COVID-19

Infectious Diseases
158
Pipeline Programs
30
Companies
50
Clinical Trials
3 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
41
7
49
18
37
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2041%
Monoclonal Antibody
1633%
RNA Therapeutic
714%
Vaccine
612%
+ 158 programs with unclassified modality

On Market (2)

Approved therapies currently available

U
REBIFApproved
interferon beta-1a
Unknown Company
Interferon beta [EPC]subcutaneous2002
GS
VEKLURYApproved
remdesivir
Gilead Sciences
SARS-CoV-2 Nucleotide Analog RNA Polymerase Inhibitor [EPC]intravenous2020

Competitive Landscape

86 companies ranked by most advanced pipeline stage

GS
12 programs
3
7
1
ObeldesivirPhase 3Small Molecule1 trial
ObeldesivirPhase 3Small Molecule2 trials
ObeldesivirPhase 3Small Molecule
RDVPhase 32 trials
RDVPhase 3
+7 more programs
Active Trials
NCT05175339Completed26Est. Nov 2023
NCT04582266Completed54Est. Apr 2022
NCT05996744Terminated3Est. Feb 2024
+11 more trials
Moderna
7 programs
2
2
2
mRNA-1273Phase 4RNA Therapeutic1 trial
mRNA-1283.251 Variant-containing FormulationPhase 4RNA Therapeutic1 trial
mRNA-1083Phase 3RNA Therapeutic1 trial
mRNA-1283.222Phase 3RNA Therapeutic1 trial
mRNA-1273Phase 1RNA Therapeutic1 trial
+2 more programs
Active Trials
NCT05765578Completed1,713Est. Jun 2024
NCT04283461Completed120Est. Apr 2022
NCT04785144Completed135Est. Jul 2022
+4 more trials
Providence Therapeutics
1
HydroxychloroquinePhase 41 trial
The Measurement of Chemicals in Exhaled Breath Can Identify If a Person is Infected with COVID-19N/A1 trial
Active Trials
NCT06571136RecruitingEst. Feb 2025
NCT04334967SuspendedEst. May 2022
Bayer
2 programs
1
1
Rivaroxaban 10 mgPhase 41 trial
RivaroxabanPhase 21 trial
Active Trials
NCT04416048Terminated111Est. Jul 2021
NCT04757857Terminated660Est. Aug 2022
Pfizer
10 programs
3
1
1
nirmatrelvirPhase 3Small Molecule1 trial
PF-06650833Phase 21 trial
PF-07321332Phase 11 trial
PF-07817883Phase 11 trial
PF-07817883Phase 11 trial
+5 more programs
Active Trials
NCT04880447Completed1,075Est. Apr 2022
NCT04848584Completed1Est. Apr 2025
NCT06085924Completed8,252,912Est. Feb 2025
+7 more trials
Allergy Therapeutics
4
1
2
BamlanivimabPhase 3Monoclonal Antibody
Interferon beta-1aPhase 31 trial
Ad26.COV2.SPhase 1/21 trial
ChAdV68-SPhase 11 trial
Double-Blind NT-I7Phase 11 trial
+4 more programs
Active Trials
NCT04394884WithdrawnEst. Feb 2022
NCT04776317CompletedEst. Sep 2023
NCT04501796TerminatedEst. Feb 2023
+3 more trials
Invivyd
InvivydNEW HAVEN, CT
7 programs
2
2
2
VYD222Phase 31 trial
VYD2311-SDPhase 31 trial
ADG20Phase 2/31 trial
ADG20Phase 2/31 trial
VYD222Phase 11 trial
+2 more programs
Active Trials
NCT06004128No Longer Available
NCT05791318Completed30Est. May 2024
NCT06523153Active Not Recruiting40Est. May 2025
+4 more trials
AbCellera
6 programs
1
2
1
1
BamlanivimabPhase 3Monoclonal Antibody
LY3819253Phase 2/3
BamlanivimabPhase 2Monoclonal Antibody
BamlanivimabPhase 2Monoclonal Antibody
LY3819253Phase 1
+1 more programs
AstraZeneca
6 programs
1
1
2
AZD 1222Phase 31 trial
AZD7442Phase 35 trials
AZD1222Phase 1/25 trials
AZD9838Phase 11 trial
EvusheldN/A1 trial
+1 more programs
Active Trials
NCT06156982Completed397Est. Jan 2024
NCT05222750Completed41,200,246Est. May 2023
NCT05252442Completed7,641,136Est. Jul 2023
+12 more trials
Walvax Biotechnology
3
1
1
1
SARS-CoV-2 mRNA VaccinePhase 3RNA Therapeutic1 trial
202-CoV low adjuvant dosePhase 21 trial
ZR-202-CoVPhase 1/21 trial
202-CoV low adjuvant dosePhase 11 trial
RQ3013Phase 11 trial
+1 more programs
Active Trials
NCT04982068UnknownEst. Jun 2023
NCT05394012UnknownEst. Jun 2023
NCT05396573UnknownEst. Jul 2023
+3 more trials
Brii Biosciences
3
2
1
BRII-196Phase 31 trial
BRII-196 and BRII-198Phase 21 trial
BRII-196 and BRII-198Phase 21 trial
BRII-196Phase 11 trial
BRII-196 and BRII-198Phase 11 trial
+1 more programs
Active Trials
NCT04479631CompletedEst. Jan 2021
NCT04691180CompletedEst. Sep 2021
NCT04479644CompletedEst. Feb 2021
+3 more trials
Grifols
GrifolsNEW YORK, NY
6 programs
5
1
C19-IG 20%Phase 31 trial
Convalescent anti-SARS-CoV-2 MBT PlasmaPhase 21 trial
GAMUNEX-CPhase 21 trial
Intravenous Immune GlobulinPhase 21 trial
Liquid Alpha1-Proteinase InhibitorPhase 21 trial
+1 more programs
Active Trials
NCT04547127CompletedEst. Feb 2021
NCT04480424CompletedEst. Oct 2021
NCT04432324CompletedEst. Mar 2021
+3 more trials
Verona Pharma
4 programs
3
Acetylsalicylic acidPhase 31 trial
Bamlanivimab EtesevimabPhase 3Monoclonal Antibody1 trial
SotrovimabPhase 3Monoclonal Antibody1 trial
NETosis markersN/A1 trial
Active Trials
NCT04412382Unknown100Est. Dec 2021
NCT04808895Unknown204Est. Aug 2021
NCT05205759Terminated319Est. Apr 2022
+1 more trials
Vicore Pharma
Vicore PharmaSweden - Stockholm
3 programs
1
1
C21Phase 31 trial
C21Phase 21 trial
C21N/A1 trial
Active Trials
NCT04878913Completed35Est. Aug 2021
NCT04452435Completed206Est. Oct 2020
NCT04880642Completed272Est. Apr 2022
Molecular Partners
Molecular PartnersSchlieren-Zurich, Switzerland
3 programs
1
1
1
MP0420Phase 31 trial
ensovibepPhase 2/31 trial
EnsovibepPhase 11 trial
Active Trials
NCT04870164Terminated53Est. Jan 2022
NCT04828161Terminated407Est. Jan 2022
NCT05780463Completed485Est. Jun 2023
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
3 programs
1
1
1
QLS1128Phase 31 trial
QLS1128Phase 21 trial
QLS1128 A-Dose 1~5 and RitonavirPhase 1Small Molecule1 trial
Active Trials
NCT05458076UnknownEst. Sep 2022
NCT05689203UnknownEst. Feb 2023
NCT05758519UnknownEst. Jun 2023
Atea Pharmaceuticals
2
1
RO7496998Phase 3
AT-527Phase 2
AT-527Phase 21 trial
Active Trials
NCT04396106TerminatedEst. Feb 2022
Vir Biotechnology
Vir BiotechnologyCA - San Francisco
3 programs
2
1
VIR-7831Phase 31 trial
BamlanivimabPhase 2Monoclonal Antibody
SotrovimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05124210Terminated8Est. Jun 2023
NCT05780281Completed367Est. Oct 2022
Sanofi
3 programs
1
2
EnoxaparinPhase 35 trials
NVX-CoV2705Phase 31 trial
Sanofi-GSK monovalentPhase 21 trial
Active Trials
NCT05518487Completed15Est. Nov 2024
NCT05819112Terminated14,799Est. Dec 2023
NCT04492254Terminated219Est. Nov 2021
+4 more trials
Celltrion
CelltrionKorea - Incheon
2 programs
1
1
CT-P63 and CT-P66 / PlaceboPhase 31 trial
InfliximabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT04922827CompletedEst. Jul 2023
NCT05224856Withdrawn0Est. Jan 2023
AbbVie
2 programs
1
1
ArtesunatePhase 31 trial
Lopinavir/Ritonavir 400 mg/100 mgPhase 21 trial
Active Trials
NCT04372628Completed452Est. Jan 2022
NCT04330690Unknown2,900Est. May 2024
Hamilton medical
1
Convalescent plasmaPhase 31 trial
Active Trials
NCT04348656TerminatedEst. Jun 2021
Pulse Biosciences
Pulse BiosciencesCA - Hayward
1 program
1
INOpulsePhase 31 trial
Active Trials
NCT04421508TerminatedEst. Jan 2021
Vigonvita
VigonvitaChina - Suzhou
1 program
1
JT001Phase 31 trial
Active Trials
NCT05341609CompletedEst. May 2022
Fulcrum Therapeutics
1 program
1
Losmapimod oral tabletPhase 31 trial
Active Trials
NCT04511819TerminatedEst. Mar 2021
Octapharma
1 program
1
Octagam 10%Phase 31 trial
Active Trials
NCT04400058Completed207Est. Feb 2022
Regeneron
RegeneronTARRYTOWN, NY
5 programs
2
1
1
1
SarilumabPhase 2/3Monoclonal Antibody
casirivimab+imdevimabPhase 2Monoclonal Antibody1 trial
REGN10933+REGN10987 combination therapyPhase 1/21 trial
Casirivimab and Imdevimab Antibody CocktailPhase 11 trial
casirivimab+imdevimabPhase 1Monoclonal Antibody1 trial
Active Trials
NCT05157997Withdrawn0Est. Jan 2025
NCT05092581Terminated2Est. Jun 2022
NCT04426695Completed2,252Est. Oct 2021
+1 more trials
Boehringer Ingelheim
1
2
BI 767551 intravenousPhase 2/31 trial
BI 767551 intravenousPhase 2/31 trial
BI 764198Phase 21 trial
Pulmonary function testsN/A1 trial
Active Trials
NCT04416100Unknown130Est. Apr 2022
NCT04604184Terminated133Est. May 2021
NCT04822701Terminated5Est. Oct 2021
+1 more trials
ImmunityBio
ImmunityBioSAN DIEGO, CA
4 programs
2
1
1
hAd5-S-Fusion+N-ETSDPhase 2/31 trial
AAHI-SC2 VaccinePhase 1/2Vaccine1 trial
N-803Phase 11 trial
hAd5-S-Fusion+N-ETSD vaccinePhase 1Vaccine1 trial
Active Trials
NCT04385849Terminated1Est. Jul 2020
NCT04591717Completed34Est. Jan 2023
NCT05370040Terminated60Est. Mar 2024
+1 more trials
T-Therapeutics
3 programs
1
1
chloroquinePhase 2/31 trial
Dental pulp mesenchymal stem cellsPhase 11 trial
duration infectiousnessN/A1 trial
Active Trials
NCT05346042Active Not RecruitingEst. Dec 2025
NCT04302519UnknownEst. Jul 2021
NCT04333628TerminatedEst. Sep 2020

+56 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
ModernamRNA-1273
ModernamRNA-1283.251 Variant-containing Formulation
AstraZenecaAZD1222
AstraZenecaAZD1222
BayerRivaroxaban 10 mg
Providence TherapeuticsHydroxychloroquine
SanofiEnoxaparin
SanofiEnoxaparin
SanofiEnoxaparin
SanofiEnoxaparin
InvivydVYD2311-SD
SanofiNVX-CoV2705
ModernamRNA-1083
InvivydVYD222
ModernamRNA-1283.222

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 450,678 patients across 50 trials

Effectiveness of mRNA-1273 Variant-Containing Vaccine Formulation Against Severe Outcomes in Adults Aged 50-64 Years Without Risk Factors for Severe COVID-19

Start: Dec 2025Est. completion: Aug 2026285,000 patients
Phase 4Active Not Recruiting
NCT07089706ModernamRNA-1283.251 Variant-containing Formulation

A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Variant-containing Formulations

Start: Jul 2025Est. completion: May 2026832 patients
Phase 4Recruiting

A Study of AZD1222, a Vaccine for the Prevention of COVID-19 in Immunocompromised Adults

Start: Jan 2022Est. completion: Apr 202334 patients
Phase 4Terminated

Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death

Start: Aug 2021Est. completion: Sep 202275,012 patients
Phase 4Completed
NCT04757857BayerRivaroxaban 10 mg

COVID-19 Antithrombotic Rivaroxaban Evaluation

Start: Sep 2020Est. completion: Aug 2022660 patients
Phase 4Terminated

Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care

Start: Mar 2020Est. completion: May 2022
Phase 4Suspended

Ischemia Driven Enoxaparin Therapy in ACS Presenting as Low Risk (IDEAL)

Start: Aug 2007Est. completion: Aug 200911 patients
Phase 4Terminated

HENOX: Enoxaparine in Hemodialysis

Start: May 2006Est. completion: Jun 2007100 patients
Phase 4Completed

Enoxaparin in Acute Venous Thromboembolic Disease

Start: Dec 2004Est. completion: Jan 2009251 patients
Phase 4Completed

Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)

Start: Dec 1999Est. completion: Nov 2004200 patients
Phase 4Completed

Study of VYD2311 for the Prevention of COVID-19

Start: Jan 2026Est. completion: Jun 20261,770 patients
Phase 3Recruiting

Safety and Immunogenicity of NVX-CoV2705

Start: Oct 2025Est. completion: Jun 2026676 patients
Phase 3Active Not Recruiting

Study to Investigate the Immunogenicity, Reactogenicity, and Safety of mRNA-1083 Vaccine (SARS-CoV-2 [COVID-19] and Influenza) in Adults ≥50 Years of Age

Start: Nov 2024Est. completion: Nov 20252,457 patients
Phase 3Completed

A Study to Investigate the Prevention of COVID-19 WithVYD222 in Adults with Immune Compromise and in Participants Aged 12 Years or Older Who Are At Risk of Exposure to SARS-CoV-2

Start: Sep 2023Est. completion: Nov 2024790 patients
Phase 3Completed
NCT05815498ModernamRNA-1283.222

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

Start: Mar 2023Est. completion: Apr 202514,246 patients
Phase 3Completed

A Study to Compare QLS1128 With Placebo in Symptomatic Participants With Mild to Moderate COVID-19

Start: Mar 2023Est. completion: Jun 2023
Phase 3Unknown

Study of Obeldesivir in Nonhospitalized Participants With COVID-19

Start: Feb 2023Est. completion: Jan 20242,011 patients
Phase 3Completed

Study of Obeldesivir in Participants With COVID-19 Who Have a High Risk of Developing Serious or Severe Illness

Start: Nov 2022Est. completion: Nov 2023468 patients
Phase 3Terminated

Efficacy and Safety of JT001 (VV116) Compared With Paxlovid

Start: Apr 2022Est. completion: May 2022
Phase 3Completed
NCT05224856CelltrionCT-P63 and CT-P66 / Placebo

To Evaluate the Safety and Efficacy of Inhaled CT-P63 and CT-P66 Combination Therapy in Symptomatic Patients With COVID-19 Not Requiring Supplemental Oxygen

Start: Apr 2022Est. completion: Jan 20230
Phase 3Withdrawn
NCT05261139Pfizernirmatrelvir

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

Start: Mar 2022Est. completion: Jul 2026160 patients
Phase 3Recruiting

Non-inferiority Trial on Treatments in Early COVID-19

Start: Mar 2022Est. completion: Oct 2023536 patients
Phase 3Completed
NCT05205759Verona PharmaBamlanivimab Etesevimab

Non-inferiority Trial on Monoclonal Antibodies in COVID-19

Start: Dec 2021Est. completion: Apr 2022319 patients
Phase 3Terminated

A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects

Start: Sep 2021Est. completion: Apr 2022272 patients
Phase 3Completed

Incidence of COVID-19 Following Vaccination in Botswana Against SARS CoV 2

Start: Sep 2021Est. completion: Dec 202210,888 patients
Phase 3Completed
NCT04847102Walvax BiotechnologySARS-CoV-2 mRNA Vaccine

A Phase III Clinical Study of a SARS-CoV-2 Messenger Ribonucleic Acid (mRNA) Vaccine Candidate Against COVID-19 in Population Aged 18 Years and Above

Start: Jul 2021Est. completion: May 2023
Phase 3Unknown

MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

Start: Jun 2021Est. completion: Jun 2023485 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of C19-IG 20% in SARS-CoV-2 Infected Asymptomatic Ambulatory Outpatients

Start: Apr 2021Est. completion: Dec 2021
Phase 3Terminated

ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

Start: Apr 2021Est. completion: Nov 2022473 patients
Phase 3Completed
NCT04808895Verona PharmaAcetylsalicylic acid

Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients With COVID-19

Start: Apr 2021Est. completion: Aug 2021204 patients
Phase 3Unknown

Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19)

Start: Mar 2021Est. completion: May 2022249 patients
Phase 3Terminated

AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

Start: Feb 2021Est. completion: Jun 20231,455 patients
Phase 3Completed

Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults

Start: Jan 2021Est. completion: Oct 2022910 patients
Phase 3Completed

BRII-196/BRII-198 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

Start: Dec 2020Est. completion: Oct 2022
Phase 3Completed

VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

Start: Dec 2020Est. completion: Oct 2022367 patients
Phase 3Completed

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Post- Exposure Prophylaxis of COVID-19 in Adults

Start: Dec 2020Est. completion: Jul 20221,131 patients
Phase 3Completed

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.

Start: Nov 2020Est. completion: Dec 20235,197 patients
Phase 3Completed

Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients

Start: Oct 2020Est. completion: Nov 2021219 patients
Phase 3Terminated

Study to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of Coronavirus Disease 2019 (COVID-19) in an Outpatient Setting

Start: Sep 2020Est. completion: May 2021584 patients
Phase 3Terminated

AZD1222 Vaccine for the Prevention of COVID-19

Start: Sep 2020Est. completion: May 20220
Phase 3Withdrawn

Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults

Start: Aug 2020Est. completion: Feb 202332,450 patients
Phase 3Completed
NCT04511819Fulcrum TherapeuticsLosmapimod oral tablet

Losmapimod Safety and Efficacy in COVID-19

Start: Aug 2020Est. completion: Mar 2021
Phase 3Terminated

Adaptive COVID-19 Treatment Trial 3 (ACTT-3)

Start: Aug 2020Est. completion: Dec 2020
Phase 3Completed

A Study to Assess Pulsed Inhaled Nitric Oxide vs Placebo in Subjects With Mild or Moderate COVID-19

Start: Jul 2020Est. completion: Jan 2021
Phase 3Terminated

Octagam 10% Therapy in COVID-19 Patients With Severe Disease Progression

Start: Jun 2020Est. completion: Feb 2022207 patients
Phase 3Completed

Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial

Start: Mar 2020Est. completion: May 20242,900 patients
Phase 3Unknown

Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Moderate Coronavirus Disease (COVID-19) Compared to Standard of Care Treatment

Start: Mar 2020Est. completion: Jun 20201,113 patients
Phase 3Completed
NCT04348656Hamilton medicalConvalescent plasma

CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)

Start: Mar 2020Est. completion: Jun 2021
Phase 3Terminated

Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19)

Start: Mar 2020Est. completion: Jun 20204,891 patients
Phase 3Completed

Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Elective Knee Replacement Surgery

Start: Jul 2008Est. completion: May 20091,150 patients
Phase 3Completed

Related Jobs in Infectious Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

37 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 450,678 patients
30 companies competing in this space