus Injectable Paliperidone Palmitate for Treating First-Episode Schizophrenia
A Comparison of the Effectiveness of Seroquel XR and Seroquel XR Plus Lithium in Patients With Acute Bipolar Mania: An Open-label, Randomized, Parallel Groups, Rater-blinded, 4 Week, Multicenter, Comparative,Study
Compare the Effect on Cognitive Functioning of Two Formulations of Seroquel, Seroquel XR and IR in Patients With Stable Schizophrenia
Twelve Month Study Comparing Paliperidone Palmitate and Select Oral Antipsychotics in Adults With Schizophrenia Who Have Been Recently Discharged From an Inpatient Psychiatric Hospital
Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolam
15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated
A Study of the Neurobiology of Depression
Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry
A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children
A Positron-Emission-Tomography (PET) Study to Measure the Blockade of Dopamine Receptors (D2) in Specific Areas of the Brain in Relation to the Plasma Concentrations of Paliperidone Extended Release (ER) and Oral Risperidone in Schizophrenia Patients and Healthy Controls
A Study of Patients With Major Depressive Disorder and Residual Apathy
Contrasting the Brain Effects of Risperidone and Invega With Functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) Scanning
28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years
Adult Bipolar Mania
Study Comparing the Tolerability of Seroquel IR With Seroquel XR in Patients With Bipolar Depression
Quetiapine Augmentation for Primary Anxiety Disorder or Mood Disorders With Co-morbid Anxiety Symptoms
Identifying Very Early Response to Seroquel Extended Release (XR) Augmentation for Major Depressive Disorder
Study Evaluating Effexor XR in Chinese Subjects With Major Depressive Disorder
Brain Imaging of Quetiapine Response in Anxious Depression
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression
Paliperidone Extended-Release (ER) Versus Risperidone for Neurocognitive Function in Patients With Schizophrenia
Study of the Efficacy and Safety of Quetiapine Fumarate Extended Release (Seroquel XR)
Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia