Arthritis

Pipeline Programs

Companies

Clinical Trials

1 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody

2100%

+ 34 programs with unclassified modality

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

StrykerCA - San Jose

6 programs

VitagelPhase 41 trial

Foot and Ankle DevicesN/A1 trial

INBONE™ Total Ankle Prosthesis with Long Talar StemN/A1 trial

Knee ReplacementN/A1 trial

Triathlon CS Knee System with all-polyethylene tibial componentsN/A1 trial

+1 more programs

Active Trials

NCT04118894Terminated119Est. Jul 2023

NCT01641848Terminated1Est. Dec 2012

NCT02905097Unknown100Est. Aug 2024

+3 more trials

PfizerNEW YORK, NY

5 programs

tanezumabPhase 3Monoclonal Antibody1 trial

tanezumab 10 mgPhase 31 trial

MethotrexateN/A1 trial

Mobile ApplicationN/A1 trial

Active Trials

NCT01414257Completed2,860Est. Mar 2014

NCT02822521Completed190Est. Sep 2025

NCT00733902Completed697Est. Jan 2010

+2 more trials

Sharp TherapeuticsPA - Pittsburgh

2 programs

Golimumab 50 mg SCPhase 3

Blood Draws for Serum TitersN/A

MSDIreland - Ballydine

2 programs

Golimumab 50 mg SCPhase 31 trial

Blood Draws for Serum TitersN/A1 trial

Active Trials

NCT00573651Completed43Est. Oct 2014

NCT01004432Completed433Est. Oct 2013

AbbVieNORTH CHICAGO, IL

2 programs

intra-articular botulinum toxin type aPhase 31 trial

Botulinum Toxin Type APhase 21 trial

Active Trials

NCT00211679Unknown40Est. Jun 2007

NCT00211718Unknown40Est. Jun 2007

BioSurface TechnologiesMT - Bozeman

1 program

AmplexPhase 1/21 trial

Active Trials

NCT01224119Unknown24Est. Apr 2012

UNION therapeuticsDenmark - Hellerup

1 program

68Ga-FAPIPhase 11 trial

Active Trials

NCT04514614Unknown100Est. Dec 2022

Zimmer BiometFL - Jacksonville

9 programs

Anterolateral approachN/A1 trial

Comparison of ARPE Prosthesis With the LiteratureN/A1 trial

ReCap Total Hip ResurfacingN/A1 trial

ReCap Total Hip Resurfacing SystemN/A1 trial

Reverse Shoulder ArthroplastyN/A1 trial

+4 more programs

Active Trials

NCT00750984Completed49Est. Feb 2017

NCT01904019Completed100Est. May 2021

NCT00758472Terminated82Est. Mar 2010

+6 more trials

MedactaSwitzerland - Castel San Pietro

3 programs

GMK Sphere Knee ReplacementN/A1 trial

GMK Sphere cementless Knee ReplacementN/A1 trial

Hydrogel coatingN/A1 trial

Active Trials

NCT02199600Active Not Recruiting500Est. Oct 2029

NCT05003414Active Not Recruiting200Est. Dec 2032

NCT05679232Recruiting56Est. Dec 2027

Precision BioSciencesDURHAM, NC

1 program

Custom Fabricated SplintN/A1 trial

Active Trials

NCT05351060Unknown10Est. Aug 2022

Integra LifeSciencesAustralia - Clayton

1 program

HRAN/A1 trial

Active Trials

NCT02369497Terminated59Est. Jul 2014

Alliance PharmaceuticalsUK - Wiltshire

1 program

Total hip replacementN/A1 trial

Active Trials

NCT00738803Unknown100Est. Apr 2010

Innovation PharmaceuticalsMA - Wakefield

1 program

WysaN/A1 trial

Active Trials

NCT04620668Completed79Est. Oct 2022

UCB PharmaBelgium - Brussels

1 program

CDP6038PHASE_1_21 trial

Active Trials

NCT01009242Completed40Est. Sep 2010

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

StrykerVitagel

MSDGolimumab 50 mg SC

Pfizertanezumab 10 mg

Pfizertanezumab

AbbVieintra-articular botulinum toxin type a

AbbVieBotulinum Toxin Type A

BioSurface TechnologiesAmplex

UCB PharmaCDP6038

UNION therapeutics68Ga-FAPI

MedactaHydrogel coating

Precision BioSciencesCustom Fabricated Splint

Innovation PharmaceuticalsWysa

StrykerFoot and Ankle Devices

MedactaGMK Sphere cementless Knee Replacement

Showing 15 of 34 trials with date data

Clinical Trials (34)

Total enrollment: 9,005 patients across 34 trials

NCT01027286 StrykerVitagel

Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty

Start: Jul 2009Est. completion: Jun 2010108 patients

Phase 4Completed

NCT01004432 MSDGolimumab 50 mg SC

Golimumab in Rheumatoid Arthritis Participants With an Inadequate Response to Etanercept (ENBREL) or Adalimumab (HUMIRA)

Start: Dec 2009Est. completion: Oct 2013433 patients

Phase 3Completed

NCT00830063 Pfizertanezumab 10 mg

Tanezumab In Osteoarthritis Of The Knee (2)

Start: May 2009Est. completion: Aug 2010832 patients

Phase 3Completed

NCT00744471 Pfizertanezumab

Tanezumab in Osteoarthritis Of The Hip

Start: Nov 2008Est. completion: Aug 2010627 patients

Phase 3Completed

NCT00733902 Pfizertanezumab

Tanezumab in Osteoarthritis of the Knee

Start: Sep 2008Est. completion: Jan 2010697 patients

Phase 3Completed

NCT00211718 AbbVieintra-articular botulinum toxin type a

Intra-Articular Injection of Botulinum Toxin Type A for Shoulder Pain

Start: Jul 2004Est. completion: Jun 200740 patients

Phase 3Unknown

NCT00211679 AbbVieBotulinum Toxin Type A

Intra-articularInjection of Botulinum Toxin Type

Start: Jun 2004Est. completion: Jun 200740 patients

Phase 2Unknown

NCT01224119 BioSurface TechnologiesAmplex

A Study Evaluating Amplex Compared To Autograft Bone In Foot and Ankle Fusion Surgery

Start: Jan 2011Est. completion: Apr 201224 patients

Phase 1/2Unknown

NCT01009242 UCB PharmaCDP6038

To Evaluate the Blood Levels and Safety of IV and Subcutaneous CDP6038 in Subjects With Rheumatoid Arthritis Using Methotrexate

Start: Oct 2009Est. completion: Sep 201040 patients

Phase 1/2Completed

NCT04514614 UNION therapeutics68Ga-FAPI

Characterizing Rheumatoid Arthritis With 68Ga-FAPI PET/CT

Start: Sep 2020Est. completion: Dec 2022100 patients

Phase 1Unknown

NCT05679232 MedactaHydrogel coating

Hydrogel Coating to Reduce Post-surgical Infection After Joint Arthroplasty

Start: Dec 2022Est. completion: Dec 202756 patients

N/ARecruiting

NCT05351060 Precision BioSciencesCustom Fabricated Splint

Novel Splinting Technique Using 3D Models

Start: May 2022Est. completion: Aug 202210 patients

N/AUnknown

NCT04620668 Innovation PharmaceuticalsWysa

Can Mental Health Chatbots Help Chronic Disease Populations?

Start: Oct 2021Est. completion: Oct 202279 patients

N/ACompleted

NCT04118894 StrykerFoot and Ankle Devices

Wright Foot & Ankle Post-Market Observational Study

Start: Jan 2020Est. completion: Jul 2023119 patients

N/ATerminated

NCT05003414 MedactaGMK Sphere cementless Knee Replacement

The Medacta International GMK Sphere Cementless Post-Marketing Surveillance Study

Start: Jan 2020Est. completion: Dec 2032200 patients

N/AActive Not Recruiting

NCT02905097 StrykerKnee Replacement

Post-marketing Surveillance Study of the Triathlon Tritanium Baseplate

Start: Jan 2018Est. completion: Aug 2024100 patients

N/AUnknown

NCT03058380 Zimmer BiometStated-Preferences Evaluation Instrument

Stated-Preferences in Knee Arthroplasty

Start: Aug 2017Est. completion: Jun 2018348 patients

N/ACompleted

NCT02822521 PfizerMobile Application

A Novel Mobile App & Population Management System to Manage Rheumatoid Arthritis Flares

Start: Nov 2016Est. completion: Sep 2025190 patients

N/ACompleted

NCT04358575 StrykerTriathlon CS Knee System with all-polyethylene tibial components

Migration and Survival of All-polyethylene Tibial All Poly Components Compared to the Metal-backed Modular Components of the Triathlon CS Total Knee System. A Single Center RSA Study

Start: Feb 2014Est. completion: Apr 202560 patients

N/ACompleted

NCT01904019 Zimmer BiometComparison of ARPE Prosthesis With the Literature

Comparison of ARPE Prosthesis With the Literature

Start: Apr 2013Est. completion: May 2021100 patients

N/ACompleted

NCT01884077 Zimmer BiometReverse Shoulder Arthroplasty

Total vs. Reverse Shoulder Replacement: Pain Relief Two Years After Surgery

Start: Nov 2012Est. completion: Jun 201619 patients

N/ATerminated

NCT02199600 MedactaGMK Sphere Knee Replacement

The Medacta International GMK Sphere Post-Marketing Surveillance Study

Start: Oct 2012Est. completion: Oct 2029500 patients

N/AActive Not Recruiting

NCT01469806 Zimmer BiometZimmer Gender Solutions PFJ Knee Prosthesis

Patello-Femoral Joint Post Market Clinical Follow-up Within the Knee Registry

Start: Nov 2011Est. completion: Oct 20230

N/AWithdrawn

NCT01414257 PfizerMethotrexate

Methotrexate (Rheumatrex) High Dose Special Investigation (Regulatory Post Marketing Commitment Plan)

Start: May 2011Est. completion: Mar 20142,860 patients

N/ACompleted

NCT01641848 StrykerINBONE™ Total Ankle Prosthesis with Long Talar Stem

INBONE™ Total Ankle Prosthesis With Long Talar Stem

Start: Dec 2010Est. completion: Dec 20121 patients

N/ATerminated

NCT01285024 StrykerVitagel

A Prospective Study to Evaluate the Effectiveness of a Haemostatic Agent in Primary Unilateral Total Hip Arthroplasty

Start: Dec 2010Est. completion: Dec 2014109 patients

N/ACompleted

NCT00750984 Zimmer BiometAnterolateral approach

A Comparison of Two Different Surgical Techniques for Total Hip Resurfacing

Start: Sep 2008Est. completion: Feb 201749 patients

N/ACompleted

NCT02369497 Integra LifeSciencesHRA

Ascension® Humeral Resurfacing Arthroplasty (HRA) Follow-Up Study

Start: Dec 2007Est. completion: Jul 201459 patients

N/ATerminated

NCT00573651 MSDBlood Draws for Serum Titers

Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis

Start: Nov 2007Est. completion: Oct 201443 patients

N/ACompleted

NCT00738803 Alliance PharmaceuticalsTotal hip replacement

Restoration of Leg Length, Offset, and Center of Rotation in Total Hip Replacement

Start: Jun 2007Est. completion: Apr 2010100 patients

N/AUnknown

NCT00751673 Zimmer BiometTESS Shoulder Arthroplasty Data Collection

TESS Shoulder Arthroplasty Data Collection

Start: Jan 2006Est. completion: Oct 2019600 patients

N/ATerminated

NCT00758472 Zimmer BiometReCap Total Hip Resurfacing

ReCap Total Hip Resurfacing Prospective Data Collection

Start: Mar 2005Est. completion: Mar 201082 patients

N/ATerminated

NCT00604734 Zimmer BiometReCap Total Hip Resurfacing System

A Prospective Clinical Study On A Total Hip Resurfacing System

Start: Oct 2004Est. completion: Oct 2012280 patients

N/ACompleted

NCT00754416 Zimmer BiometS.E.S Shoulder Arthroplasty Data Collection

S.E.S Shoulder Arthroplasty Data Collection

Start: Mar 2003Est. completion: Sep 2016100 patients

N/ATerminated

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

6 late-stage (Phase 3) programs, potential near-term approvals

1 actively recruiting trials targeting 9,005 patients

16 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.