Skip to main content

Cardiovascular Diseases

57
Pipeline Programs
30
Companies
50
Clinical Trials
10
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
15
0
7
0
9
26
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
11100%
+ 147 programs with unclassified modality

On Market (10)

Approved therapies currently available

Boehringer Ingelheim
JARDIANCEApproved
empagliflozin
Boehringer Ingelheim
Sodium-Glucose Cotransporter 2 Inhibitor [EPC]oral2014
8.8B Part D
Otsuka
JYNARQUEApproved
tolvaptan
Otsuka
Vasopressin V2 Receptor Antagonist [EPC]oral2018
76M Part D
Otsuka
SAMSCAApproved
tolvaptan
Otsuka
Vasopressin V2 Receptor Antagonist [EPC]oral2009
12M Part D
Merck & Co.
ZETIAApproved
ezetimibe
Merck & Co.
Dietary Cholesterol Absorption Inhibitor [EPC]oral2002
7M Part D
Otsuka
TOLVAPTANApproved
tolvaptan
Otsuka
oral2025
3M Part D
Bayer
BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAINApproved
aspirin
Bayer
oral2001
Bayer
DURLAZAApproved
aspirin
Bayer
oral2015
Bayer
MEASURINApproved
aspirin
Bayer
oral1965
Bayer
VAZALOREApproved
aspirin
Bayer
oral2013
Bayer
8-HOUR BAYERApproved
aspirin
Bayer
oral1965

Competitive Landscape

70 companies ranked by most advanced pipeline stage

Merck & Co.
Merck & Co.RAHWAY, NJ
5 programs
1
B-COMPASS implementationN/A
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other VariablesN/A
ErtugliflozinPHASE_1Small Molecule
Elbasvir / Grazoprevir Oral Tablet [Zepatier]PHASE_4
ezetimibe/simvastatin 10/20 mg + placeboPHASE_4
Sharp Therapeutics
1
3
Elbasvir / Grazoprevir Oral Tablet [Zepatier]Phase 41 trial
ezetimibePhase 41 trial
ezetimibe/simvastatin 10/20 mg + placeboPhase 41 trial
ErtugliflozinPhase 1Small Molecule1 trial
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other VariablesN/A1 trial
Active Trials
NCT00005232CompletedEst. Jul 1993
NCT04167761Completed61Est. Dec 2023
NCT03823911Completed87Est. Dec 2022
+2 more trials
MSD
5 programs
1
3
Elbasvir / Grazoprevir Oral Tablet [Zepatier]Phase 4
ezetimibePhase 4
ezetimibe/simvastatin 10/20 mg + placeboPhase 4
ErtugliflozinPhase 1Small Molecule
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other VariablesN/A
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
5 programs
1
The African-PREDICT StudyN/A
Dabigatran etexilatePHASE_11 trial
EmpagliflozinPHASE_4Small Molecule
EmpagliflozinPHASE_4Small Molecule
TelmisartanPHASE_4Small Molecule1 trial
Active Trials
NCT01241539Completed7
NCT00153101Completed31,546
Bayer
4 programs
3
AspirinPhase 41 trial
AspirinPhase 41 trial
Estradiol+MPAPhase 41 trial
Stroke Prevention and Rhythm Interventions in Atrial FibrillationN/A1 trial
Active Trials
NCT01733160Completed2,499Est. Aug 2017
NCT00272311Completed70Est. Jan 2009
NCT00272337Completed37Est. Jun 2009
+1 more trials
Prevail Therapeutics
1
2
1
EmpagliflozinPhase 4Small Molecule1 trial
EvacetrapibPhase 31 trial
raloxifenePhase 31 trial
PrasugrelPhase 21 trial
Active Trials
NCT00059215Completed905Est. Jan 2004
NCT01687998Terminated12,092Est. Jul 2016
NCT00190593Completed10,000Est. Nov 2005
+1 more trials
Medtronic
3 programs
1
Managed Ventricular Pacing programmed ON/OFFPhase 41 trial
Profiling Implantable Cardiac Device Diagnostics Trends During Clinical Events .N/A1 trial
Treatment armN/A1 trial
Active Trials
NCT03091959Completed200Est. Apr 2018
NCT04172883Terminated79Est. Jul 2021
NCT00293241Completed630Est. Aug 2011
Applied Medical
1
EmpagliflozinPhase 4Small Molecule1 trial
Active Trials
NCT04461041Completed169Est. Jul 2022
HLS Therapeutics
1
Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]Phase 41 trial
Active Trials
NCT04562467Completed70Est. May 2023
MicroPort
1 program
1
PrasugrelPhase 4
Biocorp
1 program
1
cardiomyopeptidinPhase 41 trial
Active Trials
NCT06155110Completed160Est. May 2025
Otsuka
1 program
1
tolvaptanPhase 41 trial
Active Trials
NCT01346072Completed21Est. Dec 2014
Human BioSciences
1
calciumPhase 31 trial
ARROW:identificAtion of postpRandial biomaRkers tOWards Cardiovascular PreventionN/A1 trial
D2i2N/A1 trial
Disease Risk AssessmentN/A
Active Trials
NCT03531879Completed116Est. Jun 2019
NCT02902913Completed9Est. Sep 2015
NCT00000534CompletedEst. Jun 2000
Abbott
AbbottABBOTT PARK, IL
3 programs
1
Extended release niacinPhase 31 trial
MitraClipN/A1 trial
NiacinN/A1 trial
Active Trials
NCT01772108Terminated42Est. Jan 2015
NCT01200160Completed128Est. May 2012
NCT00120289Terminated3,414Est. Dec 2012
Amarin
1 program
1
AMR101Phase 31 trial
Active Trials
NCT01492361Completed8,179Est. May 2018
Eppendorf
1 program
1
Ferric carboxymaltosePhase 31 trial
Active Trials
NCT03991000Terminated8Est. Dec 2021
LIB Therapeutics
1
lerodalcibepPhase 31 trial
Active Trials
NCT04797247Unknown900Est. Feb 2024
Medpace
1 program
1
lerodalcibepPhase 3
Dr. Reddy's Laboratories
1
polypillPhase 31 trial
Active Trials
NCT01057537Completed2,004Est. Sep 2012
Colorado Therapeutics
1
Fasudil HydrochloridePhase 21 trial
Chronic disease management Web-based softwareN/A1 trial
Coronary Artery Calcification in Type 1 DiabetesN/A1 trial
Enhanced practice transformation supportN/A1 trial
Evaluating the Effect of Neighborhood Environments on Cardiovascular Risk FactorsN/A1 trial
+6 more programs
Active Trials
NCT00608387Completed149Est. Jun 2012
NCT00005754Completed1,420Est. Jun 2008
NCT02515578Completed5,508Est. Jul 2018
+8 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
5 programs
1
2
ApelinPhase 21 trial
MEDI6012Phase 21 trial
AZD0780 tabletPhase 1
Optimising Secondary Prevention and Quality of Life in Early Cardiac RehabilitationN/A1 trial
Primary Care Audit of Global Risk ManagementN/A1 trial
Active Trials
NCT04781699Unknown498Est. Sep 2022
NCT00950703Completed3,015Est. Sep 2015
NCT03449251Unknown170Est. Sep 2025
+1 more trials
Oregon Therapeutics
1
Team-based interventionPhase 21 trial
Heat therapyN/A1 trial
Lifestyle Management for Women With CHD and NIDDMN/A1 trial
Worksite Issues in Organizational Health Promotion (Take Heart)N/A1 trial
Active Trials
NCT02518399Completed20Est. Apr 2016
NCT00005441CompletedEst. Mar 1998
NCT00005723CompletedEst. Sep 1996
+1 more trials
Cumberland Pharmaceuticals
1
Ifetroban SodiumPhase 21 trial
Active Trials
NCT03962855Completed57Est. Nov 2022
Astellas
AstellasChina - Shenyang
1 program
1
LexiscanPhase 21 trial
Active Trials
NCT03103061Completed24Est. Jun 2018
Chong Kun Dang Pharmaceutical
8
CKD-330 1 Tab. and D085 1 Tab.Phase 11 trial
CKD-385Phase 11 trial
CKD-385Phase 11 trial
Reference drugPhase 11 trial
Reference drugPhase 11 trial
+3 more programs
Active Trials
NCT04627207Unknown51Est. Apr 2021
NCT04906785Unknown52Est. Aug 2021
NCT04906798Unknown52Est. Jul 2021
+5 more trials
Boston Scientific
1
Percutaneous Coronary InterventionPhase 11 trial
Pressure GuidewireN/A1 trial
SYNERGYTM Coronary Stent SystemN/A1 trial
SYNERGYTM Stent SystemN/A1 trial
Active Trials
NCT04098172Completed39Est. Mar 2020
NCT02499692Completed103Est. Aug 2017
NCT03736226Active Not Recruiting2,000Est. Mar 2028
+1 more trials
Servier
2 programs
1
S 95010Phase 11 trial
B-COMPASS implementationN/A
Active Trials
NCT03494712Completed49Est. Apr 2019
Quotient Therapeutics
1
AZD0780 tabletPhase 11 trial
Active Trials
NCT05817461Completed8Est. Jun 2023
HD Medical
1 program
1
HD medical devicePhase 11 trial
Active Trials
NCT00507312Terminated41Est. Dec 2010
Innovation Pharmaceuticals
Cardiac rehabilitationN/A1 trial
FAITH! App digital interventionN/A1 trial
Genetic risk variantsN/A1 trial
Glucose controlN/A1 trial
Quality Improvement SupportN/A1 trial
+2 more programs
Active Trials
NCT06241534Completed45Est. May 2024
NCT03084822Completed50Est. Jun 2018
NCT05339048Enrolling By Invitation619Est. Oct 2034
+4 more trials

+40 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Applied MedicalEmpagliflozin
Novo NordiskSGLT2 inhibitor, GLP-1 RA
HLS TherapeuticsIcosapent Ethyl 1000 MG Oral Capsule [Vascepa]
Biocorpcardiomyopeptidin
Sharp TherapeuticsElbasvir / Grazoprevir Oral Tablet [Zepatier]
Prevail TherapeuticsEmpagliflozin
Daiichi SankyoPrasugrel
Otsukatolvaptan
BayerEstradiol+MPA
Sharp Therapeuticsezetimibe/simvastatin 10/20 mg + placebo
BayerAspirin
BayerAspirin
MedtronicManaged Ventricular Pacing programmed ON/OFF
Sharp Therapeuticsezetimibe
Boehringer IngelheimTelmisartan

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 104,848 patients across 50 trials

Empagliflozin and Cardiac Remodelling in People Without Diabetes

Start: Apr 2021Est. completion: Jul 2022169 patients
Phase 4Completed
NCT06046560Novo NordiskSGLT2 inhibitor, GLP-1 RA

Diabetes Remote Intervention to improVe Use of Evidence-based Medications

Start: Mar 2021Est. completion: Jul 2023200 patients
Phase 4Completed
NCT04562467HLS TherapeuticsIcosapent Ethyl 1000 MG Oral Capsule [Vascepa]

The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk

Start: Sep 2020Est. completion: May 202370 patients
Phase 4Completed
NCT06155110Biocorpcardiomyopeptidin

A Randomized, Single-blind, Controlled Clinical Study of Cardiomyopeptidin on Improving Ischemia-reperfusion Injury in Patients With Acute ST-segment Elevation Myocardial Infarction After Primary PCI

Start: Nov 2019Est. completion: May 2025160 patients
Phase 4Completed
NCT03823911Sharp TherapeuticsElbasvir / Grazoprevir Oral Tablet [Zepatier]

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

Start: Nov 2018Est. completion: Dec 202287 patients
Phase 4Completed

Are the "Cardiac Benefits" of Empagliflozin Independent of Its Hypoglycemic Activity? (ATRU-4).

Start: May 2018Est. completion: Feb 202084 patients
Phase 4Completed

CRUSHed vs. Uncrushed Prasugrel in STEMI Patients Undergoing PCI

Start: Nov 2017Est. completion: May 2021729 patients
Phase 4Completed

Pilot Study of Using Copeptin to Predict Response to Tolvaptan

Start: Apr 2011Est. completion: Dec 201421 patients
Phase 4Completed
NCT01109979BayerEstradiol+MPA

Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function

Start: Dec 2009Est. completion: Jun 201624 patients
Phase 4Completed
NCT00738985Sharp Therapeuticsezetimibe/simvastatin 10/20 mg + placebo

Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk Factors

Start: Nov 2009Est. completion: Sep 20100
Phase 4Withdrawn

Aspirin Dose and Atherosclerosis in Patients With Heart Disease

Start: Oct 2006Est. completion: Jun 200937 patients
Phase 4Completed

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Start: Oct 2006Est. completion: Jan 200970 patients
Phase 4Completed
NCT00293241MedtronicManaged Ventricular Pacing programmed ON/OFF

PreFER Managed Ventricular Pacing (MVP) For Elective Replacement

Start: Feb 2006Est. completion: Aug 2011630 patients
Phase 4Completed

Vytorin on Carotid Intima-media Thickness and Overall Rigidity

Start: Apr 2005Est. completion: Dec 200590 patients
Phase 4Completed

Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo.

Start: Nov 200131,546 patients
Phase 4Completed

Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reduction

Start: Apr 2021Est. completion: Feb 2024900 patients
Phase 3Unknown
NCT03991000EppendorfFerric carboxymaltose

Iron in Patients With Cardiovascular Disease

Start: Feb 2019Est. completion: Dec 20218 patients
Phase 3Terminated

A Study of Evacetrapib in High-Risk Vascular Disease

Start: Oct 2012Est. completion: Jul 201612,092 patients
Phase 3Terminated

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

Start: Nov 2011Est. completion: May 20188,179 patients
Phase 3Completed

UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events

Start: Jun 2010Est. completion: Sep 20122,004 patients
Phase 3Completed

Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Start: Jul 2008Est. completion: Mar 20135,614 patients
Phase 3Completed

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Start: Jun 2007Est. completion: Jan 20093,221 patients
Phase 3Completed

Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness

Start: Jun 2007Est. completion: May 20116,758 patients
Phase 3Completed

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)

Start: Mar 2007Est. completion: Sep 20095,407 patients
Phase 3Completed

Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Start: Nov 2006Est. completion: May 20083,608 patients
Phase 3Completed
NCT00120289AbbottExtended release niacin

Niacin Plus Statin to Prevent Vascular Events

Start: Sep 2005Est. completion: Dec 20123,414 patients
Phase 3Terminated
NCT00047411PhilipsCardiopulmonary Resuscitation

Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest

Start: Sep 2002Est. completion: Sep 20077,001 patients
Phase 3Completed

Raloxifene Use for The Heart

Start: Jun 1998Est. completion: Nov 200510,000 patients
Phase 3Completed

Calcium for Pre-Eclampsia Prevention (CPEP)

Start: Mar 1991Est. completion: Jun 2000
Phase 3Completed

Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Start: Dec 2022Est. completion: Jul 2024180 patients
Phase 2Completed

Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19

Start: May 2020Est. completion: Jun 2022300 patients
Phase 2Unknown

Thromboxane Receptor Antagonist to Improve Endothelial Function

Start: Sep 2019Est. completion: Nov 202257 patients
Phase 2Completed

Study to Evaluate the Effects of MEDI6012 on Apolipoprotein B100 Metabolism

Start: Jan 2019Est. completion: Aug 20207 patients
Phase 2Terminated

A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin

Start: Mar 2018Est. completion: Sep 2025170 patients
Phase 2Unknown

Red Blood Cell ATP Release and Vascular Function in Humans

Start: Jul 2017Est. completion: Oct 201831 patients
Phase 2Completed

Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System

Start: Feb 2016Est. completion: Jun 201824 patients
Phase 2Completed

A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)

Start: Apr 2003Est. completion: Jan 2004905 patients
Phase 2Completed
NCT00006181Oregon TherapeuticsTeam-based intervention

Promoting Healthy Lifestyles Among Firefighters

Start: Apr 1999Est. completion: Mar 2003600 patients
Phase 2Completed

A Study to Evaluate Safety of Single Doses of BMS-986177 in Patients With End Stage Renal Disease (ESRD) Treated With Hemodialysis

Start: May 2017Est. completion: Oct 201732 patients
Phase 1/2Completed

Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype

Start: Jun 2016Est. completion: Apr 20198 patients
Phase 1/2Terminated

Effects of NT-0796 in Obese Participants at Risk of Cardiovascular Disease

Start: Oct 2023Est. completion: Apr 202467 patients
Phase 1Completed

An ADME Study of [14C]AZD0780 in Healthy Male Subjects

Start: Apr 2023Est. completion: Jun 20238 patients
Phase 1Completed

Treating Congestive HF With hiPSC-CMs Through Endocardial Injection

Start: Sep 2021Est. completion: Jul 202320 patients
Phase 1Unknown

Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fasting Conditions

Start: Jun 2021Est. completion: Jul 202152 patients
Phase 1Unknown

Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fed Conditions

Start: Jun 2021Est. completion: Aug 202152 patients
Phase 1Unknown
NCT04627207Chong Kun Dang PharmaceuticalCKD-330 1 Tab. and D085 1 Tab.

A Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of CKD-333 or Co-administration of CKD-333 and D085 in Healthy Volunteers

Start: Nov 2020Est. completion: Apr 202151 patients
Phase 1Unknown

Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fasting Conditions

Start: Oct 2020Est. completion: Dec 202024 patients
Phase 1Unknown

Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fed Conditions

Start: Oct 2020Est. completion: Dec 202024 patients
Phase 1Unknown

Ertugliflozin: Cardioprotective Effects on Epicardial Fat

Start: Jul 2020Est. completion: Dec 202361 patients
Phase 1Completed

Clinical Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-385 in Healthy Volunteers

Start: Sep 2019Est. completion: Oct 201952 patients
Phase 1Completed

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

9 late-stage (Phase 3) programs, potential near-term approvals
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.