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Brain Injuries, Traumatic

4
Pipeline Programs
12
Companies
15
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Defence Therapeutics
Defence TherapeuticsBC - Vancouver
1 program
1
7.5% Hypertonic Saline in 6% Dextran-70Phase 31 trial
Active Trials
NCT00316004Terminated1,331Est. Jan 2010
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
CannabidiolPhase 21 trial
Active Trials
NCT05632627Completed43Est. Jul 2025
Neuren Pharmaceuticals
Neuren PharmaceuticalsAustralia - Camberwell
2 programs
2
NNZ-2566Phase 11 trial
NNZ-2566Phase 11 trial
Active Trials
NCT01420042Completed24Est. Sep 2012
NCT00961779Completed39Est. Sep 2010
BrainScope
BrainScopeMD - Bethesda
5 programs
BrainScope Ahead 200iDN/A1 trial
BrainScope Ahead 200iDN/A1 trial
BrainScope Ahead 200iDN/A1 trial
BrainScope Ahead 300iPN/A1 trial
BrainScope Ahead 300iPN/A1 trial
Active Trials
NCT02661633Completed177Est. Jul 2017
NCT02957461Completed420Est. Mar 2018
NCT02477943Completed520Est. Jul 2017
+2 more trials
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
Morning Bright Light TherapyN/A1 trial
TIPS InterventionN/A
Active Trials
NCT03578003Recruiting200Est. Dec 2026
Connect Biopharma
Connect BiopharmaSAN DIEGO, CA
1 program
Blood/saliva samples for protein/molecular analysisN/A1 trial
Active Trials
NCT00178659Active Not Recruiting260Est. Dec 2030
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
1 program
Blood/saliva samples for protein/molecular analysisN/A
Syneos Health
Syneos HealthNC - Morrisville
1 program
I-PAS GogglesN/A1 trial
Active Trials
NCT03515967Withdrawn0Est. Apr 2019
Alliance Pharmaceuticals
1 program
Medical Care and Resource FacilitationN/A1 trial
Active Trials
NCT03429322Completed415Est. Dec 2022
Innovation Pharmaceuticals
1 program
Spatial Navigation InterventionN/A1 trial
Active Trials
NCT04331392Recruiting84Est. Feb 2027
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
TIPS InterventionN/A1 trial
Active Trials
NCT03867968Completed132Est. Mar 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Defence Therapeutics7.5% Hypertonic Saline in 6% Dextran-70
Colorado TherapeuticsCannabidiol
Neuren PharmaceuticalsNNZ-2566
Neuren PharmaceuticalsNNZ-2566
Human BioSciencesTIPS Intervention
Alliance PharmaceuticalsMedical Care and Resource Facilitation
Innovation PharmaceuticalsSpatial Navigation Intervention
BrainScopeBrainScope Ahead 300iP
BrainScopeBrainScope Ahead 300iP
Syneos HealthI-PAS Goggles
Oregon TherapeuticsMorning Bright Light Therapy
BrainScopeBrainScope Ahead 200iD
BrainScopeBrainScope Ahead 200iD
BrainScopeBrainScope Ahead 200iD
Connect BiopharmaBlood/saliva samples for protein/molecular analysis

Clinical Trials (15)

Total enrollment: 4,222 patients across 15 trials

NCT00316004Defence Therapeutics7.5% Hypertonic Saline in 6% Dextran-70

Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)

Start: May 2006Est. completion: Jan 20101,331 patients
Phase 3Terminated
NCT05632627Colorado TherapeuticsCannabidiol

Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial

Start: Apr 2023Est. completion: Jul 202543 patients
Phase 2Completed
NCT01420042Neuren PharmaceuticalsNNZ-2566

Safety Study of NNZ-2566 in Healthy Subjects, Following Oral Administration

Start: Feb 2012Est. completion: Sep 201224 patients
Phase 1Completed
NCT00961779Neuren PharmaceuticalsNNZ-2566

Safety Study of NNZ-2566 in Healthy Female Subjects

Start: Mar 2010Est. completion: Sep 201039 patients
Phase 1Completed
NCT03867968Human BioSciencesTIPS Intervention

Traumatic Brain Injury Positive Strategies

Start: Feb 2019Est. completion: Mar 2020132 patients
N/ACompleted
NCT03429322Alliance PharmaceuticalsMedical Care and Resource Facilitation

Medical and Resource Facilitation Intervention After Traumatic Brain Injury

Start: Jan 2019Est. completion: Dec 2022415 patients
N/ACompleted
NCT04331392Innovation PharmaceuticalsSpatial Navigation Intervention

Online Memory Intervention for Individuals with Traumatic Brain Injury

Start: Oct 2018Est. completion: Feb 202784 patients
N/ARecruiting
NCT03671083BrainScopeBrainScope Ahead 300iP

Validation of Brain Function Assessment Algorithm for mTBI/Concussion

Start: Oct 2018Est. completion: Mar 2019309 patients
N/ACompleted
NCT03963804BrainScopeBrainScope Ahead 300iP

Objective Brain Function Assessment of mTBI/Concussion

Start: Jun 2018Est. completion: Mar 2019268 patients
N/ACompleted
NCT03515967Syneos HealthI-PAS Goggles

Testing Mild Traumatic Brain Injury (mTBI) in Diverse Athletic Groups

Start: Mar 2018Est. completion: Apr 20190
N/AWithdrawn
NCT03578003Oregon TherapeuticsMorning Bright Light Therapy

Morning Bright Light to Improve Sleep Quality in Veterans

Start: Aug 2017Est. completion: Dec 2026200 patients
N/ARecruiting
NCT02957461BrainScopeBrainScope Ahead 200iD

Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes

Start: Feb 2017Est. completion: Mar 2018420 patients
N/ACompleted
NCT02661633BrainScopeBrainScope Ahead 200iD

Objective Brain Function Assessment of mTBI/Concussion in High School Athletes

Start: Jan 2016Est. completion: Jul 2017177 patients
N/ACompleted
NCT02477943BrainScopeBrainScope Ahead 200iD

Objective Brain Function Assessment of mTBI/Concussion in College Athletes

Start: Aug 2015Est. completion: Jul 2017520 patients
N/ACompleted
NCT00178659Connect BiopharmaBlood/saliva samples for protein/molecular analysis

Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)

Start: Jul 2004Est. completion: Dec 2030260 patients
N/AActive Not Recruiting

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 4,222 patients
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.