NDAORALTABLET, EXTENDED RELEASEPriority Review
Approved
Aug 1985
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
Priority Review
UROCIT-K (potassium citrate) by Mission Therapeutics is orally, the metabolism of absorbed citrate produces an alkaline load. First approved in 1985.
Drug data last refreshed 5h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
UROCIT-K (potassium citrate) is an oral extended-release tablet that prevents kidney stone formation by increasing urinary citrate and pH, thereby reducing the crystallization of stone-forming salts. It works by metabolizing absorbed citrate to produce an alkaline load that modifies renal handling of citrate and increases urinary potassium. The drug is indicated for patients at risk of recurrent kidney stones, particularly those with hypocitraturia or renal tubular acidosis.
$0.113MPart D
LOE ApproachingDeclining Medicare utilization and approaching loss of exclusivity signal contraction; brand teams should expect portfolio rationalization and reduced headcount.
Mechanism of Action
orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.