HIV/AIDS
Pipeline by Development Stage
Drug Modality Breakdown
Infectious Diseases is an $11.9B market dominated by HIV and hepatitis C treatments in their peak revenue phases, reflecting a mature but stable therapeutic area.
Key Trends
- HIV antiretroviral dominance: Nucleoside Reverse Transcriptase Inhibitors account for 44% of spending
- Patent cliff pressure: $2.8B in revenue from major products facing LOE between 2027–2031
- High trial velocity: 9,337 active trials indicate sustained pipeline development despite market maturity
Career Verdict
Infectious Diseases offers stable, well-compensated roles with strong commercial demand, but limited growth upside—ideal for risk-averse professionals seeking established franchises rather than high-growth opportunities.
AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data
Market Leaders
| # | Product | Company | Revenue | Share | Stage | Trend | LOE |
|---|---|---|---|---|---|---|---|
| 1 | BIKTARVY (bictegravir sodium, emtricitabine, and tenofovir alafenamide fumarate) | Gilead Sciences | $3.2B | 27% | Peak | Stable | 10.5yr |
| 2 | EPCLUSA (velpatasvir and sofosbuvir) | Gilead Sciences | $877M | 7% | Peak | Stable | 8.2yr |
| 3 | TIVICAY (dolutegravir sodium) | GSK | $657M | 6% | Peak | Declining | 4.1yr |
| 4 | TRIUMEQ (abacavir sulfate, dolutegravir sodium, lamivudine) | GSK | $632M | 5% | Peak | Declining | 4.1yr |
| 5 | GENVOYA (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) | Gilead Sciences | $626M | 5% | Peak | Stable | 6.9yr |
Drug Class Breakdown
backbone of HIV treatment, stable demand
hepatitis C treatment, mature market
boosting agents in combination regimens
niche mechanism, limited growth
Career Outlook
StableInfectious Diseases offers predictable career progression and above-average compensation in Commercial roles, supported by 780 current openings and sustained demand from market incumbents. However, patent cliffs affecting $2.8B in near-term revenue (2027–2031) will compress margins and slow hiring after 2028, particularly in Commercial support and field-based roles. The area is best suited for mid-career professionals seeking stability over rapid growth, with limited appeal for early-career scientists pursuing innovation-driven research.
Breaking In
Enter via Commercial or Manufacturing roles at GSK, Sanofi, or Becton Dickinson to build market expertise and commanding salaries ($160K–$237K); avoid pure R&D tracks unless you target specific mechanisms like long-acting injectables.
For Experienced Professionals
Experienced professionals should pursue Market Access, Medical Affairs, or Commercial Leadership roles where patent cliff expertise commands premium compensation; consider consulting or biotech transition if R&D innovation is your priority.
In-Demand Skills
Best For
Hiring Landscape
Infectious Diseases hiring is heavily weighted toward Commercial roles (247 positions, 32% of total), reflecting mature market dynamics focused on market access and brand management. GSK and Becton Dickinson lead hiring (214 and 188 roles), but Gilead Sciences—the market leader by revenue—shows surprisingly low hiring (25 roles), signaling efficiency-driven operations. Salary progression favors Commercial ($275K avg) over R&D ($184K avg), indicating career acceleration through sales and marketing functions.
Top Hiring Companies
By Department
Strong Commercial hiring with premium salaries suggests Infectious Diseases is an excellent landing spot for brand, sales, and market access professionals, but limited R&D hiring indicates reduced innovation investment.
Competitive Landscape
32 companies ranked by most advanced pipeline stage
+2 more companies
Trial Timeline
Clinical trial activity over time
Showing 15 of 50 trials with date data
Clinical Trials (50)
Total enrollment: 318,136 patients across 50 trials
Rapid Start vs. Standard Start Antiretroviral Therapy (ART) in HIV
DHFS for Medication Adherence Support During Hospital Admissions for Person Living With HIV
Feasibility and Acceptability of Digital Pills to Monitor PrEP Adherence in MSM With Substance Use
Evaluating the Feasibility and Acceptability of Implementing a PrEP Program in PR-CoNCRA (San Juan, Puerto Rico)- Part B
PrEPared and Strong: Clinic-Based PrEP for Black MSM
Efficacy, Acceptability and Safety of Event-driven HIV PrEP Using TAF/FTC in MSM in Thailand and France.
The Late Presenter Treatment Optimisation Study
Treatment Options for Protease Inhibitor-exposed Children
Impact of Metformin on Immuno-virologic Parameters in HIV
Darunavir/Cobicistat and Dolutegravir to Maintain Virologic Suppression and Reduce NRTI-associated Toxicity
An Integrated Intervention Using a Pill Ingestible Sensor System
INSTI's For The Management of HIV-associated TB
Safety, Tolerability and Immunogenicity of MVA.HTI and ChAdOx1.HTI With Vesatolimod in HIV-1 Positive Patients
REMUNE HIV/AIDS Vaccine Phase II Pediatric Safety & Efficacy Clinical Study
Combinatorial Therapy to Induce an HIV Remission
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)
Evaluating Distribution of a Tenofovir Douche With Tap Water Douching and Simulated Receptive Anal Intercourse
Tenofovir Rectal Douche to Prevent HIV Transmission Among Adolescents (ATN DREAM)
Tenofovir Rectal Douche to Prevent HIV Transmission
Innovative Tools to Expand HIV Self-Testing
Pharmacokinetics and Pharmacodynamics of DMPA With HIV PrEP
Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults
Study in Healthy Males to Measure Maraviroc in Blood, Saliva, Seminal Fluid, and Rectal Tissue
Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing
MyPEEPS LITE Trial
Bridges2Scale: Testing Implementation Strategies
Targeted Universal TB Testing With Simultaneous TPT Prescribing Among People Living With HIV in South Africa
Community-based, Peer-delivered PrEP for Female Sex Workers in Rural Uganda: The Peers for PrEP (P4P) Study
Oregon PrEP at Home Study
ResIlience-based Stigma REdUction Program ("Rise-up")
Tools to Identify People At Risk or Already Infected with HIV and HCV
Making PrEP Smart: An HIV Testing and PrEP Electronic Support Tool ("SmartPrEP" App) for Women on PrEP
Prevent TB: Choice Architecture for TPT Delivery
ADAPT for Adolescents Adolescents
Choice Architecture Based TB Preventive Therapy Prescribing
Simplifying Treatment and Monitoring for HIV (STREAM HIV)
Harambee: Integrated Community-based HIV/NCD Care & Microfinance Groups in Kenya
Epividian / AHF: Positive Pathways - HIV Retention in Care
Biomedical HIV/AIDS Prevention Program Yunnan
HIV Reengagement and Assessment Mobile Program (Project RAMP)
Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM
Quantification of Tenofovir Alafenamide Adherence (QUANTI-TAF)
Peer-Educator-coordinated vs Nurse-coordinated ART Refill for Adolescents and Young Adults Living With HIV in Lesotho
Comparison of Men's Prevention Apps to Research Efficacy
Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV
Youth Services Navigation Intervention for HIV+ Youth Being Released From or At-risk for Incarceration
Harm Reduction Program For Informal PrEP Users In A Community-based Setting (seguiPrEP)
Evaluation of Pre-Exposure Prophylaxis for High Risk Adolescent Girls and Young Women
Standardized Patient Encounters to Improve PrEP Counseling for Adolescent Girls and Young Women in Kenya
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
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Key Insights
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.