Inflammation

34
Pipeline Programs
9
Companies
33
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
13
0
9
0
5
7
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 32 programs with unclassified modality

On Market (5)

Approved therapies currently available

Bausch + Lomb
ALREXApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic1998
U
BROMFENAC SODIUMApproved
bromfenac
Unknown Company
ophthalmic2024
Bausch + Lomb
LOTEMAXApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic2011
Bausch + Lomb
LOTEMAX SMApproved
loteprednol etabonate
Bausch + Lomb
ophthalmic2019
U
LOTEPREDNOL ETABONATEApproved
loteprednol etabonate
Unknown Company
ophthalmic2024

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Bausch + Lomb
Bausch + LombNJ - Bridgewater
8 programs
5
2
BromfenacPhase 41 trial
Loteprednol etabonate 0.5% and tobramycin 0.3%Phase 41 trial
Loteprednol Etabonate GelPhase 31 trial
Loteprednol Etabonate GelPhase 31 trial
Loteprednol etabonatePhase 31 trial
+3 more programs
Active Trials
NCT01060787Completed98Est. Jun 2019
NCT01996839Completed514Est. Jul 2014
NCT02208297Completed326Est. Mar 2015
+5 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
18 programs
10
8
NNC 0151-0000-0000Phase 21 trial
NNC0109-0012Phase 21 trial
NNC0109-0012Phase 21 trial
NNC0109-0012Phase 21 trial
NNC0114-0006Phase 21 trial
+13 more programs
Active Trials
NCT01018238Withdrawn0Est. Nov 2009
NCT02151409Completed60Est. Oct 2009
NCT01208506Completed64Est. Feb 2012
+15 more trials
CSL Behring
CSL BehringIL - Bradley
1 program
1
ClazakizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05727384Active Not Recruiting29Est. Jul 2026
Sandoz
SandozAustria - Kundl
2 programs
2
Diclofenac Sodium 75 mg Tablets Under Fasting ConditionsPhase 11 trial
Indomethacin 75mg Extended-Release Capsules, SandozPhase 11 trial
Active Trials
NCT00913887CompletedEst. May 1994
NCT00858195CompletedEst. Jul 2006
Rhythm Pharmaceuticals
1 program
1
Vagal Nerve StimulationPhase 11 trial
Active Trials
NCT01944228Completed22Est. Oct 2013
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's GranulomatosisN/A1 trial
Active Trials
NCT00001541CompletedEst. Jan 2003
CytoSorbents
CytoSorbentsPRINCETON, NJ
1 program
CytoSorb cytokine eliminationN/A1 trial
Active Trials
NCT02606799Terminated5Est. Apr 2017
C
ColoplastAustralia - Mulgrave
1 program
tinzaparinN/A1 trial
Active Trials
NCT00135863TerminatedEst. May 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Bausch + LombBromfenac
Bausch + LombLoteprednol etabonate 0.5% and tobramycin 0.3%
Bausch + LombLoteprednol Etabonate Gel
Bausch + LombLoteprednol Etabonate Gel
Bausch + LombMapracorat
Bausch + LombLoteprednol etabonate
Bausch + LombVehicle of Loteprednol Etabonate
CSL BehringClazakizumab
Novo NordiskNNC0109-0012
Novo NordiskNNC0114-0006
Novo NordiskNNC0109-0012
Novo Nordiskcatridecacog
Novo NordiskNNC0114-0006
Novo NordiskNNC0109-0012
Novo NordiskNNC109-0012

Showing 15 of 33 trials with date data

Clinical Trials (33)

Total enrollment: 3,419 patients across 33 trials

Clinical Outcomes of Bromday (Bromfenac Ophthalmic Solution) 0.09% QD vs. Nevanac (Nepafenac Ophthalmic Suspension) 0.1%

Start: Nov 2010Est. completion: May 201123 patients
Phase 4Completed
NCT00532961Bausch + LombLoteprednol etabonate 0.5% and tobramycin 0.3%

Ocular Tolerance and Intraocular Pressure (IOP) Effects of Zylet Versus Tobradex

Start: Feb 2005Est. completion: Jun 2005310 patients
Phase 4Completed
NCT02208297Bausch + LombLoteprednol Etabonate Gel

Loteprednol Etabonate Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Start: Sep 2014Est. completion: Mar 2015326 patients
Phase 3Completed
NCT01996839Bausch + LombLoteprednol Etabonate Gel

Loteprednol Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Start: Dec 2013Est. completion: Jul 2014514 patients
Phase 3Completed

Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation Following Cataract Surgery

Start: Feb 2011Est. completion: Nov 2011177 patients
Phase 3Terminated
NCT01060072Bausch + LombLoteprednol etabonate

Evaluation of Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery

Start: Feb 2010Est. completion: Oct 2010407 patients
Phase 3Completed
NCT01010633Bausch + LombVehicle of Loteprednol Etabonate

Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery

Start: Nov 2009Est. completion: Aug 2010406 patients
Phase 3Completed

Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study

Start: Aug 2023Est. completion: Jul 202629 patients
Phase 2Active Not Recruiting

A Trial Investigating the Mechanism of Action of NNC0109-0012 (Anti-IL-20 mAb) Through Synovial Biopsies in Subjects With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Start: Sep 2014Est. completion: Sep 20150
Phase 2Withdrawn

A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy and Safety of NNC0114-0006 in Subjects With Active Crohn's Disease

Start: Feb 2013Est. completion: Dec 201453 patients
Phase 2Completed

A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Methotrexate

Start: Oct 2012Est. completion: Nov 2014298 patients
Phase 2Terminated

A Placebo-controlled Trial With rFXIII Administered to Subjects With Mild to Moderate Active Ulcerative Colitis

Start: Oct 2012Est. completion: Jul 201320 patients
Phase 2Terminated

A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0114-0006 in Subjects With Active Rheumatoid Arthritis

Start: Sep 2012Est. completion: Aug 201362 patients
Phase 2Completed

A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa Biologics

Start: Aug 2012Est. completion: Nov 2014239 patients
Phase 2Terminated

Efficacy of NNC109-0012 in Subjects With Active Rheumatoid Arthritis

Start: Feb 2011Est. completion: Jan 201267 patients
Phase 2Completed
NCT01223911Novo NordiskNNC 0151-0000-0000

A Multiple Dose Trial of NNC 0151-0000-0000 in Subjects With Rheumatoid Arthritis

Start: Jan 2011Est. completion: Feb 201334 patients
Phase 2Completed

A Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0215-0384 Administered to Subjects With Moderate to Severe Rheumatoid Arthritis

Start: Sep 2013Est. completion: Oct 201424 patients
Phase 1Completed
NCT01944228Rhythm PharmaceuticalsVagal Nerve Stimulation

Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study

Start: Aug 2013Est. completion: Oct 201322 patients
Phase 1Completed

An Investigation of Safety and Tolerability of NNC0114-0006 in Subjects With Systemic Lupus Erythematosus (SLE)

Start: Sep 2012Est. completion: Feb 201410 patients
Phase 1Terminated

First Human Dose Trial of NNC0215-0384 in Subjects With Rheumatoid Arthritis

Start: Jun 2012Est. completion: Jun 201336 patients
Phase 1Completed

Safety and Tolerability of NNC0114-0006 at Increasing Dose Levels in Subjects With Rheumatoid Arthritis

Start: Mar 2012Est. completion: Oct 201332 patients
Phase 1Completed
NCT01208506Novo NordiskNNC0114-0000-0005

First-in-Man Trial of NNC114-0005 in Healthy Subjects and Subjects With Rheumatoid Arthritis

Start: Sep 2010Est. completion: Feb 201264 patients
Phase 1Completed

Safety and Tolerability of Anti-IL-20 in Subjects With Rheumatoid Arthritis

Start: Feb 2010Est. completion: Dec 201016 patients
Phase 1Completed
NCT01018238Novo NordiskNNC 0151-0000-0000

An Investigation of NNC 0151-0000-0000 in Subjects With Systemic Lupus Erythematosus (SLE)

Start: Nov 2009Est. completion: Nov 20090
Phase 1Withdrawn

Safety and Tolerability of Anti-IL-20 in Healthy Volunteers and Patients With Rheumatoid Arthritis

Start: Dec 2008Est. completion: Jan 201032 patients
Phase 1Completed
NCT02151409Novo NordiskNNC 0151-0000-0000

Dose-escalation Trial of Anti-C5aR Antibody in Healthy Subjects

Start: Jun 2008Est. completion: Oct 200960 patients
Phase 1Completed

First Human Dose Study of Anti-IL-20 in Psoriasis: A Study of Safety, Tolerability and Early Signals of Biologic and Clinical Effects

Start: Apr 2008Est. completion: Jan 201155 patients
Phase 1Terminated
NCT00858195SandozIndomethacin 75mg Extended-Release Capsules, Sandoz

A Relative Bioavailability Study of 75mg Indomethacin Extended-Release Capsules

Start: Jun 2006Est. completion: Jul 2006
Phase 1Completed
NCT00913887SandozDiclofenac Sodium 75 mg Tablets Under Fasting Conditions

To Demonstrate the Relative Bioavailability of Diclofenac Sodium 75 mg Enteric-Coated Tablets Under Non-Fasting Conditions

Start: Apr 1994Est. completion: May 1994
Phase 1Completed
NCT02606799CytoSorbentsCytoSorb cytokine elimination

Extracorporeal Elimination of Cytokines Following Abdominal-thoracic Esophagectomy

Start: May 2016Est. completion: Apr 20175 patients
N/ATerminated
NCT01060787Bausch + LombFluocinolone Acetonide 0.59 mg

Evaluation of Corneal Endothelial Cell Density in Subjects Who Have Had a Fluocinolone Acetonide Implant

Start: Feb 2016Est. completion: Jun 201998 patients
N/ACompleted

MesoHep II: Intraperitoneal Low Molecular Weight Heparin in Peritoneal Dialysis

Start: May 2004Est. completion: May 2005
N/ATerminated
NCT00001541Allergy TherapeuticsAnalysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis

Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis

Start: Apr 1996Est. completion: Jan 2003
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs — potential near-term approvals
9 companies competing in this space