Cardiovascular Diseases

33
Pipeline Programs
29
Companies
50
Clinical Trials
5 recruiting
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
0
3
0
3
22
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
6100%
+ 51 programs with unclassified modality

On Market (10)

Approved therapies currently available

Bayer
8-HOUR BAYERApproved
aspirin
Bayer
oral1965
Bayer
BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAINApproved
aspirin
Bayer
oral2001
U
DURLAZAApproved
aspirin
Unknown Company
oral2015
U
EMPAGLIFLOZINApproved
empagliflozin
Unknown Company
oral
Boehringer Ingelheim
JARDIANCEApproved
empagliflozin
Boehringer Ingelheim
Sodium-Glucose Cotransporter 2 Inhibitor [EPC]oral2014
Bayer
MEASURINApproved
aspirin
Bayer
oral1965
Boehringer Ingelheim
MICARDISApproved
telmisartan
Boehringer Ingelheim
Angiotensin 2 Receptor Blocker [EPC]oral1998
U
PRASUGREL HYDROCHLORIDEApproved
prasugrel
Unknown Company
oral2023
U
RALOXIFENE HYDROCHLORIDEApproved
raloxifene
Unknown Company
oral2014
U
VAZALOREApproved
aspirin
Unknown Company
oral2013

Competitive Landscape

29 companies ranked by most advanced pipeline stage

M&
Merck & Co.RAHWAY, NJ
5 programs
1
2
Elbasvir / Grazoprevir Oral Tablet [Zepatier]Phase 41 trial
ezetimibe/simvastatin 10/20 mg + placeboPhase 41 trial
ErtugliflozinPhase 1Small Molecule1 trial
B-COMPASS implementationN/A
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other VariablesN/A1 trial
Active Trials
NCT00005232CompletedEst. Jul 1993
NCT04167761Completed61Est. Dec 2023
NCT03823911Completed87Est. Dec 2022
+1 more trials
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
5 programs
1
3
EmpagliflozinPhase 4Small Molecule1 trial
EmpagliflozinPhase 4Small Molecule1 trial
TelmisartanPhase 4Small Molecule1 trial
Dabigatran etexilatePhase 11 trial
The African-PREDICT StudyN/A1 trial
Active Trials
NCT03292094Active Not Recruiting1,202Est. Dec 2027
NCT01241539Completed7
NCT03485222Completed84Est. Feb 2020
+2 more trials
Bayer
BayerLEVERKUSEN, Germany
4 programs
3
AspirinPhase 41 trial
AspirinPhase 41 trial
Estradiol+MPAPhase 41 trial
Stroke Prevention and Rhythm Interventions in Atrial FibrillationN/A1 trial
Active Trials
NCT01733160Completed2,499Est. Aug 2017
NCT00272337Completed37Est. Jun 2009
NCT00272311Completed70Est. Jan 2009
+1 more trials
Rhythm Pharmaceuticals
3 programs
1
Managed Ventricular Pacing programmed ON/OFFPhase 41 trial
Profiling Implantable Cardiac Device Diagnostics Trends During Clinical Events .N/A1 trial
Treatment armN/A1 trial
Active Trials
NCT03091959Completed200Est. Apr 2018
NCT04172883Terminated79Est. Jul 2021
NCT00293241Completed630Est. Aug 2011
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
EmpagliflozinPhase 4Small Molecule1 trial
raloxifenePhase 31 trial
Active Trials
NCT00190593Completed10,000Est. Nov 2005
NCT02792400Completed24Est. Jul 2018
DS
Daiichi SankyoChina - Shanghai
1 program
1
PrasugrelPhase 41 trial
Active Trials
NCT03296540Completed729Est. May 2021
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
SGLT2 inhibitor, GLP-1 RAPhase 41 trial
Active Trials
NCT06046560Completed200Est. Jul 2023
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
1
1
Metoprolol controlled releasePhase 31 trial
ApelinPhase 21 trial
Optimising Secondary Prevention and Quality of Life in Early Cardiac RehabilitationN/A1 trial
Primary Care Audit of Global Risk ManagementN/A1 trial
Active Trials
NCT04781699Unknown498Est. Sep 2022
NCT00950703Completed3,015Est. Sep 2015
NCT03449251Unknown170Est. Sep 2025
+1 more trials
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
1
Metoprolol controlled releasePhase 3
Bristol Myers Squibb
1 program
1
EnoxaparinPhase 21 trial
Active Trials
NCT04377997Unknown300Est. Jun 2022
Silence Therapeutics
Silence TherapeuticsGermany - Berlin
1 program
1
SLN360Phase 21 trial
Active Trials
NCT05537571CompletedEst. Jul 2024
Bial
BialPortugal - Coronado
1 program
1
400 mg of BIA 5-1058Phase 11 trial
Active Trials
NCT04069130CompletedEst. May 2019
NodThera
NodTheraPA - Philadelphia
1 program
1
NT-0796Phase 11 trial
Active Trials
NCT06129409Completed67Est. Apr 2024
HELP Therapeutics
HELP TherapeuticsChina - Nanjing
1 program
1
hiPSC-CM therapyPhase 11 trial
Active Trials
NCT04982081UnknownEst. Jul 2023
Genomics
GenomicsUK - Oxford
4 programs
AngioDefenderN/A1 trial
AngioDefenderN/A1 trial
CVD Integrated Risk TestN/A1 trial
KIF6 genetic testN/A1 trial
Active Trials
NCT02468336Completed171Est. Feb 2017
NCT02641197Completed20Est. May 2016
NCT05294419Completed862Est. Sep 2022
+1 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
B-COMPASS implementationN/A1 trial
High risk assessmentN/A1 trial
Nurse administeredN/A1 trial
Peer Coach Phone CallsN/A
Active Trials
NCT06856902Recruiting7,410Est. Dec 2025
NCT00627159Unknown375Est. Jun 2008
NCT00123058Completed777Est. Jun 2007
Alliance Pharmaceuticals
2 programs
BagelN/A1 trial
Point of CareN/A1 trial
Active Trials
NCT03624569Completed32Est. Jul 2020
NCT02598284Completed226Est. Dec 2018
Amgen
AmgenTHOUSAND OAKS, CA
2 programs
Early InterventionN/A1 trial
Quality Improvement InterventionN/A1 trial
Active Trials
NCT05325034Recruiting2,000Est. Dec 2026
NCT02851732Completed1,623Est. Sep 2018
Mission Therapeutics
Mission TherapeuticsUK - Cambridge
2 programs
Evaluation Using ClearView in Determining Association to the Cardiac Risk FactorsN/A1 trial
Traditional Cardiac RehabilitationN/A1 trial
Active Trials
NCT01740739Suspended60Est. Jun 2013
NCT06424119Recruiting450Est. Dec 2027
Abbott
AbbottABBOTT PARK, IL
2 programs
MitraClipN/A5 trials
NiacinN/A2 trials
Active Trials
NCT05455489Recruiting264Est. Aug 2029
NCT04259411Completed51Est. Mar 2025
NCT04350372Completed16Est. Oct 2020
+4 more trials
Novartis
NovartisBASEL, Switzerland
2 programs
StatinN/ASmall Molecule1 trial
The African-PREDICT StudyN/A
Active Trials
NCT05285085Completed2,133,900Est. Dec 2021
Plus Therapeutics
1 program
Abuja Heart Study: Prospective Epidemiological Investigation of Cardiovascular DiseasesN/A1 trial
Active Trials
NCT00629954UnknownEst. Nov 2016
Genomics PLC
Genomics PLCUK - Oxford
1 program
CVD Integrated Risk TestN/A
Sensydia
SensydiaCA - Los Angeles
1 program
Cardiac Performance SystemN/A1 trial
Active Trials
NCT06870591Recruiting1,000Est. May 2026
C
CordisFL - Miami Lakes
1 program
Cypher StentN/A1 trial
Active Trials
NCT00489320Completed7,759Est. Jul 2006
HM
Huadong MedicineChina - Hangzhou
1 program
MelatoninN/A1 trial
Active Trials
NCT04631341Not Yet RecruitingEst. Dec 2026
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Peer Coach Phone CallsN/A1 trial
Active Trials
NCT00948714Completed130Est. Jan 2011
Sanofi
SanofiPARIS, France
1 program
Targeted digital interventionN/A1 trial
Active Trials
NCT04584645Completed49,138Est. Apr 2021
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
The Impact of Conventional Hemodialysis and Renal Transplantation on the Global Longitudinal Strain N/A1 trial
Active Trials
NCT05685823UnknownEst. Oct 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Boehringer IngelheimEmpagliflozin
Novo NordiskSGLT2 inhibitor, GLP-1 RA
Merck & Co.Elbasvir / Grazoprevir Oral Tablet [Zepatier]
Boehringer IngelheimEmpagliflozin
Daiichi SankyoPrasugrel
AbbottMitraClip
BayerEstradiol+MPA
Merck & Co.ezetimibe/simvastatin 10/20 mg + placebo
BayerAspirin
BayerAspirin
Rhythm PharmaceuticalsManaged Ventricular Pacing programmed ON/OFF
Boehringer IngelheimTelmisartan
AbbottNiacin
AstraZenecaMetoprolol controlled release
Eli Lilly and Companyraloxifene

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 2,252,382 patients across 50 trials

Empagliflozin and Cardiac Remodelling in People Without Diabetes

Start: Apr 2021Est. completion: Jul 2022169 patients
Phase 4Completed
NCT06046560Novo NordiskSGLT2 inhibitor, GLP-1 RA

Diabetes Remote Intervention to improVe Use of Evidence-based Medications

Start: Mar 2021Est. completion: Jul 2023200 patients
Phase 4Completed
NCT03823911Merck & Co.Elbasvir / Grazoprevir Oral Tablet [Zepatier]

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

Start: Nov 2018Est. completion: Dec 202287 patients
Phase 4Completed

Are the "Cardiac Benefits" of Empagliflozin Independent of Its Hypoglycemic Activity? (ATRU-4).

Start: May 2018Est. completion: Feb 202084 patients
Phase 4Completed

CRUSHed vs. Uncrushed Prasugrel in STEMI Patients Undergoing PCI

Start: Nov 2017Est. completion: May 2021729 patients
Phase 4Completed

(MitraClip in Non-Responders to Cardiac Resynchronization Therapy)

Start: Sep 2015Est. completion: Oct 201830 patients
Phase 4Unknown
NCT01109979BayerEstradiol+MPA

Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function

Start: Dec 2009Est. completion: Jun 201624 patients
Phase 4Completed
NCT00738985Merck & Co.ezetimibe/simvastatin 10/20 mg + placebo

Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk Factors

Start: Nov 2009Est. completion: Sep 20100
Phase 4Withdrawn

Aspirin Dose and Atherosclerosis in Patients With Heart Disease

Start: Oct 2006Est. completion: Jun 200937 patients
Phase 4Completed

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Start: Oct 2006Est. completion: Jan 200970 patients
Phase 4Completed
NCT00293241Rhythm PharmaceuticalsManaged Ventricular Pacing programmed ON/OFF

PreFER Managed Ventricular Pacing (MVP) For Elective Replacement

Start: Feb 2006Est. completion: Aug 2011630 patients
Phase 4Completed

Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo.

Start: Nov 200131,546 patients
Phase 4Completed

Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia

Start: Jan 2001Est. completion: Feb 200530 patients
Phase 4Completed
NCT00182039AstraZenecaMetoprolol controlled release

POISE Trial: Perioperative Ischemic Evaluation Study

Start: Oct 2002Est. completion: Aug 20078,351 patients
Phase 3Terminated

Raloxifene Use for The Heart

Start: Jun 1998Est. completion: Nov 200510,000 patients
Phase 3Completed

Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Start: Dec 2022Est. completion: Jul 2024
Phase 2Completed

Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19

Start: May 2020Est. completion: Jun 2022300 patients
Phase 2Unknown

A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin

Start: Mar 2018Est. completion: Sep 2025170 patients
Phase 2Unknown

Effects of NT-0796 in Obese Participants at Risk of Cardiovascular Disease

Start: Oct 2023Est. completion: Apr 202467 patients
Phase 1Completed

Treating Congestive HF With hiPSC-CMs Through Endocardial Injection

Start: Sep 2021Est. completion: Jul 2023
Phase 1Unknown

Ertugliflozin: Cardioprotective Effects on Epicardial Fat

Start: Jul 2020Est. completion: Dec 202361 patients
Phase 1Completed
NCT04069130Bial400 mg of BIA 5-1058

Absorption, Distribution, Metabolism and Excretion of [14C] Labelled BIA 5-1058

Start: Jan 2019Est. completion: May 2019
Phase 1Completed

Pharmacokinetics of Dabigatran Etexilate (Pradaxa®) During Haemodialysis

Start: Nov 20107 patients
Phase 1Completed
NCT06870591SensydiaCardiac Performance System

Pivotal Study for the Cardiac Performance System (CPS)

Start: Apr 2025Est. completion: May 20261,000 patients
N/ARecruiting
NCT06856902PfizerB-COMPASS implementation

BEhavioral and Adherence Model for Improving Quality, Health Outcomes and Cost-Effectiveness of healthcaRe

Start: Mar 2025Est. completion: Dec 20257,410 patients
N/ARecruiting
NCT06424119Mission TherapeuticsTraditional Cardiac Rehabilitation

Multi-Center Study of Clinical and Inflammatory Outcomes in Intensive Cardiac Rehabilitation and Traditional Cardiac Rehabilitation Programs

Start: Apr 2024Est. completion: Dec 2027450 patients
N/ARecruiting

GISE Registry of Transcatheter Treatment of Mitral Valve Regurgitation With the MitraClip G4

Start: Jan 2023Est. completion: Aug 2029264 patients
N/ARecruiting
NCT05325034AmgenEarly Intervention

Guideline Oriented Approach To Lipid Lowering In Asia-Pacific

Start: Sep 2022Est. completion: Dec 20262,000 patients
N/ARecruiting

MitraClip China PMS

Start: Dec 2021Est. completion: Mar 202551 patients
N/ACompleted

Real World Evidence Study of Statin Use in Brazil

Start: Nov 2021Est. completion: Dec 20212,133,900 patients
N/ACompleted
NCT05294419GenomicsCVD Integrated Risk Test

The Healthcare Evaluation of Absolute Risk Testing Study

Start: Nov 2021Est. completion: Sep 2022862 patients
N/ACompleted
NCT04781699AstraZenecaOptimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation

Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation

Start: Mar 2021Est. completion: Sep 2022498 patients
N/AUnknown

Melatonin and Risk Of Cardiovascular Events And Malignant Tumors In The Elderly

Start: Jan 2021Est. completion: Dec 2026
N/ANot Yet Recruiting
NCT04584645SanofiTargeted digital intervention

A Digital Flu Intervention for People With Cardiovascular Conditions

Start: Sep 2020Est. completion: Apr 202149,138 patients
N/ACompleted

MitraClip Russia Trial

Start: Feb 2020Est. completion: Oct 202016 patients
N/ACompleted

MitraClip EXPAND G4 Study

Start: Jan 2020Est. completion: Mar 20281,164 patients
N/AActive Not Recruiting
NCT05685823T-TherapeuticsThe Impact of Conventional Hemodialysis and Renal Transplantation on the Global Longitudinal Strain

The Impact of Conventional Hemodialysis and Renal Transplantation on the Global Longitudinal Strain of the Left Ventricle

Start: Oct 2019Est. completion: Oct 2023
N/AUnknown

Management of Device Detected AT and Impact of Device Treatment Algorithms on Atrial Fibrillation

Start: Oct 2019Est. completion: Jul 202179 patients
N/ATerminated

Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure (The EVOLVE-MR Trial)

Start: Mar 2019Est. completion: May 20249 patients
N/ATerminated

Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome

Start: Aug 2018Est. completion: Jul 202032 patients
N/ACompleted

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Start: Jun 2018Est. completion: Jun 2028103 patients
N/AActive Not Recruiting

Noninferiority Trial of MitraClip Implantation Strategies: 1 Clip vs. 2 Clips in Patients With Functional Mitral Regurgitation

Start: May 2018Est. completion: Dec 20200
N/AWithdrawn

MitraClip NT System Post-marketing Surveillance Study - Japan

Start: Apr 2018Est. completion: Mar 2022500 patients
N/ACompleted
NCT03091959Rhythm PharmaceuticalsProfiling Implantable Cardiac Device Diagnostics Trends During Clinical Events .

Profiling Implantable Cardiac Device Diagnostics Trends During Clinical Events .

Start: Mar 2017Est. completion: Apr 2018200 patients
N/ACompleted

MitraClip in Acute Mitral Regurgitation

Start: Jan 2017Est. completion: Dec 202150 patients
N/ACompleted
NCT02851732AmgenQuality Improvement Intervention

Brazilian inteRvention to Increase eviDence usaGe in practicE - Cardiovascular Prevention

Start: Aug 2016Est. completion: Sep 20181,623 patients
N/ACompleted

The Role of Glucagon in the Effects of Dipeptidyl Peptidase-4 Inhibitors and Sodium-glucose Co-transporter-2 Inhibitors

Start: May 2016Est. completion: Jul 201824 patients
N/ACompleted
NCT02641197GenomicsAngioDefender

Vascular Reactivity Assessment by the AngioDefender Device -- A Precision Study

Start: Apr 2016Est. completion: May 201620 patients
N/ACompleted

Healthy Hearts in the Heartland

Start: Jan 2016Est. completion: Dec 2018226 patients
N/ACompleted
NCT02468336GenomicsAngioDefender

AngioDefender Versus Brachial Artery Ultrasound Imaging

Start: Aug 2015Est. completion: Feb 2017171 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
5 actively recruiting trials targeting 2,252,382 patients
29 companies competing in this space