Keratoconus

6
Pipeline Programs
5
Companies
14
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
4
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Glaukos
GlaukosALISO VIEJO, CA
8 programs
1
3
1
Riboflavin 5'-PhosphatePhase 41 trial
riboflavin solutionPhase 31 trial
riboflavin solutionPhase 31 trial
riboflavin solutionPhase 31 trial
GLK-221 Ophthalmic SolutionPhase 21 trial
+3 more programs
Active Trials
NCT03990506CompletedEst. Jan 2023
NCT04668924UnknownEst. Feb 2026
NCT01069848CompletedEst. Mar 2011
+5 more trials
Abbott
AbbottABBOTT PARK, IL
1 program
1
CrosslinkingPhase 31 trial
Active Trials
NCT02613780Unknown24Est. Jan 2019
Bausch + Lomb
Bausch + LombNJ - Bridgewater
3 programs
KeraSoft IC Soft Contact LensesN/A1 trial
ZenLensN/A1 trial
ZenLens™N/A1 trial
Active Trials
NCT01416272Terminated12Est. Feb 2013
NCT02806921Completed13Est. Feb 2018
NCT03249233Unknown40Est. Dec 2020
Precision BioSciences
1 program
Scleral lens wearing keratoconicsN/A1 trial
Active Trials
NCT03091101Completed8Est. Mar 2018
Thea Pharma
Thea PharmaMA - Waltham
1 program
T4020N/A1 trial
Active Trials
NCT02979054CompletedEst. Mar 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
GlaukosRiboflavin 5'-Phosphate
AbbottCrosslinking
Glaukosriboflavin solution
Glaukosriboflavin solution
Glaukosriboflavin solution
GlaukosGLK-221 Ophthalmic Solution
GlaukosEpi-on PiXL
GlaukosEpi-on PiXL in high oxygen
Bausch + LombZenLens™
Precision BioSciencesScleral lens wearing keratoconics
Thea PharmaT4020
Bausch + LombZenLens
Bausch + LombKeraSoft IC Soft Contact Lenses
GlaukosVedera KXS

Clinical Trials (14)

Total enrollment: 97 patients across 14 trials

NCT03245853GlaukosRiboflavin 5'-Phosphate

Epi-On Corneal Crosslinking for Keratoconus

Start: Jul 2017Est. completion: Sep 2019
Phase 4Completed
NCT02613780AbbottCrosslinking

Refractive Treatment of Early Keratoconus

Start: Jan 2016Est. completion: Jan 201924 patients
Phase 3Unknown
NCT01972854Glaukosriboflavin solution

Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Nov 2013Est. completion: Apr 2017
Phase 3Terminated
NCT01643226Glaukosriboflavin solution

Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Jul 2012Est. completion: Sep 2016
Phase 3Completed
NCT01344187Glaukosriboflavin solution

Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Start: Jul 2012Est. completion: Jun 2016
Phase 3Completed
NCT07400952GlaukosGLK-221 Ophthalmic Solution

Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

Start: Dec 2025Est. completion: Apr 2027
Phase 2Recruiting
NCT03990506GlaukosEpi-on PiXL

Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus

Start: Apr 2019Est. completion: Jan 2023
N/ACompleted
NCT04668924GlaukosEpi-on PiXL in high oxygen

Epi-on PiXL for the Treatment of Progressive Keratoconus.

Start: Mar 2019Est. completion: Feb 2026
N/AUnknown
NCT03249233Bausch + LombZenLens™

Corneal Thickness Changes With Scleral Contact Lenses

Start: Jun 2017Est. completion: Dec 202040 patients
N/AUnknown
NCT03091101Precision BioSciencesScleral lens wearing keratoconics

Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus

Start: Mar 2017Est. completion: Mar 20188 patients
N/ACompleted
NCT02979054Thea PharmaT4020

Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking

Start: Dec 2016Est. completion: Mar 2018
N/ACompleted
NCT02806921Bausch + LombZenLens

Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes

Start: Aug 2016Est. completion: Feb 201813 patients
N/ACompleted
NCT01416272Bausch + LombKeraSoft IC Soft Contact Lenses

Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses

Start: Apr 2011Est. completion: Feb 201312 patients
N/ATerminated
NCT01069848GlaukosVedera KXS

Feasibility Study of the Vedera KXS for Treatment of Keratoconus

Start: Jan 2010Est. completion: Mar 2011
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 97 patients
5 companies competing in this space