NDAORALTABLETPriority Review
Approved
Aug 1988
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
Priority Review
THIOLA (tiopronin) by Mission Therapeutics is cystine disulfide reduction [moa]. First approved in 1988.
Drug data last refreshed 8h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
THIOLA (tiopronin) is an oral small-molecule reducing agent approved in 1988 for cystinuria, a rare genetic disorder characterized by excessive urinary cystine excretion. It works by reducing cystine disulfide bonds to more soluble cysteine monomers, preventing kidney stone formation. The drug addresses a narrow, chronic patient population with limited treatment alternatives.
$0.003BPart D
LOE ApproachingPost-LOEDeclining market phase with modest Medicare utilization (512 claims, $3M annual spend) signals a shrinking commercial footprint and small marketing team.
Mechanism of Action
Cystine Disulfide Reduction
Pharmacologic Class:
Reducing and Complexing Thiol
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
THIOLA roles are limited and declining; zero linked job openings reflect the small, stable patient population and approaching loss of exclusivity. Career opportunities are primarily in maintaining physician relationships and reimbursement support rather than growth-driven expansion.
Brand ManagerField Sales Representative
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.