Mission Therapeutics

Mission Therapeutics

UK - Cambridge
Biotechnology1 H-1B visas (FY2023)
WebsiteLinkedInCareers Page

Focus: Small Molecules

Mission Therapeutics is a life sciences company focused on Small Molecules.

Infectious DiseasesImmunologyNeurologyGastroenterologyRespiratory
Funding Stage
PUBLIC
Open Jobs
0

Products & Portfolio (8)

6 discontinued products not shown

LITHOSTAT
acetohydroxamic acid
LOE Approaching
ORAL · TABLET
Urease Inhibitors
1983
30
PREDNISOLONE SODIUM PHOSPHATE
prednisolone sodium phosphate
Post-LOE
ORAL · SOLUTION
CLINICAL PHARMACOLOGY Naturally occurring glucocorticoids (hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties. Some of these properties reproduce the physiological actions of endogenous glucocorticosteroids, but others do not necessarily reflect any of the adrenal hormones' normal functions; they are seen only after administration of large therapeutic doses of the drug. The pharmacological effects of prednisolone which are due to its glucocorticoid properties include: promotion of gluconeogenesis; increased deposition of glycogen in the liver; inhibition of the utilization of glucose; anti-insulin activity; increased catabolism of protein; increased lipolysis; stimulation of fat synthesis and storage; increased glomerular filtration rate and resulting increase in urinary excretion of urate (creatinine excretion remains unchanged); and increased calcium excretion. Depressed production of eosinophils and lymphocytes occurs, but erythropoiesis and production of polymorphonuclear leukocytes are stimulated. Inflammatory processes (edema, fibrin deposition, capillary dilatation, migration of leukocytes and phagocytosis) and the later stages of wound healing (capillary proliferation, deposition of collagen, cicatrization) are inhibited. Prednisolone can stimulate secretion of various components of gastric juice. Suppression of the production of corticotropin may lead to suppression of endogenous corticosteroids. Prednisolone has slight mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is particularly evident in the kidney, where rapid ion exchange leads to sodium retention and hypertension. Prednisolone is rapidly and well absorbed from the gastrointestinal tract following oral administration. Prednisolone sodium phosphate oral solution produces a 14% higher peak plasma level of prednisolone which occurs 20% faster than that seen with tablets. Prednisolone is 70-90% protein-bound in the plasma, and it is eliminated from the plasma with a half-life of 2 to 4 hours. It is metabolized mainly in the liver and excreted in the urine as sulfate and glucuronide conjugates. The systemic availability, metabolism and elimination of prednisolone after administration of single weight-based doses (0.8 mg/kg) of intravenous (IV) prednisolone and oral prednisone were reported in a small study of 19 young (23 to 34 years) and 12 elderly (65 to 89 years) subjects. Results showed that the systemic availability of total and unbound prednisolone, as well as interconversion between prednisolone and prednisone were independent of age. The mean unbound fraction of prednisolone was higher, and steady-state volume o
the following conditions: 1systemic lupus erythematosusdermatomyositis (polymyositis)+11 more
2010
30
TEXACORT
hydrocortisone
Post-LOE
TOPICAL · SOLUTION
Corticosteroid Hormone Receptor Agonists
1992
30
THIOLA
tiopronin
LOE Approaching
ORAL · TABLET
Cystine Disulfide Reduction
1988
30
TINDAMAX
tinidazole
LOE Approaching
SMORAL · TABLET
2004
30
TINDAMAX
tinidazole
LOE Approaching
SMORAL · TABLET
2004
30
TINDAMAX
tinidazole
LOE Approaching
SMORAL · TABLET
2004
30
UROCIT-K
potassium citrate
LOE Approaching
ORAL · TABLET, EXTENDED RELEASE
1985
30

Pipeline & Clinical Trials

A Study to Determine the Role of Physician Gestalt in Predicting COVID-19 in Patients
All Patients Undergoing COVID 19 Specific Testing
N/A
Clinical Trials (1)
NCT04974177A Study to Determine the Role of Physician Gestalt in Predicting COVID-19 in Patients
N/A
HEAVEN CRITERIA vs Modified LEMON Score for Predicting Difficult Intubation
Intubation; Difficult or Failed
N/A
Clinical Trials (1)
NCT05954533HEAVEN CRITERIA vs Modified LEMON Score for Predicting Difficult Intubation
N/A
montelukast in treatment of ENL reaction
Erythema Nodosum Leprosum
N/A
Clinical Trials (1)
NCT00406861Montelukast in ENL Reaction
N/A
Rehabilitation exercises
Low Back Pain
N/A
Clinical Trials (1)
NCT02864732Stabilization Exercises Alone vs Stabilization Exercises Plus Neuromuscular Electrical Stimulation in People With Chronic Low Back Pain
N/A
Traditional Cardiac Rehabilitation
Cardiovascular Diseases
N/A
Clinical Trials (1)
NCT06424119Multi-Center Study of Clinical and Inflammatory Outcomes in Intensive Cardiac Rehabilitation and Traditional Cardiac Rehabilitation Programs
N/A
N/A
Clinical Trials (1)
NCT02415296Screening for Excessive Gambling Behaviors on the Internet
N/A
Hemostatic Variables In Snakebite Study
Snake Bites
N/A
Clinical Trials (1)
NCT04520282Hemostatic Variables In Snakebite Study
N/A
N/A
Clinical Trials (1)
NCT04977037A Telerehabilitation Program for SCI
N/A
Spectacles
Hyperopia
N/A
Clinical Trials (1)
NCT05538182Zimbabwe Eyecare And Learning(ZEAL):Formative Research on Hyperopia and Educational Outcomes in Primary School Children
N/A
indigenously developed ultrasound phantom
Simulation Training
N/A
Clinical Trials (1)
NCT04527120Indigenously Developed Ultrasound Phantom Model
N/A
External Focus of Attention
Stroke, Acute
N/A
Clinical Trials (1)
NCT05874661FOA on Sit to Stand in Individuals Post Stroke
N/A
Predictive Accuracy of PLR and PNR in Detecting ETIC
Trauma Injury
N/A
Clinical Trials (1)
NCT07046858Predictive Accuracy of PLR and PNR in Detecting ETIC
N/A
Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes
Coronary Artery Disease
N/A
Clinical Trials (1)
NCT05369702Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes
N/A
Elective Induction
Pregnancy Related
N/A
Clinical Trials (1)
NCT04597528Elective Induction of Labour at Thirty Nine Weeks: a Prospective Observational Study
N/A
Wound Healing
Wound Heal
N/A
Clinical Trials (1)
NCT03204851Microlyte Dressing in the Management of Wounds
N/A
Blood/saliva samples for protein/molecular analysis
Brain Injuries, Traumatic
N/A
Clinical Trials (1)
NCT00178659Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
N/A
Focus of attention
Cerebrovascular Accident
N/A
Clinical Trials (1)
NCT04696302Focus of Attention in Individuals With Stroke
N/A
Online self-administrated and anonymous survey questionnaire
Psychoactive Substances Consumption
N/A
Clinical Trials (1)
NCT02954679French Study on COgnitive Enhancement and Consumption of Psychoactive Substances Among Youth Students
N/A
Azithromycin and standard of care
Endometritis
N/A
Clinical Trials (1)
NCT01235546Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
N/A
N/A
Clinical Trials (1)
NCT02291575Improving the Quality of Private Sector Health Care in West Bengal
N/A
Vivally system stimulation
Neurogenic Bladder
N/A
Clinical Trials (1)
NCT06661057Avation Electric Stimulation System for Spinal Cord Injury Neurogenic Bladder
N/A
N/A
Clinical Trials (1)
NCT04325542Prevalence of HBV in Pregnant Women Attending Antenatal Care in Tanzania
N/A
History, examination, bite documentation, SSS scoring,Baseline labs as per institutional protocol
Snake Bite
N/A
Clinical Trials (1)
NCT07079137A Prospective Observational Study to Determine the Predictive Accuracy of Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Amongst Envenomated Patients Presenting to the Emergency Department.
N/A
Umbilical Cord Milking
Hypoxic-Ischemic Encephalopathy
N/A
Clinical Trials (1)
NCT03123081Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates
N/A
Door-to-door
HIV/AIDS
N/A
Clinical Trials (1)
NCT01459120Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
N/A
N/A
Clinical Trials (1)
NCT07213986Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction
N/A
local infiltration and TAP block
Pain, Postoperative
N/A
Clinical Trials (1)
NCT02997124Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?
N/A
N/A
Clinical Trials (1)
NCT06657274EARLY-COGN^3 - Smart Digital Solutions for EARLY Treatment of COGnitive Disability: a Neuropsychological, Neurophysiological and Neurobiological Perspective in Chronic Neurological Diseases - PNRR-MCNT2-2023-12377069
N/A
Interview
Trauma
N/A
Clinical Trials (1)
NCT04577924Pre-hospital Care Profile of Road Traffic Injury Victims- Kerala
N/A
RISK STRATIFICATION USING AIMS65 SCORE AND RDW
Upper Gastrointestinal Bleeding
N/A
Clinical Trials (1)
NCT04825977Risk Stratification of Patients Presenting With Upper Gastrointestinal Bleeding to the Emergency Department Using AIMS65 Score and Red Cell Distribution Width
N/A
Intact Umbilical Cord Milking
Preterm Infant
N/A
Clinical Trials (1)
NCT03200301Effect of Intact Umbilical Cord Milking on Neonatal and First Year Neurodevelopmental Outcomes in Very Preterm Infants.
N/A
Antivenom Snakes
Envenomation, Snakebite
N/A
Clinical Trials (1)
NCT05954806Clinical Profile and Antivenom Use in Hump-nosed Pit Viper Bites in Kerala, South India: A Review.
N/A
Clinical management informed by HIV-1 genotypic resistance testing
HIV-1-infection
N/A
Clinical Trials (1)
NCT04233242Genotype-Informed Versus Empiric Management of VirEmia
N/A
FAST BEE Stroke Education Video
Healthy
N/A
Clinical Trials (1)
NCT07440602From FAST to FAST BEE - Video-Based Stroke Mnemonic Pilot
N/A
Register follow-up
Transients and Migrants
N/A
Clinical Trials (1)
NCT04446949Maternal Health Care and Pregnancy Outcomes in Undocumented Migrant Women in Norway.
N/A
N/A
Clinical Trials (1)
NCT03498287Non-invasive CTS Device Clinical Trial
N/A
Indian version of a 'Portfolio' diet
Lifestyle Risk Reduction
N/A
Clinical Trials (1)
NCT06420817Effect of a Customised Lifestyle Medicine Strategy on Lowering Blood Lipid Levels in Indian Physicians
N/A
Water Quality Assurance Fund
Water Quality
N/A
Clinical Trials (1)
NCT06570005Evaluating a Water Quality Assurance Fund Intervention in Ghana and Kenya
N/A
20'Whole Blood ClottingTest
Coagulation Defect
N/A
Clinical Trials (1)
NCT03890016Study Comparing Modified Lee White Clotting Time Against Twenty Minute Whole Blood Clotting Test in Snakebite Victims
N/A
Motivate Aim: CHW text message reminders and counseling
Older Adults Without Any Specific Clinical Condition
N/A
Clinical Trials (1)
NCT07171164A Study to Evaluate Community-Based Measures to Increase RSV Vaccine Use Among Latino Adults
N/A
Betacarotene
Diabetes Mellitus
N/A
Clinical Trials (1)
NCT01477112Low Dose β-carotene Supplementation Diminishes Oxidative Stress in Type 2 Diabetics and Healthy Individuals
N/A
Evaluation of Feasibility of Radial Access for Primary Angioplasty and to Assess it in High Risk Sub
Primary Angioplasty
N/A
Clinical Trials (1)
NCT03488407Evaluation of Feasibility of Radial Access for Primary Angioplasty and to Assess it in High Risk Subgroups
N/A
Antibiotics, Vasopressors
Sepsis
N/A
Clinical Trials (1)
NCT07171918Prospective Observational Study to Compare REMS vs NEWS2 for Patients Presenting to the ED With Sepsis
N/A
Pre-visit prep
Epilepsy; Seizure
N/A
Clinical Trials (1)
NCT03548779North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
N/A
Ivacaftor 150 MG
Chronic Pancreatitis
N/A
Clinical Trials (1)
NCT07022327Ivacaftor Impact in an Adolescent Without a Cystic Fibrosis-Associated CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Mutation for Chronic Pancreatitis: Single-Patient Study Tracking Flare Frequency and Health Data Compared to Historical Records.
N/A
N/A
Clinical Trials (1)
NCT03775460Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum
N/A
Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a P
SNAKEBITE
N/A
Clinical Trials (1)
NCT04845022Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome
N/A
Pain Relief by Platelet-rich Plasma (PRP) Treatment
Sciatica
N/A
Clinical Trials (1)
NCT01749839Pain Relief by Platelet-rich Plasma (PRP) Treatment
N/A
N/A
Clinical Trials (1)
NCT03249454Effects of Transcutaneous Spinal Direct Current Stimulation in Incomplete Spinal Cord Injury
N/A
HIV Drug resistance testing
HIV Drug Resistance
N/A
Clinical Trials (1)
NCT03557021Impact of HIV Drug Resistance Testing, and Subsequent Change to an Individualized Therapy in Tanzania
N/A

Open Jobs (0)

No open positions listed yet. Check their careers page directly.

Interview Prep Quick Facts
Founded: 2011
Portfolio: 14 approved products, 80 clinical trials
Top TAs: Immunology, Gastroenterology, Hematology
H-1B (2023): 1 approval
Portfolio Health
LOE Approaching7 (50%)
Post-LOE7 (50%)
14 total products
Therapeutic Area Focus
Immunology
2 marketed
Hematology
1 marketed
Neurology
1 marketed
Respiratory
1 marketed
Marketed
Pipeline

Visa Sponsorship

Sponsors Work Visas
H-1B Petitions (FY2023)
1
Approved
0
Denied
100%
Rate

Source: USCIS H-1B Employer Data Hub