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Encephalitis

6
Pipeline Programs
12
Companies
13
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
2
0
3
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
2100%
+ 13 programs with unclassified modality

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Valneva
ValnevaAustria - Vienna
2 programs
2
IC51Phase 31 trial
IC51 Japanese EncephalitisPhase 31 trial
Active Trials
NCT01047839Completed100Est. Aug 2013
NCT01041573Completed1,869Est. Jul 2011
CSL Seqirus
CSL SeqirusUK - Maidenhead
1 program
1
Immunoglobulins, IntravenousPhase 3
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
1
MVA-BN-WEVPhase 2
JPM
JPMJordan - Naour
1 program
1
MVA-BN-WEVPhase 2
Sarepta Therapeutics
1 program
1
AVI-4065 InjectionPhase 11 trial
Active Trials
NCT00381433Completed12Est. Jun 2009
Sanofi
SanofiPARIS, France
3 programs
Live attenuated Japanese encephalitis virus, then ChimeriVax diluentPHASE_21 trial
ChimeriVax-JE, Japanese Encephalitis vaccinePHASE_3Vaccine1 trial
Japanese encephalitis chimeric virus vaccinePHASE_3Vaccine4 trials
Active Trials
NCT00981175Completed202Est. Feb 2008
NCT00314132Completed2,004Est. Nov 2006
NCT02492165Completed250Est. Jun 2016
+3 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Structure of the Herpes Simplex Virus ReceptorN/A1 trial
Active Trials
NCT00001648Completed60Est. Apr 2010
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
mNGS for pathogen detectionN/A
Precision BioSciences
1 program
mNGS for pathogen detectionN/A
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
mNGS for pathogen detectionN/A1 trial
Active Trials
NCT02910037Completed214Est. Jul 2017
Bavarian Nordic
Bavarian NordicDenmark - Kvistgard
1 program
MVA-BN-WEVPHASE_21 trial
Active Trials
NCT06899802Active Not Recruiting411Est. Mar 2027
CSL Behring
CSL BehringIL - Bradley
1 program
Immunoglobulins, IntravenousPHASE_31 trial
Active Trials
NCT02308982Completed18Est. Sep 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
CSL BehringImmunoglobulins, Intravenous
SanofiJapanese encephalitis chimeric virus vaccine
SanofiJapanese encephalitis chimeric virus vaccine
ValnevaIC51 Japanese Encephalitis
SanofiJapanese encephalitis chimeric virus vaccine
ValnevaIC51
SanofiJapanese encephalitis chimeric virus vaccine
SanofiChimeriVax-JE, Japanese Encephalitis vaccine
Bavarian NordicMVA-BN-WEV
SanofiLive attenuated Japanese encephalitis virus, then ChimeriVax diluent
Sarepta TherapeuticsAVI-4065 Injection
Angeles TherapeuticsmNGS for pathogen detection
Allergy TherapeuticsStructure of the Herpes Simplex Virus Receptor

Clinical Trials (13)

Total enrollment: 6,310 patients across 13 trials

NCT02308982CSL BehringImmunoglobulins, Intravenous

Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis

Start: Jan 2016Est. completion: Sep 202218 patients
Phase 3Completed
NCT02492165SanofiJapanese encephalitis chimeric virus vaccine

Study of a Single Primary Dose Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV®) in Healthy Subjects

Start: Jun 2015Est. completion: Jun 2016250 patients
Phase 3Completed
NCT01396512SanofiJapanese encephalitis chimeric virus vaccine

Study of a Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV™) Compared to CD.JEVAX™ in Toddlers

Start: Jul 2011Est. completion: Jun 2013274 patients
Phase 3Completed
NCT01041573ValnevaIC51 Japanese Encephalitis

Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population

Start: Mar 2010Est. completion: Jul 20111,869 patients
Phase 3Completed
NCT01092507SanofiJapanese encephalitis chimeric virus vaccine

A Study of Japanese Encephalitis Chimeric Virus Vaccine Compared With SA14-14-2 Vaccine in Infants and Toddlers

Start: Mar 2010Est. completion: Oct 2011300 patients
Phase 3Completed

Immunogenicity and Safety of the Japanese Encephalitis Vaccine IC51 (IXIARO®, JESPECT®) in a Pediatric Population in Non-endemic Countries

Start: Jan 2010Est. completion: Aug 2013100 patients
Phase 3Completed
NCT01001988SanofiJapanese encephalitis chimeric virus vaccine

Long-term Follow-up of Immunogenicity of a Single Dose of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Toddlers

Start: Aug 2009Est. completion: Oct 2013596 patients
Phase 3Completed
NCT00314132SanofiChimeriVax-JE, Japanese Encephalitis vaccine

Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis.

Start: Oct 2005Est. completion: Nov 20062,004 patients
Phase 3Completed

A Phase 2 Trial in Healthy Adult Participants of the Recombinant MVA-BN-WEV Vaccine

Start: Mar 2025Est. completion: Mar 2027411 patients
Phase 2Active Not Recruiting
NCT00981175SanofiLive attenuated Japanese encephalitis virus, then ChimeriVax diluent

A Study of ChimeriVax™-JE Live Attenuated Vaccine in Healthy Adults

Start: Apr 2003Est. completion: Feb 2008202 patients
Phase 2Completed

Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid

Start: Sep 2006Est. completion: Jun 200912 patients
Phase 1Completed
NCT02910037Angeles TherapeuticsmNGS for pathogen detection

Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort

Start: Jun 2016Est. completion: Jul 2017214 patients
N/ACompleted
NCT00001648Allergy TherapeuticsStructure of the Herpes Simplex Virus Receptor

Structure of the Herpes Simplex Virus Receptor

Start: Aug 1997Est. completion: Apr 201060 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.