Keratoconus

Pipeline Programs

Companies

Clinical Trials

4 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Epion TherapeuticsMA - Burlington

2 programs

Riboflavin and Sodium Iodide solution and Ultraviolet-A treatmentPhase 31 trial

Active Trials

NCT06100952Active Not Recruiting400Est. Nov 2025

NCT06100939Active Not Recruiting400Est. Oct 2025

AbbottABBOTT PARK, IL

1 program

CrosslinkingPhase 31 trial

Active Trials

NCT02613780Unknown24Est. Jan 2019

GlaukosALISO VIEJO, CA

8 programs

Epi-on PiXLN/A1 trial

Epi-on PiXL in high oxygenN/A1 trial

Vedera KXSN/A1 trial

GLK-221 Ophthalmic SolutionPHASE_21 trial

riboflavin solutionPHASE_31 trial

+3 more programs

Active Trials

NCT03990506Completed32Est. Jan 2023

NCT04668924Unknown32Est. Feb 2026

NCT01069848Completed23Est. Mar 2011

+5 more trials

Bausch HealthQUEBEC, Quebec, Canada

3 programs

KeraSoft IC Soft Contact LensesN/A1 trial

ZenLensN/A1 trial

ZenLens™N/A1 trial

Active Trials

NCT01416272Terminated12Est. Feb 2013

NCT02806921Completed13Est. Feb 2018

NCT03249233Unknown40Est. Dec 2020

Oregon TherapeuticsFrance - Paris

3 programs

Laser Custom Corneal Collagen Cross-LinkingN/A1 trial

Optical Coherence TomographyN/A1 trial

Scleral Lens Fitting Using Wide-Field OCTN/A1 trial

Active Trials

NCT03760432Recruiting100Est. Dec 2027

NCT03504800Recruiting445Est. Feb 2031

NCT04570020Recruiting258Est. Dec 2028

Bausch + LombNJ - Bridgewater

2 programs

KeraSoft IC Soft Contact LensesN/A

ZenLensPhase N/A

Azalea TherapeuticsCA - Berkeley

2 programs

NOA lens type 1N/A1 trial

Ocular Topography and Wavefront AberrometryN/A1 trial

Active Trials

NCT07559188Not Yet Recruiting16Est. Jun 2026

NCT06859398Completed52Est. Nov 2025

Precision BioSciencesDURHAM, NC

1 program

Scleral lens wearing keratoconicsN/A1 trial

Active Trials

NCT03091101Completed8Est. Mar 2018

Thea PharmaMA - Waltham

1 program

T4020N/A1 trial

Active Trials

NCT02979054CompletedEst. Mar 2018

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

GlaukosRiboflavin 5'-Phosphate

Epion TherapeuticsRiboflavin and Sodium Iodide solution and Ultraviolet-A treatment

AbbottCrosslinking

Glaukosriboflavin solution

GlaukosGLK-221 Ophthalmic Solution

Azalea TherapeuticsNOA lens type 1

Azalea TherapeuticsOcular Topography and Wavefront Aberrometry

Oregon TherapeuticsScleral Lens Fitting Using Wide-Field OCT

GlaukosEpi-on PiXL

GlaukosEpi-on PiXL in high oxygen

Oregon TherapeuticsLaser Custom Corneal Collagen Cross-Linking

Oregon TherapeuticsOptical Coherence Tomography

Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 2,533 patients across 21 trials

NCT03245853 GlaukosRiboflavin 5'-Phosphate

Epi-On Corneal Crosslinking for Keratoconus

Start: Jul 2017Est. completion: Sep 201920 patients

Phase 4Completed

NCT06100952 Epion TherapeuticsRiboflavin and Sodium Iodide solution and Ultraviolet-A treatment

Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus

Start: Nov 2023Est. completion: Nov 2025400 patients

Phase 3Active Not Recruiting

NCT06100939 Epion TherapeuticsRiboflavin and Sodium Iodide solution and Ultraviolet-A treatment

Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

Start: Oct 2023Est. completion: Oct 2025400 patients

Phase 3Active Not Recruiting

NCT02613780 AbbottCrosslinking

Refractive Treatment of Early Keratoconus

Start: Jan 2016Est. completion: Jan 201924 patients

Phase 3Unknown

NCT01972854 Glaukosriboflavin solution

Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Nov 2013Est. completion: Apr 201792 patients

Phase 3Terminated

NCT01344187 Glaukosriboflavin solution

Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Jul 2012Est. completion: Jun 2016236 patients

Phase 3Completed

NCT01643226 Glaukosriboflavin solution

Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Jul 2012Est. completion: Sep 2016230 patients

Phase 3Completed

NCT07400952 GlaukosGLK-221 Ophthalmic Solution

Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

Start: Dec 2025Est. completion: Apr 2027100 patients

Phase 2Recruiting

NCT07559188 Azalea TherapeuticsNOA lens type 1

Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus

Start: May 2026Est. completion: Jun 202616 patients

N/ANot Yet Recruiting

NCT06859398 Azalea TherapeuticsOcular Topography and Wavefront Aberrometry

KeratoConus Data Acquisition With Topography and Aberrometry

Start: Jun 2025Est. completion: Nov 202552 patients

N/ACompleted

NCT04570020 Oregon TherapeuticsScleral Lens Fitting Using Wide-Field OCT

Scleral Lens Fitting Using Wide-Field OCT

Start: Sep 2020Est. completion: Dec 2028258 patients

N/ARecruiting

NCT03990506 GlaukosEpi-on PiXL

Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus

Start: Apr 2019Est. completion: Jan 202332 patients

N/ACompleted

NCT04668924 GlaukosEpi-on PiXL in high oxygen

Epi-on PiXL for the Treatment of Progressive Keratoconus.

Start: Mar 2019Est. completion: Feb 202632 patients

N/AUnknown

NCT03760432 Oregon TherapeuticsLaser Custom Corneal Collagen Cross-Linking

Collagen Cross-linking in Keratoconus

Start: Jun 2018Est. completion: Dec 2027100 patients

N/ARecruiting

NCT03504800 Oregon TherapeuticsOptical Coherence Tomography

OCT in Diagnosis of Irregular Corneas

Start: May 2018Est. completion: Feb 2031445 patients

N/ARecruiting

NCT03249233 Bausch HealthZenLens™

Corneal Thickness Changes With Scleral Contact Lenses

Start: Jun 2017Est. completion: Dec 202040 patients

N/AUnknown

NCT03091101 Precision BioSciencesScleral lens wearing keratoconics

Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus

Start: Mar 2017Est. completion: Mar 20188 patients

N/ACompleted

NCT02979054 Thea PharmaT4020

Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking

Start: Dec 2016Est. completion: Mar 2018

N/ACompleted

NCT02806921 Bausch HealthZenLens

Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes

Start: Aug 2016Est. completion: Feb 201813 patients

N/ACompleted

NCT01416272 Bausch HealthKeraSoft IC Soft Contact Lenses

Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses

Start: Apr 2011Est. completion: Feb 201312 patients

N/ATerminated

NCT01069848 GlaukosVedera KXS

Feasibility Study of the Vedera KXS for Treatment of Keratoconus

Start: Jan 2010Est. completion: Mar 201123 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals

4 actively recruiting trials targeting 2,533 patients

9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.