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Carpal Tunnel Syndrome

5
Pipeline Programs
11
Companies
13
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
1
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Pfizer
NEURONTINApproved
gabapentin
Pfizer
oral2002
20M Part D

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Spine BioPharma
Spine BioPharmaNY - New York
2 programs
1
Lidocaine 1.8%Phase 41 trial
Study DeviceN/A
Active Trials
NCT04245371Completed45Est. May 2023
Pfizer
PfizerNEW YORK, NY
1 program
1
1
GabapentinPhase 31 trial
Active Trials
NCT00137735Completed150Est. Dec 2006
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
Botulinum Toxin Type APhase 21 trial
Active Trials
NCT02070302Completed10Est. Feb 2016
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
neodymium permanent magnetPhase 21 trial
Active Trials
NCT00521495Unknown60Est. Aug 2009
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
6-item Carpal Tunnel Syndrome Symptoms ScaleN/A1 trial
Local Anesthetics LidocaineN/A1 trial
Active Trials
NCT05927896CompletedEst. Oct 2021
NCT04833777CompletedEst. Dec 2022
Sonex Health
Sonex HealthMN - Eagan
2 programs
Carpal Tunnel ReleaseN/A1 trial
UltraGuideCTRN/A1 trial
Active Trials
NCT05031338Terminated411Est. Aug 2022
NCT06071468Active Not Recruiting2,000Est. Dec 2027
PAVmed
PAVmedNY - New York
1 program
CarpX DeviceN/A1 trial
Active Trials
NCT03747510Completed20Est. Dec 2019
Combined Therapeutics
1 program
Conservative ApproachN/A1 trial
Active Trials
NCT06060314Completed60Est. Sep 2022
Relief Therapeutics
Relief TherapeuticsSwitzerland - Geneva
1 program
Interossei Lumbricals Neuro InterfaceN/A1 trial
Active Trials
NCT02101294Completed31Est. Jul 2008
Eusol Biotech
Eusol BiotechTaiwan - Taipei
1 program
Sono-guided injection with ES135N/A1 trial
Active Trials
NCT06328166Completed24Est. May 2025
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
1 program
Study DeviceN/A1 trial
Active Trials
NCT03498287Completed88Est. Apr 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Spine BioPharmaLidocaine 1.8%
PfizerGabapentin
AbbVieBotulinum Toxin Type A
Oregon Therapeuticsneodymium permanent magnet
Eusol BiotechSono-guided injection with ES135
Sonex HealthUltraGuideCTR
Combined TherapeuticsConservative Approach
Sonex HealthCarpal Tunnel Release
City TherapeuticsLocal Anesthetics Lidocaine
City Therapeutics6-item Carpal Tunnel Syndrome Symptoms Scale
PAVmedCarpX Device
Mission TherapeuticsStudy Device
Relief TherapeuticsInterossei Lumbricals Neuro Interface

Clinical Trials (13)

Total enrollment: 2,899 patients across 13 trials

NCT04245371Spine BioPharmaLidocaine 1.8%

Lidocaine Patch 1.8% for Moderate to Severe Pain From Carpal Tunnel Syndrome

Start: Feb 2020Est. completion: May 202345 patients
Phase 4Completed
NCT00137735PfizerGabapentin

Gabapentin for Carpal Tunnel Syndrome

Start: Oct 2003Est. completion: Dec 2006150 patients
Phase 3Completed
NCT02070302AbbVieBotulinum Toxin Type A

BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome

Start: Oct 2014Est. completion: Feb 201610 patients
Phase 2Completed
NCT00521495Oregon Therapeuticsneodymium permanent magnet

Carpal Tunnel Syndrome and Static Magnetic Field Therapy

Start: Sep 2006Est. completion: Aug 200960 patients
Phase 2Unknown
NCT06328166Eusol BiotechSono-guided injection with ES135

The Effect and Safety of Recombinant Fibroblast Growth Factor-1 for Carpal Tunnel Syndrome

Start: Mar 2024Est. completion: May 202524 patients
N/ACompleted
NCT06071468Sonex HealthUltraGuideCTR

Registry of the Patient Experience for Carpal Tunnel Release

Start: Jan 2024Est. completion: Dec 20272,000 patients
N/AActive Not Recruiting
NCT06060314Combined TherapeuticsConservative Approach

Comparison of Efficacy Between Conservative Versus Operative Management of Carpel Tunnel Syndrome

Start: Mar 2022Est. completion: Sep 202260 patients
N/ACompleted
NCT05031338Sonex HealthCarpal Tunnel Release

Carpal Tunnel Release Using Ultrasound

Start: Jul 2021Est. completion: Aug 2022411 patients
N/ATerminated
NCT04833777City TherapeuticsLocal Anesthetics Lidocaine

Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?

Start: Jul 2021Est. completion: Dec 2022
N/ACompleted
NCT05927896City Therapeutics6-item Carpal Tunnel Syndrome Symptoms Scale

Reliability and Validity of the Turkish Version of the 6-item Carpal Tunnel Syndrome Symptoms Scale

Start: Apr 2021Est. completion: Oct 2021
N/ACompleted
NCT03747510PAVmedCarpX Device

PAVmed CarpX Device Clinical Study

Start: Jan 2019Est. completion: Dec 201920 patients
N/ACompleted
NCT03498287Mission TherapeuticsStudy Device

Non-invasive CTS Device Clinical Trial

Start: Oct 2018Est. completion: Apr 202088 patients
N/ACompleted
NCT02101294Relief TherapeuticsInterossei Lumbricals Neuro Interface

Study Protocol for CTS and Keyboard Controlled Randomized Trial

Start: Jan 1997Est. completion: Jul 200831 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.