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Smoking

22
Pipeline Programs
23
Companies
42
Clinical Trials
3 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
1
7
0
2
9
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
1100%
+ 48 programs with unclassified modality

On Market (1)

Approved therapies currently available

BUPROPION HYDROCHLORIDEApproved
bupropion
Unknown Company
oral2014

Competitive Landscape

22 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
8 programs
1
1
2
VareniclinePhase 41 trial
vareniclinePhase 41 trial
VareniclinePhase 21 trial
NIC7-001Phase 11 trial
Brief adviceN/A
+3 more programs
Active Trials
NCT01243203Completed300Est. Nov 2011
NCT00813800Completed11Est. Feb 2011
NCT00352781Completed1,767Est. Aug 2009
+4 more trials
Human BioSciences
Human BioSciencesWV - Martinsburg
5 programs
1
2
Nicotine patchPhase 41 trial
Progesterone 200 MG Oral CapsulePhase 41 trial
Nicotine Replacement TherapyPhase 21 trial
Anti-smoking Socialization ProgramN/A1 trial
Group commitment contractN/A1 trial
Active Trials
NCT00056927Completed1,007Est. Aug 2002
NCT01311115Completed201Est. Mar 2012
NCT00341432Completed300Est. Apr 2011
+2 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
5 programs
1
1
1
2
NicotinePhase 4
bupropion SRPhase 4
NicotinePhase 3
Nicotine lower dosePhase 2
nicotinePhase 1
Enterprise Therapeutics
1 program
1
BupropionPhase 41 trial
Active Trials
NCT00846339Completed12Est. Jun 2009
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
non-smoker oral placeboPhase 41 trial
Active Trials
NCT02591238Completed68Est. Oct 2015
Shield Therapeutics
Shield TherapeuticsMA - Wellesley
1 program
1
Tobacco Tactics Web-Based InterventionPhase 31 trial
Active Trials
NCT01124110Completed232Est. Aug 2014
Prevail Therapeutics
1 program
1
BrenipatidePhase 2Peptide1 trial
Active Trials
NCT07223840Recruiting222Est. Feb 2027
Modus Therapeutics
Modus TherapeuticsSweden - Stockholm
1 program
1
LIBERTAL- a phospholipid mixturePhase 21 trial
Active Trials
NCT00317213Completed500Est. Jul 2002
MSD
MSDIreland - Ballydine
1 program
1
taranabantPhase 21 trial
Active Trials
NCT00109135Completed300Est. Jun 2005
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
taranabantPhase 2
Temple Therapeutics
Temple TherapeuticsNetherlands - Geleen
1 program
1
Cognitive-behavioral treatmentPhase 1/21 trial
Active Trials
NCT00297440Unknown80Est. Aug 2011
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
5 programs
1
BupropionPhase 11 trial
CBMEN/A1 trial
Electronic hookah vaping with nicotineN/A1 trial
Resistance TrainingN/A1 trial
Tailored CBME Therapy via TechnologyN/A1 trial
Active Trials
NCT00631020Completed34Est. Oct 2009
NCT04133376Completed33Est. May 2023
NCT01705951Unknown100Est. Dec 2013
+2 more trials
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
7 programs
Assisted referral & IVRN/A1 trial
E-cigarettes with varying concentrations of nicotine & flavorN/A1 trial
Person-centered inhibitory control trainingN/A1 trial
Physiological Responses in Tobacco ChippersN/A1 trial
Study AgentN/A1 trial
+2 more programs
Active Trials
NCT01236079Completed900Est. Jul 2016
NCT03332953Completed19Est. Jun 2018
NCT02945371Completed103Est. May 2016
+4 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
Helpers Stay Quit TrainingN/A1 trial
Repetitive transcranial magnetic stimulation, MagStim Rapid2N/A1 trial
Active Trials
NCT05641974Active Not Recruiting940Est. Feb 2027
NCT02590640Completed40Est. Sep 2019
GSK
GSKLONDON, United Kingdom
2 programs
nicotinePHASE_11 trial
bupropion SRPHASE_41 trial
Active Trials
NCT01702519Completed40Est. Mar 2012
NCT00181818Completed248Est. Dec 2003
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Brief adviceN/A1 trial
Active Trials
NCT01589211Terminated347Est. Apr 2013
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
Integrative-omics of the Disordered COPD Small Airway EpitheliumN/A1 trial
Active Trials
NCT02183818Completed42Est. Oct 2020
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
1 program
Monoamine Oxidases in Smoking Pregnant Women and NewbornsN/A1 trial
Active Trials
NCT00169390Completed59Est. Nov 2007
March Biosciences
March BiosciencesTX - Houston
1 program
Smoking Relapse PreventionN/A1 trial
Active Trials
NCT01131156Completed54Est. Jun 2010
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Smoking status as a routine vital signN/A1 trial
Active Trials
NCT00245323Completed2,000Est. Mar 2014
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Usual brand cigarettesN/A1 trial
Active Trials
NCT02600273Completed18Est. Jun 2019
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
V0018PHASE_21 trial
Active Trials
NCT02359201Completed30Est. Apr 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Human BioSciencesProgesterone 200 MG Oral Capsule
UNION therapeuticsnon-smoker oral placebo
PfizerVarenicline
Human BioSciencesNicotine patch
Pfizervarenicline
Enterprise TherapeuticsBupropion
GSKbupropion SR
Shield TherapeuticsTobacco Tactics Web-Based Intervention
Prevail TherapeuticsBrenipatide
Pierre FabreV0018
Human BioSciencesNicotine Replacement Therapy
MSDtaranabant
PfizerVarenicline
Modus TherapeuticsLIBERTAL- a phospholipid mixture
Temple TherapeuticsCognitive-behavioral treatment

Showing 15 of 42 trials with date data

Clinical Trials (42)

Total enrollment: 13,374 patients across 42 trials

NCT04783857Human BioSciencesProgesterone 200 MG Oral Capsule

Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

Start: Apr 2022Est. completion: Jun 2026279 patients
Phase 4Recruiting
NCT02591238UNION therapeuticsnon-smoker oral placebo

Melatonin in Smoke-induced Vascular Injury

Start: Jun 2015Est. completion: Oct 201568 patients
Phase 4Completed

Varenicline for Light Smokers

Start: Jan 2013Est. completion: Jun 201693 patients
Phase 4Completed

Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines

Start: Apr 2010Est. completion: Nov 2011987 patients
Phase 4Completed

Long-term Varenicline Treatment for Smoking Cessation

Start: Jan 2009Est. completion: Feb 2011101 patients
Phase 4Completed

PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration

Start: Nov 2008Est. completion: Jun 200912 patients
Phase 4Completed
NCT00181818GSKbupropion SR

Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease

Start: Oct 1999Est. completion: Dec 2003248 patients
Phase 4Completed
NCT01124110Shield TherapeuticsTobacco Tactics Web-Based Intervention

Tobacco Tactics Website for Operating Engineers

Start: Jan 2010Est. completion: Aug 2014232 patients
Phase 3Completed

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

Start: Nov 2025Est. completion: Feb 2027222 patients
Phase 2Recruiting

Assessment of V0018 1.5 mg Effect on Craving

Start: Feb 2015Est. completion: Apr 201530 patients
Phase 2Completed
NCT00341432Human BioSciencesNicotine Replacement Therapy

Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers

Start: Aug 2005Est. completion: Apr 2011300 patients
Phase 2Completed
NCT00109135MSDtaranabant

A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers (0364-007)

Start: Jan 2005Est. completion: Jun 2005300 patients
Phase 2Completed

A Study of the Efficacy and Safety of Varenicline in Japanese Smokers Motivated to Quit Smoking

Start: May 2004Est. completion: Aug 200430 patients
Phase 2Completed
NCT00317213Modus TherapeuticsLIBERTAL- a phospholipid mixture

Smoking Cessation Assistance With LIBERTAL, A Phospholipid Mixture

Start: Feb 2002Est. completion: Jul 2002500 patients
Phase 2Completed
NCT00297440Temple TherapeuticsCognitive-behavioral treatment

Exercise, Smoking Cessation and Adolescents

Start: Mar 2006Est. completion: Aug 201180 patients
Phase 1/2Unknown

A Study to Assess the Safety and Tolerability of Different Doses of PF-05402536 and PF-06413367 in Healthy Adult Smokers.

Start: Jun 2012Est. completion: Dec 2015277 patients
Phase 1Completed

A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers

Start: Mar 2012Est. completion: Mar 201240 patients
Phase 1Completed

Bupropion and Cigarette-Related Cues in Smokers

Start: Jan 2004Est. completion: Dec 200534 patients
Phase 1Completed
NCT05641974Colorado TherapeuticsHelpers Stay Quit Training

Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

Start: Dec 2022Est. completion: Feb 2027940 patients
N/AActive Not Recruiting

Effects of a Specific Substance in Smokers

Start: Feb 2020Est. completion: Dec 202560 patients
N/ARecruiting
NCT04133376Angeles TherapeuticsElectronic hookah vaping with nicotine

Electronic Hookah and Endothelial Cell Function

Start: Jan 2020Est. completion: May 202333 patients
N/ACompleted
NCT02021175Angeles TherapeuticsTailored CBME Therapy via Technology

Korean Youth Smoking Cessation Study

Start: Jun 2018Est. completion: Jan 20190
N/AWithdrawn
NCT03332953Oregon TherapeuticsE-cigarettes with varying concentrations of nicotine & flavor

Sensory Perception of Sweet Flavors in E-Cigarette

Start: Jan 2018Est. completion: Jun 201819 patients
N/ACompleted
NCT02600273Allergy TherapeuticsUsual brand cigarettes

Novel Approaches to Reducing Tobacco Related Harm

Start: Jan 2017Est. completion: Jun 201918 patients
N/ACompleted
NCT02590640Colorado TherapeuticsRepetitive transcranial magnetic stimulation, MagStim Rapid2

Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers

Start: Nov 2015Est. completion: Sep 201940 patients
N/ACompleted
NCT02183818Boehringer IngelheimIntegrative-omics of the Disordered COPD Small Airway Epithelium

Integrative-omics of the Disordered COPD Small Airway Epithelium

Start: Apr 2015Est. completion: Oct 202042 patients
N/ACompleted

Web and Mobile Smoking Cessation

Start: Feb 2015Est. completion: Aug 20181,266 patients
N/ACompleted
NCT02945371Oregon TherapeuticsPerson-centered inhibitory control training

Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life

Start: Sep 2014Est. completion: May 2016103 patients
N/ACompleted

Web and Phone Intervention to Maintain Postpartum Tobacco Abstinence

Start: Dec 2013Est. completion: May 201562 patients
N/ACompleted

Brief Intervention Study for Quitting Smoking

Start: Dec 2011Est. completion: Apr 2013347 patients
N/ATerminated
NCT01236079Oregon TherapeuticsAssisted referral & IVR

Cessation Service Use and Effectiveness for Hospitalized Smokers

Start: Dec 2011Est. completion: Jul 2016900 patients
N/ACompleted

Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk

Start: Apr 2011Est. completion: Dec 2013100 patients
N/AUnknown
NCT01237834Oregon TherapeuticsPhysiological Responses in Tobacco Chippers

Physiological Responses in Tobacco Chippers

Start: Nov 2010Est. completion: Jan 2013178 patients
N/ACompleted
NCT01311115Human BioSciencesGroup commitment contract

Using Group Commitment for Smoking Cessation

Start: Nov 2010Est. completion: Mar 2012201 patients
N/ACompleted
NCT01131156March BiosciencesSmoking Relapse Prevention

Prevention of Postpartum Smoking Relapse in Mothers of Infants in the Neonatal Intensive Care Unit (NICU)

Start: May 2009Est. completion: Jun 201054 patients
N/ACompleted

Varenicline in Bipolar Depressed Patients

Start: Jan 2009Est. completion: Feb 201111 patients
N/ACompleted

Youth Smoking Cessation: Therapy +/- "The Patch"

Start: Dec 2007Est. completion: Oct 200934 patients
N/ACompleted

Smoking Cessation Program in the Preadmission Clinic: The Use of a Teachable Moment

Start: Nov 2007Est. completion: Nov 2011300 patients
N/ACompleted
NCT00352781Pfizernicotine replacement therapy

Stop Smoking Therapy for Ontario Patients

Start: Jul 2006Est. completion: Aug 20091,767 patients
N/ACompleted
NCT00169390Mission TherapeuticsMonoamine Oxidases in Smoking Pregnant Women and Newborns

Monoamine Oxidases in Smoking Pregnant Women and Newborns

Start: Mar 2004Est. completion: Nov 200759 patients
N/ACompleted
NCT00245323Johnson & JohnsonSmoking status as a routine vital sign

Checking Smoking Status as a Routine Vital Sign: A Cluster-Randomized Trial of Its Effect on Cessation Counseling

Start: Nov 2003Est. completion: Mar 20142,000 patients
N/ACompleted
NCT00056927Human BioSciencesAnti-smoking Socialization Program

Anti-Smoking Program for Parents: Effects on Child Smoking

Start: Sep 1997Est. completion: Aug 20021,007 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 13,374 patients
23 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.